CN105477487A - 一种治疗慢性咽炎的药物及其制备方法 - Google Patents

一种治疗慢性咽炎的药物及其制备方法 Download PDF

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CN105477487A
CN105477487A CN201510984643.9A CN201510984643A CN105477487A CN 105477487 A CN105477487 A CN 105477487A CN 201510984643 A CN201510984643 A CN 201510984643A CN 105477487 A CN105477487 A CN 105477487A
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王莉
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王莉
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Abstract

本发明公开了一种治疗慢性咽炎的药物及其制备方法,其主要是由丹参、射干、生地黄、北沙参、薄荷、络石藤、牛蒡子、桔梗、玉竹、海浮石、麦冬、甘草、半夏、大青叶、石斛、金银花、胖大海、太子参、淫羊藿、牡丹皮、蝉蜕、百部、款冬花、赤芍、远志、佛手花、皂角刺按一定重量配比制备而成。本发明药物具有养阴清肺,祛痰止咳,清热健脾,润肺利咽的功能,用于治疗慢性咽炎见效快、疗效好,不复发。

Description

-种治疗慢性咽炎的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗慢性咽炎的药物及其制备方法,属中药领域。
背景技术
[0002] 慢性咽炎是咽粘膜的慢性炎症,多因急性咽炎反复发作或治疗不彻底,W及邻近 器官病灶刺激如鼻窦炎、扁桃体炎,鼻咽炎、气管炎等引起。烟酒过度,粉尘及有害气体刺激 亦为常见病因。中医则认为慢性咽炎与阴虚肺燥,疲热蕴结,肺脾气虚有关。由于西药治疗 副作用大,因此人们对有效治疗慢性咽炎的中药药物存在极大的需求,至今为止,还没有发 现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗慢性 咽炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗慢性咽炎的中药组合药物。
[000引本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006]本发明药物是选择丹参、射干、生地黄、北沙参、薄荷、络石藤、牛募子、枯梗、玉竹、 海浮石、麦冬、甘草、半夏、大青叶、石解、金银花、胖大海、太子参、淫羊蕾、牡丹皮、赠蚁、百 部、款冬花、赤巧、远志、佛手花、皂角刺、重楼、紫苏叶、桃仁、构杞子药物进行组合制备的, 将运些药物组合使得各药物功效产生协同作用,从而能够有效治疗慢性咽炎。其中,选用丹 参是因为其性味苦,微溫,入屯、、肝经,有活血去疲,安神宁屯、,排脈,止痛的功能,治屯、绞痛, 月经不调,痛经,W闭,血崩带下,瘤瘤,积聚,疲血腹痛,骨节疼痛,惊惇不眠,恶疮肿毒。选 用射干是因为其性味苦,寒,有毒,入肺、肝经,有降火,解毒,散血,消疲的功能,治喉搏咽 痛,咳逆上气,疲诞塞盛,療痛结核,追母,妇女经闭,痴肿疮毒。选用生地黄是因为其性味 甘,寒,归屯、、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内 热消渴,吐血,赃血,发斑发疹。选用北沙参是因为其性味甘苦淡,凉,入肺、脾经,有养阴清 肺,桂疲止咳的功能,治肺热燥咳,虚瘦久咳,阴伤咽干、口渴。选用薄荷是因为其性味辛, 凉,入肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风热,头痛,目赤,咽喉肿痛,食滞气 胀,口疮,牙痛,疮巧,癒疹。选用络石藤是因为其性味苦,凉,入肝、肾经,有桂风,通络,止 血,消疲的功能,治风湿搏痛,筋脉拘李,痴肿,喉搏,吐血,跌打损伤,产后恶露不行。选用牛 募子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳 嗽,咽喉肿痛,斑疹不透,风疹作痒,痴肿疮毒。选用枯梗是因为其性味苦辛,平,入肺、胃经, 有开宣肺气,桂疲排脈的功能,治外感咳嗽,咽喉肿痛,肺痴吐脈,胸满胁痛,频疾腹痛。选用 玉竹是因为其性味甘,平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳嗽, 烦渴,虚劳发热,消谷易饥,小便频数。选用海浮石是因为其性味咸寒,入肺、胃经,有清肺 火,化老疲,软坚,通淋的功能,治疲热喘嗽,老疲积块,瘦瘤,療痛,痛气,疮肿,目繫。选用麦 冬是因为其性味甘微苦,寒,入肺、胃、屯、经,有养阴润肺,清屯、除烦,益胃生津的功能,治肺 燥干咳,吐血,咯血,肺瘦,肺痴,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用甘草是因 为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用,治脾胃虚 弱,食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊癖;生用,治咽喉肿痛,消化性溃瘍,痴痘 疮瘍,解药毒及食物中毒。选用半夏是因为其性味辛,溫,有毒,入脾、胃经,有燥湿化疲,降 逆止呕,消瘡散结的功能,治湿疲冷饮,呕吐,反胃,咳喘疲多,胸隔胀满,疲厥头痛,头晕不 目民,外消痴肿。选用大青叶是因为其性味苦,寒,入肝、屯、、胃经,有清热,解毒,凉血,止血的 功能,治溫病热盛烦渴,流行性感冒,急性传染性肝炎,菌频,急性胃肠炎,急性肺炎,丹毒, 吐血,赃血,黄痘,频疾,喉搏,口疮,痴痘肿毒。选用石解是因为其性味甘淡微咸,寒,入有、 肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用 金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治溫病发热,热毒血频,痴瘍, 肿毒,療痛,持漏。选用胖大海是因为其性味甘淡,凉,有清热,润肺,利咽,解毒的功能,治干 咳无疲,喉痛,音哑,骨蒸内热,吐赃下血,目赤,牙痛,持疮漏管。选用太子参是因为其性味 甘苦,微溫,入屯、、脾、肺=经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,屯、惇目汗,精神 疲乏。选用淫羊蕾是因为其性味辛甘,溫,入肝、肾经,有补肾壮阳,桂风除湿的功能,治阳瘦 不举,小便淋渐,筋骨李急,半身不遂,腰膝无力,风湿搏痛,四脚不仁。选用牡丹皮是因为其 性味辛苦,凉,入屯、、肝、肾经,有清热,凉血,和血,消疲的功能,治热入血分,发斑,惊癖,吐、 赃、便血,骨蒸劳热,经闭,瘤瘤,痴瘍,扑损。选用赠蚁是因为其性味甘咸,凉,入肺、肝经,有 散风热,宣肺,定疫的功能,治外感风热,咳嗽音哑,麻疹透发不杨,风疹痊痒,小儿惊癖,目 赤,繫障,疗疮肿毒,破伤风。选用百部是因为其性味甘苦,微溫,入肺经,有溫润肺气,止咳, 杀虫的功能,治风寒咳嗽,百日咳,肺结核,老年咳喘、咖虫、晓虫病,皮肤巧癖、湿疹。选用款 冬花是因为其性味辛,溫,入肺经,有润肺下气,化疲止嗽的功能,治咳逆喘息,喉搏。选用赤 巧是因为其性味苦,微寒,归肝经,有清热凉血,散疲止痛的功能,治溫毒发狂,吐血赃血,目 赤肿痛,肝郁胁痛,经闭痛经,癖瘤腹痛,跌扑损伤,痴肿疮瘍。选用远志是因为其性味苦辛, 溫,入屯、、肾经,有安神益智,桂疲,解郁的功能,治惊惇,健忘,梦遗,失眠,咳嗽多疲,痴痘疮 月中。选用佛手花是因为其性味辛酸,溫,有理气化疲的功能,治胃痛,胁胀,呕吐,喧隔咳喘。 选用皂角刺是因为其性味辛,溫,有捜风,拔毒,消肿,排脈的功能,治痴肿,疮毒,巧风,癖 疮,胎衣不下。选用重楼是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉 肝定惊的功能,治疗疮痴肿,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽摇。选用紫苏叶是因为 其性味辛,溫,入肺、脾经,有发表,散寒,理气,和营的功能,治感冒风寒,恶寒发热,咳嗽,气 喘,胸腹胀满,胎动不安,并能解鱼蟹毒。选用桃仁是因为其性味苦甘,平,入屯、、肝、大肠经, 有破血行疲,润燥滑经的功能,治经闭,瘤瘤,热病蓄血,血搏,追疾,跌打损伤,疲血肿痛,血 燥便秘。选用构杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰 膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗清。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 丹参10-20克,射干4-8克,生地黄10-20克,北沙参10-15克,薄荷5-10克,络石藤10-15 克,牛募子10-15克,枯梗5-15克,玉竹10-15克,海浮石15-25克,麦冬10-15克,甘草10-20 克,半夏5-15克,大青叶10-20克,石解10-15克,金银花5-15克,胖大海10-15克,太子参5-15 克,淫羊蕾7-12克,牡丹皮5-15克,赠蚁7-12克,百部5-15克,款冬花5-15克,赤巧7-12克,远 志10-15克,佛手花5-10克,皂角刺10-15克,重楼10-20克,紫苏叶5-15克,桃仁5-15克,构杞 子5-15克。
[000引优选为: 丹参15克,射干6克,生地黄15克,北沙参12克,薄荷8克,络石藤12克,牛募子12克,枯梗 10克,玉竹12克,海浮石20克,麦冬12克,甘草15克,半夏10克,大青叶15克,石解12克,金银 花10克,胖大海12克,太子参10克,淫羊蕾9克,牡丹皮10克,赠蚁9克,百部10克,款冬花10 克,赤巧9克,远志12克,佛手花8克,皂角刺12克,重楼15克,紫苏叶10克,桃仁10克,构杞子 10克。
[0009]本发明药物的制备方法如下 一、备料 1、 丹参:炼净杂质,除去根茎,洗净,拱出,润透后切片,惊干; 2、 射干:炼去杂质,水洗净,稍浸泡,拱出,润透,切片,晒干,筛去须、屑; 3、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; 4、 北沙参:炼去杂质,除去茎基,用水略洗,拱出,稍润,切段,晒干; 5、 薄荷:炼净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒干, 再与叶和匀; 6、 络石藤:用水洗去泥±,炼净杂质,稍浸泡,润透,切断,晒干; 7、 牛募子:炼去杂质,筛去泥屑; 8、 枯梗:炼净杂质,除去芦头,洗净拱出,润透后切片,晒干; 9、 玉竹:除去杂质,洗净泥±,闷润至内外湿度均匀,切片,晒干; 10、 海浮石:洗净晒干,娠碎; 11、 麦冬:炼净杂质,用水浸泡,拱出,润透后抽去屯、,再洗净晒干; 12、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透切片,晒干; 13、 半夏:炼去杂质,筛去灰屑; 14、 大青叶:炼去杂质及枯叶,洗净,稍润,切段,晒干; 15、 石解:取干燥的石解,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; 16、 金银花:筛去泥沙,炼净杂质; 17、 胖大海:除去杂质,筛去泥沙即可,不能用水洗; 18太子参:摘除须根,晒干; 19、 淫羊蕾:炼净杂质,去梗,切丝,筛去碎屑; 20、 牡丹皮:炼去杂质,除去木屯、,洗净,润透,切片,惊干; 21、 赠蚁:炼去杂质,洗净晒干; 22、 百部:炼净杂质,除去须根,洗净,润透后切段,晒干; 23、 款冬花:取炼净的款冬花同炼蜜加适量开水,拌匀,稍闷,放锅内用文火炒至深黄 色,不粘手为止,取出放凉,每款冬花10斤用炼蜜25斤; 24赤巧:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; 25、 远志:炼去杂质,切段,筛去灰屑; 26、 佛手花:于早晨日出前疏花时采收,或拾取落花,晒干或烘干; 27、 皂角刺:炼去杂质,用水浸泡,润透后切片,晒干; 28、 重楼:除去须根,洗净,干燥; 29、 紫苏叶:炼净杂质,晒干; 30、 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,拱出,浸入凉水中,磋去种皮,晒 干,鑛净; 31、 构杞子:鑛净杂质,摘去残留的梗和蒂; 二制备 1、 将炮制好的丹参、射干、生地黄、北沙参、薄荷、络石藤、牛募子、枯梗、玉竹、海浮石、 麦冬、甘草、半夏、大青叶、石解、金银花、胖大海、太子参、淫羊蕾、牡丹皮、赠蚁、百部、款冬 花、赤巧、远志、佛手花、皂角刺、重楼、紫苏叶、桃仁、构杞子放入煎药容器内,第一次加水8 倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一 次煎煮液倒入容器内; 2、 将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合揽拌均匀即得,分为4剂服用。
[0010] 组方中北沙参有养阴清肺,桂疲止咳的功能为君药;太子参补肺,健脾;胖大海有 清热,润肺,利咽的功能,二者为臣药,;味药共同发挥养阴清肺,桂疲止咳,补肺,健脾,清 热,润肺,利咽的作用,治疗慢性咽炎效力全面,且W养阴清肺,清热健脾,去咳止疲,润肺利 咽为主可治本,构杞子有滋肾,润肺,补肝,明目的功能为佐药,海浮石有清肺火,化老疲的 功能为使药,与余下诸药是治标。
[0011] 本发明药物具有养阴清肺,桂疲止咳,清热健脾,润肺利咽的功能,用于治疗慢性 咽炎,疗程短、见效快、治愈后不复发。
[0012] W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[001引[试验例1]本发明药物的动物韋性试验报告: 取家兔30只,雌雄兼用,体重2.0-2 .化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为IOmVkg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药 物无不良毒副作用。
[0014][试验例2]本发明药物的临床疗效观察 1、一般资料 收治慢性咽炎口诊患者共26例。
[001引 2、诊断标准 典型症状为咽部不适,发干、异物感或轻度疼痛、干咳、恶屯、,咽部充血呈暗红色,咽后 壁可见淋己滤泡等症状。
[0016] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服 用3个疗程。
[0017] 4、疗效评定标准 显效:慢性咽炎症状消失,体质恢复正常,痊愈; 好转:患者咽喉异物感,疼痛,干咳的症状减轻,慢性咽炎症状明显好转,体质逐步恢 复; 无效:达不到好转标准者。
[0〇1引5、治疗结果(见下表)
Figure CN105477487AD00081
在上述治疗中,用本发明药物治疗慢性咽炎患者26例,结果显效21例,显效率为 80.76%,好转4例,好转率为15.38%,无效1例,总有效率为96.14%。

Claims (3)

1. 一种治疗慢性咽炎的药物,其特征在于:它是由下列重量范围内的原料药制成: 丹参10-20克,射干4-8克,生地黄10-20克,北沙参10-15克,薄荷5-10克,络石藤10-15 克,牛蒡子10-15克,桔梗5-15克,玉竹10-15克,海浮石15-25克,麦冬10-15克,甘草10-20 克,半夏5-15克,大青叶10-20克,石斛10-15克,金银花5-15克,胖大海10-15克,太子参5-15 克,淫羊藿7-12克,牡丹皮5-15克,蝉蜕7-12克,百部5-15克,款冬花5-15克,赤芍7-12克,远 志10-15克,佛手花5-10克,皂角刺10-15克,重楼10-20克,紫苏叶5-15克,桃仁5-15克,枸杞 子5-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 丹参15克,射干6克,生地黄15克,北沙参12克,薄荷8克,络石藤12克,牛蒡子12克,桔梗 10克,玉竹12克,海浮石20克,麦冬12克,甘草15克,半夏10克,大青叶15克,石斛12克,金银 花10克,胖大海12克,太子参10克,淫羊藿9克,牡丹皮10克,蝉蜕9克,百部10克,款冬花10 克,赤芍9克,远志12克,佛手花8克,皂角刺12克,重楼15克,紫苏叶10克,桃仁10克,枸杞子 10克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,瞭干; (2) 射干:拣去杂质,水洗净,稍浸泡,捞出,润透,切片,晒干,筛去须、肩; (3) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (4) 北沙参:拣去杂质,除去茎基,用水略洗,捞出,稍润,切段,晒干; (5) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; (6) 络石藤:用水洗去泥土,拣净杂质,稍浸泡,润透,切断,晒干; (7) 牛蒡子:拣去杂质,筛去泥肩; (8) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (9 )玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; (10) 海浮石:洗净晒干,碾碎; (11) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (12) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; (13) 半夏:拣去杂质,筛去灰肩; (14) 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; (15) 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; (16) 金银花:筛去泥沙,拣净杂质; (17) 胖大海:除去杂质,筛去泥沙即可,不能用水洗; (18) 太子参:摘除须根,晒干; (19) 淫羊藿:拣净杂质,去梗,切丝,筛去碎肩; (20 )牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (21)蝉蜕:拣去杂质,洗净晒干; (22 )百部:拣净杂质,除去须根,洗净,润透后切段,晒干; (23) 款冬花:取拣净的款冬花同炼蜜加适量开水,拌匀,稍闷,放锅内用文火炒至深黄 色,不粘手为止,取出放凉,每款冬花10斤用炼蜜25斤; (24) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (25) 远志:拣去杂质,切段,筛去灰肩; (26 )佛手花:于早晨日出前疏花时采收,或拾取落花,晒干或烘干; (27) 皂角刺:拣去杂质,用水浸泡,润透后切片,晒干; (28) 重楼:除去须根,洗净,干燥; (29) 紫苏叶:拣净杂质,晒干; (30) 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒 干,簸净; (31) 枸杞子:簸净杂质,摘去残留的梗和蒂; (二)制备 (1) 将炮制好的丹参、射干、生地黄、北沙参、薄荷、络石藤、牛蒡子、桔梗、玉竹、海浮石、 麦冬、甘草、半夏、大青叶、石斛、金银花、胖大海、太子参、淫羊藿、牡丹皮、蝉蜕、百部、款冬 花、赤芍、远志、佛手花、皂角刺、重楼、紫苏叶、桃仁、枸杞子放入煎药容器内,加水8倍量,浸 泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液 倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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CN106692696A (zh) * 2016-12-28 2017-05-24 王勤 一种治疗喉炎的药物及其制备方法
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