CN105381411A - 一种治疗癫痫的药物及其制备方法 - Google Patents

一种治疗癫痫的药物及其制备方法 Download PDF

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CN105381411A
CN105381411A CN201510947632.3A CN201510947632A CN105381411A CN 105381411 A CN105381411 A CN 105381411A CN 201510947632 A CN201510947632 A CN 201510947632A CN 105381411 A CN105381411 A CN 105381411A
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张朝兰
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张朝兰
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Abstract

本发明公开了一种治疗癫痫的药物及其制备方法,其主要是由磁石、蜈蚣、天麻、僵蚕、乌梅、地花生、天南星、陈皮、重楼、瓜蒂、茯神、琥珀、青黛、羌活、牵牛子、何首乌、郁金、牡蛎、党参、乳香、白术、淫羊藿、川贝母、钩藤、石菖蒲、白豆蔻、茜草、蝉蜕按一定重量配比制备而成。本发明药物具有,熄风定惊,理气健脾,燥湿化痰,补肝,益肾的功能,用于治疗癫痫见效快、疗效好,不复发。

Description

-种治疗癒搁的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗癒痛的药物及其制备方法,属中药领域。
背景技术
[0002] 癒痛是指脑部兴奋性过高的神经元突然、过度的重复放电,导致脑功能突发性、暂 时性素乱。中医则认为癒痛与肝肾阴虚,疲诞内结,肝阳上亢,脾失健运有关。由于西药治 疗副作用大,因此人们对有效治疗癒痛的中药药物存在极大的需求,至今为止,还没有发现 关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗癒痛 的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗癒痛的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择磁石、娱蚁、天麻、僵蚕、乌梅、地花生、天南星、陈皮、重楼、瓜 蒂、巧神、青黛、弟活、牵牛子、何首乌、郁金、牡颇、党参、乳香、马鞭草、白术、淫羊蕾、川贝 母、钩藤、石富蒲、白豆違、茜草、赠蚁、珍珠母、甘草、防风药物进行组合制备的,将运些药物 组合使得各药物功效产生协同作用,从而能够有效治疗癒痛。其中,选用磁石是因为其性 味辛咸,平,有潜阳纳气,镇惊安神的功能,治头目眩晕,耳鸣耳聋,虚喘,惊癖。选用娱蚁是 因为其性味辛,溫,有毒,入肝经,有桂风,定惊,攻毒,散结的功能,治中风,惊癖,破伤风,百 日咳,冀痛,结核,瘤积瘤块,疮瘍肿毒,风癖,白秀,持漏,烫伤。选用天麻是因为其性味甘, 平,入肝经,有息风,定惊的功能,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小 儿惊癖动风。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。桂风解疫,化疲散结。用于中 风口眼歪斜,惊痛抽摇,头赐,喉搏,療巧结核,风疹丹毒。选用乌梅是因为其性味酸,溫,入 肝,脾,肺,大肠经,有收敛生津,安咖驱虫的功能,治久咳,虚热烦渴,久追,频疾,便血,尿 血,血崩,咖厥腹痛,呕吐,钩虫病,牛皮癖,诱肉。选用地花生是因为其性味甘溫,有补屯、安 神桂疲的功能,治血虚屯、惇,失眠多梦。选用天南星是因为其性味苦辛,溫,有毒,入肺、肝、 脾经,有燥湿化疲,桂风定惊,消肿散结的功能,治中风疲塞,口眼喝斜,半身不遂,癒癖,惊 风,破伤风,风疲眩晕,喉搏,療痛,痴肿,跌扑折伤,蛇虫咬伤。选用陈皮是因为其性味苦、 辛,溫,归肺、脾经,有理气健脾,燥湿化疲的功能,治胸腕胀满,食少吐泻,咳嗽疲多。选用 重楼是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉肝定惊的功能,治疗 疮痴肿,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽摇。选用瓜蒂是因为其性味苦,寒,有毒,入 肺、脾、胃、大肠经,有泻屯、火,利湿,消水的功能,治癒癖,黄痘鼻塞,喉搏。选用巧神是因为 其性味甘淡,平,入屯、、脾经,有宁屯、,安神,利水的功能,治屯、虚惊惇,健忘,失眠,惊癖,小便 不利。选用班巧是因为其性味甘,平,入屯、、肝、小肠经,有镇惊安神,散疲止血,利水通淋的 功能,治惊风癒癖,惊惇失眠,血淋血尿,小便不通,妇女闭经,产后停疲腹痛,痴痘疮毒,跌 打创伤。选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉血,解毒的功能,治溫病热 盛,斑疹,吐血、咯血,小儿惊癖,疮肿,丹毒,蛇虫咬伤。选用弟活是因为其性味辛苦,溫,入 膀脫、肾经,有散表寒,桂风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿搏,项强筋急, 骨节酸疼,风水浮肿,痴痘疮毒。选用牵牛子是因为其性味苦,寒,有毒,归肺、肾、大肠经,有 泻水通便,消疲涂饮,杀虫攻积的功能,治水肿胀痛,二便不通,疲饮积聚,气逆喘咳,虫积腹 痛,咖虫、缘虫病。选用何首乌是因为其性味苦甘涩,微溫,入肝、肾经,有补肝,益肾,养血, 桂风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久追,久 频,慢性肝炎,痴肿,療痛,肠风,持疾。选用郁金是因为其性味辛苦,凉,入屯、、肺、肝经,有行 气解随,凉血破疲的功能,治胸腹胁肋诸痛,失屯、癒狂,热病神昏,吐血,赃血,尿血,血淋,妇 女倒经,黄痘。选用牡颇是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化疲, 软坚的功能,治惊癖,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,療痛,瘦瘤。选用党参是因为 其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦 无力,食少,口渴,久泻,脱肛。选用乳香是因为其性味辛苦,溫,入屯、、肝、脾经,有调气活血, 定痛,追毒的功能,治气血凝滞,屯、腹疼痛,痴疮肿毒,跌打损伤,痛经,产后疲血刺痛。选用 马鞭草是因为其性味苦,凉,有清热解毒,活血散疲,利水消肿的功能,治外感发热,湿热黄 痘,水肿,喉搏。选用白术是因为其性味苦甘,溫,入脾、胃经,有补脾,益胃,燥湿,和中的功 能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,疲饮,水肿,黄痘,湿搏,小便不利,头晕, 自汗,胎气不安。选用淫羊蕾是因为其性味辛甘,溫,入肝、肾经,有补肾壮阳,桂风除湿的功 能,治阳瘦不举,小便淋渐,筋骨李急,半身不遂,腰膝无力,风湿搏痛,四脚不仁。选用川贝 母是因为其性味苦甘,凉,入肺经,有润肺散结,止嗽化疲的功能,治虚劳咳嗽,吐疲咯血,屯、 胸郁结,肺瘦,肺痴,瘦瘤,療痛,喉搏,乳痴。选用钩藤是因为其性味苦,凉,入肝、屯、经,有清 热平肝,焰风定惊的功能,治小儿惊癖瘦疵,大人血压偏高,头晕、目眩,妇人子癖。选用石富 蒲是因为其性味辛苦,微溫,入屯、、肝、脾经,有开资,豁疲,理气,活血,散风,去湿的功能,治 癒癖,疲厥,热病神昏,健忘,气闭耳聋,屯、胸烦闷,胃痛,腹痛,风寒湿搏,痴痘肿毒,跌打损 伤。选用白豆違是因为其性味辛,溫,入肺、脾经,有行风,暖胃,消食,宽中的功能,治气滞, 食滞,胸闷,腹胀,噫气,喧隔,吐逆,反胃,追疾。选用茜草是因为其性味苦,寒,有凉血止血, 桂疲通经的功能,治吐血,赃血,崩漏,外伤出血,疲阻经闭,关节搏痛,跌扑肿痛。选用赠蚁 是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定疫的功能,治外感风热,咳嗽音哑,麻 疹透发不杨,风疹痊痒,小儿惊癖,目赤,繫障,疗疮肿毒,破伤风。选用珍珠母是因为其性 味咸,凉,入屯、、肝两经,有平肝,潜阳,定惊,止血的功能,治头眩,耳鸣,屯、惇,失眠,癒狂,惊 癖,吐血,赃血,妇女血崩。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺, 解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊癖; 生用治咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用防风是因为其性味辛甘, 溫,入膀脫、肺、脾经,有发表,桂风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒 湿搏,骨节酸痛,四肢李急,破伤风。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 磁石10-20克,娱蚁3-8克,天麻5-15克,僵蚕5-15克,乌梅5-15克,地花生10-15克, 天南星7-12克,陈皮5-15克,重楼10-20克,瓜蒂5-8克,巧神5-15克,班巧6-10克,青黛 15-20克,弟活5-15克,牵牛子5-10克,何首乌5-15克,郁金10-15克,牡颇10-20克,党参 10-20克,乳香5-15克,马鞭草10-20克,白术5-15克,淫羊蕾10-20克,川贝母7-12克, 钩藤15-25克,石富蒲10-20克,白豆違7-10克,茜草5-15克,赠蚁5-10克,珍珠母10-20 克,甘草10-20克,防风5-15克。
[000引优选为: 磁石15克,娱蚁6克,天麻10克,僵蚕10克,乌梅10克,地花生12克,天南星9克,陈 皮10克,重楼15克,瓜蒂6克,巧神10克,班巧8克,青黛18克,弟活10克,牵牛子8克, 何首乌10克,郁金12克,牡颇15克,党参15克,乳香10克,马鞭草15克,白术10克,淫羊 蕾15克,川贝母9克,钩藤20克,石富蒲15克,白豆違9克,茜草10克,赠蚁8克,珍珠母 15克,甘草15克,防风10克。
[0009] 本发明药物的制备方法如下 一、备料 1、 磁石:除去杂质,打成碎块; 2、 娱蚁:拭净,除去头足,剪断用; 3、 天麻:炼去杂质,大小分档,用水浸泡至屯成透,拱出,稍惊,再润至内外溫度均匀,切 片,晒干; 4、 僵蚕:取原药材,除去残丝,杂质; 5、 乌梅:炼净杂质,筛去灰屑,洗净,晒干; 6、 地花生:春秋采根,洗净,切片晒干; 7、 天南星:炼去杂质,洗净灰屑,晒干; 8、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低溫干燥,筛 去灰屑; 9、 重楼:除去须根,洗净,干燥; 10、 瓜蒂:6-7月间采摘尚未老熟的果实,切取果蒂,阴干; 11、 巧神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干; 12、 班巧:炼净杂质,用时捣碎研成细粉; 13、 青黛:炼去杂质,过萝; 14、 弟活:炼去杂质,洗净,润透,切片,惊干; 15、 牵牛子:取原药材,除去杂质、痕粒及果壳,用时捣碎; 16、 何首乌:炼去杂质,洗净,用水泡至八成透,拱出,润至内外湿度均匀,切片或切成方 块,晒干; 17、 郁金:用水浸泡,洗净,拱出晒惊,润透,切片,晒干; 18、 牡颇:洗净,晒干,娠碎用; 19、 党参:洗净泥沙后润透去芦,切片或切段,晒干; 20、 乳香:炼去砂子杂质; 21、 马鞭草:炼净杂质,洗净,润软切段,晒干; 22、 白术:炼净杂质,用水浸泡,泡后拱出,润透,切片,晒干; 23、 淫羊蕾:炼净杂质,去梗,切丝,筛去碎屑; 24、 川贝母:炼去杂质,用水稍泡,拱出,闷润,剥去屯、,晒干; 25、 钩藤:炼去老梗、杂质,洗净,晒干; 26、 石富蒲:炼去杂质,洗净,稍稍浸泡,润透,切片,晒干; 27、 白豆違:炼净杂质,筛去皮屑,打碎,或剥去果壳,取仁打碎用; 28、 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑; 29、 赠蚁:炼去杂质,洗净晒干; 30、 珍珠母:炼去杂质,敲成碎块,筛去灰屑; 31、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透切片,惊干; 32、 防风:除去残茎,用水浸泡,拱出,润透切片,晒干。
[0010] 二、制备 1、将炮制好的磁石、娱蚁、天麻、僵蚕、乌梅、地花生、天南星、陈皮、重楼、瓜蒂、巧神、青 黛、弟活、牵牛子、何首乌、郁金、牡颇、党参、乳香、马鞭草、白术、淫羊蕾、川贝母、钩藤、石富 蒲、白豆違、茜草、赠蚁、珍珠母、甘草、防风放入煎药容器内,第一次加水8倍量,浸泡100分 钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容 器内。
[0011] 2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液。
[0012] 3、将两次煎煮液混合揽拌均匀,分为4剂服用。
[0013] 组方中石富蒲有开资,豁疲,理气,活血,散风的功能为君药;钩藤清热平肝,焰风 定惊;陈皮有理气健脾,燥湿化疲,治咳嗽疲多的功能,二者为臣药,Ξ味药共同发挥,清热 平肝,理气健脾,燥湿化疲,焰风定惊的作用,治疗癒痛效力全面,且W燥湿化疲,理气健 脾,清热平肝,为主可治本,何首乌有补肝,益肾,养血,桂风的功能为佐药,甘草有和中缓 急,润肺,解毒,调和诸药解药毒及食物中毒的功能为使药,与余下诸药是治标。
[0014] 本发明药物具有清热平肝,焰风定惊,理气健脾,燥湿化疲,补肝,益肾的功能,用 于治疗癒痛,疗程短、见效快、治愈后不复发。
[0015]
具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0016] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为lOml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不 良毒副作用。
[0017] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治癒痛口诊患者共27例。
[001引 2、诊断标准 典型症状为突然发作的全身肌肉疫李,意识丧失,两眼上翻,口吐白沫,喉头发出叫声, 有时可有舌咬伤及二便失禁。发作持续1-5分钟或更长,发作停止后转入昏睡,醒后常诉头 痛,全身乏力,精神恍惚等症状。
[001引3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,服药时取四分之一班巧粉,用药液冲服,每 天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
[0020] 4、疗效评定标准 显效:癒痛症状消失,体质恢复正常,痊愈; 好转:患者肌肉疫李,精神恍惚等症状减轻,癒痛症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0021] 5、治疗结果(见下表)
Figure CN105381411AD00081
在上述治疗中,用本发明药物治疗癒痛患者27例,结果显效23例,显效率为85. 18%,好 转3例,好转率为11. 11%,无效1例,总有效率为96. 29%。

Claims (3)

1. 一种治疗癫痫的药物,其特征在于:它是由下列重量范围内的原料药制成: 磁石10-20克,蜈蚣3-8克,天麻5-15克,僵蚕5-15克,乌梅5-15克,地花生10-15克, 天南星7-12克,陈皮5-15克,重楼10-20克,瓜蒂5-8克,茯神5-15克,琥珀6-10克,青黛 15-20克,羌活5-15克,牵牛子5-10克,何首乌5-15克,郁金10-15克,牡蛎10-20克,党参 10-20克,乳香5-15克,马鞭草10-20克,白术5-15克,淫羊藿10-20克,川贝母7-12克, 钩藤15-25克,石菖蒲10-20克,白豆蔻7-10克,茜草5-15克,蝉蜕5-10克,珍珠母10-20 克,甘草10-20克,防风5-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 磁石15克,蜈蚣6克,天麻10克,僵蚕10克,乌梅10克,地花生12克,天南星9克,陈 皮10克,重楼15克,瓜蒂6克,茯神10克,琥珀8克,青黛18克,羌活10克,牵牛子8克, 何首乌10克,郁金12克,牡蛎15克,党参15克,乳香10克,马鞭草15克,白术10克,淫羊 藿15克,川贝母9克,钩藤20克,石菖蒲15克,白豆蔻9克,茜草10克,蝉蜕8克,珍珠母 15克,甘草15克,防风10克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 磁石:除去杂质,打成碎块; (2) 蜈蚣:拭净,除去头足,剪断用; (3) 天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀, 切片,晒干; (4) 僵蚕:取原药材,除去残丝,杂质; (5) 乌梅:拣净杂质,筛去灰肩,洗净,晒干; (6) 地花生:春秋采根,洗净,切片晒干; (7) 天南星:拣去杂质,洗净灰肩,晒干; (8) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (9) 重楼:除去须根,洗净,干燥; (10) 瓜蒂:6-7月间采摘尚未老熟的果实,切取果蒂,阴干; (11) 茯神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干; (12) 琥珀:拣净杂质,用时捣碎研成细粉; (13) 青黛:拣去杂质,过箩; (14) 羌活:拣去杂质,洗净,润透,切片,晾干; (15) 牵牛子:取原药材,除去杂质、瘪粒及果壳,用时捣碎; (16) 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成 方块,晒干; (17) 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (18) 牡蛎:洗净,晒干,碾碎用; (19) 党参:洗净泥沙后润透去芦,切片或切段,晒干; (20) 乳香:拣去砂子杂质; (21) 马鞭草:拣净杂质,洗净,润软切段,晒干; (22) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (23) 淫羊藿:拣净杂质,去梗,切丝,筛去碎肩; (24) 川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干; (25) 钩藤:拣去老梗、杂质,洗净,晒干; (26) 石菖蒲:拣去杂质,洗净,稍稍浸泡,润透,切片,晒干; (27) 白豆蔻:拣净杂质,筛去皮肩,打碎,或剥去果壳,取仁打碎用; (28) 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎肩; (29) 蝉蜕:拣去杂质,洗净晒干; (30) 珍珠母:拣去杂质,敲成碎块,筛去灰肩; (31) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干; (32) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (二)制备 (1) 将炮制后的磁石、蜈蚣、天麻、僵蚕、乌梅、地花生、天南星、陈皮、重楼、瓜蒂、茯神、 青黛、羌活、牵牛子、何首乌、郁金、牡蛎、党参、乳香、马鞭草、白术、淫羊藿、川贝母、钩藤、石 菖蒲、白豆蔻、茜草、蝉蜕、珍珠母、甘草、防风放入煎药容器内,加水8倍量,浸泡100分钟 后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器 内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液; (3) 将两次煎煮液混合搅拌均匀,分为4剂服用。
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