CN106492122A - 一种治疗癫痫的药物及其制备方法 - Google Patents
一种治疗癫痫的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗癫痫的药物及其制备方法,其主要是由茯苓、龙骨、牡蛎、钩藤、石决明、党参、僵蚕、生地黄、黄芩、白术、石菖蒲、栀子、枳实、胆星按一定重量配比制备而成,本发明药物具有清热散结,镇惊定癎的功能,用于治疗癫痫见效快,疗效好,无副作用。
Description
技术领域
本发明涉及一种治疗癫痫的药物及其制备方法,属中药领域。
背景技术
癫痫,是大脑神经元突发性异常放电,导致短暂的大脑功能障碍的一种慢性疾病。由脑部疾患或脑外伤等引起,发作时突然昏倒,全身痉挛,有的口吐白沫,俗称羊痫风羊角风。由于西药无法有效快速治疗癫痫,因此人们对有效治疗癫痫的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗癫痫的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗癫痫的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择茯苓、龙骨、牡蛎、钩藤、石决明、党参、僵蚕、生地黄、黄芩、白术、石菖蒲、栀子、枳实、胆星、柴胡、半夏、陈皮、远志、竹茹、天麻、甘草、朱砂、竹沥、蜈蚣、全蝎、琥珀、牛黄、郁金、红花原料药进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗癫痫。其中选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用龙骨是因为其性味甘涩,平,归入心、肝、肾、大肠经,有镇惊安神,敛汗固精的功能,治惊癎癫狂,怔忡健忘,失眠多梦,自汗盗汗。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈瘲,大人血压偏高,头晕、目眩,妇人子癎。选用石决明是因为其性味咸,平,入肝、肾经,有平肝潜阳,除热,明目的功能,治风阳上扰、头痛眩晕,惊搐,骨蒸劳热,青盲内障。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用胆星是因为其性味苦,性凉,入心、肝、肺三经,有清火化痰,镇惊定癎,痰火喘嗽,头风眩晕。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,清痞散结的功能,治湿痰冷饮呕吐,反胃,咳喘痰多,我膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用远志是因为其性味苦辛,温,入心、肾经,有安神益智,祛痰,解郁的功能,治惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉血,化痰,止吐的功能,治烦热呕吐、呃逆,痰热咳喘,吐血,衄血,崩漏,恶阻,胎动,惊癎。选用天麻是因为其性味甘,平,入肝经,有息风,定惊的功能,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊癎动风。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用朱砂是因为其性味甘,凉,有毒,入心经,有安神,定惊,明目,解毒的功能,治癫狂,惊悸,心烦,失眠,眩晕,目昏,肿毒,疮疡,疥癣。选用竹沥是因为其性味甘苦,寒,入心、胃经,有清热滑痰,镇惊利窍的功能,治中风痰迷,肺热痰壅,惊风,癫癎,壮热烦渴,子烦,破伤风。选用蜈蚣是因为其性味辛,温,有毒,入肝经,有祛风,定惊,攻毒,散结的功能,治中风,惊癎,破伤风,百日咳,冀疬,结核,癥积瘤块,疮疡肿毒,风癣,白秃,痔漏,烫伤。选用全蝎是因为其性味咸辛,平,有毒,入足厥阴经,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风、半身不遂、口眼喎斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用琥珀是因为其性味甘,平,入心、肝、小肠经,有镇惊安神,散瘀止血,利水通淋的功能,治惊风癫癎,惊悸失眠,血淋血尿,小便不通,妇女闭经,产后停瘀腹痛,痈疽疮毒,跌打创伤。选用牛黄是因为其性味苦甘,凉,入心、肝经,有清心,化痰,利胆,镇惊的功能,治热病神昏、谵语,癫癎发狂,小儿惊风抽搐,牙疳,喉肿,口舌生疮,痈疽,疔毒。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
茯苓15-25克,龙骨15-25克,牡蛎15-25克,钩藤15-25克,石决明10-20克,党参10-20克,僵蚕10-20克,生地黄10-20克,黄芩10-14克,白术10-14克,石菖蒲10-14克,栀子10-14克,枳实10-14克,胆星10-14克,柴胡8-12克,半夏8-12克,陈皮8-12克,远志8-12克,竹茹8-12克,天麻8-12克,甘草4-8克,朱砂1-2克,竹沥8-11毫升,蜈蚣4-6条,全蝎2-4克,琥珀2-3克,牛黄0.5-0.6克,郁金8-12 克,红花4-6克。
优选为:
茯苓20克,龙骨20克,牡蛎20克,钩藤20克,石决明15克,党参15克,僵蚕15克,生地黄15克,黄芩12克,白术12克,石菖蒲12克,栀子12克,枳实12克,胆星12克,柴胡10克,半夏10克,陈皮10克,远志10克,竹茹10克,天麻10克,甘草6克,朱砂1克,竹沥10毫升,蜈蚣5条,全蝎3克,琥珀3克,牛黄0.6克,郁金10 克,红花5克。
本发明药物的制备方法如下
一、备料
1、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
2、龙骨:刷净泥土,打碎;
3、牡蛎:洗净,晒干,打碎用;
4、钩藤:拣去老梗、杂质,洗净,晒干;
5、石决明:洗净晾干,敲成碎块;
6、党参:洗净泥沙后润透去芦,切片或切段,晒干;
7、僵蚕:取原药材,除去残丝,杂质;
8、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
9、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
10、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
11、石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
12、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
13、枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
14、胆星:取原药材,拣去杂质;
15、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
16、半夏:拣去杂质,筛去灰屑;
17、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
18、远志:拣去杂质,切段,筛去灰屑;
19、竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
20、天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
21、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
22、朱砂:用吸铁石吸净铁屑,研成细粉,或用水飞法制成极细的粉末;
23、竹沥:取鲜竹杆,截成30-50厘米长,两端去节,劈开,架起,中部用火烤之,两端即有液汁流出,以器盛之;
24、蜈蚣:拭净,除去头足,剪断用;
25、全蝎:清水漂去盐质,晒干,或微火焙用;
26、琥珀:拣净杂质,用时捣碎研成细粉;
27、牛黄:研为极细粉末用;
28、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
29、红花:拣净杂质,除去茎叶、蒂头,晒干。
二、制备
1、将炮制后的茯苓、龙骨、牡蛎、钩藤、石决明、党参、僵蚕、生地黄、黄芩、白术、石菖蒲、栀子、枳实、胆星、柴胡、半夏、陈皮、远志、竹茹、天麻、甘草、竹沥、蜈蚣、全蝎、郁金、红花药物放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒入容器内;
3、将两次煎煮液加入朱砂、琥珀、牛黄混合搅拌均匀,即得混合药液,分成4剂服用。
组方中龙骨有镇惊安神的功能为君药;钩藤清热平肝,熄风定惊,僵蚕祛风解痉,化痰散结。二者为臣药,三味药共同发挥祛风解痉,清热平肝的作用,治疗癫痫效力全面,且以祛风解痉为主,可治本;胆星清火化痰,镇惊定癎为佐药;天麻息风,定惊为使药,与下余诸药是治标。
本发明药物具有清热散结,镇惊定癎的功能,用于治疗癫痫,疗程短、见效快、治愈后不复发、无毒副作用。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治癫痫门诊患者共28例。
2、诊断标准
临床上,临床上存在多种多样的发作性事件,既包括癫痫发作,也包括非癫痫发作。非癫痫发作在各年龄段都可以出现,非癫痫发作包括多种原因,其中一些是疾病状态,如晕厥、短暂性脑缺血发作(TIA)、发作性运动诱发性运动障碍、睡眠障碍、多发性抽动症、偏头痛等,另外一些是生理现象,如屏气发作、睡眠肌阵挛、夜惊等。
鉴别诊断过程中应详细询问发作史,努力寻找引起发作的原因。此外,脑电图特别是视频脑电图监测对于鉴别癫痫性发作与非癫痫性发作有非常重要的价值。
3、治疗方法
选用上述药剂,给患者服用,一日2次,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:癫痫症状消失,痊愈,体质恢复正常;
好转:癫痫症状明显好转,恶寒、发热症状已消除,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗癫痫患者28例,结果显效16例,显效率为57.14%,好转10例,好转率为35.71%,无效2例,总有效率为92.86%。
Claims (3)
1.一种治疗癫痫的药物,其特征在于:它是由下列用量范围内的原料药制成:
茯苓15-25克,龙骨15-25克,牡蛎15-25克,钩藤15-25克,石决明10-20克,党参10-20克,僵蚕10-20克,生地黄10-20克,黄芩10-14克,白术10-14克,石菖蒲10-14克,栀子10-14克,枳实10-14克,胆星10-14克,柴胡8-12克,半夏8-12克,陈皮8-12克,远志8-12克,竹茹8-12克,天麻8-12克,甘草4-8克,朱砂1-2克,竹沥8-11毫升,蜈蚣4-6条,全蝎2-4克,琥珀2-3克,牛黄0.5-0.6克,郁金8-12 克,红花4-6克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
茯苓20克,龙骨20克,牡蛎20克,钩藤20克,石决明15克,党参15克,僵蚕15克,生地黄15克,黄芩12克,白术12克,石菖蒲12克,栀子12克,枳实12克,胆星12克,柴胡10克,半夏10克,陈皮10克,远志10克,竹茹10克,天麻10克,甘草6克,朱砂1克,竹沥10毫升,蜈蚣5条,全蝎3克,琥珀3克,牛黄0.6克,郁金10 克,红花5克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(2)龙骨:刷净泥土,打碎;
(3)牡蛎:洗净,晒干,打碎用;
(4)钩藤:拣去老梗、杂质,洗净,晒干;
(5)石决明:洗净晾干,敲成碎块;
(6)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(7)僵蚕:取原药材,除去残丝,杂质;
(8)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(9)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(10)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(11)石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
(12)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(13)枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
(14)胆星:取原药材,拣去杂质;
(15)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
(16)半夏:拣去杂质,筛去灰屑;
(17)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(18)远志:拣去杂质,切段,筛去灰屑;
(19)竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
(20)天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
(21)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(22)朱砂:用吸铁石吸净铁屑,研成细粉,或用水飞法制成极细的粉末;
(23)竹沥:取鲜竹杆,截成30-50厘米长,两端去节,劈开,架起,中部用火烤之,两端即有液汁流出,以器盛之;
(24)蜈蚣:拭净,除去头足,剪断用;
(25)全蝎:清水漂去盐质,晒干,或微火焙用;
(26)琥珀:拣净杂质,用时捣碎研成细粉;
(27)牛黄:研为极细粉末用;
(28)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(29)红花:拣净杂质,除去茎叶、蒂头,晒干;
(二)制备
(1)将炮制后的茯苓、龙骨、牡蛎、钩藤、石决明、党参、僵蚕、生地黄、黄芩、白术、石菖蒲、栀子、枳实、胆星、柴胡、半夏、陈皮、远志、竹茹、天麻、甘草、竹沥、蜈蚣、全蝎、郁金、红花药物放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒入容器内;
(3)将两次煎煮液加入朱砂、琥珀、牛黄混合搅拌均匀,即得混合药液,分成4剂服用。
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CN103285192A (zh) * | 2012-02-29 | 2013-09-11 | 黑龙江康元神经专科医院有限责任公司 | 治疗癫痫病的中药制剂 |
CN105381411A (zh) * | 2015-12-17 | 2016-03-09 | 张朝兰 | 一种治疗癫痫的药物及其制备方法 |
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CN103285192A (zh) * | 2012-02-29 | 2013-09-11 | 黑龙江康元神经专科医院有限责任公司 | 治疗癫痫病的中药制剂 |
CN105381411A (zh) * | 2015-12-17 | 2016-03-09 | 张朝兰 | 一种治疗癫痫的药物及其制备方法 |
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