CN104383498A - 一种治疗蛔虫病的药物及其制备方法 - Google Patents

一种治疗蛔虫病的药物及其制备方法 Download PDF

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CN104383498A
CN104383498A CN201410703617.XA CN201410703617A CN104383498A CN 104383498 A CN104383498 A CN 104383498A CN 201410703617 A CN201410703617 A CN 201410703617A CN 104383498 A CN104383498 A CN 104383498A
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侯德润
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Abstract

本发明公开了一种治疗蛔虫病的药物及其制备方法，其主要是由藿香、党参、乌梅、附子、当归、白芍、连翘、苍术、厚朴、槟榔、莱菔子、使君子、木香、砂仁、干姜、陈皮按一定重量配比制备而成，本发明药物具有清热散结，安蛔驱虫，杀虫消积的功能，用于治疗蛔虫病见效快，疗效好，无副作用。

Description

一种治疗蛔虫病的药物及其制备方法
技术领域
本发明涉及一种治疗蛔虫病的药物及其制备方法，属中药领域。
背景技术
似蚓蛔线虫简称蛔虫，是人体内最常见的寄生虫之一。成虫寄生于小肠，可引起蛔虫病。此外，犬弓首线虫是犬类常见的肠道寄生虫，其幼虫能在人体内移行，引起内脏幼虫移行症。目前，由于西药无法有效治疗蛔虫病，且长期服用西药有较多副作用，因此，人们对有效治疗蛔虫病的中药存在很大的需求。
发明内容
本发明人依据中医理论的研究及临床反复的试验和验证，终于找到了有效治疗蛔虫病的药物，从而完成了本发明。
本发明的目的就是提供一种能够有效治疗蛔虫病的组合药物。
本发明的另一个目的就是提供了该组合药物的制备方法。
本发明药物是选择藿香、党参、乌梅、附子、当归、白芍、连翘、苍术、厚朴、槟榔、莱菔子、使君子、木香、砂仁、干姜、陈皮、黄连、紫苏梗、柴胡、桂枝、甘草、吴茱萸、细辛药物进行组合的，将这些药物组合使得各药物功效产生协同作用，从而能够快速治疗蛔虫病的复发。其中选用藿香是因为其性味辛，微温，入肺、脾、胃经，有快气，和中，辟秽，祛湿的功能，治感冒暑湿，寒热，头痛，胸脘痞闷，呕吐泄泻，疟疾，痢疾，口臭。选用党参是因为其性味甘，平，入手、足太阴经气分，有补中益气，生津的功能，治脾胃虚弱，气血两亏，体倦无力，食少，口渴，久泻，脱肛。选用乌梅是因为其性味酸，温，入肝，脾，肺，大肠经，有收敛生津，安蛔驱虫的功能，治久咳，虚热烦渴，久疟，痢疾，便血，尿血，血崩，蛔厥腹痛，呕吐，钩虫病，牛皮癣，胬肉。选用附子是因为其性味辛甘，热，有毒，入心、脾、肾经，有回阳补火，散寒除湿的功能，治阴盛格阳，大汗亡阳，吐利厥逆，心腹冷痛，脾泄冷痢，脚气水肿，小儿慢惊，风寒湿痹，踒躄拘挛，阴疽疮漏及一切沉寒痼冷之疾。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用连翘是因为其性味苦，凉，入心、肝、胆经，有清热，解毒，散结，消肿的功能，治温热，丹毒，斑疹，痈疡肿毒，瘰疬，小便淋闭。选用苍术是因为其性味辛苦，温，入脾、胃经，有健脾，燥湿，解郁，辟秽的功能，治湿盛困脾，倦怠嗜卧，脘痞腹胀，食欲不振，呕吐，泄泻，痢疾，疟疾，痰饮，水肿，时气感冒，风寒湿痹，足痿，夜盲。选用厚朴是因为其性味苦辛，温，入脾、胃、大肠经，有温中，下气，燥湿，消痰的功能，治胸腹痞满胀痛，反胃、呕吐，宿食不消，痰饮喘咳，寒湿泻痢。选用槟榔是因为其性味苦辛，温，入脾、胃、大肠经，有杀虫，破积，下气，行水的功能，治虫积、食滞，脘腹胀痛，泻痢后重，疟疾，水肿，脚气，痰癖，癥结。选用莱菔子是因为其性味辛甘，平，入肺、胃经，有下气定喘，消食化痰的功能，治咳嗽痰喘，食积气滞，胸闷腹胀，下痢后重。选用使君子是因为其性味甘，温，有毒，入脾、胃经，有杀虫，消积，健脾的功能，治蛔虫腹痛，小儿疳积，乳食停滞，腹胀，泻痢。选用木香是因为其性味辛苦，温，入肺、肝、脾经，有行气止痛，温中和胃的功能，治中寒气滞，胸腹胀痛，呕吐，泄泻，下痢里急后重，寒疝。选用砂仁是因为其性味辛，温，入脾、胃经，有行气调中，和胃、醒脾的功能，治腹痛痞胀，胃呆食滞，噎隔呕吐，寒泻冷痢，妊娠胎动。选用干姜是因为其性味辛，热，入脾、胃、肺经，有温中逐寒，回阳通脉的功能，治心腹冷痛，吐泻，肢冷脉微，寒饮喘咳，风寒湿痹，阳虚吐、衄、下血。选用陈皮是因为其性味苦、辛，温，归肺、脾经，有理气健脾，燥湿化痰的功能，治胸脘胀满，食少吐泻，咳嗽痰多。选用黄连是因为其性味苦，寒，入心、肝、胃、大肠经，有泻火，燥湿，解毒，杀虫的功能，治时行热毒、伤寒，热盛心烦，痞满呕逆，菌痢，热泻腹痛，肺结核，吐、衄、下血，消渴，疳积，蛔虫病，百日咳，咽喉肿痛，火眼，口疮，痈疽疮毒，湿疹，汤火烫伤。选用紫苏梗是因为其性味辛甘，微温，入肺、胃、肺三经，有理气，舒郁，止痛，安胎的功能，治气郁，食滞，胸膈痞闷，脘腹疼痛，胎气不和。选用柴胡是因为其性味苦，凉，入肝、胆经，有和解表里，疏肝，升阳的功能，治寒热往来，胸满胁痛，口苦耳聋，头痛目眩，疟疾，下利脱肛，月经不调，子宫下垂。选用桂枝是因为其性味辛甘，温，入膀胱、心、肺经，有发汗解肌，温经通脉的功能，治风寒表证，肩背肢节酸疼，胸痹痰饮，经闭癥瘕。选用甘草是因为其性味甘，平，入脾、胃、肺经，有和中缓急，润肺，解毒，调和诸药的功能，炙用，治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊癎；生用，治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。选用吴茱萸是因为其性味辛苦，温，有毒，入肝、胃经，有温中，止痛，理气，燥湿的功能，治呕逆吞酸，厥阴头痛，脏寒吐泻，脘腹胀痛，脚气，疝气，口疮溃疡，齿痛，湿疹，黄水疮。选用细辛是因为其性味辛，温，入肺、肾经，有祛风，散寒，行水，开窍的功能，治风冷头痛，鼻渊，止痛，痰饮咳逆，风湿痹痛。
具体实施方式：
本发明组合的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好疗效： 
藿  香    10-12克    党  参    10-12克       乌  梅      10-12克
附  子    10-12克    当  归    10-12克       白  芍      10-12克
连  翘    10-12克    苍  术    8-10克         厚  朴      8-10克
槟  榔    8-10克      莱菔子    8-10克         使君子      8-10克
木  香    8-10克      砂  仁    5-8克        干  姜 5-8克
陈  皮    5-8克      黄  连    5-8克        紫苏梗      5-8克
柴  胡    5-8克      桂  枝    5-8克        甘  草 2-3克
吴茱萸    2-3克      细  辛    2-3克  
优选用量为：
藿  香    12克       党  参    12克        乌  梅  12克
附  子    12克       当  归    12克        白  芍  12克
连  翘    12克       苍  术    9克          厚  朴  9克
槟  榔    9克         莱菔子    9克          使君子  9克
木  香    9克         砂  仁    7克          干  姜  7克
陈  皮    7克         黄  连    7克          紫苏梗  7克
柴  胡    7克         桂  枝    7克          甘  草  3克
吴茱萸    3克         细  辛    3克     
本发明药物的制备方法如下：
一、备料
1、藿香：拣去杂质，除去残根及老茎，先将叶摘下另放，茎用水润透，切段，晒干，然后与叶和匀；
2、党参：洗净泥沙后润透去芦，切片或切段，晒干；
3、乌梅：拣净杂质，筛去灰屑，洗净，晒干；
4、炮附片：取盐附子洗净，清水浸泡一夜，除去皮脐，切片，再加水泡至口尝稍有麻辣感时，取出，用姜汤浸1-3天，然后蒸熟，再焙至七成干，倒入锅内用武火急炒至烟起，微鼓裂时，取出放凉；
5、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
6、白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，切片，干燥；
7、连翘：拣净杂质，搓开，除去枝梗；
8、苍术：拣去杂质，用水泡至七、八成透，捞出，切片，晒干；
9、厚朴：用水浸泡捞出，润透后刮去粗皮，洗净，切丝，晾干；
10、槟榔：拣去杂质，以清水浸泡，按气温情况换水，至泡透为止，捞起，切片，晾干；
11、莱菔子：簸去杂质，漂净泥土，捞出，晒干，用时捣碎；
12、使君子仁：除去外壳，取净仁；
13、木香：将原生药放清水内洗净，捞出，闷润12-24小时使软，切片，晒干；
14、砂仁：拣去杂质及果壳，捣碎；
15、干姜：拣净杂质，用水浸泡3-6小时，捞出，闷润后切片或切成小方块，晒干；
16、陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
17、黄连：拣去杂质，洗净泥砂，润透，切片，阴干；
18、紫苏梗：拣去杂质，用水浸泡后，润透，切片，晒干；
19、柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，随即晒干；
20、桂枝：用水稍浸泡，捞出，闷润至透，切片，晾干，筛去屑；
21、甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，晾干；
22、吴茱萸：取原药材，除去果柄、枝及杂质，筛去碎屑；
23、细辛：除净杂质，用水喷润，及时切段，晒干。
二、制备
1、将所述重量的藿香、党参、乌梅、附子、当归、白芍、连翘、苍术、厚朴、槟榔、莱菔子、使君子、木香、砂仁、干姜、陈皮、黄连、紫苏梗、柴胡、桂枝、甘草、吴茱萸、细辛加水煎煮二次，第一次加水6倍量，武火煎煮沸腾，再用文火煎煮30分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内。
2、将第一次过滤后的药渣加水4倍量，煎煮沸腾，再用文火煎煮30分钟过滤得第二次煎煮液。
3、将两次煎煮液混合即得药液，将药液分为3剂服用。
本发明选用乌梅为君药，黄连、柴胡为臣药，陈皮为佐药，甘草为使药，将上述药物与诸药组合制成治疗蛔虫病的药物。
本发明药物具有清热散结，安蛔驱虫，杀虫消积的功效，治疗蛔虫病见效快、疗程短，不复发。
以下通过试验例来进一步阐述本发明药物的有益效果，这些试验包括本发明药物的动物毒性试验报告和临床观察资料。
[试验例1] 本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0-2.3kg，分两组，每组20只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2] 本发明药物的临床观察资料：
1、一般资料：
收治门诊患者39例。
2、诊断标准：
临床表现：因虫体的寄生部位和发育阶段不同而异。
蛔蚴移行症蛔蚴在寄主体内移行时引起发热、全身不适、荨麻疹等。抵达肺脏后引起咳嗽、哮喘、痰中带血丝等症状，重者可有胸痛、呼吸困难和发绀。肺部X射线检查可见迁徙性浸润性阴影,临床上称为过敏性肺炎或勒夫勒氏综合征。末梢血液嗜酸性粒细胞明显增多，约10%的患者痰中可查到蛔蚴。
肠蛔虫症常见症状有脐周陷痛、食欲不振、善饥、腹泻、便秘、荨麻疹等，儿童有流涎、磨牙、烦躁不安等，重者出现营养不良。一旦寄生环境发生变化如高热时，蛔虫可在肠腔内扭结成团，阻塞肠腔而形成蛔虫性肠梗阻，患者出现剧烈的阵发性腹部绞痛，以脐部为甚，伴有恶心、呕吐，并可吐出蛔虫，腹部可触及能移动的腊肠样肿物。有时蛔虫性肠梗阻可发展成绞窄性肠梗阻、肠扭转或套叠，必须及时手术治疗。蛔虫也可穿过肠壁，引起肠穿孔及腹膜炎，若不及时手术即可死亡。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，2-3岁儿童每次服1/4剂，3-6岁儿童每次服1/3剂，6-10岁儿童每次服1/2剂，10岁以上按成人量服，每天早、晚各服1次，连续服用3天。
4、疗效评定标准
显效：蛔虫病痊愈，观察半年后无复发； 
好转：蛔虫病症状减轻，食欲增加； 
无效：症状无改善，达不到好转标准者。
5、治疗结果
                                                  
在上述的治疗中，用本发明药物治疗蛔虫病患者39例，结果显效35例，显效率为89.74%，好转4例，好转率为10.26%，总有效率为100%。

Claims (3)

1.一种治疗蛔虫病的药物，其特征求在于：它是由下列重量范围内的原料药制成： 
藿  香 10-12克   党  参    10-12克      乌  梅  10-12克
附  子 10-12克   当  归    10-12克      白  芍  10-12克
连  翘 10-12克   苍  术    8-10克    厚  朴  8-10克
槟  榔 8-10克 莱菔子    8-10克    使君子  8-10克
木  香 8-10克 砂  仁    5-8克        干  姜  5-8克
陈  皮 5-8克      黄  连 5-8克       紫苏梗  5-8克
柴  胡 5-8克      桂  枝 5-8克        甘  草  2-3克
吴茱萸 2-3克      细  辛 2-3克  。
2.根据权利要求所述的药物，其中各原料药的用量为：
藿  香 12克       党  参 12克        乌  梅   12克
附  子 12克       当  归 12克        白  芍   12克
连  翘 12克       苍  术 9克         厚  朴   9克
槟  榔 9克        莱菔子 9克         使君子   9克
木  香 9克        砂  仁 7克         干  姜   7克
陈  皮 7克        黄  连 7克         紫苏梗   7克
柴  胡 7克        桂  枝 7克         甘  草   3克
吴茱萸 3克        细  辛 3克。
3.根据权利要求1或2所述药物的制备方法，其特征在于，它包括下列步骤：
一、备料
1、藿香：拣去杂质，除去残根及老茎，先将叶摘下另放，茎用水润透，切段，晒干，然后与叶和匀；
2、党参：洗净泥沙后润透去芦，切片或切段，晒干；
3、乌梅：拣净杂质，筛去灰屑，洗净，晒干；
4、炮附片：取盐附子洗净，清水浸泡一夜，除去皮脐，切片，再加水泡至口尝稍有麻辣感时，取出，用姜汤浸1-3天，然后蒸熟，再焙至七成干，倒入锅内用武火急炒至烟起，微鼓裂时，取出放凉；
5、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
6、白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，切片，干燥；
7、连翘：拣净杂质，搓开，除去枝梗；
8、苍术：拣去杂质，用水泡至七、八成透，捞出，切片，晒干；
9、厚朴：用水浸泡捞出，润透后刮去粗皮，洗净，切丝，晾干；
10、槟榔：拣去杂质，以清水浸泡，按气温情况换水，至泡透为止，捞起，切片，晾干；
11、莱菔子：簸去杂质，漂净泥土，捞出，晒干，用时捣碎；
12、使君子仁：除去外壳，取净仁；
13、木香：将原生药放清水内洗净，捞出，闷润12-24小时使软，切片，晒干；
14、砂仁：拣去杂质及果壳，捣碎；
15、干姜：拣净杂质，用水浸泡3-6小时，捞出，闷润后切片或切成小方块，晒干；
16、陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
17、黄连：拣去杂质，洗净泥砂，润透，切片，阴干；
18、紫苏梗：拣去杂质，用水浸泡后，润透，切片，晒干；
19、柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，随即晒干；
20、桂枝：用水稍浸泡，捞出，闷润至透，切片，晾干，筛去屑；
21、甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，晾干；
22、吴茱萸：取原药材，除去果柄、枝及杂质，筛去碎屑；
23、细辛：除净杂质，用水喷润，及时切段，晒干；
二、制备
1、将所述重量的藿香、党参、乌梅、附子、当归、白芍、连翘、苍术、厚朴、槟榔、莱菔子、使君子、木香、砂仁、干姜、陈皮、黄连、紫苏梗、柴胡、桂枝、甘草、吴茱萸、细辛加水煎煮二次，第一次加水6倍量，武火煎煮沸腾，再用文火煎煮30分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内，
2、将第一次过滤后的药渣加水4倍量，煎煮沸腾，再用文火煎煮30分钟过滤得第二次煎煮液，
3、将两次煎煮液混合即得药液。
CN201410703617.XA 2014-11-30 2014-11-30 一种治疗蛔虫病的药物及其制备方法 Pending CN104383498A (zh)

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CN101168039A (zh) * 2007-09-29 2008-04-30 罗华祥 治疗蛔厥症的中药
CN102861306A (zh) * 2012-09-06 2013-01-09 李承平 一组乌梅组合片
CN103479985A (zh) * 2013-09-27 2014-01-01 周复礼 一种治疗蛔虫病的药物及其制备方法

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CN102861306A (zh) * 2012-09-06 2013-01-09 李承平 一组乌梅组合片
CN103479985A (zh) * 2013-09-27 2014-01-01 周复礼 一种治疗蛔虫病的药物及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104888047A (zh) * 2015-05-16 2015-09-09 陈久洲 一种治疗小儿蛔虫病的中药组合物

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