CN105381409A - 一种治疗胆石症的药物及其制备方法 - Google Patents
一种治疗胆石症的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗胆石症的药物及其制备方法,其主要是由金钱草、鸡内金、枳壳、金银花、茵陈蒿、青皮、半夏、陈皮、厚朴、虎杖、姜黄、大黄、白芍、佛手、猪苓、芒硝、党参、石斛、黄芩、青风藤、地榆、海金沙、白花蛇舌草、川楝子、威灵仙、玉米须、牡蛎、龙胆、瓜蒌按一定重量配比制备而成。本发明药物具有疏肝破气,清热利湿,益血柔肝,治脾胃虚弱的功能,用于治疗胆石症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗胆石症的药物及其制备方法,属中药领域。
背景技术
胆石症主要见于成人,女性多于男性,40岁后发病率随年龄增长而增高。结石为胆固醇结石或以胆固醇为主的混合性结石和黑色胆色素结石,任何影响胆固醇与胆汁酸浓度比例改变和造成胆汁淤滞的因素都能导致结石形成。中医则认为胆石症与肝气郁结,肝胃不和肝阴不足有关。由于西药治疗副作用大,因此人们对有效治疗胆石症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人经过反复的研究和临床试验的反复验证,终于找到了有效治疗胆石症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗胆石症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择金钱草、鸡内金、枳壳、金银花、茵陈蒿、青皮、半夏、陈皮、厚朴、虎杖、姜黄、大黄、白芍、佛手、猪苓、芒硝、党参、石斛、黄芩、青风藤、地榆、海金沙、白花蛇舌草、川楝子、威灵仙、玉米须、牡蛎、龙胆、瓜蒌、五灵脂、甘草、山楂药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗胆石症。其中,选用金钱草是因为其性味苦辛,凉,有清热,利尿,镇咳,消肿,解毒的功能,治黄疸,水肿,膀胱结石,疟疾,肺痈,咳嗽,吐血,淋浊,带下,风湿痹痛,小儿疳积,惊癎,痈肿,疮癣,湿疹。选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用枳壳是因为其性味苦辛、凉。入肺、脾、大肠经。破气,行痰,消积。治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用茵陈蒿是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒疮疥。选用青皮是因为其性味苦辛,微温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久疟癖块。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,清痞散结的功能,治湿痰冷饮呕吐,反胃,咳喘痰多,我膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用姜黄是因为其性味辛苦,温,入脾、肝经,有破血,行气,通经,止痛的功能,治心腹痞满胀痛,臂痛,癥瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用白芍药是因为其性味苦酸,凉,归肝脾经,有益血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调。选用佛手是因为其性味辛苦酸,温,入肝、胃经,有理气,化痰的功能,治胃痛,胁胀,呕吐,噎膈,痰饮咳喘,并能解酒。选用猪苓是因为其性味甘淡,平,入脾、肾、膀胱经,有利尿渗湿的功能,治小便不利,水肿胀满,脚气,泄泻,淋、浊,带下。选用芒硝是因其性味咸、苦,寒。归胃、大肠经,治泻下通便,润燥软坚,清火消肿。用于实热积滞,腹满胀痛,大便燥结,肠痈肿痛;外治乳痈,痔疮肿痛。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用青风藤是因为其性味苦平,有祛风湿,利不便的功能,治风湿痹痛,鹤膝风,水肿,脚气。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用海金沙是因为其性味甘淡,寒,入小肠、膀胱经,有清热解毒,利水通淋的功能,治尿路感染,尿路结石,白浊,白带,肝炎,肾炎水肿,咽喉肿痛,痄腮,肠炎,痢疾,皮肤湿疹,带状疱疹。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。选用玉米须是因为其性味甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖尿病,吐血衄血,鼻渊,乳痈。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用,治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
金钱草15-25克,鸡内金10-20克,枳壳10-20克,金银花10-20克,茵陈蒿15-25克,青皮5-15克,半夏10-15克,陈皮10-20克,厚朴5-15克,虎杖15-25克,姜黄5-15克,大黄5-15克,白芍10-20克,佛手5-15克,猪苓7-12克,芒硝10-15克,党参10-15克,石斛10-20克,黄芩7-12克,青风藤5-15克,地榆5-15克,海金沙10-20克,白花蛇舌草10-20克,川楝子5-10克,威灵仙10-15克,玉米须15-25克,牡蛎10-20克,龙胆5-15克,瓜蒌5-15克,五灵脂5-10克,甘草15-25克,山楂10-20克。
优选为:
金钱草20克,鸡内金15克,枳壳15克,金银花15克,茵陈蒿20克,青皮10克,半夏12克,陈皮15克,厚朴10克,虎杖20克,姜黄10克,大黄10克,白芍15克,佛手10克,猪苓9克,芒硝12克,党参12克,石斛15克,黄芩9克,青风藤10克,地榆10克,海金沙15克,白花蛇舌草15克,川楝子8克,威灵仙12克,玉米须20克,牡蛎15克,龙胆10克,瓜蒌10克,五灵脂8克,甘草20克,山楂15克。
本发明药物的制备方法如下
一、备料
1、金钱草:拣净杂质,筛去灰屑,晒干;
2、鸡内金:拣去杂质,漂净晒干;
3、枳壳:除去瓤、核,洗净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干;
4、金银花:筛去泥沙,拣净杂质;
5、茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
6、青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
7、半夏:半夏:拣去杂质,筛去灰屑;
8、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
9、厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
10、虎杖:春秋采挖,切段,晒干;
11、姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干;
12、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
13、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
14、佛手:拣去杂质,用水喷润后,切碎,晒干;
15、猪苓:洗净泥砂,润软切片,晾干;
16、芒硝:取原药材,除去杂质;
17、党参:洗净泥沙后润透去芦,切片或切段,晒干;
18、石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
19、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
20、青风藤:秋冬采老藤,切段,晒干;
21、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
22、海金沙:取原药材,过细筛,筛取孢子,除去杂质;
23、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
24、川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
25、威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
26、玉米须:取原药材,除去杂质,筛去灰屑;
27、牡蛎:洗净,晒干,碾碎用;
28、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
29、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
30、五灵脂:拣净杂质,打碎或筛去灰屑;
31、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
32、山楂:拣净杂质,筛去核。
二、制备
1、将炮制好的金钱草、鸡内金、枳壳、金银花、茵陈蒿、青皮、半夏、陈皮、厚朴、虎杖、姜黄、大黄、白芍、佛手、猪苓、党参、石斛、黄芩、青风藤、地榆、海金沙、白花蛇舌草、川楝子、威灵仙、玉米须、牡蛎、龙胆、瓜蒌、五灵脂、甘草、山楂放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
3、将两次煎煮液混合搅拌均匀再将芒硝溶入煎煮液中搅匀即得,分为4剂服用。
组方中茵陈蒿有清热利湿,治湿热黄疸的功能为君药;青皮疏肝破气,散结消痰;党参有补中益气,生津,治脾胃虚弱,气血两亏的功能,二者为臣药,三味药共同发挥清热利湿,疏肝破气,补中益气,治脾胃虚弱,气血两亏的作用,治疗胆石症效力全面,且以清热利湿,疏肝破气为主可治本,白芍有益血柔肝,缓中止痛,敛阴收汗的功能为佐药,甘草有和中缓急,润肺,解毒,调和诸药的功能为使药,与余下诸药是治标。
本发明药物具有疏肝破气,清热利湿,益血柔肝,治脾胃虚弱的功能,用于治疗胆石症,疗程短、见效快、治愈后不复发。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治胆石症门诊患者共25例。
2、诊断标准
典型症状为右上腹或上腹部疼痛,呈阵发性,或者持续疼痛阵发性加剧,可向右肩胛部和背部放射,可伴恶心、呕吐。饱胀不适、嗳气、呃逆等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:胆石症症状消失,体质恢复正常,痊愈;
好转:患者,上腹部疼痛减轻,恶心,呕吐,饱胀感消除,胆石症症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗胆石症患者25例,结果显效20例,显效率为80%,好转3例,好转率为12%,无效2例,总有效率为92%。
Claims (3)
1.一种治疗胆石症的药物,其特征在于:它是由下列重量范围内的原料药制成:
金钱草15-25克,鸡内金10-20克,枳壳10-20克,金银花10-20克,茵陈蒿15-25克,青皮5-15克,半夏10-15克,陈皮10-20克,厚朴5-15克,虎杖15-25克,姜黄5-15克,大黄5-15克,白芍10-20克,佛手5-15克,猪苓7-12克,芒硝10-15克,党参10-15克,石斛10-20克,黄芩7-12克,青风藤5-15克,地榆5-15克,海金沙10-20克,白花蛇舌草10-20克,川楝子5-10克,威灵仙10-15克,玉米须15-25克,牡蛎10-20克,龙胆5-15克,瓜蒌5-15克,五灵脂5-10克,甘草15-25克,山楂10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
金钱草20克,鸡内金15克,枳壳15克,金银花15克,茵陈蒿20克,青皮10克,半夏12克,陈皮15克,厚朴10克,虎杖20克,姜黄10克,大黄10克,白芍15克,佛手10克,猪苓9克,芒硝12克,党参12克,石斛15克,黄芩9克,青风藤10克,地榆10克,海金沙15克,白花蛇舌草15克,川楝子8克,威灵仙12克,玉米须20克,牡蛎15克,龙胆10克,瓜蒌10克,五灵脂8克,甘草20克,山楂15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)金钱草:拣净杂质,筛去灰屑,晒干;
(2)鸡内金:拣去杂质,漂净晒干;
(3)枳壳:除去瓤、核,洗净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干;
(4)金银花:筛去泥沙,拣净杂质;
(5)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
(6)青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
(7)半夏:半夏:拣去杂质,筛去灰屑;
(8)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(9)厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
(10)虎杖:春秋采挖,切段晒干;
(11)姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干;
(12)大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
(13)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(14)佛手:拣去杂质,用水喷润后,切碎,晒干;
(15)猪苓:洗净泥砂,润软切片,晾干;
(16)芒硝:取原药材,除去杂质;
(17)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(18)石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
(19)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(20)青风藤:秋冬采老藤,切段,晒干;
(21)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(22)海金沙:取原药材,过细筛,筛取孢子,除去杂质;
(23)白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
(24)川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
(25)威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干;
(26)玉米须:取原药材,除去杂质,筛去灰屑;
(27)牡蛎:洗净,晒干,碾碎用;
(28)龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
(29)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(30)五灵脂:拣净杂质,打碎或筛去灰屑;
(31)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(32)山楂:拣净杂质,筛去核;
(二)制备
(1)将炮制好的金钱草、鸡内金、枳壳、金银花、茵陈蒿、青皮、半夏、陈皮、厚朴、虎杖、姜黄、大黄、白芍、佛手、猪苓、党参、石斛、黄芩、青风藤、地榆、海金沙、白花蛇舌草、川楝子、威灵仙、玉米须、牡蛎、龙胆、瓜蒌、五灵脂、甘草、山楂放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀再将芒硝溶入煎煮液中搅匀即得,分为4剂服用。
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