CN105412830A - 一种治疗急性黄疸型肝炎的药物及其制备方法 - Google Patents

一种治疗急性黄疸型肝炎的药物及其制备方法 Download PDF

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CN105412830A
CN105412830A CN201510941886.4A CN201510941886A CN105412830A CN 105412830 A CN105412830 A CN 105412830A CN 201510941886 A CN201510941886 A CN 201510941886A CN 105412830 A CN105412830 A CN 105412830A
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徐士魁
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徐士魁
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Abstract

本发明公开了一种治疗急性黄疸型肝炎的药物及其制备方法,其主要是由茵陈蒿、白茅根、茯苓、板蓝根、茜草、甘草、黄芩、凤尾草、柴胡、赤小豆、夏枯草、金银花、枳壳、白鲜皮、栀子、车前子、当归、砂仁、丹参、蒲公英、川楝子、半枝莲、白花蛇舌草、黄芪、薏苡仁按一定重量配比制备而成。本发明药物具有清热利湿,清肝,散结,行气解随,凉血破瘀,治脾胃虚弱的功能,用于治疗急性黄疸型肝炎见效快、疗效好,不复发。

Description

-种治疗急性黄捏型肝炎的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗急性黄痘型肝炎的药物及其制备方法,属中药领域。
背景技术
[0002] 急性黄痘型肝炎是各种原因导致的W胆红素代谢和排泄障碍为主要表现的肝脏 损伤临床类型,病因包括药物引起的药物性肝炎,生物因素(如细菌性、病毒性)引起的各类 肝炎,物理因素引起的放射性肝炎及酒精性肝炎和自身免疫性肝炎。中医则认为急性黄痘 型肝炎与湿热之邪熏蒸肝胆,蕴郁脾胃,迫使胆汁疏泄失常,湿热入于血,疲阻血脉有关。由 于西药治疗副作用大,因此人们对有效治疗急性黄痘型肝炎的中药药物存在极大的需求, 至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人经过反复的研究和临床试验的反复验证,终于找到了有效治疗急性黄痘 型肝炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗急性黄痘型肝炎的中药组合药物。
[000引本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006]本发明药物是选择茵陈葛、白茅根、巧等、板蓝根、茜草、甘草、黄琴、凤尾草、柴胡、 赤小豆、大青叶、夏枯草、红花、金银花、积壳、白鲜皮、檐子、车前子、当归、砂仁、丹参、蒲公 英、延胡索、川棟子、半枝莲、白花蛇舌草、黄巧、慧巧仁、厚朴、郁金原料药进行组合制备的, 将运些药物组合使得各药物功效产生协同作用,从而能够有效治疗急性黄痘型肝炎。其中, 选用茵陈葛是因为其性味苦辛,凉,入肝、脾、膀脫经,有清热利湿的功能,治湿热黄痘,小便 不利,风痒疮巧。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利 尿的功能,治热病烦渴,吐血,赃血,肺热喘急,胃热吵逆,淋病,小便不利,水肿,黄痘。选用 巧等是因为其性味甘淡,平,入屯、、脾、肺经,有渗湿利水,益脾和胃,宁屯、安神的功能,治小 便不利水肿胀痛,疲饮咳逆,呕吵,泄泻,遗精,淋浊,惊惇,健忘。选用板蓝根是因为其性味 苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑, 神昏吐赃,咽肿,巧腮,火眼,疮疹。选用茜草是因为其性味苦,寒,有凉血止血,桂疲通经的 功能,治吐血,赃血,崩漏,外伤出血,疲阻经闭,关节搏痛,跌扑肿痛。选用甘草是因为其性 味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少, 腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊痴,生用治咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药 毒及食物中毒。选用黄琴是因为其性味苦寒,入屯、肺、胆、大肠经,有泻实火,除湿热,止血安 胎的功能,治壮热烦渴,肺热咳嗽。选用凤尾草是因为其性味淡微苦,寒,入肾、胃二经,有清 热利湿,凉血止血,消肿解毒的功能,治黄痘型肝炎,肠炎,菌频,淋浊,带下,吐血,赃血,便 血,尿血,扁桃体炎,腮腺炎,痴肿疮毒,湿疹。选用柴胡是因为其性味甘苦,凉,入肝、胃经, 有清热凉血的功能,治虚劳骨蒸,阴虚久追,小儿巧热贏瘦。选用赤小豆是因为其性味甘酸, 平,入屯、、小肠经,有利水除湿,和血排脈,消肿解毒的功能,治水肿,脚气,黄痘,泻频,便血, 痴肿。选用大青叶是因为其性味苦,寒,入肝、屯、、胃经,有清热,解毒,凉血,止血的功能,治 溫病热盛烦渴,流行性感冒,急性传染性肝炎,菌频,急性胃肠炎,急性肺炎,丹毒,吐血,赃 血,黄痘,频疾,喉搏,口疮,痴痘肿毒。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清 肝,散结的功能,治療痛,瘦瘤,乳痴,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨 疼痛,肺结核,急性黄痘型传染性肝炎,血崩,带下。选用红花是因为其性味辛,溫,入屯、、肝 经,有活血通经,去疲止痛的功能,治经闭,瘤瘤,难产,死胎,产后恶露不行,疲血作痛,痴 肿,跌扑损伤。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治溫病发 热,热毒血频,痴瘍,肿毒,療痛,持漏。选用积壳是因为其性味苦辛,凉,入肺、脾、大肠经,有 破气,行疲,消积的功能,治胸隔疲滞,胸瘡,胁胀,食积,噫气,呕逆,下频后重,脱肛,子宫脱 垂。选用白鲜皮是因为其性味苦,咸,寒,入脾、胃经,有桂风,燥湿,清热,解毒的功能,治风 热疮毒,巧癖,皮肤痒疹,风湿搏痛,黄痘。选用檐子是因为其性味苦,寒,入屯、、肝、肺、胃经, 有清热,泻火,凉血的功能,治热病虚烦不眠,黄痘,淋病,消渴,目赤,咽痛,吐血,赃血,血 频,尿血,热毒疮瘍,扭伤肿痛。选用车前子是因为其性味甘,寒,入肾、膀脫经,有利水,清 热,明目,桂疲的功能,治小便不通,淋浊,带下,尿血,暑湿泻频,咳嗽多疲,湿搏,目赤障繫。 选用当归是因为其性味甘辛,溫,入屯、、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能, 治月经不调,经闭腹痛,瘤瘤结聚,崩漏,血虚头痛,眩晕,瘦搏,肠燥难便,赤频后重,痴痘疮 瘍,金疮,跌扑损伤。选用砂仁是因为其性味辛,溫,入脾、胃经,有行气调中,和胃、醒脾的功 能,治腹痛瘡胀,胃呆食滞,喧隔呕吐,寒泻冷频,妊娠胎动。选用丹参是因为其性味苦,微 溫,入屯、、肝经,有活血去疲,安神宁屯、,排脈,止痛的功能,治屯、绞痛,月经不调,痛经,W闭, 血崩带下,瘤瘤,积聚,疲血腹痛,骨节疼痛,惊惇不眠,恶疮肿毒。选用蒲公英是因为其性味 苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋己腺炎,療痛,疗毒疮 月中,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选 用延胡索是因为其性味辛苦,溫,入肝、胃经,有活血,散疲,理气,止痛的功能,治屯、腹腰膝 诸痛,月经不调,瘤瘤,崩中,产后血晕,恶露不尽,跌打损伤。选用川棟子是因为其性味苦, 寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥屯、痛,胁痛,痛痛, 虫积腹痛。选用半枝莲是因为其性味苦,寒,有清热,解毒的功能,治咽喉肿痛,烫伤,跌打损 伤,湿疮。选用白花蛇舌草是因为其性味苦甘,寒,入屯、、肝、脾Ξ经,有清热,利湿,解毒的功 能,治肺热喘咳,扁桃体炎,咽喉炎,阔尾炎,频疾,黄痘,盆腔炎,附件炎,痴肿疗疮,毒蛇咬 伤。选用黄巧是因为其性味甘,微溫,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的 功能,治自汗,盗汗,血搏,浮肿,痴痘不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾 虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用慧巧仁是因为其性味甘淡,凉,入 脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿搏,筋脉拘李,屈伸不利,水肿,脚 气,肺瘦,肺痴,肠痴,淋浊,白带。选用厚朴是因为其性味苦辛,溫,入脾、胃、大肠经,有溫 中,下气,燥湿,消疲的功能,治胸腹瘡满胀痛,反胃、呕吐,宿食不消,疲饮喘咳,寒湿泻频。 选用郁金是因为其性味辛苦,凉,入屯、、肺、肝经,有行气解随,凉血破疲的功能,治胸腹胁肋 诸痛,失屯、癒狂,热病神昏,吐血,赃血,尿血,血淋,妇女倒经,黄痘。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 茵陈葛15-25克,白茅根15-25克,巧等10-20克,板蓝根15-25克,茜草15-25克,甘草10-20克,黄琴5-15克,凤尾草10-20克,柴胡5-15克,赤小豆10-20克,大青叶15-25克,夏枯草5-15克,红花10-20克,金银花10-20克,积壳5-15克,白鲜皮10-20克,檐子5-15克,车前子15-20克,当归10-20克,砂仁5-15克,丹参5-15克,蒲公英5-15克,延胡索5-15克,川棟子10-20 克,半枝莲10-20克,白花蛇舌草10-20克,黄巧10-20克,慧巧仁10-20克,厚朴5-15克,郁金 5-10 克。
[000引优选为: 茵陈葛化克,白茅根20克,巧等15克,板蓝根20克,茜草20克,甘草15克,黄琴10克,凤尾 草15克,柴胡10克,赤小豆15克,大青叶20克,夏枯草10克,红花15克,金银花15克,积壳10 克,白鲜皮15克,檐子10克,车前子20克,当归15克,砂仁10克,丹参10克,蒲公英10克,延胡 索10克,川棟子15克,半枝莲15克,白花蛇舌草15克,黄巧15克,慧巧仁15克,厚朴10克,郁金 诚。
[0009]本发明药物的制备方法如下 一、备料 1、 茵陈葛:过筛,炼去杂质,除去残根,娠碎,再过萝去净泥屑; 2、 白茅根:炼净杂质,洗净,微润,切段,晒干,鑛净碎屑; 3、 巧等:用水浸泡,洗净拱出,闷透后,切片,晒干; 4、 板蓝根:炼净杂质,洗净,润透,切片,晒干; 5、 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑; 6、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透,切片,凉干; 7、 黄琴:炼去杂质,除去残茎,用凉水浸润或置开水中稍浸拱出,切片,晒干; 8、 凤尾草:除去杂质,切段; 9、 柴胡:炼去杂质,除去残茎,洗净泥沙,拱出,润透后及时切片,晒干; 10、 赤小豆:取原药材,除去杂质,用时捣碎; 11、 大青叶:炼去杂质及枯叶,洗净,稍润,切段,晒干; 12、 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑; 13、 红花:炼净杂质,除去茎叶、蒂头,晒干; 14、 金银花:筛去泥沙,炼净杂质; 15、 积壳:除去飄、核,洗净,稍浸,拱出,润软,W手能捏对折为止,切片,惊干; 16、 白鲜皮:炼净杂质,除去粗皮,洗净,稍润,切片,晒干; 17、 檐子:筛去灰屑,炼去杂质,娠碎过筛; 18、 车前子:炼去杂质,筛去泥屑,空粒; 19、 当归:炼去杂质,洗净,闷润,稍惊,切片晒干; 20、 砂仁:炼去杂质及果壳,捣碎; 21、 丹参:炼净杂质,除去根茎,洗净,拱出,润透后切片,惊干; 22、 蒲公英:炼去杂质,洗净泥±,切段,晒干; 23、 延胡索:炼去杂质,用水浸泡,洗净,晒惊,润至内外湿度均匀,切片或打碎; 24、 川棟子:炼去杂质,洗净,烘干,社碎或劈成两半; 25、 半枝莲:除去杂质,洗净,稍润,切段,干燥; 26、 白花蛇舌草:取原药材,除去杂质,抢水洗净,稍惊,切段,干燥,筛去灰屑; 27、 黄巧:炼净杂质,除去残留的根头和空屯、较大者,用水浸泡,拱出,润透后及时切片, 晒干; 28、 慧巧仁:取原药材,除去残留皮壳、杂质; 29、 厚朴:用水浸泡拱出,润透后刮去粗皮,洗净,切丝,惊干; 30、 郁金:用水浸泡,洗净,拱出晒惊,润透,切片,晒干。
[0010] 二、制备 1、将炮制后的茵陈葛、白茅根、巧等、板蓝根、茜草、甘草、黄琴、凤尾草、柴胡、赤小豆、 大青叶、夏枯草、红花、金银花、积壳、白鲜皮、檐子、车前子、当归、砂仁、丹参、蒲公英、延胡 索、川棟子、半枝莲、白花蛇舌草、黄巧、慧巧仁、厚朴、郁金放入煎药容器内,第一次加水8倍 量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次 煎煮液倒入容器内。
[0011] 2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液。
[001引3、将两次煎煮液混合揽拌均匀即得,分为4剂服用。
[0013]组方中茵陈葛有清热利湿,治湿热黄痘,小便不利的功能为君药;丹参活血去疲, 安神宁屯、,止痛;夏枯草有清肝,散结的功能,二者为臣药,Ξ味药共同发挥清热利湿,清肝, 散结,活血去疲的作用,治疗急性黄痘型肝炎效力全面,且W清热利湿,清肝为主可治本,郁 金有行气解随,凉血破疲的功能为佐药,甘草和中缓急,润肺,解毒,调和诸药,治脾胃虚弱, 解药毒及食物中毒的功能为使药,与余下诸药是治标。
[0014]本发明药物具有清热利湿,清肝,散结,行气解随,凉血破疲,治脾胃虚弱的功能, 用于治疗急性黄痘型肝炎,疗程短、见效快、治愈后不复发。
[001引具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0016 ][试验例1 ]本发明药物的动物韋性试验报告: 取家兔30只,雌雄兼用,体重2.0-2 .化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为lOml/kg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药 物无不良毒副作用。
[0017][试验例2]本发明药物的临床疗效观察 1、一般资料 收治急性黄痘型肝炎口诊患者共25例。
[001引 2、诊断标准 典型症状为转氨酶升高,凝血酶原时间异常;严重肝病时,也可出现胆固醇、胆固醇醋、 胆碱醋酶活力下降等;伴有肝内疲胆时,碱性憐酸酶可升高;血清白蛋白下降,会出现胁痛、 口苦、呕恶、厌油、纳差瘡满、尿黄,身目俱黄、色鲜明、全身乏力,湿热等症状。
[0019] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服 用3个疗程。
[0020] 4、疗效评定标准 显效:急性黄痘型肝炎症状消失,体质恢复正常,痊愈; 好转:患者胁痛,乏力,呕恶,厌油现象减轻,急性黄痘型肝炎症状明显好转,体质逐步 恢复; 无效:达不到好转标准者。
[0021] 5、治疗结果(见下表)
Figure CN105412830AD00081
在上述治疗中,用本发明药物治疗急性黄痘型肝炎患者25例,结果显效17例,显效率为 68%,好转7例,好转率为28%,无效2例,总有效率为96%。

Claims (3)

1. 一种治疗急性黄疸型肝炎的药物,其特征在于:它是由下列重量范围内的原料药制 成: 茵陈蒿15-25克,白茅根15-25克,茯苓10-20克,板蓝根15-25克,茜草15-25克,甘草10-20克,黄芩5-15克,凤尾草10-20克,柴胡5-15克,赤小豆10-20克,大青叶15-25克,夏枯草5-15克,红花10-20克,金银花10-20克,枳壳5-15克,白鲜皮10-20克,栀子5-15克,车前子15-20克,当归10-20克,砂仁5-15克,丹参5-15克,蒲公英5-15克,延胡索5-15克,川楝子10-20 克,半枝莲10-20克,白花蛇舌草10-20克,黄芪10-20克,薏苡仁10-20克,厚朴5-15克,郁金 5-10 克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 茵陈蒿25克,白茅根20克,茯苓15克,板蓝根20克,茜草20克,甘草15克,黄芩10克,凤尾 草15克,柴胡10克,赤小豆15克,大青叶20克,夏枯草10克,红花15克,金银花15克,枳壳10 克,白鲜皮15克,栀子10克,车前子20克,当归15克,砂仁10克,丹参10克,蒲公英10克,延胡 索10克,川楝子15克,半枝莲15克,白花蛇舌草15克,黄芪15克,薏苡仁15克,厚朴10克,郁金 8克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (I) 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥肩; (2 )白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (3 )茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; (4) 板蓝根:拣净杂质,洗净,润透,切片,晒干; (5) 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎肩; (6) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (7) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (8) 凤尾草:除去杂质,切段; (9) 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干; (10) 赤小豆:取原药材,除去杂质,用时捣碎; (II) 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; (12) 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰肩; (13) 红花:拣净杂质,除去茎叶、蒂头,晒干; (14) 金银花:筛去泥沙,拣净杂质; (15) 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干; (16 )白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; (17 )栀子:筛去灰肩,拣去杂质,碾碎过筛; (18)车前子:拣去杂质,筛去泥肩,空粒; (19 )当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (20) 砂仁:拣去杂质及果壳,捣碎; (21) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (22 )蒲公英:拣去杂质,洗净泥土,切段,晒干; (23)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; (24)川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; (25 )半枝莲:除去杂质,洗净,稍润,切段,干燥; (26 )白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰肩; (27) 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切 片,晒干; (28) 意该仁:取原药材,除去残留皮壳、杂质; (29) 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (30 )郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (二)制备 (1) 将炮制后的茵陈蒿、白茅根、茯苓、板蓝根、茜草、甘草、黄芩、凤尾草、柴胡、赤小豆、 大青叶、夏枯草、红花、金银花、枳壳、白鲜皮、栀子、车前子、当归、砂仁、丹参、蒲公英、延胡 索、川楝子、半枝莲、白花蛇舌草、黄芪、薏苡仁、厚朴、郁金放入煎药容器内,加水8倍量,浸 泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液 倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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CN106491805A (zh) * 2016-10-27 2017-03-15 吴安相 一种治疗急性黄疸型肝炎的中药配方

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