CN105434874A - 一种治疗毛囊炎的药物及其制备方法 - Google Patents

一种治疗毛囊炎的药物及其制备方法 Download PDF

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CN105434874A
CN105434874A CN201510986707.9A CN201510986707A CN105434874A CN 105434874 A CN105434874 A CN 105434874A CN 201510986707 A CN201510986707 A CN 201510986707A CN 105434874 A CN105434874 A CN 105434874A
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herba
rhizoma
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卢文华
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Abstract

本发明公开了一种治疗毛囊炎的药物及其制备方法,其主要是由金银花、鱼腥草、蒲公英、紫花地丁、连翘、忍冬藤、野菊花、车前子、薄荷、败酱、黄芩、茯苓、夏枯草、防风、赤芍、黄芪、浙贝母、泽泻、鹿角胶、北沙参、重楼、黄连、葛根、丹参、马齿苋、大黄、桔梗按一定重量配比制备而成。本发明药物具有疏风清热,清热解毒,补血和血,泻实火,除湿热的功能,用于治疗毛囊炎见效快、疗效好,不复发。

Description

一种治疗毛囊炎的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗毛囊炎的药物及其制备方法,属中药领域。
背景技术
[0002] 毛囊炎是整个毛囊细菌感染发生化脓性炎症。初起为红色丘疹,逐渐演变成丘疹 性脓疱,孤立散在,自觉轻度疼痛。在成人主要发生于多毛的部位,在小儿则好发于头部,其 皮疹有时可互相融合,愈后可留有小片状秃发斑。中医则认为毛囊炎与湿热内蕴,外感毒 邪,素体虚弱有关。由于西药治疗副作用大,因此人们对有效治疗毛囊炎的中药药物存在极 大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗毛囊 炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗毛囊炎的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择金银花、鱼腥草、蒲公英、紫花地丁、连翘、忍冬藤、野菊花、车前 子、薄荷、败酱、黄芩、茯苓、夏枯草、防风、赤芍、黄芪、浙贝母、泽泻、鹿角胶、北沙参、重楼、 黄连、葛根、丹参、马齿苋、白及、大黄、桔梗、当归、马勃、苦参药物进行组合制备的,将这些 药物组合使得各药物功效产生协同作用,从而能够有效治疗毛囊炎。其中,选用金银花是因 为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬, 痔漏。选用鱼腥草是因为其性味辛,寒,入手太阴经,有清热解毒,利尿消肿的功能,治肺炎, 肺脓疡,热痢,疟疾,水肿,淋病,白带,痈肿,痔疮,脱肛,湿疹,秃疮,疥癣。选用蒲公英是因 为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰 疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿 路感染。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能, 治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清 热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用忍冬藤是 因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝 炎,痈肿疮毒,筋骨疼痛。选用野菊花是因为其性味苦辛,凉,入肺、肝经,有疏风清热,消肿 解毒的功能,治风热感冒,肺炎,白喉,胃肠炎,高血压,疔,痈,口疮,丹毒,湿疹,天泡疮。选 用车前子是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通, 淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用 薄荷是因为其性味辛,凉,入肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风热,头痛, 目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮疥,瘾疹。选用败酱是因为其性味苦,平,入肝、胃、 大肠经,有清热解毒,排脓破瘀的功能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛, 痈肿疥癣。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的 功能,治壮热烦渴,肺热咳嗽。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水, 益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸, 健忘。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,癭瘤,乳 痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性 肝炎,血崩,带下。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止 痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用赤芍 是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤 肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用黄芪是因为其性味甘,微 温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈 疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一 切气衰血虚之症。选用浙贝母是因为其性味苦,微寒,归肺、心经,有清热散结,化痰止咳的 功能,治风热犯肺,痰火咳嗽,肺痈,乳痈,瘰疬,疮毒,心胸郁闷。选用泽泻是因为其性味甘, 寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋 病,尿血。选用鹿角胶是因为其性味甘咸,温,入肝、肾经,有补血,益精的功能,治肾气不足, 虚劳羸瘦,腰痛,阴疽,男子阳痿、滑精,妇女子宫虚冷,崩漏,带下。选用北沙参是因为其性 味甘苦淡,凉,入肺、脾经,有养阴清肺,祛痰止咳的功能,治肺热燥咳,虚痨久咳,阴伤咽干、 口渴。选用重楼是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉肝定惊的 功能,治疔疮痈肿,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽搐。选用黄连是因为其性味苦, 寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞 满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼, 口疮,痈疽疮毒,湿疹,汤火烫伤。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌, 透疹止泻,除烦止喝的功能,治伤寒,治伤寒,温热头痛项强,烦热消渴,泄泻,痢疾,癍疹不 透,高血压,心绞痛,耳聋。选用丹参是因为其性味苦,微温,入心、肝经,有活血祛痰,安神宁 心,排脓,止痛的功能,治心绞痛,月经不调,痛经,经闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨 节疼痛,惊悸不眠,恶疮肿毒。选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解 毒,散血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用白及是因为 其性味甘苦、凉,入肺经,有补肺、止血、消肿、生肌,敛疮的功能,治肺伤咳血,衄血,痈疽肿 毒,溃疡疼痛。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的 功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热 疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用桔梗是因为 其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐 脓,胸满胁痛,痢疾腹痛。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经 止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥 难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用马勃是因为其性味辛,平。入肺经。清肺利 咽,解毒,止血。治喉痹咽痛,咳嗽失音,吐血,衄血,外伤出血。选用苦参是因为其性味苦, 寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带 下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 金银花10-20克,鱼腥草10-20克,蒲公英7-12克,紫花地丁15-25克,连翘15-20克,忍冬 藤10-20克,野菊花7-12克,车前子10-20克,薄荷5-15克,败酱10-15克,黄芩10-20克,茯苓 10-20克,夏枯草10-20克,防风10-15克,赤芍7-12克,黄芪10-20克,浙贝母7-12克,泽泻5-15克,鹿角胶5-10克,北沙参10-20克,重楼10-15克,黄连5-15克,葛根10-20克,丹参7-12 克,马齿苋10-15克,白及5-15克,大黄5-15克,桔梗5-15克,当归7-12克,马勃5-6克,苦参 10-20 克。
[0008] 优选为: 金银花15克,鱼腥草15克,蒲公英9克,紫花地丁20克,连翘18克,忍冬藤15克,野菊花9 克,车前子15克,薄荷10克,败酱12克,黄芩15克,茯苓15克,夏枯草15克,防风12克,赤芍9 克,黄芪15克,浙贝母9克,泽泻10克,鹿角胶8克,北沙参15克,重楼12克,黄连10克,葛根15 克,丹参9克,马齿苋12克,白及10克,大黄10克,桔梗10克,当归9克,马勃6克,苦参15克。
[0009] 本发明药物的制备方法如下 一、备料 1、 金银花:筛去泥沙,拣净杂质; 2、 鱼腥草:去净杂质,除去残根,洗净切段,晒干; 3、 蒲公英:拣去杂质,洗净泥土,切段,晒干; 4、 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; 5、 连翘:拣净杂质,搓开,除去枝梗; 6、 忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干; 7、 野菊花:去净杂质,除去残根,洗净切段,晒干; 8、 车前子:拣去杂质,筛去泥肩、空粒; 9、 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒干, 再与叶和匀; 10、 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; 11、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 12、 茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; 13、 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰肩; 14、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; 15、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; 16、 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片, 晒干; 17、 浙贝母:除去杂质,大小分档,洗净,润透,切厚片,晒干; 18、 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; 19、 鹿角胶:取原药材,除去杂质,用时捣碎; 20、 北沙参:拣去杂质,除去茎基,用水略洗,捞出,稍润,切段,晒干; 21、 重楼:除去须根,洗净,干燥; 22、 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; 23、 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; 24、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 25、 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; 26、 白及:除去杂质,用水浸泡,捞出,稍晾,切片,干燥; 27、 大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干; 28、 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; 29、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 30、 马勃:除去硬皮,切成方块; 31、 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干。
[0010] 二、制备 1、 将炮制好的金银花、鱼腥草、蒲公英、紫花地丁、连翘、忍冬藤、野菊花、车前子、薄荷、 败酱、黄芩、茯苓、夏枯草、防风、赤芍、黄芪、浙贝母、泽泻、鹿角胶、北沙参、重楼、黄连、葛 根、丹参、马齿苋、白及、大黄、桔梗、当归、马勃、苦参放入煎药容器内,第一次加水8倍量,浸 泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液 倒入容器内; 2、 将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀即得,分为4剂服用。
[0011] 组方中金银花有清热解毒,治温病发热的功能为君药;黄芩泻实火,除湿热;当归 有补血和血,调经止痛,的功能,二者为臣药,三味药共同发挥清热解毒,治温病发热,补血 和血,泻实火,除湿热的作用,治疗毛囊炎效力全面,且以清热解毒,泻实火,除湿热,补血和 血为主可治本,野菊花有疏风清热,消肿解毒的功能为佐药,苦参有清热,燥湿,治热毒血 痢,皮肤瘙痒,阴疮湿痒的功能为使药,与余下诸药是治标。
[0012] 本发明药物具有疏风清热,清热解毒,补血和血,泻实火,除湿热的功能,用于治疗 毛囊炎,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[00M][试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为IOmVkg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药 物无不良毒副作用。
[0015][试验例2 ]本发明药物的临床疗效观察 1、一般资料 收治毛囊炎门诊患者共29例。
[0016] 2、诊断标准 典型症状初起为与毛囊口一致的红色充实性丘疹或由毛囊性脓疱疮开始,以后迅速发 展演变成丘疹性脓疱,中间贯穿毛发,四周红晕有炎症,继而干燥结痂,反复发作,多年不 愈,有的也可发展为深在的感染,形成疖、痈等症状。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,6天为一个疗程,连续服 用3个疗程。
[0018] 4、疗效评定标准 显效:毛囊炎症状消失,体质恢复正常,痊愈; 好转:患者局部皮肤瘙痒,丘疹脓疱、炎症减轻,毛囊炎症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN105434874AD00081
在上述治疗中,用本发明药物治疗毛囊炎患者29例,结果显效25例,显效率为86.21%, 好转3例,好转率为10.34%,无效1例,总有效率为96.55%。

Claims (3)

1. 一种治疗毛囊炎的药物,其特征在于:它是由下列重量范围内的原料药制成: 金银花10-20克,鱼腥草10-20克,蒲公英7-12克,紫花地丁15-25克,连翘15-20克,忍冬 藤10-20克,野菊花7-12克,车前子10-20克,薄荷5-15克,败酱10-15克,黄芩10-20克,茯苓 10-20克,夏枯草10-20克,防风10-15克,赤芍7-12克,黄芪10-20克,浙贝母7-12克,泽泻5-15克,鹿角胶5-10克,北沙参10-20克,重楼10-15克,黄连5-15克,葛根10-20克,丹参7-12 克,马齿苋10-15克,白及5-15克,大黄5-15克,桔梗5-15克,当归7-12克,马勃5-6克,苦参 10-20 克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 金银花15克,鱼腥草15克,蒲公英9克,紫花地丁20克,连翘18克,忍冬藤15克,野菊花9 克,车前子15克,薄荷10克,败酱12克,黄芩15克,茯苓15克,夏枯草15克,防风12克,赤芍9 克,黄芪15克,浙贝母9克,泽泻10克,鹿角胶8克,北沙参15克,重楼12克,黄连10克,葛根15 克,丹参9克,马齿苋12克,白及10克,大黄10克,桔梗10克,当归9克,马勃6克,苦参15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 金银花:筛去泥沙,拣净杂质; (2) 鱼腥草:去净杂质,除去残根,洗净切段,晒干; (3 )蒲公英:拣去杂质,洗净泥土,切段,晒干; (4) 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; (5) 连翘:拣净杂质,搓开,除去枝梗; (6) 忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干; (7 )野菊花:去净杂质,除去残根,洗净切段,晒干; (8) 车前子:拣去杂质,筛去泥肩、空粒; (9) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; (10) 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; (11) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (12 )茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; (13) 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰肩; (14) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (15) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (16) 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切 片,晒干; (17) 浙贝母:除去杂质,大小分档,洗净,润透,切厚片,晒干; (18) 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; (19) 鹿角胶:取原药材,除去杂质,用时捣碎; (20) 北沙参:拣去杂质,除去茎基,用水略洗,捞出,稍润,切段,晒干; (21) 重楼:除去须根,洗净,干燥; (22 )黄连:拣去杂质,洗净泥砂,润透,切片,阴干; (23) 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; (24) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (25) 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; (26) 白及:除去杂质,用水浸泡,捞出,稍晾,切片,干燥; (27) 大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干; (28) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (29 )当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (30 )马勃:除去硬皮,切成方块; (31)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; (二)制备 (1) 将炮制好的金银花、鱼腥草、蒲公英、紫花地丁、连翘、忍冬藤、野菊花、车前子、薄 荷、败酱、黄芩、茯苓、夏枯草、防风、赤芍、黄芪、浙贝母、泽泻、鹿角胶、北沙参、重楼、黄连、 葛根、丹参、马齿苋、白及、大黄、桔梗、当归、马勃、苦参放入煎药容器内,加水8倍量,浸泡 100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒 入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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