CN105343865A - 一种治疗神经性呕吐的药物及其制备方法 - Google Patents

一种治疗神经性呕吐的药物及其制备方法 Download PDF

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CN105343865A
CN105343865A CN201510951001.9A CN201510951001A CN105343865A CN 105343865 A CN105343865 A CN 105343865A CN 201510951001 A CN201510951001 A CN 201510951001A CN 105343865 A CN105343865 A CN 105343865A
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fructus
radix
rhizoma
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徐士杰
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徐士杰
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Abstract

本发明公开了一种治疗神经性呕吐的药物及其制备方法,其主要是由柴胡、半夏、竹茹、白芍、茯苓、白术、厚朴、陈皮、紫苏、党参、山药、砂仁、桂枝、旋复花、代赭石、香附等按一定重量配比制备而成,本发明药物具有降逆止呕,清痞散结,益脾和胃,宁心安神的功能,用于治疗神经性呕吐见效快,疗效好,无副作用。

Description

-种治疗神经性呕吐的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗神经性呕吐的药物及其制备方法,属中药领域。
背景技术
[0002] 神经性呕吐指一组自发性反复呕吐的精神障碍,呕吐物为刚吃进的食物。该病不 伴有其他的明显症状,无患者有害怕发胖和减轻体重的愿望,但体重无明显减轻。本病女性 比男性多见,通常发生于成年早期和中期。由于西药无法有效快速治疗神经性呕吐,因此人 们对有效治疗神经性呕吐的中药药物存在极大的需求,至今为止,还没有发现关于本发明 的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗神经 性呕吐的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗神经性呕吐的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择柴胡、半夏、竹茹、白巧、巧等、白术、厚朴、陈皮、紫苏、党参、山 药、砂仁、桂枝、旋复花、代髓石、香附、附子、甘草、生姜、大要、积实、鸡内金、神曲、山植、麦 芽、谷芽、吴荣英、木香、下香药物进行组合制备的,将运些药物组合使得各药物功效产生协 同作用,从而能够有效治疗神经性呕吐。其中,选用柴胡是因为其性味苦,凉,入肝、胆经,有 和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,追疾,下利脱肛, 月经不调,子宫下垂。选用半夏是因为其性味辛,溫,有毒,入脾、胃经,有燥湿化疲,降逆止 呕,清瘡散结的功能,治湿疲冷饮呕吐,反胃,咳喘疲多,我隔胀满,疲厥头痛,头晕不眠,外 消痴肿。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉血,化疲,止吐的功能,治烦热 呕吐、呢逆,疲热咳喘,吐血,赃血,崩漏,恶阻,胎动,惊癖。选用白巧是因为其性味苦酸,凉, 入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻频腹痛,自汗盗 汗,阴虚发热,月经不调,崩漏,带下。选用巧等是因为其性味甘淡,平,入屯、、脾、肺经,有渗 湿利水,益脾和胃,宁屯、安神的功能,治小便不利水肿胀痛,疲饮咳逆,呕吵,泄泻,遗精,淋 浊,惊惇,健忘。选用白术是因为其性味苦甘,溫,入脾、胃经,有补脾,益胃,燥湿,和中的功 能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,疲饮,水肿,黄痘,湿搏,小便不利,头晕, 自汗,胎气不安。选用厚朴是因为其性味苦辛,溫,入脾、胃、大肠经,有溫中,下气,燥湿,消 疲的功能,治胸腹瘡满胀痛,反胃、呕吐,宿食不消,疲饮喘咳,寒湿泻频。选用陈皮是因为 其性味苦、辛,溫,归肺、脾经,有理气健脾,燥湿化疲的功能,治胸腕胀满,食少吐泻,咳嗽疲 多。选用紫苏叶是因为其性味辛,溫,入肺、脾经,有发表,散寒,理气,和营的功能,治感冒风 寒,恶寒发热,咳嗽,气喘,胸腹胀满,胎动不安,并能解鱼蟹毒。选用党参是因为其性味甘, 平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少, 口渴,久泻,脱肛。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精 的功能,治脾虚泄泻,久频,虚劳咳嗽,消渴,遗精、带下,小便频数。选用砂仁是因为其性味 辛,溫,入脾、胃经,有行气调中,和胃、醒脾的功能,治腹痛瘡胀,胃呆食滞,喧隔呕吐,寒泻 冷频,妊娠胎动。选用桂枝是因为其性味辛甘,溫,入膀脫、屯、、肺经,有发汗解肌,溫经通脉 的功能,治风寒表证,肩背肢节酸疼,胸搏疲饮,经闭瘤瘤。选用旋复花是因为其性味咸,溫, 入肺、肝、胃经,有消疲,下气,软坚,行水的功能,治胸中疲结,胁下胀满,咳喘,呢逆,唾如胶 漆,屯、下瘡硬,噫气不除,大腹水肿。选用代髓石是因为其性味苦甘,平,入肝、胃、屯、胞经,有 平肝镇逆,凉血止血的功能,治噫气呕逆,喧隔反胃,哮喘,惊癖,吐血,鼻赃,肠风,持瘦,崩 漏带下。选用香附是因为其性味辛微苦干,平,入肝、=焦经,有理气解郁,止痛调经的功能, 治肝胃不和,气郁不舒,胸腹胁肋胀痛,疲饮瘡满,月经不调,崩漏带下。选用附子是因为其 性味辛甘,热,有毒,入屯、、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛络阳,大汗亡阳, 吐利厥逆,屯、腹冷痛,脾泄冷频,脚气水肿,小儿慢惊,风寒湿搏,曝磬拘李,阴痘疮漏及一切 沉寒瘤冷之疾。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调 和诸药的功能;炙用,治脾胃食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊癖;生用,治咽 喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用生姜是因为其性味辛,溫,入肺、 胃、脾经,有发表,散寒,止呕,开疲的功能,治感冒风寒,呕吐,疲饮,喘咳,胀满,泄泻,解半 夏、天南星及鱼蟹、鸟兽肉毒。选用大要是因为其性味甘,溫,入脾、胃经,有补脾和胃,益气 生津,调营卫,解药毒的功能,治胃虚食少,脾弱便漉,气血津液不足,营卫不和,屯、惇怔忡, 妇人脏躁。选用积实是因为其性味苦,寒,入脾、胃经,有破气,散瘡,泻疲,消积的功能,治胸 腹胀痛,胸搏,瘡痛,疲癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用鸡内金是因为其 性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻频,巧积,消渴, 遗溺,喉搏乳蛾,牙巧口疮。选用神曲是因为其性味甘辛,溫,入碑、胃经,有健脾和胃,消食 调中的功能,治饮食停滞,胸瘡腹胀,呕吐泻频,产后疲血腹痛,小儿腹大坚积。选用山植是 因为其性味酸甘,微溫,入脾、胃、肝经,有消食积,散疲血,驱缘虫的功能,治肉积,瘤瘤,疲 饮,瘡满,吞酸,泻频,肠风,腰痛,痛气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用麦芽是 因为其性味甘,微溫,入脾、胃经,有消食,和中,下气的功能,治食积不消,胀腹胀满,食欲不 振,呕吐泄泻,乳胀不消。选用谷芽是因为其性味甘溫,入脾胃经,有健脾开胃,和中消食的 功能,治宿食不化,胀满泄泻,不思饮食。选用吴荣英是因为其性味辛苦,溫,有毒,入肝、胃 经,有溫中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,腕腹胀痛,脚气,痛 气,口疮溃瘍,齿痛,湿疹,黄水疮。选用木香是因为其性味辛苦,溫,入肺、肝、脾经,有行气 止痛,溫中和胃的功能,治中寒气滞,胸腹胀痛,呕吐,泄泻,下频里急后重,寒痛。选用下香 是因为其性味辛,溫,入胃、脾、肾经,有溫中,暖肾,降逆的功能,治呢逆,呕吐,反胃,泻频, 屯、腹冷痛,疫癖,痛气,癖疾。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 柴胡15-20克、半夏5-12克、竹茹8-12克、白巧8-15克、巧等8-15克、白术8-15克、 厚朴8-12克、陈皮8-12克、紫苏15-20克、党参15-25克、山药10-20克、砂仁10-15克、桂 枝10-15克、旋复花10-15克、代髓石15-25克、香附5-10克、附子8-12克、甘草5-10克、 生姜8-10片、大要8-10克、积实5-10克、鸡内金8-12克、神曲10-15克、山植10-15克、 麦芽5-15克、谷芽10-15克、吴荣英3-5克、木香3-8克、下香2-3克。
[000引优选为: 柴胡16克、半夏10克、竹茹10克、白巧10克、巧等10克、白术10克、厚朴10克、陈 皮10克、紫苏15克、党参15克、山药15克、砂仁12克、桂枝12克、旋复花10克、代髓石20 克、香附8克、附子10克、甘草6克、生姜8片、大要10克、积实8克、鸡内金10克、神曲 10克、山植10克、麦芽10克、谷芽10克、吴荣英3克、木香3克、下香2克。
[0009]本发明药物的制备方法如下 一、备料 1、 柴胡:炼去杂质,除去残茎,洗净泥沙,拱出,润透后及时切片,晒干; 2、 半夏:炼去杂质,筛去灰屑; 3、 竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段 4、 白巧:炼去杂质,分开大小个,用水浸泡至八成透,拱出,晒惊,润至内外湿度均匀,切 片,干燥; 5、 巧等:用水浸泡,洗净拱出,闷透后,切片,晒干; 6、 白术:炼净杂质,用水浸泡,泡后拱出,润透,切片,晒干; 7、 厚朴:用水浸泡拱出,润透后刮去粗皮,洗净,切丝,惊干; 8、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低溫干燥,筛 去灰屑; 9、 紫苏叶:炼去杂质,晒干; 10、 党参:洗净泥沙后润透去芦,切片或切段,晒干; 11、 山药:炼净杂质,用水浸泡至山药中屯、部软化为止,拱出稍惊,切片晒干或烘干; 12、 砂仁:炼去杂质及果壳,捣碎; 13、 桂枝:用水稍浸泡,拱出,闷润至透,切片,惊干,筛去屑; 14、 旋复花:炼净杂质,除去梗叶,筛去泥上; 15、 代髓石:除去杂质,砸碎,过筛; 16、 香附:炼去杂质,娠成碎粒,鑛去细毛及细末; 17、 附子:取盐附子用水浸漂,每日换水2-3次,至咸味漂尽,取出,与甘草、黑豆加水同 煮透屯、,至切开后口尝无麻舌感时,取出,除去甘草、黑豆,切薄片,干燥,筛去碎屑,每100 斤盐附子,用甘草5斤,黑豆10斤; 18、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透切片,晒干; 19、 生姜:炼去杂质,洗净泥±,用时切片; 20、 大要:炼净杂质,晒干; 21、 积实:炼净杂质,用水浸泡至八成透,拱出,润至内无硬屯、,切片,惊干; 22、 鸡内金:炼去杂质,漂净晒干; 23、 神曲:取教皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去教皮,放 凉; 24、 山植:取炼净的山植,置锅内用武火炒至外面焦褐色,内部黄褐色为止,喷淋清水, 取出,晒干; 25、 麦芽:取麦芽置锅内微炒至黄色,取出放凉; 26、 谷芽:置锅内用文火炒至深黄色,并大部爆裂,取出,放凉; 27、 吴荣英:取原药材,除去果柄、枝及杂质,筛去碎屑; 28、 木香:将原生药放清水内洗净,拱出,闷润12-24小时使软,切片,晒干; 29、 下香:炼去杂质、花梗,筛去灰屑,用时捣碎; 二、制备 1、将所述重量的柴胡、半夏、竹茹、白巧、巧等、白术、厚朴、陈皮、紫苏、党参、山药、砂 仁、桂枝、旋复花、代髓石、香附、附子、甘草、生姜、大要、积实、鸡内金、神曲、山植、麦芽、谷 芽、吴荣英、木香、下香放入煎药容器,第一次加水8倍量,浸泡80分钟后,武火煎煮沸腾,再 用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
[0010] 2、将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次 煎煮液倒入容器内。
[0011]3、将两次煎煮液混合揽拌均匀,分成4剂服用。
[0012] 组方中半夏有降逆止呕,清瘡散结的功能为君药;吴荣英理气,燥湿,治呕逆吞酸, 代髓石有凉血止血,治噫气呕逆的功能二者为臣药,=味药共同发挥降逆止呕的作用,治疗 神经性呕吐效力全面,且W清热凉血,清瘡散结为主可治本;巧等益脾和胃,宁屯、安神为佐 药;生姜有止呕,解毒的功能,与下余诸药是治标。
[0013] 本发明药物具有降逆止呕,清瘡散结,益脾和胃,宁屯、安神的功能,用于治疗神经 性呕吐,疗程短、见效快、治愈后不复发、无毒副作用。
[0014]
具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0015][试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化克,分两组,每组15只,其中一组为超剂量试 验组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为lOml/kg,给药方 式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正 常,药物无不良毒副作用。
[0016][试验例2]本发明药物的临床疗效观察 1、一般资料 收治神经性呕吐口诊患者共45例。
[0017] 2、诊断标准 神经性呕吐一般在进食后呕吐,无明显恶屯、及其他不适,W后在类似情况下反复发作。 呕吐患者否认自己有怕胖的屯、理和要求减轻体重的愿望,对自身的健康很关屯、,常常在呕 吐后进食,甚至边吐边吃,呕吐不影响下次进食的食欲。患者因总的进食量不减少,故体重 无显著减轻,体重常保持在正常体重的80%W上。无内分泌素乱等现象。
[001引 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用2个疗程。
[0019] 4、疗效评定标准 显效:神经性呕吐症状消失,痊愈,体质恢复正常; 好转:神经性呕吐症状明显减轻好转,体质逐步恢复; 无效:达不到好转标准者。
[0020] 5、治疗结果(见下表)
Figure CN105343865AD00081
在上述治疗中,用本发明药物治疗神经性呕吐患者45例,结果显效42例,显效率为 93. 33%,好转2例,好转率为4. 45%,无效1例,总有效率为97. 78%。

Claims (3)

1. 一种治疗神经性呕吐的药物,其特征在于:它是由下列用量范围内的原料药制成: 柴胡15-20克、半夏5-12克、竹茹8-12克、白芍8-15克、茯苓8-15克、白术8-15克、 厚朴8-12克、陈皮8-12克、紫苏15-20克、党参15-25克、山药10-20克、砂仁10-15克、桂 枝10-15克、旋复花10-15克、代赭石15-25克、香附5-10克、附子8-12克、甘草5-10克、 生姜8-10片、大枣8-10克、枳实5-10克、鸡内金8-12克、神曲10-15克、山楂10-15克、 麦芽5-15克、谷芽10-15克、吴茱萸3-5克、木香3-8克、丁香2-3克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 柴胡16克、半夏10克、竹茹10克、白芍10克、茯苓10克、白术10克、厚朴10克、陈 皮10克、紫苏15克、党参15克、山药15克、砂仁12克、桂枝12克、旋复花10克、代赭石20 克、香附8克、附子10克、甘草6克、生姜8片、大枣10克、枳实8克、鸡内金10克、神曲 10克、山楂10克、麦芽10克、谷芽10克、吴茱萸3克、木香3克、丁香2克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干; (2) 半夏:拣去杂质,筛去灰肩; (3) 竹茹:除去硬竹签、杂质,抖掉灰肩,揉成小团或切段 (4) 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀, 切片,干燥; (5) 茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; (6) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (7) 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (8) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (9) 紫苏叶:拣去杂质,晒干; (10) 党参:洗净泥沙后润透去芦,切片或切段,晒干; (11) 山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干; (12) 砂仁:拣去杂质及果壳,捣碎; (13) 桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去肩; (14) 旋复花:拣净杂质,除去梗叶,筛去泥土; (15) 代赭石:除去杂质,砸碎,过筛; (16) 香附:拣去杂质,碾成碎粒,簸去细毛及细末; (17) 附子:取盐附子用水浸漂,每日换水2-3次,至咸味漂尽,取出,与甘草、黑豆加水 同煮透心,至切开后口尝无麻舌感时,取出,除去甘草、黑豆,切薄片,干燥,筛去碎肩,每100 斤盐附子,用甘草5斤,黑豆10斤; (18) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; (19) 生姜:拣去杂质,洗净泥土,用时切片; (20) 大枣:拣净杂质,晒干; (21) 枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; (22) 鸡内金:拣去杂质,漂净晒干; (23) 神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放 凉; (24) 山楂:取拣净的山楂,置锅内用武火炒至外面焦褐色,内部黄褐色为止,喷淋清水, 取出,晒干; (25) 麦芽:取麦芽置锅内微炒至黄色,取出放凉; (26) 谷芽:置锅内用文火炒至深黄色,并大部爆裂,取出,放凉; (27) 吴朱英:取原药材,除去果柄、枝及杂质,师去碎肩; (28) 木香:将原生药放清水内洗净,捞出,闷润12 - 24小时使软,切片,晒干; (29) 丁香:拣去杂质、花梗,筛去灰肩,用时捣碎; (二)制备 (1) 将所述重量的柴胡、半夏、竹茹、白芍、茯苓、白术、厚朴、陈皮、紫苏、党参、山药、砂 仁、桂枝、旋复花、代赭石、香附、附子、甘草、生姜、大率、枳实、鸡内金、神曲、山楂、麦芽、谷 芽、吴茱萸、木香、丁香放入煎药容器,第一次加水8倍量,浸泡80分钟后,武火煎煮沸腾,再 用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次煎 煮液倒入容器内; (3) 将两次煎煮液混合搅拌均匀,分成4剂服用。
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