CN106729550A - 一种治疗妊娠恶阻的药物及其制备方法 - Google Patents
一种治疗妊娠恶阻的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗妊娠恶阻的药物及其制备方法,其主要是由伏龙肝、竹茹、代赭石、党参、砂仁,紫苏梗、苏叶、茯苓、柚皮、黄连、芦根、黄芪、竹叶、当归、陈皮、玉米须、藿香、柿蒂、白术、香附、葫芦茶、菊花、甘草按一定重量配比制备而成,本发明药物具有补益肝肾,理气健脾,祛湿化痰,和胃降逆的功能,用于治疗妊娠恶阻见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗妊娠恶阻的药物及其制备方法,属中药领域。
技术背景
妊娠恶阻是指患者在妊娠早期(一般系妊娠二、三个月)反复出现恶心呕吐,头晕倦怠,甚至食入即吐。中医则认为此病多与脾胃虚弱、痰滞中焦、肝郁犯脾和气阴两伤等有关。由于西药治疗副作用大,因此人们对有效治疗妊娠恶阻的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗妊娠恶阻的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗妊娠恶阻的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择伏龙肝、半夏、竹茹、代赭石、党参、砂仁,紫苏梗、苏叶、茯苓、柚皮、黄连、芦根、黄芪、竹叶、当归、陈皮、玉米须、藿香、柿蒂、白术、山药、黄芩、香附、葫芦茶、菊花、甘草、瓜蒌、丁香、炮姜药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗妊娠恶阻。其中选用伏龙肝是因为其性味辛,温,入肝、脾、胃,有温中燥湿,止呕止血的功能,治呕吐反胃,腹痛泄泻,吐血、衄血、便血、尿血,妇女妊娠恶阻,崩漏带下,痈肿溃疡。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,消痞散结的功能,治湿痰冷饮,呕吐,反胃,咳喘痰多,胸膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉血,化痰,止吐的功能,治烦热呕吐、呃逆,痰热咳喘,吐血,衄血,崩漏,恶阻,胎动,惊癎。选用代赭石是因为其性味苦甘,平,入肝、胃、心胞经,有平肝镇逆,凉血止血的功能,治噫气呕逆,噎膈反胃,哮喘,惊癎,吐血,鼻衄,肠风,痔痿,崩漏带下。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用砂仁是因为其性味辛,温,入脾、胃经,有行气调中,和胃、醒脾的功能,治腹痛痞胀,胃呆食滞,噎隔呕吐,寒泻冷痢,妊娠胎动。选用紫苏梗是因为其性味辛甘,微温,入脾、胃、肺三经,有理气,舒郁,止痛,安胎的功能,治气郁,食滞,胸膈痞闷,脘腹疼痛,胎气不和。选用紫苏叶是因为其性味辛,温,入肺、脾经,有发表,散寒,理气,和营的功能,治感冒风寒,恶寒发热,咳嗽,气喘,胸腹胀满,胎动不安,并能解鱼蟹毒。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用柚皮是因为其性味辛甘苦,温,入脾、肾、膀胱三经,有化痰,消食,下气,快膈的功能,治气郁胸闷,脘腹冷痛,食滞,咳喘,疝气。选用黄连是因为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用芦根是因为其性味甘,寒,入肺、胃经,有清热,生津,除烦,止呕的功能,治热病烦渴,胃热呕吐,噎膈,反胃,肺痿,肺痈,并解河豚鱼毒。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用竹叶是因为其性味甘淡,寒,入心、肺、胆、胃经,有清热除烦,生津利尿的功能,治热病烦喝,小儿惊癎,咳逆吐衄,面赤,小便短赤,口糜舌疮。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用玉米须是因为其性味甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖尿病,吐血衄血,鼻渊,乳痈。选用藿香是因为其性味辛,微温,入肺、脾、胃经,有快气,和中,辟秽,祛湿的功能,治感冒暑湿,寒热,头痛,胸脘痞闷,呕吐泄泻,疟疾,痢疾,口臭。选用柿蒂是因为其性味苦涩,平,入手太阴肺经,有降逆气的功能,止呃忒、呕哕。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用葫芦茶是因为其性味苦涩,凉,入肺、肝、膀胱经,有清热,利湿,消滞,杀虫的功能,治感冒,咽痛,肺病咳血,肠炎,痢疾,黄疸,风湿关节痛,钩虫病,妊娠呕吐,小儿疳积,疮疥。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用丁香是因为其性味辛,温,入胃、脾、肾经,有温中,暖肾,降逆的功能,治呃逆,呕吐,反胃,泻痢,心腹冷痛,痃癖,疝气,癣疾。选用炮姜是因为其性味辛,热,归脾、胃、肾、心、肺经,有温中散寒,温经止血的功能,治脾胃虚寒,腹痛吐泻,吐衄崩漏,阳虚失血。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
伏龙肝12-18克、半夏6-10克、竹茹12-18克、代赭石12-18克、党参10-15克、砂仁12-18克、紫苏梗8-12克、紫苏叶8-12克、茯苓12-18克、柚皮8-12克、黄连8-12克、芦根10-15克、黄芪8-12克、竹叶8-12克、当归8-12克、陈皮12-18克、玉米须8-12克、藿香8-12克、柿蒂10-15克、白术12-18克、山药10-15克、黄芩8-12克、香附8-12克、葫芦茶8-12克、菊花8-12克、甘草10-15克、瓜蒌8-12克、丁香12-18克、炮姜8-12克。
优选用量为
伏龙肝15克、半夏8克、竹茹15克、代赭石15克、党参12克、砂仁15克、紫苏梗10克、紫苏叶10克、茯苓15克、柚皮10克、黄连10克、芦根12克、黄芪10克、竹叶10克、当归10克、陈皮15克、玉米须10克、藿香10克、柿蒂12克、白术15克、山药12克、黄芩10克、香附10克、葫芦茶10克、菊花10克、甘草12克、瓜蒌10克、丁香15克、炮姜10克。
本发明药物的制备方法如下
一、备料
1、伏龙肝:在拆修柴火灶(或烧柴的窑)时,将烧结的土块取下,用刀削去焦黑部分及杂质即得;
2、姜半夏:取净半夏,用凉水浸漂,避免日晒,浸泡10日后起白沫时,每半夏100斤加白矾2斤,泡1日后再进行换水,至口尝稍有麻辣感后,另取生姜切片煎汤,加白矾与半夏共煮透,取出,晾至六成干,闷润后,切片,晾干,每半夏100斤,用生姜25斤,白矾12斤8两—14斤8两;
3、竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
4、代赭石:除去杂质,砸碎,过筛;
5、党参:洗净泥沙后润透去芦,切片或切段,晒干;
6、砂仁:拣去杂质及果壳,捣碎;
7、紫苏梗:拣去杂质,用水浸泡后,润透,切片,晒干;
8、紫苏叶:拣去杂质,晒干;
9、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
10、柚皮:秋末、冬初收集,剖成5~7瓣,悬起晒干或阴干;
11、黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
12、芦根:拣去杂质及根,切段,晒干;
13、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
14、竹叶:拣净杂质,除去梗叶,晾干;
15、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
16、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
17、玉米须:取原药材,除去杂质,筛去灰屑;
18、藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
19、柿蒂:取原药材,除去杂质;
20、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
21、山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
22、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
23、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
24、葫芦茶:夏秋采收,洗净切细,晒干;
25、菊花:拣净叶梗、花柄及泥屑杂质;
26、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
27、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
28、丁香:找去杂质、花梗,筛去灰屑,用时捣碎;
29、炮姜:取干姜片或片,炒至鼓起,表面棕褐色。
二、制备
1、将所述重量的伏龙肝、半夏、竹茹、代赭石、党参、砂仁,紫苏梗、苏叶、茯苓、柚皮、黄连、芦根、黄芪、竹叶、当归、陈皮、玉米须、藿香、柿蒂、白术、山药、黄芩、香附、葫芦茶、菊花、甘草、瓜蒌、丁香、炮姜放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中丁香有温中,暖肾,降逆的功能为君药;砂仁行气调中,和胃、醒脾;陈皮有理气健脾,燥湿化痰的功能,二者为臣药,三味药共同发挥温中,暖肾,降逆,和胃,理气,健脾,化痰的作用,治疗妊娠恶阻效力全面,且以补肾,降逆,和胃,健脾,化痰为主可治本,茯苓有渗湿利水,益脾和胃,宁心安神的功能为佐药,甘草有和中缓急,润肺,解毒,调和诸药的功能为使药,与余下诸药是治标。
本发明药物具有补益肝肾,理气健脾,祛湿化痰,和胃降逆的功能,用于治疗妊娠恶阻,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治妊娠恶阻门诊患者共32例。
2、诊断标准
(1)脾胃虚弱型:妊娠早期呕恶不食,脘腹胀满,全身乏力,头晕思睡,口淡或呕吐清涎,舌质淡,苔白,脉沉弱;
(2)肝胃不和型:妊娠初期,呕吐苦水或酸水,胸满胁痛,嗳气叹息,头胀而晕,烦渴口苦,精神抑郁,舌淡红苔黄,脉弦滑;
(3)气阴两虚型:恶心呕吐日久,出现精神萎靡形体消瘦,眼眶下陷,发热口渴,尿少便结,唇舌干燥,呕吐带血水样物,舌红,苔薄黄或光剥,脉细数无力。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,5天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:妊娠恶阻症状消失,体质恢复正常,痊愈;
好转:患者乏力、恶心现象减轻,妊娠恶阻症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗妊娠恶阻患者32例,结果显效29例,显效率为90.62%,好转2例,好转率为6.25%,无效1例,总有效率为96.87%。
Claims (3)
1.一种治疗妊娠恶阻的药物,其特征在于:它是由下列重量范围内的原料药制成:
伏龙肝12-18克、半夏6-10克、竹茹12-18克、代赭石12-18克、党参10-15克、砂仁12-18克、紫苏梗8-12克、紫苏叶8-12克、茯苓12-18克、柚皮8-12克、黄连8-12克、芦根10-15克、黄芪8-12克、竹叶8-12克、当归8-12克、陈皮12-18克、玉米须8-12克、藿香8-12克、柿蒂10-15克、白术12-18克、山药10-15克、黄芩8-12克、香附8-12克、葫芦茶8-12克、菊花8-12克、甘草10-15克、瓜蒌8-12克、丁香12-18克、炮姜8-12克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
伏龙肝15克、半夏8克、竹茹15克、代赭石15克、党参12克、砂仁15克、紫苏梗10克、紫苏叶10克、茯苓15克、柚皮10克、黄连10克、芦根12克、黄芪10克、竹叶10克、当归10克、陈皮15克、玉米须10克、藿香10克、柿蒂12克、白术15克、山药12克、黄芩10克、香附10克、葫芦茶10克、菊花10克、甘草12克、瓜蒌10克、丁香15克、炮姜10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)伏龙肝:在拆修柴火灶(或烧柴的窑)时,将烧结的土块取下,用刀削去焦黑部分及杂质即得;
(2)姜半夏:取净半夏,用凉水浸漂,避免日晒,浸泡10日后起白沫时,每半夏100斤加白矾2斤,泡1日后再进行换水,至口尝稍有麻辣感后,另取生姜切片煎汤,加白矾与半夏共煮透,取出,晾至六成干,闷润后,切片,晾干,每半夏100斤,用生姜25斤,白矾12斤8两—14斤8两;
(3)竹茹:除去硬竹签、杂质,抖掉灰屑,揉成小团或切段;
(4)代赭石:除去杂质,砸碎,过筛;
(5)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(6)砂仁:拣去杂质及果壳,捣碎;
(7)紫苏梗:拣去杂质,用水浸泡后,润透,切片,晒干;
(8)紫苏叶:拣去杂质,晒干;
(9)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(10)柚皮:秋末、冬初收集,剖成5~7瓣,悬起晒干或阴干;
(11)黄连:拣去杂质,洗净泥砂,润透,切片,阴干;
(12)芦根:拣去杂质及根,切段,晒干;
(13)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(14)竹叶:拣净杂质,除去梗叶,晾干;
(15)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(16)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(17)玉米须:取原药材,除去杂质,筛去灰屑;
(18)藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
(19)柿蒂:取原药材,除去杂质;
(20)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(21)山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
(22)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(23)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(24)葫芦茶:夏秋采收,洗净切细,晒干;
(25)菊花:拣净叶梗、花柄及泥屑杂质;
(26)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(27)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(28)丁香:找去杂质、花梗,筛去灰屑,用时捣碎;
(29)炮姜:取干姜片或片,炒至鼓起,表面棕褐色;
(二)制备
(1)将所述重量的伏龙肝、半夏、竹茹、代赭石、党参、砂仁,紫苏梗、苏叶、茯苓、柚皮、黄连、芦根、黄芪、竹叶、当归、陈皮、玉米须、藿香、柿蒂、白术、山药、黄芩、香附、葫芦茶、菊花、甘草、瓜蒌、丁香、炮姜放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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CN105343865A (zh) * | 2015-12-19 | 2016-02-24 | 徐士杰 | 一种治疗神经性呕吐的药物及其制备方法 |
CN105362889A (zh) * | 2015-12-16 | 2016-03-02 | 张朝兰 | 一种治疗耳鸣的药物及其制备方法 |
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CN104474445A (zh) * | 2014-12-04 | 2015-04-01 | 马桂凤 | 一种治疗妊娠恶阻症的中药制剂 |
CN105362889A (zh) * | 2015-12-16 | 2016-03-02 | 张朝兰 | 一种治疗耳鸣的药物及其制备方法 |
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