CN106620458A - 一种治疗颈淋巴结结核的药物及其制备方法 - Google Patents

一种治疗颈淋巴结结核的药物及其制备方法 Download PDF

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CN106620458A
CN106620458A CN201710183029.1A CN201710183029A CN106620458A CN 106620458 A CN106620458 A CN 106620458A CN 201710183029 A CN201710183029 A CN 201710183029A CN 106620458 A CN106620458 A CN 106620458A
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李少伦
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李少伦
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Abstract

本发明公开了一种治疗颈淋巴结结核的药物及其制备方法，其主要是由玄参、大枣、海藻、全蝎、白芍、浙贝母、白术、当归、夏枯草、百部、白及、忍冬藤、五味子、黄连、太子参、瓜蒌皮、乳香、没药、陈皮、白芷、昆布、天葵子按一定重量配比制备而成，本发明药物具有滋阴降火，理气健脾，燥湿化痰，益气生津的功能，用于治疗颈淋巴结结核见效快、疗效好，不复发。

Description

一种治疗颈淋巴结结核的药物及其制备方法
技术领域
本发明涉及一种治疗颈淋巴结结核的药物及其制备方法，属中药领域。
背景技术
颈淋巴结结核为结核杆菌多由口腔（龋齿）或扁桃体侵入，在侵入部位临床上多无结核病变可见。少数继发于肺或支气管的结核病变。中医则认为颈淋巴结结核与肝气郁结，情志不遂，脾失健运，痰火凝结有关。由于西药治疗副作用大，因此人们对有效治疗颈淋巴结结核的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗颈淋巴结结核的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗颈淋巴结结核的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择玄参、大枣、海藻、全蝎、白芍、浙贝母、白术、当归、夏枯草、百部、白及、忍冬藤、五味子、黄连、太子参、瓜蒌皮、乳香、没药、陈皮、白芷、昆布、天葵子、牛蒡子、青皮、红花、地骨皮、牡蛎进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗颈淋巴结结核。其中选用玄参是因为其性味苦，咸，凉，入肺、肾经，有滋阴，降火，除烦，解毒的功能，治热病烦渴，发斑，骨蒸劳热，夜寐不宁，自汗盗汗，津伤便秘，吐血衄血，咽喉肿痛，痈肿，瘰疬。选用大枣是因为其性味甘，温，入脾、胃经，有补脾和胃，益气生津，调营卫，解药毒的功能，治胃虚食少，脾弱便溏，气血津液不足，营卫不和，心悸怔忡，妇人脏躁。选用海藻是因为其性味苦咸，寒，入肺、脾、肾经，有软坚，消痰，利水，泄热的功能，治瘰疬，瘿瘤，积聚，水肿，脚气，睾丸肿痛。选用全蝎是因为其性味咸辛，平，有毒，有祛风，止痉，通络，解毒的功能，治惊风抽搐，癫癎，中风，半身不遂，口眼斜，偏头痛，风湿痹痛，破伤风，淋巴结结核，风疹疮肿。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用浙贝母是因为其性味苦，微寒，归肺、心经，有清热散结，化痰止咳的功能，治风热犯肺，痰火咳嗽，肺痈，乳痈，瘰疬，疮毒，心胸郁闷。选用白术是因为其性味苦甘，温，入脾、胃经，有补脾，益胃，燥湿，和中的功能，治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用夏枯草是因为其性味苦辛，寒，入肝、胆经，有清肝，散结的功能，治瘰疬，瘿瘤，乳痈，乳癌，目珠夜痛，羞明流泪，头目眩晕，口眼歪斜，筋骨疼痛，肺结核，急性黄疸型传染性肝炎，血崩，带下。选用百部是因为其性味甘苦，微温，入肺经，有温润肺气，止咳，杀虫的功能，治风寒咳嗽，百日咳，肺结核，老年咳喘、蛔虫、蛲虫病，皮肤疥癣、湿疹。选用白及是因为其性味苦甘，凉，入肺经，有补肺，止血，消肿，生观，敛疮的功能，治肺伤咳血，衄血，金疮出血，痈疽肿毒，溃疡疼痛，汤火灼伤，手足皲裂。选用忍冬藤是因为其性味甘，寒，入心、肺经，有清热，解毒，通络的功能，治温病发热，热毒血痢，传染性肝炎，痈肿疮毒，筋骨疼痛。选用五味子是因为其性味酸，温，入肺、肾经，有敛肺，滋肾，生津，收汗，涩精的功能，治肺虚喘咳，口干作渴，自汗，盗汗，劳伤羸瘦，梦遗滑精，久泻久痢。选用黄连是因为其性味苦，寒，入心、肝、胃、大肠经，有泻火，燥湿，解毒，杀虫的功能，治时行热毒、伤寒，热盛心烦，痞满呕逆，菌痢，热泻腹痛，肺结核，吐、衄、下血，消渴，疳积，蛔虫病，百日咳，咽喉肿痛，火眼，口疮，痈疽疮毒，湿疹，汤火烫伤。选用太子参是因为其性味甘苦，微温，入心、脾、肺三经，有补肺、健脾的功能，治肺虚咳嗽，脾虚食少，心悸目汗，精神疲乏。选用瓜蒌皮是因为其性味甘，寒，归肺、胃经，有清热化痰，利气宽胸的功能，治痰热咳嗽，胸闷胁痛。选用乳香是因为其性味辛苦，温，入心、肝、脾经，有调气活血，定痛，追毒的功能，治气血凝滞，心腹疼痛，痈疮肿毒，跌打损伤，痛经，产后瘀血刺痛。选用没药是因为其性味苦，平，入肝经，有散血去瘀，消肿定痛的功能，治跌损，金疮，筋骨，心腹诸痛，癥瘕，经闭，痈疽肿痛，痔漏，目障。选用陈皮是因为其性味苦、辛，温，归肺、脾经，有理气健脾，燥湿化痰的功能，治胸脘胀满，食少吐泻，咳嗽痰多。选用白芷是因为其性味辛，温，入肺、脾、胃经，有祛风，燥湿，消肿，止痛的功能，治头痛，眉棱骨痛，齿痛，鼻渊，寒湿腹痛，肠风痔漏，赤白带下，痈疽疮疡，皮肤燥痒，疥癣。选用昆布是因为其性味咸，寒，入胃经，有软坚，行水的功能，治瘰疬，瘿瘤，噎膈，水肿，睾丸肿痛，带下。选用天葵子是因为其性味甘苦，寒，入脾、小肠、膀胱三经，有清热，解毒，消肿，散结，利尿的功能，治痈肿，瘰疬，疔疮，淋浊，带下，肺虚咳嗽，疝气，癫癎，小儿惊风，痔疮，跌打损伤。选用青皮是因为其性味苦辛，微温，入肝、胆经，有疏肝破气，散结消痰的功能，治胸胁胃脘疼痛，疝气，食积，乳肿，乳核，久疟癖块。选用红花是因为其性味辛，温，入心、肝经，有活血通经，去瘀止痛的功能，治经闭，癥瘕，难产，死胎，产后恶露不行，瘀血作痛，痈肿，跌扑损伤。选用地骨皮是因为其性味甘，寒，入肺、肝、肾经，有清热，凉血的功能，治虚劳潮热盗汗，肺热咳喘，吐血，衄血，血淋，消渴，高血压，痈肿，恶疮。选用牡蛎是因为其性味咸涩，凉，入肝、肾经，有敛阴，潜阳，止汗，涩精的功能，治惊癎，眩晕，自汗，盗汗，遗精，淋浊，崩漏，带下，瘰疬，瘿瘤。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
玄参10-20克，大枣10-15克，海藻10-15克，全蝎5-10克，白芍5-15克，浙贝母10-20克，白术10-20克，当归15-20克，夏枯草10-20克，百部5-15克，白及5-10克，忍冬藤5-15克，五味子5-15克，黄连10-15克，太子参10-15克，瓜蒌皮10-15克，乳香5-10克，没药5-10克，陈皮5-15克，白芷10-20克，昆布10-15克，天葵子5-15克，牛蒡子5-15克，青皮5-15克，红花5-15克，地骨皮5-15克，牡蛎5-15克。
优选为：
玄参15克，大枣12克，海藻12克，全蝎8克，白芍10克，浙贝母15克，白术15克，当归18克，夏枯草15克，百部10克，白及8克，忍冬藤10克，五味子10克，黄连12克，太子参12克，瓜蒌皮12克，乳香8克，没药8克，陈皮10克，白芷15克，昆布12克，天葵子10克，牛蒡子10克，青皮10克，红花10克，地骨皮10克，牡蛎10克。
本发明药物的制备方法如下
一、备料
1、玄参：拣净杂质，除去芦头，洗净润透，切片，晾干；
2、大枣：拣净杂质，晒干；
3、海藻：拣去杂质，用水略漂，稍晾，切段，晒干；
4、全蝎：清水漂去盐质，晒干，或微火焙用；
5、白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
6、浙贝母：除去杂质，大小分档，洗净，润透，切厚片，干燥，街去碎屑，或打碎；
7、白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
8、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
9、夏枯草：取原药材，除去枝梗、叶片及杂质，筛去灰屑；
10、百部：拣净杂质，除去须根，洗净，润透后切段，晒干；
11、白及：拣去杂质，用水浸泡，捞出，晾至湿度适宜，切片，干燥；
12、忍冬藤：拣去杂质，用水浸泡，润透，切片，晒干；
13、五味子：筛去灰屑，除去杂质，置蒸笼内蒸透，取出晒干；
14、黄连：拣去杂质，洗净泥砂，润透，切片，阴干；
15、太子参：摘除须根，晒干；
16、瓜蒌皮：取原药材，除去果柄及杂质，抢水洗净，润透，切丝，干燥，筛去碎屑；
17、乳香：拣去砂子杂质；
18、没药：拣去杂质，打成碎块；
19、陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
20、白芷：拣净杂质，用水洗净，浸泡，捞出润透，略晒至外皮无滑腻感时，再闷润后，切片干燥；
21、昆布：拣去杂质，用水漂净，切成宽丝，晾干；
22、天葵子：清水洗净，切片，晒干；
23、牛蒡子：拣去杂质，筛去泥屑；
24、青皮：拣净杂质，用水浸泡，捞出，润透，切片，晒干；
25、红花：拣净杂质，除去茎叶、蒂头，晒干；
26、地骨皮：拣去杂质及木心，略洗，切段，晒干；
27、牡蛎：洗净，晒干，碾碎用。
二、制备
1、将所述重量的玄参、大枣、海藻、全蝎、白芍、浙贝母、白术、当归、夏枯草、百部、白及、忍冬藤、五味子、黄连、太子参、瓜蒌皮、乳香、没药、陈皮、白芷、昆布、天葵子、牛蒡子、青皮、红花、地骨皮、牡蛎放入煎药容器内，第一次加水8倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加水6倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
3、将两次煎煮液混合搅拌均匀，分为3剂服用。
组方中玄参有滋阴，降火，除烦，解毒的功能为君药；陈皮理气健脾，燥湿化痰；浙贝母有清热散结，化痰止咳的功能，二者为臣药，三味药共同发挥滋阴降火，理气健脾，燥湿化痰，除烦解毒的作用，治疗颈淋巴结结核效力全面，且以滋阴降火，理气健脾，燥湿化痰为主可治本，大枣有补脾和胃，益气生津，调营卫，解药毒的功能为佐药，白术有补脾，益胃，燥湿，和中的功能为使药，与下余诸药是治标。
本发明药物具有滋阴降火，理气健脾，燥湿化痰，益气生津的功能，用于治疗颈淋巴结结核，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治颈淋巴结结核门诊患者共33例。
2、诊断标准
典型症状为颈部一侧或双侧长出疙瘩，逐渐长大，不痛不痒，推入滑动，无明显压痛，如身体低抗力低，则逐渐增大，皮肤发变紫，最终破溃、流水样脓液并排出黄浊样干酪样物。少部分病人可有低热、盗汗、食欲不振、消瘦等全身中毒症状。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天早、晚各服1次，7天为一个疗程，连续服用3个疗程。
4、疗效评定标准
显效：颈淋巴结结核症状消失，痊愈；
好转：患者颈部肿块，低热、盗汗、食欲不振、消瘦，中毒的现象减轻，颈淋巴结结核症状明显好转，逐步恢复正常；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗颈淋巴结结核患者33例，结果显效30例，显效率为90.9%，好转2例，好转率为6.06%，无效1例，总有效率为96.96%。

Claims (3)

1.一种治疗颈淋巴结结核的药物，其特征在于：它是由下列重量范围内的原料药制成：
玄参10-20克，大枣10-15克，海藻10-15克，全蝎5-10克，白芍5-15克，浙贝母10-20克，白术10-20克，当归15-20克，夏枯草10-20克，百部5-15克，白及5-10克，忍冬藤5-15克，五味子5-15克，黄连10-15克，太子参10-15克，瓜蒌皮10-15克，乳香5-10克，没药5-10克，陈皮5-15克，白芷10-20克，昆布10-15克，天葵子5-15克，牛蒡子5-15克，青皮5-15克，红花5-15克，地骨皮5-15克，牡蛎5-15克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
玄参15克，大枣12克，海藻12克，全蝎8克，白芍10克，浙贝母15克，白术15克，当归18克，夏枯草15克，百部10克，白及8克，忍冬藤10克，五味子10克，黄连12克，太子参12克，瓜蒌皮12克，乳香8克，没药8克，陈皮10克，白芷15克，昆布12克，天葵子10克，牛蒡子10克，青皮10克，红花10克，地骨皮10克，牡蛎10克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）玄参：拣净杂质，除去芦头，洗净润透，切片，晾干；
（2）大枣：拣净杂质，晒干；
（3）海藻：拣去杂质，用水略漂，稍晾，切段，晒干；
（4）全蝎：清水漂去盐质，晒干，或微火焙用；
（5）白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
（6）浙贝母：除去杂质，大小分档，洗净，润透，切厚片，干燥，街去碎屑，或打碎；
（7）白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
（8）当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
（9）夏枯草：取原药材，除去枝梗、叶片及杂质，筛去灰屑；
（10）百部：拣净杂质，除去须根，洗净，润透后切段，晒干；
（11）白及：拣去杂质，用水浸泡，捞出，晾至湿度适宜，切片，干燥；
（12）忍冬藤：拣去杂质，用水浸泡，润透，切片，晒干；
（13）五味子：筛去灰屑，除去杂质，置蒸笼内蒸透，取出晒干；
（14）黄连：拣去杂质，洗净泥砂，润透，切片，阴干；
（15）太子参：摘除须根，晒干；
（16）瓜蒌皮：取原药材，除去果柄及杂质，抢水洗净，润透，切丝，干燥，筛去碎屑；
（17）乳香：拣去砂子杂质；
（18）没药：拣去杂质，打成碎块；
（19）陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
（20）白芷：拣净杂质，用水洗净，浸泡，捞出润透，略晒至外皮无滑腻感时，再闷润后，切片干燥；
（21）昆布：拣去杂质，用水漂净，切成宽丝，晾干；
（22）天葵子：清水洗净，切片，晒干；
（23）牛蒡子：拣去杂质，筛去泥屑；
（24）青皮：拣净杂质，用水浸泡，捞出，润透，切片，晒干；
（25）红花：拣净杂质，除去茎叶、蒂头，晒干；
（26）地骨皮：拣去杂质及木心，略洗，切段，晒干；
（27）牡蛎：洗净，晒干，碾碎用；
（二）制备
（1）将所述重量的玄参、大枣、海藻、全蝎、白芍、浙贝母、白术、当归、夏枯草、百部、白及、忍冬藤、五味子、黄连、太子参、瓜蒌皮、乳香、没药、陈皮、白芷、昆布、天葵子、牛蒡子、青皮、红花、地骨皮、牡蛎放入煎药容器内，加水8倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
（2）将过滤的药渣加水6倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
（3）将两次煎煮液混合搅拌均匀，分为3剂服用。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845592A (zh) * 2014-03-03 2014-06-11 马芳 一种用于治疗颈部淋巴结结核的中药
CN104825768A (zh) * 2015-04-22 2015-08-12 鄢明亮 一种治疗淋巴结核的中药口服液及制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845592A (zh) * 2014-03-03 2014-06-11 马芳 一种用于治疗颈部淋巴结结核的中药
CN104825768A (zh) * 2015-04-22 2015-08-12 鄢明亮 一种治疗淋巴结核的中药口服液及制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谢景龙: "中西医结合治疗淋巴腺结核275例疗效观察", 《河北中医》 *

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