CN106853212A - 一种治疗癫狂症的药物及其制备方法 - Google Patents

一种治疗癫狂症的药物及其制备方法 Download PDF

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CN106853212A
CN106853212A CN201710126832.1A CN201710126832A CN106853212A CN 106853212 A CN106853212 A CN 106853212A CN 201710126832 A CN201710126832 A CN 201710126832A CN 106853212 A CN106853212 A CN 106853212A
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牛健坤
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Abstract

本发明公开了一种治疗癫狂症的药物及其制备方法，其是由大黄、橘红、厚朴、栀子、黄芩、柴胡、生地黄、竹茹、紫草、龙胆、茯苓、生石膏、磁石、车前子、麦冬、陈皮、远志、砂仁、酸枣仁、半夏、香附、赤芍、陈皮、胆星、茯神、桃仁按一定重量配比制备而成，本发明药物具有消痰利气，宽中散结，清热泻火，凉血破瘀，宁心安神，养阴润肺，清心除烦的功能，用于治疗癫狂症见效快、疗效好，不复发。

Description

一种治疗癫狂症的药物及其制备方法
技术领域
本发明涉及一种治疗癫狂症的药物及其制备方法，属中药领域。
背景技术
癫狂症是是一种精神失常疾病，系由七情内伤，饮食失节，禀赋不足，致痰气郁结，或痰火暴亢，使脏气不平，阴阳失调，闭塞心窍，神机逆乱。其病位在心，与肝胆脾胃关系密切。癫病以精神抑郁，表情淡漠，沉默痴呆，语无伦次，静而多喜为特征，治以理气解郁，畅达气机为其大法；狂病以精神亢奋，狂躁不安，喧扰不宁，骂詈毁物，动而多怒为特征。由于西药治疗副作用大，因此人们对有效治疗癫狂症的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗癫狂症的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗癫狂症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择大黄、橘红、厚朴、栀子、黄芩、柴胡、生地黄、竹茹、紫草、龙胆、茯苓、生石膏、磁石、车前子、麦冬、陈皮、远志、砂仁、酸枣仁、半夏、香附、赤芍、陈皮、胆星、茯神、桃仁进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗癫狂症。其中选用大黄是因为其性味苦、寒，入胃、大肠、肝径，有泻热毒，破积滞，行瘀血的功能，治实热便秘，谵语发狂，食积痞满，痢疾初起，里急后重，瘀停经闭，癥瘕积聚，时行热疫，暴眼赤痛，吐血，衄血，阳黄，水肿，淋浊，溲赤，痈疡肿毒，疔疮，汤火伤。选用橘红是因为其性味辛苦，温，入手足太阳、太阳、阳明经，有消痰，利气，宽中，散结的功能，治风寒痰嗽，恶心，吐水，胸痛胀闷。选用厚朴是因为其性味苦辛，温，入脾、胃、大肠经，有温中，下气，燥湿，消痰的功能，治胸腹痞满胀痛，反胃、呕吐，宿食不消，痰饮喘咳，寒湿泻痢。选用栀子是因为其性味苦，寒，入心、肝、肺、胃经，有清热，泻火，凉血的功能，治热病虚烦不眠，黄疸，淋病，消渴，目赤，咽痛，吐血，衄血，血痢，尿血，热毒疮疡，扭伤肿痛。选用黄芩是因为其性味苦寒，入心肺、胆、大肠经，有泻实火，除湿热，止血安胎的功能，治壮热烦渴，肺热咳嗽。选用柴胡是因为其性味苦，凉，入肝、胆经，有和解表里，疏肝，升阳的功能，治寒热往来，胸满胁痛，口苦耳聋，头痛目眩，疟疾，下利脱肛，月经不调，子宫下垂。选用生地黄是因为其性味甘，寒，归心、肝、肾经，有清热凉血，养阴，生津的功能，治热病烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。选用竹茹是因为其性味甘，凉，入胃、胆经，有清热，凉血，化痰，止吐的功能，治烦热呕吐、呃逆，痰热咳喘，吐血，衄血，崩漏，恶阻，胎动，惊癎。选用紫草是因为其性味苦苦，寒，入心包络、肝经，有凉血，活血，清热解毒的功能，治温热斑疹，湿热黄疸，紫癜，吐、衄、尿血，淋浊，血痢，热结便秘，烧伤，湿疹，丹毒，痈疡。选用龙胆是因为其性味苦，寒，入肝、胆经，有泻肝实火，除下焦湿热的功能，治肝经热盛，惊癎狂躁，乙型脑炎，头痛，目赤，咽痛，黄疸，热痢，痈肿疮疡，阴囊肿痛，阴部湿痒。选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。选用石膏是因为其性味辛甘，寒，入肺、胃经，生用有解肌清热，除烦止渴的功能，治热病壮热不退，心烦神昏，谵语发狂，口渴咽干，肺热喘急，中暑自汗，胃火头痛、牙痛，热毒壅盛，发斑发疹，口舌生疮，煅敷生肌敛疮，外治痈疽疮疡，溃不收回，汤火烫伤。选用磁石是因为其性味辛咸，平，入肾、肝、肺经，有潜阳纳气，镇惊安神的功能，治头目眩晕，耳鸣耳聋，虚喘，惊癎，怔忡。选用车前子是因为其性味甘，寒，入肾、膀胱经，有利水，清热，明目，祛痰的功能，治小便不通，淋浊，带下，尿血，暑湿泻痢，咳嗽多痰，湿痹，目赤障翳。选用麦冬是因为其性味甘微苦，寒，入肺、胃、心经，有养阴润肺，清心除烦，益胃生津的功能，治肺燥干咳，吐血，咯血，肺痿，肺痈，虚劳烦热，清渴，热病津伤，咽干口燥，便秘。选用陈皮是因为其性味苦、辛，温，归肺、脾经，有理气健脾，燥湿化痰的功能，治胸脘胀满，食少吐泻，咳嗽痰多。选用炙远志是因为其性味苦辛，温，入心、肾经，有安神益智，祛痰，解郁的功能，治惊悸，健忘，梦遗，失眠，咳嗽多痰，痈疽疮肿。选用砂仁是因为其性味辛，温，入脾、胃经，有行气调中，和胃、醒脾的功能，治腹痛痞胀，胃呆食滞，噎隔呕吐，寒泻冷痢，妊娠胎动。选用酸枣仁是因为其性味甘，平，入心、脾、肝、胆经，有养肝，宁心，安神，敛汗的功能，治虚烦不眠，惊悸怔忡，烦渴，虚汗。选用半夏是因为其性味辛，温，有毒，入脾、胃经，有燥湿化痰，降逆止呕，清痞散结的功能，治湿痰冷饮呕吐，反胃，咳喘痰多，我膈胀满，痰厥头痛，头晕不眠，外消痈肿。选用香附是因为其性味辛微苦干，平，入肝、三焦经，有理气解郁，止痛调经的功能，治肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下。选用赤芍是因为其性味苦，微寒，归肝经，有清热凉血，散瘀止痛的功能，治温毒发狂，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，癎瘕腹痛，跌扑损伤，痈肿疮疡。选用陈皮是因为其性味苦、辛，温，归肺、脾经，有理气健脾，燥湿化痰的功能，治胸脘胀满，食少吐泻，咳嗽痰多。选用胆星是因为其性味苦，性凉，入心、肝、肺三经，有清火化痰，镇惊定癎，痰火喘嗽，头风眩晕。选用茯神是因为其性味甘淡，平，入心、脾经，有宁心，安神，利水的功能，治心虚惊悸，健忘，失眠，惊癎，小便不利。选用桃仁是因为其性味苦甘，平，入心、肝、大肠经，有破血行瘀，润燥滑经的功能，治经闭，癥瘕，热病蓄血，血痹，疟疾，跌打损伤，瘀血肿痛，血燥便秘。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
大黄10-14克、橘红10-14克，厚朴5-15克、栀子5-15克，黄芩 5-15克，柴胡7-11克，生地黄25-35克，竹茹10-20克，紫草5-15克，龙胆5-15克，茯苓10-25克，生石膏10-25克，磁石10-25克，车前子10-20克，麦冬25-35克，陈皮10-25克，远志5-15克，砂仁5-15克，酸枣仁5-15克，半夏5-15克，香附5-15克，赤芍5-15克，陈皮5-15克，胆星5-15克，茯神5-15克，桃仁10-25克。
优选为：
大黄12克、橘红12克，厚朴10克、栀子10克，黄芩 10克，柴胡9克，生地黄30克，竹茹15克，紫草10克，龙胆10克，茯苓20克，生石膏20克，磁石20克，车前子15克，麦冬30克，陈皮20克，远志10克，砂仁10克，酸枣仁10克，半夏10克，香附10克，赤芍10克，陈皮10克，胆星10克，茯神10克，桃仁20克。
本发明药物的制备方法如下
一、备料
1、大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
2、橘红：拣去杂质，刷净，用时折碎；
3、厚朴：用水浸泡捞出，润透后刮去粗皮，洗净，切丝，晾干；
4、栀子：筛去灰屑，拣去杂质，碾碎过筛或剪去两端；
5、黄芩：拣去杂质，除去残茎，用凉水浸润或置开水中稍浸捞出，切片，晒干；
6、柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，随即晒干；
7、生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
8、竹茹：除去硬竹签、杂质，抖掉灰屑，揉成小团或切段；
9、紫草：洗净，润透，切片，晒干；
10、龙胆：拣去杂质，除去残茎，洗净，润透后切段，晒干；
11、茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
12、石膏：去净杂石，洗净泥土，打碎成小块；
13、磁石：拣去杂质，砸碎，过筛；
14、车前子：拣去杂质，筛去泥屑，空粒；
15、麦冬：拣净杂质，用水浸泡，捞出，润透后抽去心，再洗净晒干；
16、陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
17、远志：拣去杂质，切段，筛去灰屑；
18、砂仁：拣去杂质及果壳，捣碎；
19、酸枣仁：原药放入竹箩内，沉入清水缸中，使仁浮在水面，壳沉水底，将枣仁捞出，晒干；
20、半夏：拣去杂质，筛去灰屑；
21、香附：拣去杂质，碾成碎粒，簸去细毛及细末；
22、赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑；
23、陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
24、胆星：取原药材，拣去杂质；
25、茯神：取原药材，除去杂质，洗净，润透，切成正方形的厚片或块，阴干；
26、桃仁：除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净。
二、制备
1、将所述重量的大黄、橘红、厚朴、栀子、黄芩、柴胡、生地黄、竹茹、紫草、龙胆、茯苓、生石膏、磁石、车前子、麦冬、陈皮、远志、砂仁、酸枣仁、半夏、香附、赤芍、陈皮、胆星、茯神、桃仁放入煎药容器内，加水8倍量，浸泡120分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
3、将两次煎煮液混合搅拌均匀，分为3剂服用。
组方中大黄有泻热毒，破积滞，行瘀血的功能为君药；橘红有消痰，利气，宽中，散结的功能；栀子有清热，泻火，凉血的功能，二者为臣药，三味药共同发挥消痰利气，宽中散结，清热泻火，凉血破瘀的作用，治疗癫狂症效力全面，且以宽中散结，凉血破瘀为主可治本，茯苓有渗湿利水，益脾和胃，宁心安神的功能为佐药，麦冬有养阴润肺，清心除烦，益胃生津的功能为使药，与下余诸药是治标。
本发明药物具有消痰利气，宽中散结，清热泻火，凉血破瘀，宁心安神，养阴润肺，清心除烦的功能，用于治疗癫狂症，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治癫狂症门诊患者共36例。
2、诊断标准
癫狂为临床常见的精神失常疾病。癫病以精神抑郁，表情淡漠，沉默痴呆，语无伦次，静而多喜为特征。狂病以精神亢奋，狂躁不安，喧扰不宁，骂詈毁物，动而多怒为特征。均以青壮年罹患者为多。因二者在临床症状上不能截然分开，又能相互转化，故以癫狂并称。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天早、中、晚各服1次，10天为一个疗程，连续服用3个疗程。
4、疗效评定标准
显效：癫狂症症状消失，体质恢复正常，痊愈；
好转：癫狂症症状明显好转，体质逐步恢复；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗癫狂症患者36例，结果显效30例，显效率为83.3%，好转4例，好转率为11.1%，无效2例，总有效率为94.4%。

Claims (3)

1.一种治疗癫狂症的药物，其特征在于：它是由下列重量范围内的原料药制成：
大黄10-14克、橘红10-14克，厚朴5-15克、栀子5-15克，黄芩 5-15克，柴胡7-11克，生地黄25-35克，竹茹10-20克，紫草5-15克，龙胆5-15克，茯苓10-25克，生石膏10-25克，磁石10-25克，车前子10-20克，麦冬25-35克，陈皮10-25克，远志5-15克，砂仁5-15克，酸枣仁5-15克，半夏5-15克，香附5-15克，赤芍5-15克，陈皮5-15克，胆星5-15克，茯神5-15克，桃仁10-25克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
大黄12克、橘红12克，厚朴10克、栀子10克，黄芩 10克，柴胡9克，生地黄30克，竹茹15克，紫草10克，龙胆10克，茯苓20克，生石膏20克，磁石20克，车前子15克，麦冬30克，陈皮20克，远志10克，砂仁10克，酸枣仁10克，半夏10克，香附10克，赤芍10克，陈皮10克，胆星10克，茯神10克，桃仁20克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
（2）橘红：拣去杂质，刷净，用时折碎；
（3）厚朴：用水浸泡捞出，润透后刮去粗皮，洗净，切丝，晾干；
（4）栀子：筛去灰屑，拣去杂质，碾碎过筛或剪去两端；
（5）黄芩：拣去杂质，除去残茎，用凉水浸润或置开水中稍浸捞出，切片，晒干；
（6）柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，随即晒干；
（7）生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
（8）竹茹：除去硬竹签、杂质，抖掉灰屑，揉成小团或切段；
（9）紫草：洗净，润透，切片，晒干；
（10）龙胆：拣去杂质，除去残茎，洗净，润透后切段，晒干；
（11）茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
（12）石膏：去净杂石，洗净泥土，打碎成小块；
（13）磁石：拣去杂质，砸碎，过筛；
（14）车前子：拣去杂质，筛去泥屑，空粒；
（15）麦冬：拣净杂质，用水浸泡，捞出，润透后抽去心，再洗净晒干；
（16）陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
（17）远志：拣去杂质，切段，筛去灰屑；
（18）砂仁：拣去杂质及果壳，捣碎；
（19）酸枣仁：原药放入竹箩内，沉入清水缸中，使仁浮在水面，壳沉水底，将枣仁捞出，晒干；
（20）半夏：拣去杂质，筛去灰屑；
（21）香附：拣去杂质，碾成碎粒，簸去细毛及细末；
（22）赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑；
（23）陈皮：取原药材，除去杂质及变黑的果皮，抢水洗净，润软，切丝，晒干或低温干燥，筛去灰屑；
（24）胆星：取原药材，拣去杂质；
（25）茯神：取原药材，除去杂质，洗净，润透，切成正方形的厚片或块，阴干；
（26）桃仁：除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净；
（二）制备
（1）将所述重量的大黄、橘红、厚朴、栀子、黄芩、柴胡、生地黄、竹茹、紫草、龙胆、茯苓、生石膏、磁石、车前子、麦冬、陈皮、远志、砂仁、酸枣仁、半夏、香附、赤芍、陈皮、胆星、茯神、桃仁放入煎药容器内，加水8倍量，浸泡120分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
（2）将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
（3）将两次煎煮液混合搅拌均匀，分为3剂服用。
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Publication number Priority date Publication date Assignee Title
CN115429857A (zh) * 2022-08-31 2022-12-06 湖南省脑科医院(湖南省第二人民医院) 治疗癫狂症的中药组合物、药剂和制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115429857A (zh) * 2022-08-31 2022-12-06 湖南省脑科医院(湖南省第二人民医院) 治疗癫狂症的中药组合物、药剂和制备方法

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