CN106668612A - 一种治疗血小板减少症的药物及其制备方法 - Google Patents
一种治疗血小板减少症的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗血小板减少症的药物及其制备方法,其主要是由青黛、紫草、牡丹皮、侧柏叶、黄柏、栀子、阿胶、生地黄、仙鹤草、丹参、木香、茜草、红花、补骨脂、枸杞子、桑葚、白茅根、小蓟、龟版、鸡血藤、菊花、何首乌、菟丝子、赤芍、地榆、藕节按一定重量配比制备而成,本发明药物具有凉血活血,清热解毒,滋阴补血,养阴生津,止血散瘀的功能,用于治疗血小板减少症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗血小板减少症的药物及其制备方法,属中药领域。
背景技术
血小板减少症是是由于血小板数量减少或功能减退导致止血栓形成不良和出血而引起的。血小板减少症可能源于血小板产生不足,脾脏对血小板的阻留,血小板破坏或利用增加以及被稀释.无论何种原因所致的严重血小板减少,都可引起典型的出血:多发性瘀斑,最常见于小腿;或在受轻微外伤的部位出现小的散在性瘀斑;胃肠道大量出血和中枢神经系统内出血可危及生命。由于西药治疗副作用大,因此人们对有效治疗血小板减少症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗血小板减少症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗血小板减少症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择青黛、紫草、牡丹皮、侧柏叶、黄柏、栀子、阿胶、生地黄、仙鹤草、丹参、木香、茜草、红花、补骨脂、枸杞子、桑葚、白茅根、小蓟、龟版、鸡血藤、菊花、何首乌、菟丝子、赤芍、地榆、藕节进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗血小板减少症。其中选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉血,解毒的功能,治温病热盛,斑疹,吐血、咯血,小儿惊癎,疮肿,丹毒,蛇虫咬伤。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便秘,烧伤,湿疹,丹毒,痈疡。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用侧柏叶是因为其性味苦涩,寒,入心、肝、大肠经,有凉血,止血,祛风湿,散肿毒的功能,治吐血,衄血,尿血,血痢,肠风,崩漏,风湿痹痛,细菌性痢疾,高血压,咳嗽,丹毒,痄腮,烫伤。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,治漏。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用仙鹤草是因为其性味苦辛,平,入肺、肝、脾经,有止血,健胃的功能,治咯血,吐血,尿血,便血,赤白痢疾,崩漏带下,劳伤脱力,痈肿,跌打、创伤出血。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用木香是因为其性味辛苦,温,入肺、肝、脾经,有行气止痛,温中和胃的功能,治中寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。选用茜草是因为其性味苦,寒,有凉血止血,祛瘀通经的功能,治吐血,衄血,崩漏,外伤出血,瘀阻经闭,关节痹痛,跌扑肿痛。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用补骨脂是因为其性味辛,温,入肾经,有补肾助阳的功能,治肾虚冷泻,遗尿,滑精,小便频数,阳痿,腰膝冷痛,虚寒喘嗽,外用治白癜风。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用桑葚是因为其性味甘,寒,入肝,肾经,有补肝,益肾,熄风,滋液的功能,治肝肾阴亏,消渴,便秘,目暗,耳鸣,瘰疬,关节不利。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用小蓟是因为其性味辛,温,入脾、胃二经,有温中,下气,消谷,杀虫的功能,治吐泻,心腹胀痛,疔肿毒疮,毒虫蛟伤。选用龟版是因为其性味咸甘,平,入肝、肾经,有滋阴,潜阳,补肾,健骨的功能,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨痿,阴虚风动,久痢,久疟,痔疮,小儿囟门不合。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用藕节是因为其性味甘涩,平,入手少阴,足阳明,厥阴经,有止血,散瘀的功能,治咳血,吐血,衄血,尿血,便血,血痢,血崩。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
青黛3-5克,紫草5-15克,牡丹皮5-15克,侧柏叶5-15克,黄柏5-15克,栀子5-15克,阿胶5-15克,生地黄5-15克,仙鹤草10-20克,丹参10-20克,木香3-5克,茜草5-15克,红花5-15克,补骨脂3-5克,枸杞子5-15克,桑葚5-15克,白茅根25-35克,小蓟10-20克,龟版10-20克,鸡血藤15-25克,菊花5-15克,何首乌10-20克,菟丝子15-25克,赤芍5-15克,地榆10-20克,藕节10-14克。
优选为:
青黛3克,紫草10克,牡丹皮10克,侧柏叶10克,黄柏10克,栀子10克,阿胶10克,生地黄10克,仙鹤草15克,丹参15克,木香3克,茜草10克,红花10克,补骨脂5克,枸杞子10克,桑葚10克,白茅根30克,小蓟15克,龟版15克,鸡血藤20克,菊花10克,何首乌15克,菟丝子20克,赤芍10克,地榆15克,藕节12克。
本发明药物的制备方法如下
一、备料
1、青黛:拣去杂质,过筛;
2、紫草:洗净,润透,切片,晒干;
3、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
4、侧柏叶:拣净杂质,揉碎去梗,筛净灰屑;
5、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
6、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
7、阿胶:捣碎用;
8、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
9、仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
10、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
11、木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干;
12、茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑;
13、红花:拣净杂质,除去茎叶、蒂头,晒干;
14、补骨脂:簸净杂质,洗净,晒干;
15、枸杞子:簸净杂质,摘去残留的梗和蒂;
16、桑葚:用水洗净,拣去杂质,摘除长柄,晒干;
17、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
18、小蓟:拣净杂质,去根,水洗润透,切段,晒干;
19、龟版:用清水浸泡,刮去残肉,洗净晒干,敲成小块;
20、鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
21、菊花:拣净叶梗、花柄及泥屑杂质;
22、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
23、菟丝子:过箩去净杂质,洗净,晒干;
24、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
25、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
26、藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥。
二、制备
1、将所述重量的青黛、紫草、牡丹皮、侧柏叶、黄柏、栀子、阿胶、生地黄、仙鹤草、丹参、木香、茜草、红花、补骨脂、枸杞子、桑葚、白茅根、小蓟、龟版、鸡血藤、菊花、何首乌、菟丝子、赤芍、地榆、藕节放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中紫草有凉血活血,清热解毒的功能为君药;阿胶有滋阴补血的功能;生地黄有凉血,养阴,生津的功能,二者为臣药,三味药共同发挥凉血活血,清热解毒,滋阴补血,养阴生津的作用,治疗血小板减少症效力全面,且以凉血活血,滋阴补血,养阴生津为主可治本,茜草有凉血止血,祛瘀通经的功能为佐药,藕节有止血散瘀的功能为使药,与下余诸药是治标。
本发明药物具有凉血活血,清热解毒,滋阴补血,养阴生津,止血散瘀的功能,用于治疗血小板减少症,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治血小板减少症门诊患者共40例。
2、诊断标准
典型症状为全身皮肤紫癜,鼻衄或女性月经过多,疲乏无力,面色苍白,尿色加深。偶尔还可见肾脏受损征象如高血压、血尿、氮质血症等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:血小板减少症症状消失,体质恢复正常,痊愈;
好转:患者乏力,肝痛,腹胀,肝脏肿大的现象减轻,血小板减少症症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗血小板减少症患者40例,结果显效32例,显效率为80%,好转6例,好转率为15%,无效2例,总有效率为95%。
Claims (3)
1.一种治疗血小板减少症的药物,其特征在于:它是由下列重量范围内的原料药制成:
青黛3-5克,紫草5-15克,牡丹皮5-15克,侧柏叶5-15克,黄柏5-15克,栀子5-15克,阿胶5-15克,生地黄5-15克,仙鹤草10-20克,丹参10-20克,木香3-5克,茜草5-15克,红花5-15克,补骨脂3-5克,枸杞子5-15克,桑葚5-15克,白茅根25-35克,小蓟10-20克,龟版10-20克,鸡血藤15-25克,菊花5-15克,何首乌10-20克,菟丝子15-25克,赤芍5-15克,地榆10-20克,藕节10-14克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
青黛3克,紫草10克,牡丹皮10克,侧柏叶10克,黄柏10克,栀子10克,阿胶10克,生地黄10克,仙鹤草15克,丹参15克,木香3克,茜草10克,红花10克,补骨脂5克,枸杞子10克,桑葚10克,白茅根30克,小蓟15克,龟版15克,鸡血藤20克,菊花10克,何首乌15克,菟丝子20克,赤芍10克,地榆15克,藕节12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)青黛:拣去杂质,过筛;
(2)紫草:洗净,润透,切片,晒干;
(3)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(4)侧柏叶:拣净杂质,揉碎去梗,筛净灰屑;
(5)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(6)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(7)阿胶:捣碎用;
(8)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(9)仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
(10)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(11)木香:将原生药放清水内洗净,捞出,闷润12—24小时使软,切片,晒干;
(12)茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑;
(13)红花:拣净杂质,除去茎叶、蒂头,晒干;
(14)补骨脂:簸净杂质,洗净,晒干;
(15)枸杞子:簸净杂质,摘去残留的梗和蒂;
(16)桑葚:用水洗净,拣去杂质,摘除长柄,晒干;
(17)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(18)小蓟:拣净杂质,去根,水洗润透,切段,晒干;
(19)龟版:用清水浸泡,刮去残肉,洗净晒干,敲成小块;
(20)鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干;
(21)菊花:拣净叶梗、花柄及泥屑杂质;
(22)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(23)菟丝子:过箩去净杂质,洗净,晒干;
(24)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(25)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(26)藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥;
(二)制备
(1)将所述重量的青黛、紫草、牡丹皮、侧柏叶、黄柏、栀子、阿胶、生地黄、仙鹤草、丹参、木香、茜草、红花、补骨脂、枸杞子、桑葚、白茅根、小蓟、龟版、鸡血藤、菊花、何首乌、菟丝子、赤芍、地榆、藕节放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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