CN106511945A - 一种治疗失眠的药物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗失眠的药物及其制备方法，其主要是由半夏、橘皮、竹茹、茯苓、枳实按一定重量配比制备而成，本发明药物具有益脾和胃，宁心安神，清热凉血，消积，益气生津的功能，用于治疗失眠见效快，疗效好，不复发。
Description
技术领域
本发明涉及一种治疗失眠的药物及其制备方法，属中药领域。
技术背景
失眠是指无法入睡或无法保持状态，导致睡眠不足。又称入睡和维持睡眠障碍，为各种原因引起入睡困难、睡眠深度或频度过短、早醒及睡眠时间不足或质量差等，是一种常见病。中医则认为失眠与情志不畅，饮食不节，心脾血虚有关。由于西药治疗副作用大，因此人们对有效治疗失眠的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗失眠的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗失眠的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择半夏、橘皮、竹茹、茯苓、枳实、生姜、大枣进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗失眠。其中选用半夏是因为其性味辛，温，有毒，入脾、胃经，有燥湿化痰，降逆止呕，消痞散结的功能，治湿痰冷饮，呕吐，反胃，咳喘痰多，胸膈胀满，痰厥头痛，头晕不眠，外消痈肿。选用橘皮是因为其性味辛苦，温，入脾、肺经，有理气，调中，燥湿，化痰的功能，治胸腹胀满，不思饮食，呕吐哕逆，咳嗽痰多。选用竹茹是因为其性味甘，凉，入胃、胆经，有清热，凉血，化痰，止吐的功能，治烦热呕吐、呃逆，痰热咳喘，吐血，衄血，崩漏，恶阻，胎动，惊癎。选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。选用枳实是因为其性味苦，寒，入脾、胃经，有破气，散痞，泻痰，消积的功能，治胸腹胀痛，胸痹，痞痛，痰癖，水肿，食积，便秘，胃下垂，子宫下垂，脱肛。选用生姜是因为其性味辛，温，入肺、胃、脾经，有发表，散寒，止呕，开痰的功能，治感冒风寒，呕吐，痰饮，喘咳，胀满，泄泻，解半夏、天南星及鱼蟹、鸟兽肉毒。选用大枣是因为其性味甘，温，入脾、胃经，有补脾和胃，益气生津，调营卫，解药毒的功能，治胃虚食少，脾弱便溏，气血津液不足，营卫不和，心悸怔忡，妇人脏躁。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
半夏4-8克，橘皮4-8克，竹茹10-15克，茯苓10-15克，枳实5-10克，生姜4-8克,大枣5-10克。
优选为：
半夏6克，橘皮6克，竹茹12克，茯苓12克，枳实8克，生姜6克,大枣8克。
本发明药物的制备方法如下
一、备料
1、半夏：拣去杂质，筛去灰屑；
2、橘皮：刷去泥土，拣净杂质，喷淋清水，闷润后切丝或切片，晾干；
3、竹茹：除去硬竹签、杂质，抖掉灰屑，揉成小团或切段；
4、茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
5、枳实：拣净杂质，用水浸泡至八成透，捞出，润至内无硬心，切片，晾干；
6、生姜：拣去杂质，洗净泥土，用时切片；
7、大枣：拣净杂质，晒干。
二、制备
1、将所述重量的半夏、橘皮、竹茹、茯苓、枳实、生姜、大枣放入煎药容器内，第一次加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
3、将两次煎煮液混合搅拌均匀，分为2剂服用。
组方中茯苓有渗湿利水，益脾和胃，宁心安神的功能为君药；竹茹清热凉血，化痰止吐；枳实有破气，散痞，泻痰，消积的功的功能，二者为臣药，三味药共同发挥渗湿利水，益脾和胃，宁心安神，清热凉血，化痰止吐，消积的作用，治疗失眠效力全面，且以益脾和胃，宁心安神，清热凉血，消积为主可治本，大枣有补脾和胃，益气生津，调营卫，解药毒的功能为佐药，半夏有燥湿化痰，降逆止呕，消痞散结的功能为使药，余下诸药是治标。
本发明药物具有益脾和胃，宁心安神，清热凉血，消积，益气生津的功能，用于治疗失眠，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治失眠门诊患者共23例。
2、诊断标准
典型症状为入睡困难，醒后疲劳感，睡眠浅，多梦，睡眠感觉障碍等。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天早、晚各服1次，5天为一个疗程，连续服用2个疗程。
4、疗效评定标准
显效：失眠症状消失，体质恢复正常，痊愈；
好转：患者入睡难，多梦，睡眠浅，醒后疲劳感的现象减轻，失眠症状明显好转，体质逐步恢复；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗失眠患者23例，结果显效20例，显效率为86.96%，好转2例，好转率为8.7%，无效1例，总有效率为95.66%。
Claims (3)
1.一种治疗失眠的药物，其特征在于：它是由下列重量范围内的原料药制成：
半夏4-8克，橘皮4-8克，竹茹10-15克，茯苓10-15克，枳实5-10克，生姜4-8克,大枣5-10克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
半夏6克，橘皮6克，竹茹12克，茯苓12克，枳实8克，生姜6克,大枣8克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）半夏：拣去杂质，筛去灰屑；
（2）橘皮：刷去泥土，拣净杂质，喷淋清水，闷润后切丝或切片，晾干；
（3）竹茹：除去硬竹签、杂质，抖掉灰屑，揉成小团或切段；
（4）茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
（5）枳实：拣净杂质，用水浸泡至八成透，捞出，润至内无硬心，切片，晾干；
（6）生姜：拣去杂质，洗净泥土，用时切片；
（7）大枣：拣净杂质，晒干；
（二）制备
（1）将炮制好的半夏、橘皮、竹茹、茯苓、枳实、生姜、大枣放入煎药容器内，加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
（2）将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
（3）将两次煎煮液混合搅拌均匀，分为2剂服用。
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| CN107348504A (zh) * | 2017-06-23 | 2017-11-17 | 天津金匮堂生物科技有限公司 | 一种改善痰火内扰导致失眠的保健品及其制备方法 |
| CN109745522A (zh) * | 2017-11-07 | 2019-05-14 | 丹阳市长富农业技术有限公司 | 一种陈皮茶及其制作方法 |
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