CN106620360A - 一种治疗急性肾炎的药物及其制备方法 - Google Patents

一种治疗急性肾炎的药物及其制备方法 Download PDF

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CN106620360A
CN106620360A CN201710126882.XA CN201710126882A CN106620360A CN 106620360 A CN106620360 A CN 106620360A CN 201710126882 A CN201710126882 A CN 201710126882A CN 106620360 A CN106620360 A CN 106620360A
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李耀宗
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李耀宗
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

本发明公开了一种治疗急性肾炎的药物及其制备方法,其是由白术、藕节、蒲黄、滑石、白茅根、生地黄、木通、白花蛇舌草、黄芩、侧柏叶、甘草、车前草、杏仁、紫苏叶、桂枝、防己、葶苈子、竹叶、蒲公英、陈皮、透骨草、鱼腥草、玉米须按一定重量配比制备而成,本发明药物具有凉血止血,活血消瘀,利尿通淋,清热解毒的功能,用于治疗急性肾炎见效快、疗效好,不复发。

Description

一种治疗急性肾炎的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗急性肾炎的药物及其制备方法,属中药领域。
背景技术
[0002] 急性肾炎是是以急性肾炎综合征为主要临床表现的一组疾病。急性肾炎多见于儿 童,男性多于女性。通常于前驱感染后1~3周(平均10天左右)起病,潜伏期相当于致病抗原 初次免疫后诱导机体产生免疫复合物所需的时间,呼吸道感染者的潜伏期较皮肤感染者 短。特点为急性起病,患者出现血尿、蛋白尿、水肿和高血压,并可伴有一过性氮质血症。多 见于链球菌感染后,而其他细菌、病毒及寄生虫感染亦可引起。由于西药治疗副作用大,因 此人们对有效治疗急性肾炎的中药药物存在极大的需求,至今为止,还没有发现关于本发 明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗急性 肾炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗急性肾炎的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择白术、藕节、蒲黄、滑石、白茅根、生地黄、木通、白花蛇舌草、黄 芩、侧柏叶、甘草、车前草、杏仁、紫苏叶、桂枝、防己、葶苈子、竹叶、蒲公英、陈皮、透骨草、鱼 腥草、玉米须进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有 效治疗急性肾炎。其中选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生 津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用黄芪是因为其性 味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹, 浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩 带及一切气衰血虚之症。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能, 治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用五灵脂是因为其性 味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作 痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。选用郁金是因为其 性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热 病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。用茵陈蒿是因为其性味苦辛,凉,入肝、脾、 膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒疮疥。选用玉米须是因为其性味 甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结 石,糖尿病,吐血衄血,鼻渊,乳痈。选用丹参是因为其性味苦,微温,入心、肝经,有活血去 瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀 血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、 脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆 腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消 食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后 儿枕痛,恶露不尽,小儿乳食停滞。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散 瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损 伤,痈肿疮疡。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕 痞块,瘀血经闭,食积胀痛,跌打肿痛,早期宫颈癌。选用白茅根是因为其性味甘、寒,入肺、 胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆, 淋病,小便不利,水肿,黄疸。选用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒, 凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痒腮,火眼,疮疹。 选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满, 食少吐泻,咳嗽痰多。白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功 能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕, 自汗,胎气不安。选用藕节是因为其性味甘涩,平,入手少阴,足阳明,厥阴经,有止血,散瘀 的功能,治咳血,吐血,衄血,尿血,便血,血痢,血崩。选用蒲黄是因为其性味甘辛苦,凉,入 肝、心经,有凉血止血,活血消瘀的功能,生用治经闭腹痛,产后瘀阻作痛,跌扑血闷,疮疖肿 毒,炒黑止吐血,衄血,崩漏,泻血,尿血,血痢,带下,外治重舌,口疮,聘耳流脓,耳中出血, 阴下湿痒。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿 解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用白茅 根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐 血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用生地黄是因为其性味甘, 寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热 消渴,吐血,衄血,发斑发疹。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行 水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳 汁不通。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功 能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬 伤。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能, 治壮热烦渴,肺热咳嗽。选用侧柏叶是因为其性味苦涩,寒,入心、肝、大肠经,有凉血,止血, 祛风湿,散肿毒的功能,治吐血,衄血,尿血,血痢,肠风,崩漏,风湿痹痛,细菌性痢疾,高血 压,咳嗽,丹毒,痄腮,烫伤。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺, 解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈, 生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用车前草是因为其性味甘, 寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水 月中,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用杏仁是因为其性味苦,温, 有毒,入肺、大肠经,有祛痰止咳,平喘,润肠的功能,治外感咳嗽,喘满,喉痹,肠燥便秘。选 用紫苏叶是因为其性味辛,温,入肺、脾经,有发表,散寒,理气,和营的功能,治感冒风寒,恶 寒发热,咳嗽,气喘,胸腹胀满,胎动不安,并能解鱼蟹毒。选用桂枝是因为其性味辛甘,温, 入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经 闭癥瘕。选用防己是因为其性味苦,寒,入膀膛、脾、肾经,有行水,泻下焦湿热的功能,治水 肿臌胀,湿热脚气,手足挛痛,癣疥疮肿。选用葶苈子是因为其性味辛苦,寒,入肺、膀胱经, 有下气行水的功能,治肺壅喘急,痰饮咳嗽,水肿胀满。选用竹叶是因为其性味甘淡,寒,入 心、肺、胆、胃经,有清热除烦,生津利尿的功能,治热病烦喝,小儿惊癎,咳逆吐衄,面赤,小 便短赤,口糜舌疮。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的 功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急 性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用陈皮是因为其性味苦、辛,温,归肺、脾经, 有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用透骨草是因为其性味 辛温,有祛风,除湿,舒筋,活血,止痛的功能,治风湿痹痛,筋骨挛缩,疮癣肿毒。选用鱼腥草 是因为其性味辛,寒,入手太阴经,有清热解毒,利尿消肿的功能,治肺炎,肺脓疡,热痢,疟 疾,水肿,淋病,白带,痈肿,痔疮,脱肛,湿疹,秃疮,疥癣。选用玉米须是因为其性味甘,平, 有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖 尿病,吐血衄血,鼻渊,乳痈。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效: 白术35-45克,藕节15-25克,蒲黄10-20克,滑石15-25克,白茅根45-55克,生地黄45-55 克,木通10-20克,白花蛇舌草10-20克,黄芩10-20克,侧柏叶5-15克,甘草5-15克,车前草 25-35克,杏仁5-15克,紫苏叶10-20克,桂枝5-15克,防己10-20克,葶苈子5-15克,竹叶5-15 克,蒲公英10-20克,陈皮5-15克,透骨草15-25克,鱼腥草10-20克,玉米须10-14克。
[0008] 优选为: 白术40克,藕节20克,蒲黄15克,滑石20克,白茅根50克,生地黄50克,木通15克,白花蛇 舌草15克,黄芩15克,侧柏叶10克,甘草10克,车前草30克,杏仁10克,紫苏叶15克,桂枝10 克,防己15克,葶苈子10克,竹叶10克,蒲公英15克,陈皮10克,透骨草20克,鱼腥草15克,玉 米须12克。
[0009] 本发明药物的制备方法如下 一、备料 1、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 2、 藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥; 3、 蒲黄:揉碎结块,过筛,除去杂质; 4、 滑石:取原药材,除去杂质,砸成小块; 5、 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; 6、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 7、 木通:用水稍浸泡,闷润至透,切片,晒干; 8、 白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰肩; 9、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 10、 侧柏叶:拣净杂质,揉碎去梗,筛净灰肩; 11、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 12、 车前草:去尽泥土,晒干; 13、 杏仁:拣净杂质,置沸水中略煮,待外皮微皱时捞出,浸凉水中,脱去种皮,晒干,簸 净; 14、 紫苏叶:拣去杂质,晒干; 15、 桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去肩; 16、 防己:原药用水洗净,捞出润透,切片,晒干; 17、 葶苈子:拣净杂质,筛去灰肩; 18、 竹叶:拣净杂质,除去梗叶,晾干; 19、 蒲公英:拣去杂质,洗净泥土,切段,晒干; 20、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; 21、 透骨草:拣净杂质,切段; 22、 鱼腥草:去净杂质,除去残根,洗净切段,晒干; 23、 玉米须:取原药材,除去杂质,筛去灰肩。
[0010] 二、制备 1、 将所述重量的白术、藕节、蒲黄、滑石、白茅根、生地黄、木通、白花蛇舌草、黄芩、侧柏 叶、甘草、车前草、杏仁、紫苏叶、桂枝、防己、葶苈子、竹叶、蒲公英、陈皮、透骨草、鱼腥草、玉 米须放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,其中滑石用布包,再用文 火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; 2、 将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为3剂服用。
[0011] 组方中蒲黄有凉血止血,活血消瘀的功能为君药;滑石有利尿通淋,清热解毒,祛 湿解暑的功能;白茅根有凉血,止血,清热,利尿的功能,二者为臣药,三味药共同发挥凉血 止血,活血消瘀,利尿通淋,清热解毒的作用,治疗急性肾炎效力全面,且以凉血止血,利尿 通淋,清热解毒为主可治本,甘草有缓急,润肺,解毒,调和诸药的功能为佐药,桂枝有发汗 解肌,温经通脉的功能为使药,与下余诸药是治标。
[0012] 本发明药物具有凉血止血,活血消瘀,利尿通淋,清热解毒的功能,用于治疗急性 肾炎,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治急性肾炎门诊患者共34例。
[0016] 2、诊断标准 典型症状为急性起病,患者出现血尿、蛋白尿、水肿和高血压,并可伴有一过性氮质血 症。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,8天为一个疗程,连 续服用3个疗程。
[0018] 4、疗效评定标准 显效:急性肾炎症状消失,体质恢复正常,痊愈; 好转:急性肾炎症状明显好转,血尿、蛋白蛋已得到有效控制,水肿好转,体质逐步恢 复; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN106620360AD00081
在上述治疗中,用本发明药物治疗急性肾炎患者34例,结果显效28例,显效率为82.3%, 好转4例,好转率为11.8%,无效2例,总有效率为94.1%。

Claims (3)

1. 一种治疗急性肾炎的药物,其特征在于:它是由下列重量范围内的原料药制成: 白术35-45克,藕节15-25克,蒲黄10-20克,滑石15-25克,白茅根45-55克,生地黄45-55 克,木通10-20克,白花蛇舌草10-20克,黄芩10-20克,侧柏叶5-15克,甘草5-15克,车前草 25-35克,杏仁5-15克,紫苏叶10-20克,桂枝5-15克,防己10-20克,葶苈子5-15克,竹叶5-15 克,蒲公英10-20克,陈皮5-15克,透骨草15-25克,鱼腥草10-20克,玉米须10-14克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 白术40克,藕节20克,蒲黄15克,滑石20克,白茅根50克,生地黄50克,木通15克,白花蛇 舌草15克,黄芩15克,侧柏叶10克,甘草10克,车前草30克,杏仁10克,紫苏叶15克,桂枝10 克,防己15克,葶苈子10克,竹叶10克,蒲公英15克,陈皮10克,透骨草20克,鱼腥草15克,玉 米须12克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一) 备料 (1) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (2) 藕节:取净藕节置锅内炒至外面呈黑色,内部呈老黄色,稍洒清水,取出,干燥; (3) 蒲黄:揉碎结块,过筛,除去杂质; (4) 滑石:取原药材,除去杂质,砸成小块; (5) 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (6) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (7) 木通:用水稍浸泡,闷润至透,切片,晒干; (8) 白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰肩; (9) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (10) 侧柏叶:拣净杂质,揉碎去梗,筛净灰肩; (11) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (12) 车前草:去尽泥土,晒干; (13) 杏仁:拣净杂质,置沸水中略煮,待外皮微皱时捞出,浸凉水中,脱去种皮,晒干,簸 净; (14) 紫苏叶:拣去杂质,晒干; (15) 桂枝:用水稍浸泡,捞出,闷润至透,切片,瞭干,筛去肩; (16) 防己:原药用水洗净,捞出润透,切片,晒干; (17) 葶苈子:拣净杂质,筛去灰肩; (18) 竹叶:拣净杂质,除去梗叶,晾干; (19) 蒲公英:拣去杂质,洗净泥土,切段,晒干; (20) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (21) 透骨草:拣净杂质,切段; (22) 鱼腥草:去净杂质,除去残根,洗净切段,晒干; (23) 玉米须:取原药材,除去杂质,筛去灰肩; (二) 制备 (1)将所述重量的白术、藕节、蒲黄、滑石、白茅根、生地黄、木通、白花蛇舌草、黄芩、侧 柏叶、甘草、车前草、杏仁、紫苏叶、桂枝、防己、葶苈子、竹叶、蒲公英、陈皮、透骨草、鱼腥草、 玉米须放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,其中滑石用布包,再用 文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为3剂服用。
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