CN107260992A - 一种治疗早泄的药物及其制备方法 - Google Patents

一种治疗早泄的药物及其制备方法 Download PDF

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CN107260992A
CN107260992A CN201710472563.4A CN201710472563A CN107260992A CN 107260992 A CN107260992 A CN 107260992A CN 201710472563 A CN201710472563 A CN 201710472563A CN 107260992 A CN107260992 A CN 107260992A
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许文华
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Abstract

本发明公开了一种治疗早泄的药物及其制备方法，其主要是由何首乌、海螵蛸、桑螵蛸、五倍子、山萸肉、阿魏、白石脂、虫白蜡、白兰花、山药、紫河车、灵芝草、党参、红参、麝香、安息香等按一定重量配比制备而成，本发明药物具有补肝益肾、养血祛风、补肾固精、养血润燥、涩精气的功能，用于治疗早泄见效快、疗效好，不复发。

Description

一种治疗早泄的药物及其制备方法
技术领域
本发明涉及一种治疗早泄的药物及其制备方法，属中药领域。
技术背景
早泄是最常见的射精功能障碍，以性交之始即行排精，甚至性交前即泄精，不能进行正常性生活。中医则认为早泄与肝经湿热、阴虚火旺、肾气不固有关。由于西药治疗副作用大，因此人们对有效治疗早泄的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗早泄的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗早泄的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择何首乌、海螵蛸、桑螵蛸、五倍子、山萸肉、阿魏、白石脂、虫白蜡、白兰花、山药、紫河车、灵芝草、党参、红参、麝香、安息香、羊肾、海参进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗早泄。其中选用何首乌是因为其性味苦甘涩，微温，入肝、肾经，有补肝，益肾，养血，祛风的功能，治肝肾阴亏，发须早白，血虚头晕，腰膝软弱，筋骨酸痛，遗精，崩带，久疟，久痢，慢性肝炎，痈肿，瘰疬，肠风，痔疾。选用海螵蛸是因为其性味咸，微温，入肝、肾经，有除湿，制酸，止血，敛疮的功能，治胃痛吞酸，吐、衄、呕血，便血，崩漏带下，血枯经闭，腹痛癥瘕，虚疟泻痢，阴蚀烂疮。选用桑螵蛸是因为其性味咸、甘、平，有补肾，固精的功能，治遗精，白浊，阳痿，早泄。选用五倍子是因为其性味酸，平，入肺，胃，大肠经，有敛肺，涩肠，止血，解毒的功能，治肺虚久咳，久痢，久泻，脱肛，自汗，盗汗，遗精，便血，衄血，崩漏，外伤出血，肿毒，疮疖，睫毛倒卷。选用山萸肉是因为其性味酸，微温，有补肝肾，涩精气的功能，治阳萎，遗精，肝虚寒热，心摇脉散。选用阿魏是因为其性味苦辛，温，入肝、脾、胃经，有消积，杀虫的功能，治癥瘕痞块，虫积，肉积，心腹冷痛，疟疾，痢疾。选用白石脂是因为其性味甘酸，平，入手、足阳明经，有涩肠，止血的功能，治久泻，久痢，崩漏带下，遗精。选用虫白蜡是因为其性味甘，温，入肝经，有止血，生肌，定痛的功能，治金疮出血，尿血，下血，疮疡久溃不敛，下疳。选用白兰花是因为其性味苦辛，温，有止咳，化浊的功能，治慢性支气管炎，前列腺炎，妇女白带。选用山药是因为其性味甘，平，入肺、脾、肾经，有健脾，补肺，固肾，益精的功能，治脾虚泄泻，久痢，虚劳咳嗽，消渴，遗精、带下，小便频数。选用紫河车是因为其性味甘咸，温，入肺、肝、肾经，有补气，养血，益精的功能，治虚损，羸瘦，劳热骨蒸，咳喘，咯血，盗汗，遗精，阳痿，妇女血气不足，不孕或乳少。选用灵芝草是因为其性味甘，平，治虚劳，咳嗽，气喘，失眠，消化不良。选用党参是因为其性味甘，平，入手、足太阴经气分，有补中益气，生津的功能，治脾胃虚弱，气血两亏，体倦无力，食少，口渴，久泻，脱肛。选用红参是因为其性味甘、微苦，温，归脾、肺、心经，有大补元气，复脉固脱，益气摄血的功能，治体虚欲脱，肢冷脉微，气不摄血，崩漏下血，心力衰竭，心源性休克。选用麝香是因为其性味辛，温，入心、脾、肝经，有开窍，辟秽，通络，散瘀的功能，治中风，痰厥，惊癎，中恶烦闷，心腹暴痛，癥瘕癖积，跌打损伤，痈疽肿毒。选用安息香是因为其性味辛苦，温，入心、肝、脾经，有开窍，辟秽，行气血的功能，治卒中暴厥，心腹疼痛，产后血晕，小儿惊癎，风痹腰痛。选用羊肾是因为其性味甘，温，有补肾气，益精髓的功能，治肾虚劳损，腰脊疼痛，足膝痿弱，耳聋，消渴，阳萎，尿频，遗溺。选用海参是因为其性味咸，温，入心、肾二经，有补肾益精，养血润燥的功能，治精血亏损，虚弱劳怯，阳痿，梦遗，小便频数，肠燥便艰。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
何首乌20-30克、海螵蛸9-15克、桑螵蛸9-20克、五倍子6-15克、山萸肉9-20克、阿魏3-9克、白石脂8-15克、虫白蜡6-12克、白兰花9-15克、山药9-20克、紫河车20-30克、灵芝草10-20克、党参6-15克、红参6-15克、麝香0.3-1.5克、安息香6-12克、羊肾25-40克、海参20-30克。
优选为：
何首乌30克、海螵蛸12克、桑螵蛸15克、五倍子10克、山萸肉20克、阿魏6克、白石脂12克、虫白蜡9克、白兰花12克、山药20克、紫河车30克、灵芝草12克、党参12克、红参15克、麝香0.9克、安息香10克、羊肾30克、海参20克。
本发明药物的制备方法如下
一、备料
1、何首乌：拣去杂质，洗净，用水泡至八成透，捞出，润至内外湿度均匀，切片或切成方块，晒干；
2、海螵蛸：刷洗干净，晒干，砸成小块；
3、桑螵蛸：将净桑螵蛸和麸皮同炒至老黄色，取出，筛去麸皮，放凉；
4、五倍子：拣净、敲开、剔去其中杂质；
5、山萸肉：洗净，除去果核及杂质，晒干；
6、阿魏：拣去杂质，斫成小块；
7、白石脂：取原药材，打碎；
8、虫白蜡：8-9月间采蜡，清晨用刀将包有蜡质的树枝切下，放入沸水锅中煮之，使蜡质熔化而浮于水面，冷后凝结成块，取出，再加水加热熔化，过滤后凝固即成；
9、白兰花：夏末秋初花开时采收，晒干；
10、山药：拣净杂质，用水浸泡至山药中心部软化为止，捞出稍晾，切片晒干或烘干；
11、紫河车：用新鲜的紫河车，横直割开血管，用水反复洗漂干净；
12、灵芝草：除去杂质，洗净，润软，切厚片，干燥，筛去碎屑；
13、党参：洗净泥沙后润透去芦，切片或切段，晒干；
14、红参：取原药材，润透，切薄片，干燥；
15、麝香：用温水浸润香囊，割开后除去皮毛内膜杂质，用时取麝香仁研细；
16、安息香：取原药材，除去杂质，打成小块；
17、羊肾：去脂膜，细切；
18、海参：海参捕得后，除去内脏，洗净腔内泥沙，用时再入水浸泡。
二、制备
1、取炮制好的何首乌、山萸肉、阿魏、紫河车、羊肾和水浸泡软的海参混合加入30克的黄酒共捣成泥状；
2、将海螵蛸、桑螵蛸、五倍子、白石脂、虫白腊、白兰花、山药、灵芝草、党参、红参、安息香去杂质及灰尘磨碎制成粗粉；
3、取上述泥状和粗粉的药物加入500克的麻油煮1.5个小时去药渣后，再加入麝香及黄蜡30克，麦面粉50克搅拌均匀，制成药丸，每丸3克。
组方中何首乌有补肝，益肾，养血，祛风的功能为君药；桑螵蛸补肾，固精；五倍子敛肺，涩肠，止血，解毒二者为臣药，三味药共同发挥补肝益肾、养血祛风、补肾固精、敛肺、止血、解毒的作用，治疗早泄效力全面，且以补肝益肾、养血祛风、补肾固精为主可治本，山萸肉有补肝肾，涩精气的功能为佐药，海参有补肾益精，养血润燥的功能为使药，与下余诸药是治标。
本发明药物具有补肝益肾、养血祛风、补肾固精、养血润燥、涩精气的功能，用于治疗早泄，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取西德兔30只，雌雄兼用，体重2.0-2.5kg，分为二组，其中一组为超剂量，另一组为正常量，服用丸剂超剂量组0.25g/kg，正常量组0.15g/kg，采用稀释灌胃法给药，每日二次，连续服用7天，观察给药反应，结果表明家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治早泄门诊患者共34例。
2、诊断标准
典型症状为射精过快，伴有焦虑、精神抑郁、头晕、神疲乏力等。
3、治疗方法
选用上述药丸，给患者服用，每次服用2丸，每天早、中、晚各服1次，15天为一个疗程，连续服用3个疗程。
4、疗效评定标准
显效：早泄症状消失，恢复正常，痊愈；
好转：患者射精过快，焦虑、精神抑郁、头晕、神疲乏力的现象减轻，早泄症状明显好转，逐步恢复正常；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗早泄患者34例，结果显效26例，显效率为76.48%，好转5例，好转率为14.7%，无效3例，总有效率为91.18%。

Claims (3)

1.一种治疗早泄的药物，其特征在于：它是由下列重量范围内的原料药制成：
何首乌20-30克、海螵蛸9-15克、桑螵蛸9-20克、五倍子6-15克、山萸肉9-20克、阿魏3-9克、白石脂8-15克、虫白蜡6-12克、白兰花9-15克、山药9-20克、紫河车20-30克、灵芝草10-20克、党参6-15克、红参6-15克、麝香0.3-1.5克、安息香6-12克、羊肾25-40克、海参20-30克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
何首乌30克、海螵蛸12克、桑螵蛸15克、五倍子10克、山萸肉20克、阿魏6克、白石脂12克、虫白蜡9克、白兰花12克、山药20克、紫河车30克、灵芝草12克、党参12克、红参15克、麝香0.9克、安息香10克、羊肾30克、海参20克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）何首乌：拣去杂质，洗净，用水泡至八成透，捞出，润至内外湿度均匀，切片或切成方块，晒干；
（2）海螵蛸：刷洗干净，晒干，砸成小块；
（3）桑螵蛸：将净桑螵蛸和麸皮同炒至老黄色，取出，筛去麸皮，放凉；
（4）五倍子：拣净、敲开、剔去其中杂质；
（5）山萸肉：洗净，除去果核及杂质，晒干；
（6）阿魏：拣去杂质，斫成小块；
（7）白石脂：取原药材，打碎；
（8）虫白蜡：8-9月间采蜡，清晨用刀将包有蜡质的树枝切下，放入沸水锅中煮之，使蜡质熔化而浮于水面，冷后凝结成块，取出，再加水加热熔化，过滤后凝固即成；
（9）白兰花：夏末秋初花开时采收，晒干；
（10）山药：拣净杂质，用水浸泡至山药中心部软化为止，捞出稍晾，切片晒干或烘干；
（11）紫河车：用新鲜的紫河车，横直割开血管，用水反复洗漂干净；
（12）灵芝草：除去杂质，洗净，润软，切厚片，干燥，筛去碎屑；
（13）党参：洗净泥沙后润透去芦，切片或切段，晒干；
（14）红参：取原药材，润透，切薄片，干燥；
（15）麝香：用温水浸润香囊，割开后除去皮毛内膜杂质，用时取麝香仁研细；
（16）安息香：取原药材，除去杂质，打成小块；
（17）羊肾：去脂膜，细切；
（18）海参：海参捕得后，除去内脏，洗净腔内泥沙，用时再入水浸泡；
（二）制备
（1）取炮制好的何首乌、山萸肉、阿魏、紫河车、羊肾和水浸泡软的海参混合加入30克的黄酒共捣成泥状；
（2）将海螵蛸、桑螵蛸、五倍子、白石脂、虫白腊、白兰花、山药、灵芝草、党参、红参、安息香去杂质及灰尘磨碎制成粗粉；
（3）取上述泥状和粗粉的药物加入500克的麻油煮1.5个小时去药渣后，再加入麝香及黄蜡30克，麦面粉50克搅拌均匀，制成药丸，每丸3克。
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