CN106880744A - 一种治疗更年期综合症的药物及其制备方法 - Google Patents
一种治疗更年期综合症的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗更年期综合症的药物及其制备方法,其主要是由菟丝子、淫羊藿、枸杞子、牡丹皮、路路通、川楝子、百合、山药、泽泻、何首乌、知母、白芍、远志、当归、龟版、酸枣仁、刺蒺藜、茯神、五味子、墨旱莲、黄芪、黄柏按一定重量配比制备而成,本发明药物具有补肝益肾,补血和血,宁心安神,凉血止血,益阴健脾,调经止痛的功能,用于治疗更年期综合症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗更年期综合症的药物及其制备方法,属中药领域。
背景技术
更年期综合症是指妇女绝经前后出现性激素波动或减少所致的一系列以自主神经系统功能紊乱为主,伴有神经心理症状的一组症候群。中医则认为更年期综合症与肝肾阴虚,肝气郁结,心肾俱虚,脾肾俱虚有关。由于西药治疗副作用大,因此人们对有效治疗更年期综合症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗更年期综合症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗更年期综合症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择菟丝子、淫羊藿、枸杞子、牡丹皮、路路通、川楝子、百合、山药、泽泻、何首乌、知母、白芍、远志、当归、龟版、酸枣仁、刺蒺藜、茯神、五味子、墨旱莲、黄芪、黄柏、火麻仁、太子参、石菖蒲、仙茅药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗更年期综合症。其中选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗清。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用百合是因为其性味甘微苦,平,入心、肺经,有润肺止咳,清心安神的功能,治肺痨久嗽,咳唾痰血,热病后余热未清,虚烦惊悸,神志恍惚,脚气浮肿。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用远志是因为其性味苦辛,温,入心、肾经,有安神益智,祛痰,解郁的功能,治惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用龟版是因为其性味咸甘,平,入肝、肾经,有滋阴,潜阳,补肾,健骨的功能,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨痿,阴虚风动,久痢,久疟,痔疮,小儿囟门不合。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用刺蒺藜是因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。选用茯神是因为其性味甘淡,平,入心、脾经,有宁心,安神,利水的功能,治心虚惊悸,健忘,失眠,惊癎,小便不利。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用黄柏是因为其性味苦,寒,入肾、膀胱经,有清热,燥湿,泻火,解毒的功能,治热痢,泄泻,消渴,黄疸,痿躄,梦遗,淋浊,痔疮,便血,赤白带下,骨蒸劳热,目赤肿痛,口舌生疮,疮疡肿毒。选用火麻仁是因为其性味甘,平,入脾、胃、大肠经,有润燥,滑肠,通淋,活血的功能,治肠燥便秘,消渴,热淋,风痹,痢疾,月经不调,疥疮,癣癫。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用石菖蒲因为其性味辛,微温。入心、肝、脾经。开窍,豁痰,理气,活血,散风,去湿。治癫痫,痰厥,热病神错,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用仙茅是因为其性味辛,温,有毒,入肾、肝经,有温肾阳,壮筋骨的功能,治阳萎精冷,小便失禁,崩漏,心腹冷痛,腰脚冷痹,痈疽,瘰疬。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
菟丝子10-15克,淫羊藿10-20克,枸杞子10-20克,牡丹皮5-15克,路路通5-10克,川楝子5-10克,百合10-20克,山药10-20克,泽泻5-15克,何首乌10-20克,知母10-20克,白芍15-20克,远志10-15克,当归15-25克,龟版15-25克,酸枣仁15-25克,刺蒺藜5-15克,茯神10-15克,五味子5-15克,墨旱莲10-15克,黄芪5-15克,黄柏5-10克,火麻仁5-15克,太子参10-15克,石菖蒲10-20克,仙茅5-15克。
优选为:
菟丝子12克,淫羊藿15克,枸杞子15克,牡丹皮10克,路路通8克,川楝子8克,百合15克,山药15克,泽泻10克,何首乌15克,知母15克,白芍18克,远志12克,当归20克,龟版20克,酸枣仁20克,刺蒺藜10克,茯神12克,五味子10克,墨旱莲12克,黄芪10克,黄柏8克,火麻仁10克,太子参12克,石菖蒲15克,仙茅10克。
本发明药物的制备方法如下
一、备料
1、菟丝子:过箩去净杂质,洗净,晒干;
2、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
3、枸杞子:簸净杂质,摘去残留的梗和蒂;
4、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
5、路路通:除去杂质,洗净,晒干;
6、川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
7、百合:拣去杂质,黑瓣,簸除灰屑;
8、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
9、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
10、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
11、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
12、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
13、远志:拣去杂质,切段,筛去灰屑;
14、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
15、龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
16、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
17、刺蒺藜:漂去泥沙,除净残留的硬刺;
18、茯神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干;
19、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
20、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
21、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
22、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
23、火麻仁:拣去杂质及残留外壳,取净仁;
24、太子参:摘除须根,晒干;
25、石菖蒲:拣去杂质,洗净,稍稍浸泡,润透,切片,晒干;
26、仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤。
二、制备
1、将炮制后的菟丝子、淫羊藿、枸杞子、牡丹皮、路路通、川楝子、百合、山药、泽泻、何首乌、知母、白芍、远志、当归、龟版、酸枣仁、刺蒺藜、茯神、五味子、墨旱莲、黄芪、黄柏、火麻仁、太子参、石菖蒲、仙茅放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中何首乌有补肝,益肾,养血,祛风的功能为君药;酸枣仁养肝,宁心,安神,敛汗;有凉血,止血,补肾,益阴的功能,二者为臣药,三味药共同发挥补肝益肾,养血,宁心安神,凉血止血,益阴,祛风,敛汗的作用,治疗更年期综合症效力全面,且以补肝益肾,养血,宁心安神,凉血止血,益阴为主可治本,山药有健脾,补肺,固肾,益精的功能为佐药,当归有补血和血,调经止痛,润燥滑肠的功能为使药,与余下诸药是治标。
本发明药物具有补肝益肾,补血和血,宁心安神,凉血止血,益阴健脾,调经止痛的功能,用于治疗更年期综合症,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治更年期综合症门诊患者共21例。
2、诊断标准
典型症状一是血管舒缩系统症状,如潮热多汗等;二是躯体症状,如疲倦、关节痛、心慌心跳、皮肤干燥等;三是精神神经系统症状,兴奋型的表现为烦躁、易激动、注意力不集中;抑郁型的就是失眠、不安、惊恐、冷淡等;四是泌尿生殖系统症状,如尿频尿急、阴道干燥、月经失调、子宫脱垂、性欲下降等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:更年期综合症症状消失,恢复正常,痊愈;
好转:患者血管舒缩系统、躯体精神神经系统、泌尿生殖系统的不良症状减轻,更年期综合症症状明显好转,体质逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗更年期综合症患者21例,结果显效17例,显效率为80.96%,好转3例,好转率为14.28%,无效1例,总有效率为95.24%。
Claims (3)
1.一种治疗更年期综合症的药物,其特征在于:它是由下列重量范围内的原料药制成:
菟丝子10-15克,淫羊藿10-20克,枸杞子10-20克,牡丹皮5-15克,路路通5-10克,川楝子5-10克,百合10-20克,山药10-20克,泽泻5-15克,何首乌10-20克,知母10-20克,白芍15-20克,远志10-15克,当归15-25克,龟版15-25克,酸枣仁15-25克,刺蒺藜5-15克,茯神10-15克,五味子5-15克,墨旱莲10-15克,黄芪5-15克,黄柏5-10克,火麻仁5-15克,太子参10-15克,石菖蒲10-20克,仙茅5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
菟丝子12克,淫羊藿15克,枸杞子15克,牡丹皮10克,路路通8克,川楝子8克,百合15克,山药15克,泽泻10克,何首乌15克,知母15克,白芍18克,远志12克,当归20克,龟版20克,酸枣仁20克,刺蒺藜10克,茯神12克,五味子10克,墨旱莲12克,黄芪10克,黄柏8克,火麻仁10克,太子参12克,石菖蒲15克,仙茅10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)菟丝子:过箩去净杂质,洗净,晒干;
(2)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(3)枸杞子:簸净杂质,摘去残留的梗和蒂;
(4)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(5)路路通:除去杂质,洗净,晒干;
(6)川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
(7)百合:拣去杂质,黑瓣,簸除灰屑;
(8)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(9)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(10)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(11)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(12)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(13)远志:拣去杂质,切段,筛去灰屑;
(14)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(15)龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
(16)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
(17)刺蒺藜:漂去泥沙,除净残留的硬刺;
(18)茯神:取原药材,除去杂质,洗净,润透,切成正方形的厚生或块,阴干;
(19)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(20)墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
(21)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(22)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(23)火麻仁:拣去杂质及残留外壳,取净仁;
(24)太子参:摘除须根,晒干;
(25)石菖蒲:拣去杂质,洗净,稍稍浸泡,润透,切片,晒干;
(26)仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤;
(二)制备
(1)将炮制后的菟丝子、淫羊藿、枸杞子、牡丹皮、路路通、川楝子、百合、山药、泽泻、何首乌、知母、白芍、远志、当归、龟版、酸枣仁、刺蒺藜、茯神、五味子、墨旱莲、黄芪、黄柏、火麻仁、太子参、石菖蒲、仙茅放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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