CN105343650A - 一种治疗肾阳不足型弱精症的药物及其制备方法 - Google Patents

一种治疗肾阳不足型弱精症的药物及其制备方法 Download PDF

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CN105343650A
CN105343650A CN201510951000.4A CN201510951000A CN105343650A CN 105343650 A CN105343650 A CN 105343650A CN 201510951000 A CN201510951000 A CN 201510951000A CN 105343650 A CN105343650 A CN 105343650A
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徐士杰
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Abstract

本发明公开了一种治疗肾阳不足型弱精症的药物及其制备方法，其主要是由萆薢、大血藤、白芷、沙苑子、南沙参、山萸肉、黑皮根、覆盆子、柴胡、菟丝子、牡蛎、川牛膝、续断、山药等按一定重量配比制备而成，本发明药物具有补肝益肾，补气益精的功能，用于治疗肾阳不足型弱精症见效快，疗效好，无副作用。

Description

一种治疗肾阳不足型弱精症的药物及其制备方法
技术领域
本发明涉及一种治疗肾阳不足型弱精症的药物及其制备方法，属中药领域。
背景技术
肾阳不足型弱精症，指精液参数中前向运动的精子(a和b级)小于50%或a级运动的精子小于25%的病症，弱精子症又称精子活力低下。（a级：表示精子活动力好，直线向前运动；b级：表示精子活动力一般，只向前曲线运动；c级：表示精子活动力差，只在原地蠕动。）一般情况下，弱精子症的临床表现并不明显，患者通常要通过精液化验结果来断定是否为弱精子症。由于西药无法有效快速治疗肾阳不足型弱精症，因此人们对有效治疗肾阳不足型弱精症的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗肾阳不足型弱精症的药物，从而完成了本发明。
本发明的目的就是提供一种更有效的治疗肾阳不足型弱精症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择萆薢、大血藤、白芷、沙苑子、南沙参、山萸肉、黑皮根、覆盆子、柴胡、菟丝子、牡蛎、川牛膝、大枣、续断、浮小麦、鳖甲、海马、巴戟天、枸杞子、生地黄、女贞子、何首乌、鹿茸、黄芪、附子、杜仲、黄精、当归、山药、茯苓药物进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗肾阳不足型弱精症。其中，选用萆薢是因为其性味苦，平，入肝、胃、膀胱经，有祛风，利湿的功能，治风湿顽痹，腰膝疼痛，小便不利，淋浊，遗精，湿热疮毒。选用大血藤是因为其性味苦，平，入肝、大肠二经，有败毒消痈，活血通络，祛风杀虫的功能，治急、慢性阑尾炎，风湿痹痛，赤痢，血淋，月经不调，疳积，虫痛，跌扑损伤。选用白芷是因为其性味辛，温，入肺、脾、胃经，有祛风，燥湿，消肿，止痛的功能，治头痛，眉棱骨痛，齿痛，鼻渊，寒湿腹痛，肠风痔漏，赤白带下，痈疽疮疡，皮肤燥痒，疥癣。选用沙苑子是因为其性味甘温，入肝、肾经，有补肝，益肾，明目，固精的功能，治肝肾不足，腰膝酸痛，目昏，遗精早泄，小便频数，遗尿，尿血，白带。选用南沙参是因为其性味甘，微寒，归肺、胃经，有养阴清肺，化痰，益气的功能，治肺热燥咳，阴虚劳咳，干咳痰黏，气阴不足，烦热口干。选用山萸肉是因为其性味酸，微温，有补肝肾，涩精气的功能，治阳萎，遗精，肝虚寒热，心摇脉散。选用黑皮根是因为其性味甘平，有健脾益胃，补肾固精的功能，治脾胃亏损，食欲不振，四肢无力，遗精。选用覆盆子是因为其性味甘酸平，有补肝肾，缩小便，助阳固精的功能，治阳痿，遗精。选用柴胡是因为其性味苦，凉，入肝、胆经，有和解表里，疏肝，升阳的功能，治寒热往来，胸满胁痛，口苦耳聋，头痛目眩，疟疾，下利脱肛，月经不调，子宫下垂。选用菟丝子是因为其性味辛甘，平，入肝、肾经，有补肝肾，益精髓，明目的功能，治腰膝酸痛，遗精，消渴，尿有余沥，目暗。选用牡蛎是因为其性味咸涩，凉，入肝、肾经，有敛阴，潜阳，止汗，涩精，化痰，软坚的功能，治惊癎，眩晕，自汗，盗汗，遗精，淋浊，崩漏，带下，瘰疬，瘿瘤。选用川牛膝是因为其性味平，味苦微苦，无毒，入肝、肾二经，有祛风，利湿，通经，活血的功能，治风湿腰膝疼痛，脚痿筋挛，血淋，尿血，妇女经闭，癥瘕。选用大枣是因为其性味甘，温，入脾、胃经，有补脾和胃，益气生津，调营卫，解药毒的功能，治胃虚食少，脾弱便溏，气血津液不足，营卫不和，心悸怔忡，妇人脏躁。选用续断是因为其性味苦辛，微温，入肝、肾经，有补肝肾，续筋骨，调血脉的功能，治腰背酸痛，足膝无力，胎漏，崩漏，带下，遗精，跌打损伤，金疮，痔漏，痈疽疮肿。选用浮小麦是因为其性味甘咸，凉，治骨蒸劳热，止自汗盗汗。选用鳖甲是因为其性味咸，平，入肝、脾经，有养阴清热，平肝熄风，软坚散结的功能，治劳热骨蒸，阴虚风动，劳疟疟母，癥瘕痃癖，经闭经漏，小儿惊癎。选用海马是因为其性味甘，温，入肝、肾经，有补肾壮阳，调气活血的功能，治阳痿，遗尿，虚喘，难产，癥积，疔疮肿毒。选用巴戟天是因为其性味辛甘，温，入肝、肾经，有补肾阳，壮筋骨，祛风湿的功能，治阳痿，少腹冷痛，小便不禁，子宫虚冷，风寒湿痹，腰膝酸痛。选用枸杞子是因为其性味甘，平，有滋肾，润肺，补肝，明目的功能，治肝肾阴亏，腰膝酸软，头晕目眩，目昏多泪，虚劳咳嗽，消渴，遗精。选用生地黄是因为其性味甘，寒，归心、肝、肾经，有清热凉血，养阴，生津的功能，治热病烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。选用女贞子是因为其性味苦甘，平，入肝、肾经，有补肝肾，强腰膝的功能，治阴虚内热，头晕，目花耳鸣，腰膝酸软，须发早白。选用何首乌是因为其性味苦甘涩，微温，入肝、肾经，有补肝，益肾，养血，祛风的功能，治肝肾阴亏，发须早白，血虚头晕，腰膝软弱，筋骨酸痛，遗精，崩带，久疟，久痢，慢性肝炎，痈肿，瘰疬，肠风，痔疾。选用鹿茸是因为其性味甘咸，温，入肝、肾经，有壮元阳，补气血，益精髓，强筋骨的功能，治虚劳羸瘦，精神倦乏，眩晕，耳聋，目暗，腰膝酸痛，阳痿，滑精；子宫虚冷，崩漏，带下。选用黄芪是因为其性味甘，微温，入肺、脾经，生用有益卫固表，利水消肿，托毒，生肌的功能，治自汗，盗汗，血痹，浮肿，痈疽不溃或溃久敛；炙用有补中益气的功能，治内伤劳倦，脾虚泄泻，脱肛，气虚血脱，崩带及一切气衰血虚之症。选用附子是因为其性味辛甘，热，有毒，入心、脾、肾经，有回阳补火，散寒除湿的功能，治阴盛格阳，大汗亡阳，吐利厥逆，心腹冷痛，脾泄冷痢，脚气水肿，小儿慢惊，风寒湿痹，踒躄拘挛，阴疽疮漏及一切沉寒痼冷之疾。选用杜仲是因为其性味甘微辛，温，入肝、肾经，有补肝肾，强筋骨，安胎的功能，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，高血压。选用黄精是因为其性味甘平，入脾、肺、肾经，有补中益气，润心肺，强筋骨的功能，治虚损寒热，肺痨咳血，病后体虚食少，筋骨软弱，风湿疼痛，风癞癣疾。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用山药是因为其性味甘，平，入肺、脾、肾经，有健脾，补肺，固肾，益精的功能，治脾虚泄泻，久痢，虚劳咳嗽，消渴，遗精、带下，小便频数。选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
萆薢15-25克，大血藤20-30克，白芷10-12克，沙苑子10-15克，南沙参10-15克，山萸肉10-15克，黑皮根20-25克，覆盆子10-20克，柴胡5-10克，菟丝子10-15克，牡蛎20-30克，川牛膝10-16克，大枣5-10克，续断10-15克，浮小麦15-20克，鳖甲15-20克，海马5-15克，巴戟天10-15克，枸杞子20-30克，生地黄10-15克，女贞子10-15克，何首乌10-15克，鹿茸10-25克，黄芪5-10克，附子5-10克，杜仲5-10克，黄精10-15克，当归15-20克，山药10-15克，茯苓10-15克。
优选为：
萆薢20克，大血藤25克，白芷10克，沙苑子12克，南沙参12克，山萸肉15克，黑皮根20克，覆盆子15克，柴胡6克，菟丝子10克，牡蛎30克，川牛膝15克，大枣10克，续断15克，浮小麦20克，鳖甲15克，海马15克，巴戟天15克，枸杞子20克，生地黄15克，女贞子15克，何首乌20克，鹿茸15克，黄芪10克，附子10克，杜仲10克，黄精10克，当归15克，山药15克，茯苓15克。
本发明药物的制备方法如下
一、备料
1、萆薢：除去杂质，切片，洗净，浸泡，润透，干燥，筛去碎屑；
2、大血藤：用水浸泡，洗净泥屑，润透，切片，晒干；
3、白芷：拣净杂质，用水洗净，浸泡，捞出润透，略晒至外皮无滑腻感时，再闷润后，切片干燥；
4、沙苑子：拣去杂质，漂净泥沙，捞出，晒干；
5、南沙参：除去须根，洗净，刮去粗皮，干燥；
6、山萸肉：洗净，除去果核及杂质，晒干；
7、黑皮根：拣净杂质，洗净，切片，晒干；
8、覆盆子：筛去灰屑，拣净杂质，去柄；
9、柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，晒干；
10、菟丝子：过箩去净杂质，洗净，晒干；
11、牡蛎：将洗净的牡蛎，置无烟炉火上煅至灰白色，取出放凉，碾碎；
12、川牛膝：拣去杂质，晾干；
13、大枣：拣净杂质，晒干；
14、续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑；
15、浮小麦：拣去杂质，筛净灰屑，漂洗后晒干；
16、鳖甲：用水浸泡，去净皮肉，洗净，晒干；
17、海马：用水刷净，切块或打碎；
18、巴戟天：拣去杂质，用热水泡透后，趁热抽去木心，切段，晒干；
19、枸杞子：簸净杂质，摘去残留的梗和蒂；
20、生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
21、女贞子：拣去杂质，洗净，晒干；
22、何首乌：拣去杂质，洗净，用水泡至八成透，捞出，润至内外湿度均匀，切片或切成方块，晒干；
23、鹿茸：用干燥的鹿茸片，碾成细末；
24、黄芪：拣净杂质，除去残留的根头和空心较大的根，用水浸泡，捞出，润透后及时切片，晒干；
25、附子：用水浸泡，捞出，切片，晾干；
26、杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
27、黄精：洗净泥土，略润，切片，晒干；
28、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
29、山药：拣净杂质，用水浸泡至山药中心部软化为度，捞出稍晾，切片晒干或烘干；
30、茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
二、制备
1、将所述重量的萆薢、大血藤、白芷、沙苑子、南沙参、山萸肉、黑皮根、覆盆子、柴胡、菟丝子、牡蛎、川牛膝、大枣、续断、浮小麦、鳖甲、海马、巴戟天、枸杞子、生地黄、女贞子、何首乌、鹿茸、黄芪、附子、杜仲、黄精、当归、山药、茯苓加水煎煮两次，第一次加水8倍量，浸泡180分钟后，武火煎煮沸腾，再用文火煎煮30分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内。
2、将过滤的药渣加水6倍量，先用武火煮沸，再用文火煎煮20分钟过滤，将第二次煎煮液倒入容器内。
3、将两次煎煮液混合搅拌均匀，分成4剂服用。
组方中沙苑子有补肝，益肾，固精的功能为君药；萆薢祛风利湿，治遗精。鹿茸有壮元阳，补气血益精髓，强筋骨的功能二者为臣药。三味药共同发挥补肝、益肾、祛风利湿，补气固精的作用，且以补肝益肾、壮阳固精为主可治本。山药固肾益精为佐药；当归有补血和血，调经止痛的功能为使药，与下余诸药是治标。
本发明药物具有补肝益肾，补气益精的功能，用于治疗肾阳不足型弱精症，疗程短、见效快、治愈后不复发、无毒副作用。
具体实施方式：
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治肾阳不足型弱精症门诊患者共45例。
2、诊断标准
临床上，弱精子症主要根据精液常规分析和病史询问作出诊断。要求禁欲3～7d后手淫取精，经连续3次以上的精液常规分析提示精子前向运动(a+b级)小于50%或快速直线前向运动的精子小于25%，精子密度大于20~106/mL，其他参数正常或基本正常者可诊断为弱精子症。或射精后1h，精子活率小于50%，实验室或其他辅助检查能发现生殖道感染，或其他影响精子活率的疾病，均可诊断为弱精子症。肾阳不足型弱精症可通过观察精液不液化，或化而不全，内有凝块或胶冻样块;阴囊及睾丸发凉或冷感;腰膝酸软，畏寒肢冷。舌质淡苔薄白，脉沉迟或沉弦或细弱。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天早、晚各服1次，10天为一个疗程，连续服用3个疗程。
4、疗效评定标准
显效：肾阳不足型弱精症症状消失痊愈，化验显示精子活动力好，直线向前运动；
好转：肾阳不足型弱精症症状明显好转，化验显示精子活动力增强；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗肾阳不足型弱精症患者45例，结果显效40例，显效率为88.89%，好转4例，好转率为8.89%，无效1例，总有效率为97.78%。

Claims (3)

1.一种治疗肾阳不足型弱精症的药物，其特征在于：它是由下列用量范围内的原料药制成：
萆薢15-25克，大血藤20-30克，白芷10-12克，沙苑子10-15克，南沙参10-15克，山萸肉10-15克，黑皮根20-25克，覆盆子10-20克，柴胡5-10克，菟丝子10-15克，牡蛎20-30克，川牛膝10-16克，大枣5-10克，续断10-15克，浮小麦15-20克，鳖甲15-20克，海马5-15克，巴戟天10-15克，枸杞子20-30克，生地黄10-15克，女贞子10-15克，何首乌10-15克，鹿茸10-25克，黄芪5-10克，附子5-10克，杜仲5-10克，黄精10-15克，当归15-20克，山药10-15克，茯苓10-15克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
萆薢20克，大血藤25克，白芷10克，沙苑子12克，南沙参12克，山萸肉15克，黑皮根20克，覆盆子15克，柴胡6克，菟丝子10克，牡蛎30克，川牛膝15克，大枣10克，续断15克，浮小麦20克，鳖甲15克，海马15克，巴戟天15克，枸杞子20克，生地黄15克，女贞子15克，何首乌20克，鹿茸15克，黄芪10克，附子10克，杜仲10克，黄精10克，当归15克，山药15克，茯苓15克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
一、备料
1、萆薢：除去杂质，切片，洗净，浸泡，润透，干燥，筛去碎屑；
2、大血藤：用水浸泡，洗净泥屑，润透，切片，晒干；
3、白芷：拣净杂质，用水洗净，浸泡，捞出润透，略晒至外皮无滑腻感时，再闷润后，切片干燥；
4、沙苑子：拣去杂质，漂净泥沙，捞出，晒干；
5、南沙参：除去须根，洗净，刮去粗皮，干燥；
6、山萸肉：洗净，除去果核及杂质，晒干；
7、黑皮根：拣净杂质，洗净，切片，晒干；
8、覆盆子：筛去灰屑，拣净杂质，去柄；
9、柴胡：拣去杂质，除去残茎，洗净泥沙，捞出，润透后及时切片，晒干；
10、菟丝子：过箩去净杂质，洗净，晒干；
11、牡蛎：将洗净的牡蛎，置无烟炉火上煅至灰白色，取出放凉，碾碎；
12、川牛膝：拣去杂质，晾干；
13、大枣：拣净杂质，晒干；
14、续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑；
15、浮小麦：拣去杂质，筛净灰屑，漂洗后晒干；
16、鳖甲：用水浸泡，去净皮肉，洗净，晒干；
17、海马：用水刷净，切块或打碎；
18、巴戟天：拣去杂质，用热水泡透后，趁热抽去木心，切段，晒干；
19、枸杞子：簸净杂质，摘去残留的梗和蒂；
20、生地黄：取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
21、女贞子：拣去杂质，洗净，晒干；
22、何首乌：拣去杂质，洗净，用水泡至八成透，捞出，润至内外湿度均匀，切片或切成方块，晒干；
23、鹿茸：用干燥的鹿茸片，碾成细末；
24、黄芪：拣净杂质，除去残留的根头和空心较大的根，用水浸泡，捞出，润透后及时切片，晒干；
25、附子：用水浸泡，捞出，切片，晾干；
26、杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
27、黄精：洗净泥土，略润，切片，晒干；
28、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
29、山药：拣净杂质，用水浸泡至山药中心部软化为度，捞出稍晾，切片晒干或烘干；
30、茯苓：用水浸泡，洗净捞出，闷透后，切片，晒干；
二、制备
1、将所述重量的萆薢、大血藤、白芷、沙苑子、南沙参、山萸肉、黑皮根、覆盆子、柴胡、菟丝子、牡蛎、川牛膝、大枣、续断、浮小麦、鳖甲、海马、巴戟天、枸杞子、生地黄、女贞子、何首乌、鹿茸、黄芪、附子、杜仲、黄精、当归、山药、茯苓加水煎煮两次，第一次加水8倍量，浸泡180分钟后，武火煎煮沸腾，再用文火煎煮30分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加水6倍量，先用武火煮沸，再用文火煎煮20分钟过滤，将第二次煎煮液倒入容器内；
3、将两次煎煮液混合搅拌均匀，分成4剂服用。
CN201510951000.4A 2015-12-19 2015-12-19 一种治疗肾阳不足型弱精症的药物及其制备方法 Pending CN105343650A (zh)

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