CN106798907A - 一种治疗肾病综合症的药物及其制备方法 - Google Patents
一种治疗肾病综合症的药物及其制备方法 Download PDFInfo
- Publication number
- CN106798907A CN106798907A CN201710125778.9A CN201710125778A CN106798907A CN 106798907 A CN106798907 A CN 106798907A CN 201710125778 A CN201710125778 A CN 201710125778A CN 106798907 A CN106798907 A CN 106798907A
- Authority
- CN
- China
- Prior art keywords
- grams
- impurity
- radix
- picked
- dried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗肾病综合症的药物及其制备方法,其主要是由黄芪、太子参、白术、生地黄、山药、山萸肉、黄精、枸杞子、菟丝子、益母草、白茅根、夏枯草、车前子、金樱子、金银花、知母、淫羊藿、泽泻按一定重量配比制备而成,本发明药物具有益卫固表,利水消肿,滋肾润肺,补肾壮阳,祛风除湿的功能,用于治疗肾病综合症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗肾病综合症的药物及其制备方法,属中药领域。
背景技术
肾病综合症可由多种病因引起,以肾小球基膜通透性增加,表现为大量蛋白尿、低蛋白血症、高度水肿、高脂血症的一组临床症候群。由于西药治疗副作用大,因此人们对有效治疗肾病综合症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗肾病综合症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗肾病综合症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄芪、太子参、白术、生地黄、山药、山萸肉、黄精、枸杞子、菟丝子、益母草、白茅根、夏枯草、车前子、金樱子、金银花、知母、淫羊藿、泽泻、当归、川芎、茯苓、川牛膝、甘草、生姜、丹参、附子进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗肾病综合症。其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用山萸肉是因为其性味酸,微温,有补肝肾,涩精气的功能,治阳萎,遗精,肝虚寒热,心摇脉散。选用黄精是因为其性味甘平,入脾、肺、肾经,有补中益气,润心肺,强筋骨的功能,治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用车前子是因为其性味甘,寒,入肾、膀胱经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。选用金樱子是因为其性味酸涩,平,有固精涩肠,缩尿止泻的功能,治滑精,遗尿,小便频数,脾虚泻痢。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用生姜是因为其性味辛,温,入肺、胃、脾经,有发表,散寒,止呕,开痰的功能,治感冒风寒,呕吐,痰饮,喘咳,胀满,泄泻,解半夏、天南星及鱼蟹、鸟兽肉毒。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛格阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄芪10-20克,太子参10-20克,白术10-20克,生地黄10-20克,山药15-25克,山萸肉10-20克,黄精5-15克,枸杞子15-25克,菟丝子15-25克,益母草25-35克,白茅根15-25克,夏枯草15-25克,车前子5-15克,金樱子10-20克,金银花10-20克,知母5-15克,淫羊藿5-15克,泽泻25-35克,当归10-14克,川芎5-15克,茯苓15-25克,川牛膝5-15克,甘草5-15克, 生姜3-7克,丹参15-25克,附子5-15克。
优选为:
黄芪15克,太子参15克,白术15克,生地黄15克,山药20克,山萸肉15克,黄精10克,枸杞子20克,菟丝子20克,益母草30克,白茅根20克,夏枯草20克,车前子10克,金樱子15克,金银花15克,知母10克,淫羊藿10克,泽泻30克,当归12克,川芎10克,茯苓20克,川牛膝10克,甘草10克, 生姜5克,丹参20克,附子10克。
本发明药物的制备方法如下
一、备料
1、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
2、太子参:摘除须根,晒干;
3、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
4、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
5、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
6、山萸肉:洗净,除去果核及杂质,晒干;
7、黄精:洗净泥土,略润,切片,晒干;
8、枸杞子:簸净杂质,摘去残留的梗和蒂;
9、菟丝子:过箩去净杂质,洗净,晒干;
10、益母草:拣去杂质,洗净,润透,切段,晒干;
11、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
12、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
13、车前子:拣去杂质,筛去泥屑,空粒;
14、金樱子:拣去杂质,切两瓣,用水稍浸泡,捞出,闷润后除去残留毛刺,挖净毛、核,干燥;
15、金银花:筛去泥沙,拣净杂质;
16、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
17、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
18、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
19、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
20、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
21、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
22、川牛膝:拣去杂质,晾干;
23、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
24、生姜:拣去杂质,洗净泥土,用时切片;
25、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
26、附子:用水浸泡,捞出,切片,晾干。
二、制备
1、将所述重量的黄芪、太子参、白术、生地黄、山药、山萸肉、黄精、枸杞子、菟丝子、益母草、白茅根、夏枯草、车前子、金樱子、金银花、知母、淫羊藿、泽泻、当归、川芎、茯苓、川牛膝、甘草、生姜、丹参、附子放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中黄芪有益卫固表,利水消肿的功能为君药;山药有健脾,补肺,固肾的功能;枸杞子有滋肾,润肺,补肝,明目的功能,二者为臣药,三味药共同发挥益卫固表,利水消肿,滋肾润肺的作用,治疗肾病综合症效力全面,且以消肿,健脾,滋肾,润肺为主可治本,淫羊藿有补肾壮阳,祛风除湿的功能为佐药,川芎有行气开郁,祛风燥湿,活血止痛的功能为使药,与下余诸药是治标。
本发明药物具有益卫固表,利水消肿,滋肾润肺,补肾壮阳,祛风除湿的功能,用于治疗肾病综合症,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治肾病综合症门诊患者共38例。
2、诊断标准
典型症状为大量蛋白尿、低蛋白血症、(高度)水肿和高脂血症,即所谓的“三高一低”,及其他代谢紊乱为特征的一组临床症候群。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用4个疗程。
4、疗效评定标准
显效:肾病综合症症状消失,体质恢复正常,痊愈;
好转:肾病综合症症状明显好转,蛋白尿及低蛋白症已得到控制,肾病症状逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗肾病综合症患者38例,结果显效31例,显效率为81.6%,好转5例,好转率为13.2%,无效2例,总有效率为94.8%。
Claims (3)
1.一种治疗肾病综合症的药物,其特征在于:它是由下列重量范围内的原料药制成:
黄芪10-20克,太子参10-20克,白术10-20克,生地黄10-20克,山药15-25克,山萸肉10-20克,黄精5-15克,枸杞子15-25克,菟丝子15-25克,益母草25-35克,白茅根15-25克,夏枯草15-25克,车前子5-15克,金樱子10-20克,金银花10-20克,知母5-15克,淫羊藿5-15克,泽泻25-35克,当归10-14克,川芎5-15克,茯苓15-25克,川牛膝5-15克,甘草5-15克, 生姜3-7克,丹参15-25克,附子5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄芪15克,太子参15克,白术15克,生地黄15克,山药20克,山萸肉15克,黄精10克,枸杞子20克,菟丝子20克,益母草30克,白茅根20克,夏枯草20克,车前子10克,金樱子15克,金银花15克,知母10克,淫羊藿10克,泽泻30克,当归12克,川芎10克,茯苓20克,川牛膝10克,甘草10克, 生姜5克,丹参20克,附子10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(2)太子参:摘除须根,晒干;
(3)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(4)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(5)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(6)山萸肉:洗净,除去果核及杂质,晒干;
(7)黄精:洗净泥土,略润,切片,晒干;
(8)枸杞子:簸净杂质,摘去残留的梗和蒂;
(9)菟丝子:过箩去净杂质,洗净,晒干;
(10)益母草:拣去杂质,洗净,润透,切段,晒干;
(11)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(12)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(13)车前子:拣去杂质,筛去泥屑,空粒;
(14)金樱子:拣去杂质,切两瓣,用水稍浸泡,捞出,闷润后除去残留毛刺,挖净毛、核,干燥;
(15)金银花:筛去泥沙,拣净杂质;
(16)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(17)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(18)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(19)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(20)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(21)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(22)川牛膝:拣去杂质,晾干;
(23)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(24)生姜:拣去杂质,洗净泥土,用时切片;
(25)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(26)附子:用水浸泡,捞出,切片,晾干;
(二)制备
(1)将所述重量的黄芪、太子参、白术、生地黄、山药、山萸肉、黄精、枸杞子、菟丝子、益母草、白茅根、夏枯草、车前子、金樱子、金银花、知母、淫羊藿、泽泻、当归、川芎、茯苓、川牛膝、甘草、生姜、丹参、附子放入煎药容器内,加水8倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710125778.9A CN106798907A (zh) | 2017-03-05 | 2017-03-05 | 一种治疗肾病综合症的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710125778.9A CN106798907A (zh) | 2017-03-05 | 2017-03-05 | 一种治疗肾病综合症的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN106798907A true CN106798907A (zh) | 2017-06-06 |
Family
ID=58987728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710125778.9A Withdrawn CN106798907A (zh) | 2017-03-05 | 2017-03-05 | 一种治疗肾病综合症的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106798907A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107334963A (zh) * | 2017-06-09 | 2017-11-10 | 王孟 | 一种治疗肾病综合征的药剂及其制备方法 |
-
2017
- 2017-03-05 CN CN201710125778.9A patent/CN106798907A/zh not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107334963A (zh) * | 2017-06-09 | 2017-11-10 | 王孟 | 一种治疗肾病综合征的药剂及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106798907A (zh) | 一种治疗肾病综合症的药物及其制备方法 | |
CN106924476A (zh) | 一种治疗视网膜中央静脉阻塞的药物及其制备方法 | |
CN106692832A (zh) | 一种治疗咳嗽的药物及其制备方法 | |
CN106798837A (zh) | 一种治疗虹膜睫状体炎的药物及其制备方法 | |
CN106692858A (zh) | 一种治疗胎动不安的药物及其制备方法 | |
CN106729117A (zh) | 一种治疗尿路感染的药物及其制备方法 | |
CN107714907A (zh) | 一种治疗阳瘘的药物及其制备方法 | |
CN106729057A (zh) | 一种治疗鼻衄的药物及其制备方法 | |
CN106729118A (zh) | 一种治疗肾盂肾炎的药物及其制备方法 | |
CN106924694A (zh) | 一种治疗习惯性便秘的药物及其制备方法 | |
CN106924591A (zh) | 一种治疗流行性咽结膜热的药物及其制备方法 | |
CN108310246A (zh) | 一种治疗肾病综合征的药物及其制备方法 | |
CN103191402B (zh) | 一种治疗风湿性心脏病的药物及其制备方法 | |
CN107737293A (zh) | 一种治疗女性不孕症的药物及其制备方法 | |
CN108785525A (zh) | 一种治疗子宫发育不良的药物及其制备方法 | |
CN106880744A (zh) | 一种治疗更年期综合症的药物及其制备方法 | |
CN109045197A (zh) | 一种治疗巩膜炎的药物及其制备方法 | |
CN108392566A (zh) | 一种治疗青光眼的药物及其制备方法 | |
CN106860784A (zh) | 一种治疗角膜溃疡的药物及其制备方法 | |
CN107029102A (zh) | 一种治疗支气管哮喘的药物及其制备方法 | |
CN108392565A (zh) | 一种治疗化脓性中耳炎的药物及其制备方法 | |
CN108310360A (zh) | 一种治疗低血压的药物及其制备方法 | |
CN108743902A (zh) | 一种治疗低血压的药物及其制备方法 | |
CN108498728A (zh) | 一种治疗急性肾炎的药物及其制备方法 | |
CN108371707A (zh) | 一种治疗膀胱癌的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170606 |