CN106924476A - 一种治疗视网膜中央静脉阻塞的药物及其制备方法 - Google Patents
一种治疗视网膜中央静脉阻塞的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗视网膜中央静脉阻塞的药物及其制备方法,其主要是由桃仁、当归、丹参、葛根、牛膝、石决明、连翘、蒲黄、决明子、夏枯草、地龙、路路通、龟甲、黄柏、蝉蜕、菊花、生地、女贞子、茺蔚子、川芎、香附、红花按一定重量配比制备而成,本发明药物具有平肝潜阳,破血行瘀,消热,明目,滋阴降火的功能,用于治疗视网膜中央静脉阻塞见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗视网膜中央静脉阻塞的药物及其制备方法,属中药领域。
背景技术
视网膜中央静脉阻塞为多因素致病。与视网膜炎症、视网膜低灌注、高血压、动脉硬化、血液高黏度和血流动力学异常等有密切关系。中医则认为视网膜中央静脉阻塞与肝阳上亢,肝火上炎,气滞血瘀有关。由于西药治疗副作用大,因此人们对有效治疗视网膜中央静脉阻塞的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗视网膜中央静脉阻塞的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗视网膜中央静脉阻塞的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择桃仁、当归、丹参、葛根、牛膝、石决明、连翘、蒲黄、决明子、夏枯草、地龙、路路通、龟甲、黄柏、蝉蜕、菊花、生地、女贞子、茺蔚子、川芎、香附、红花、陈皮、木通、泽泻、大黄、龙胆进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗视网膜中央静脉阻塞。其中选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘的。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止喝的功能,治伤寒,治伤寒,温热头痛项强,烦热消渴,泄泻,痢疾,癍疹不透,高血压,心绞痛,耳聋。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用石决明是因为其性味咸,平,入肝、肾经,有平肝潜阳,除热,明目的功能,治风阳上扰,头痛眩晕,惊搐,骨蒸劳热,青盲内障。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用蒲黄是因为其性味甘辛苦,凉,入肝、心经,有凉血止血,活血消瘀的功能,生用治经闭腹痛,产后瘀阻作痛,跌扑血闷,疮疖肿毒,炒黑止吐血,衄血,崩漏,泻血,尿血,血痢,带下,外治重舌,口疮,聤耳流脓,耳中出血,阴下湿痒。选用决明子是因为其性味苦甘,凉,入肝、肾经,有清肝,明目,利水,通便的功能,治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹化,习惯性便秘。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用地龙是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用龟甲是因为其性味咸甘,平,入肝、肾经,有滋阴,潜阳,补肾,健骨的功能,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨痿,阴虚风动,久痢,久疟,痔疮,小儿囟门不合。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用生地是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用女贞子是因为其性味苦甘,平,入肝、肾经,有补肝肾,强腰膝的功能,治阴虚内热,头晕,目花耳鸣,腰膝酸软,须发早白。选用茺蔚子是因为其性味甘辛,凉,入心胞、肝经,有活血调经,疏风清热的功能,治妇女月经不调,崩中带下,产后瘀血作痛,肝热头痛,目赤肿痛,或生翳膜。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
桃仁5-15克,当归10-15克,丹参10-20克,葛根10-20克,牛膝5-15克,石决明15-20克,连翘10-20克,蒲黄5-10克,决明子15-25克,夏枯草10-20克,地龙5-15克,路路通5-15克,龟甲10-20克,黄柏5-15克,蝉蜕5-10克,菊花5-15克,生地10-20克,女贞子10-20克,茺蔚子5-15克,川芎10-15克,香附5-10克,红花10-20克,陈皮5-15克,木通10-15克,泽泻10-15克,大黄10-15克,龙胆5-15克。
优选为:
桃仁10克,当归12克,丹参15克,葛根15克,牛膝10克,石决明18克,连翘15克,蒲黄8克,决明子20克,夏枯草15克,地龙10克,路路通10克,龟甲15克,黄柏10克,蝉蜕8克,菊花10克,生地15克,女贞子15克,茺蔚子10克,川芎12克,香附8克,红花15克,陈皮10克,木通12克,泽泻12克,大黄12克,龙胆10克。
本发明药物的制备方法如下
一、备料
1、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
2、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
3、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
4、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
5、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
6、石决明:洗净晾干,敲成碎块;
7、连翘:拣净杂质,搓开,除去枝梗;
8、蒲黄:揉碎结块,过筛,除去杂质;
9、决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
10、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
11、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
12、路路通:除去杂质,洗净,晒干;
13、龟甲:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
14、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
15、蝉蜕:拣去杂质,洗净晒干;
16、菊花:拣净叶梗、花柄及泥屑杂质;
17、生地:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
18、女贞子:拣去杂质,洗净,晒干;
19、茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
20、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
21、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
22、红花:拣净杂质,除去茎叶、蒂头,晒干;
23、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
24、木通:用水稍浸泡,闷润至透,切片,晒干;
25、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
26、大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干;
27、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干。
二、制备
1、将所述重量的桃仁、当归、丹参、葛根、牛膝、石决明、连翘、蒲黄、决明子、夏枯草、地龙、路路通、龟甲、黄柏、蝉蜕、菊花、生地、女贞子、茺蔚子、川芎、香附、红花、陈皮、木通、泽泻、大黄、龙胆放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中石决明有平肝潜阳,除热,明目功能为君药;桃仁有破血行瘀,润燥滑经的功能;菊花有疏风,消热,明目,解毒的功能,二者为臣药,三味药共同发挥平肝潜阳,除热,明目,破血行瘀,疏风,解毒的作用,治疗视网膜中央静脉阻塞效力全面,且以平肝潜阳,破血行瘀,消热,明目为主可治本,黄柏有滋阴降火,润燥滑肠的功能为佐药,泽泻有利水,渗湿,泄热的功能为使药,与余下诸药是治标。
本发明药物具有平肝潜阳,破血行瘀,消热,明目,滋阴降火的功能,用于治疗视网膜中央静脉阻塞,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治视网膜中央静脉阻塞门诊患者共32例。
2、诊断标准
典型症状为视盘正常或边界轻度模糊、水肿。黄斑区正常或有轻度水肿、出血。动脉管径正常,静脉迂曲扩张,沿着视网膜4支静脉有少量或中等量火焰状和点状出血,没有或偶见棉絮状斑,视网膜有轻度水肿。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:视网膜中央静脉阻塞症状消失,恢复正常,痊愈;
好转:患者患部水肿、出血和视力模糊、下降的症状减轻,视网膜中央静脉阻塞症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗视网膜中央静脉阻塞患者32例,结果显效28例,显效率为87.5%,好转3例,好转率为9.4%,无效1例,总有效率为96.9%。
Claims (3)
1.一种治疗视网膜中央静脉阻塞的药物,其特征在于:它是由下列重量范围内的原料药制成:
桃仁5-15克,当归10-15克,丹参10-20克,葛根10-20克,牛膝5-15克,石决明15-20克,连翘10-20克,蒲黄5-10克,决明子15-25克,夏枯草10-20克,地龙5-15克,路路通5-15克,龟甲10-20克,黄柏5-15克,蝉蜕5-10克,菊花5-15克,生地10-20克,女贞子10-20克,茺蔚子5-15克,川芎10-15克,香附5-10克,红花10-20克,陈皮5-15克,木通10-15克,泽泻10-15克,大黄10-15克,龙胆5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
桃仁10克,当归12克,丹参15克,葛根15克,牛膝10克,石决明18克,连翘15克,蒲黄8克,决明子20克,夏枯草15克,地龙10克,路路通10克,龟甲15克,黄柏10克,蝉蜕8克,菊花10克,生地15克,女贞子15克,茺蔚子10克,川芎12克,香附8克,红花15克,陈皮10克,木通12克,泽泻12克,大黄12克,龙胆10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(2)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(3)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(4)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(5)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(6)石决明:洗净晾干,敲成碎块;
(7)连翘:拣净杂质,搓开,除去枝梗;
(8)蒲黄:揉碎结块,过筛,除去杂质;
(9)决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
(10)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(11)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(12)路路通:除去杂质,洗净,晒干;
(13)龟甲:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
(14)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(15)蝉蜕:拣去杂质,洗净晒干;
(16)菊花:拣净叶梗、花柄及泥屑杂质;
(17)生地:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(18)女贞子:拣去杂质,洗净,晒干;
(19)茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
(20)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(21)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(22)红花:拣净杂质,除去茎叶、蒂头,晒干;
(23)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(24)木通:用水稍浸泡,闷润至透,切片,晒干;
(25)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(26)大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干;
(27)龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
(二)制备
(1)将炮制后的桃仁、当归、丹参、葛根、牛膝、石决明、连翘、蒲黄、决明子、夏枯草、地龙、路路通、龟甲、黄柏、蝉蜕、菊花、生地、女贞子、茺蔚子、川芎、香附、红花、陈皮、木通、泽泻、大黄、龙胆放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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US20210393547A1 (en) * | 2020-06-22 | 2021-12-23 | Hsiao-Ming Chao | Use of emodin in treating retinal ischemia or a disease, condition, or disorder associated with retinal ischemia |
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US20210393547A1 (en) * | 2020-06-22 | 2021-12-23 | Hsiao-Ming Chao | Use of emodin in treating retinal ischemia or a disease, condition, or disorder associated with retinal ischemia |
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