CN108392566A - 一种治疗青光眼的药物及其制备方法 - Google Patents
一种治疗青光眼的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗青光眼的药物及其制备方法,其是由石决明、白薇、白术、决明子、防风、羌活、蝉蜕、密蒙花、白芷、细辛、生地黄、桂枝、菊花、夏枯草、香附、当归、川芎、熟地黄、珍珠母、车前草、乌梅、槟榔、荷叶、甘草、酸枣仁、五味子、寒水石、知母、黄柏、黄芩按一定重量配比制备而成,本发明药物具有平肝潜阳,除热明目,祛风凉血,润肝明目,疏风消热的功能,用于治疗青光眼见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗青光眼的药物及其制备方法,属中药领域。
背景技术
青光眼是指眼内压间断或持续升高的一种眼病,持续的高眼压可以给眼球各部分组织和视功能带来损害,如不及时治疗,视野可以全部丧失而至失明。青光眼是导致人类失明的三大致盲眼病之一,总人群发病率为1%,45岁以后为2%。由于西药治疗副作用大,因此人们对有效治疗青光眼的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人在祖传医方的基础上,又经过临床试验的反复验证,终于找到了有效治疗青光眼的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗青光眼的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择石决明、白薇、白术、决明子、防风、羌活、蝉蜕、密蒙花、白芷、细辛、生地黄、桂枝、菊花、夏枯草、香附、当归、川芎、熟地黄、珍珠母、车前草、乌梅、槟榔、荷叶、甘草、酸枣仁、五味子、寒水石、知母、黄柏、黄芩进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗青光眼。其中选用石决明是因为其性味咸,平,入肝、肾经,有平肝潜阳,除热,明目的功能,治风阳上扰、头痛眩晕,惊搐,骨蒸劳热,青盲内障。选用白薇是因为其性味苦咸,寒,入肺、胃、肾经,有清热,凉血的功能,治阴虚内热,风湿灼热多眠,肺热咳血,温疟,瘅疟,产后虚烦血厥,热淋,血淋,风湿痛,瘰疬。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用决明子是因为其性味苦甘,凉,入肝、肾经,有清肝,明目,利水,通便的功能,治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹化,习惯性便秘。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用密蒙花是因为其性味甘,凉,入肝经,有祛风,凉血,润肝,明目的功能,治目赤肿痛,多泪羞明,青盲翳障,风弦烂眼。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用细辛是因为其性味辛,温,入肺、肾经,有祛风,散寒,行水,开窃的功能,治风冷头痛,鼻渊,止痛,痰饮咳逆,风湿痹痛。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用珍珠母是因为其性味咸,凉,入心、肝两经,有平肝,潜阳,定惊,止血的功能,治头眩,耳鸣,心悸,失眠,癫狂,惊癎,吐血,衄血,妇女血崩。选用车前草是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮癣,胬肉。选用槟榔是因为其性味苦辛,温,入脾、胃、大肠经,有杀虫,破积,下气,行水的功能,治虫积、食滞,脘腹胀痛,泻痢后重,疟疾,水肿,脚气,痰癖,癥结。选用荷叶是因为其性味苦涩,平,入心、肝、脾经,有清暑利湿,升发清阳,止血的功能,治暑湿泄泻、眩晕,水气浮肿,雷头风,吐血,衄血,崩漏,便血,产后血晕。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能;炙用,治脾胃食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疸疮疡,解药毒及食物中毒。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用寒水石是因为其性味辛咸,寒,入心、胃、肾经,有清热降火,利窍,消肿的功能,治时行热病,积热烦渴,吐泻,水肿,尿闭,齿衄,丹毒,烫伤。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用黄芩是因为其性味苦,寒,入心、肺、胆、大肠经,有泻实火,除湿热,止血,安胎的功能,治壮热烦渴,肺热咳嗽,湿热泻痢,黄疸,热淋,吐、衄、崩、漏,目赤肿痛,胎动不安,痈肿疔疮。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
石决明20-30克,白薇5-15克,白术5-15克,决明子10-20克,防风4-8克,羌活4-8克,蝉蜕4-8克,密蒙花4-8克,白芷4-8克,细辛4-8克,生地黄4-8克,桂枝3-5克,菊花5-15克,夏枯草15-25克,香附5-15克,当归5-15克,川芎4-8克,熟地黄10-20克,珍珠母15-25克,车前草15-25克,乌梅10-20克,槟榔4-8克,荷叶15-25克,甘草4-8克,酸枣仁15-25克,五味子10-20克,寒水石15-25克,知母5-15克,黄柏5-15克,黄芩5-15克。
优选为:
石决明25克,白薇10克,白术10克,决明子15克,防风6克,羌活6克,蝉蜕6克,密蒙花6克,白芷6克,细辛6克,生地黄6克,桂枝3克,菊花10克,夏枯草20克,香附10克,当归10克,川芎6克,熟地黄15克,珍珠母20克,车前草20克,乌梅15克,槟榔6克,荷叶20克,甘草6克,酸枣仁20克,五味子15克,寒水石20克,知母10克,黄柏10克,黄芩10克。
本发明药物的制备方法如下
一、备料
1、石决明:洗净晾干,敲成碎块;
2、白薇:拣净杂质,除去茎苗,洗净,稍浸,润透,切段,晒干;
3、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
4、决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
5、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
6、羌活:拣去杂质,洗净,润透,切片,晾干;
7、蝉蜕:拣去杂质,洗净晒干;
8、密蒙花:拣去杂质,筛净灰土;
9、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
10、细辛:除净杂质,用水喷润,及时切段,晒干;
11、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
12、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
13、菊花:拣净叶梗、花柄及泥屑杂质;
14、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
15、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
16、当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
17、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
18、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
19、珍珠母:拣去杂质,敲成碎块,筛去灰屑;
20、车前草:去尽泥土,晒干;
21、乌梅:拣净杂质,筛去灰屑,洗净,晒干;
22、槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
23、荷叶:以水洗净,剪去蒂与边缘,切丝,晒干;
24、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
25、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
26、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
27、寒水石:取原药材,除去杂质,洗净,干燥,打成碎块;
28、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
29、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
30、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干。
二、制备
1、将所述重量的石决明、白薇、白术、决明子、防风、羌活、蝉蜕、密蒙花、白芷、细辛、生地黄、桂枝、菊花、夏枯草、香附、当归、川芎、熟地黄、珍珠母、车前草、乌梅、槟榔、荷叶、甘草、酸枣仁、五味子、寒水石、知母、黄柏、黄芩放入煎药容器内,加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中石决明有平肝潜阳,除热,明目的功能为君药;决明子有清肝,明目,利水,通便的功能;密蒙花有祛风,凉血,润肝,明目的功能,二者为臣药,三味药共同发挥平肝潜阳,除热明目,祛风凉血,润肝明目的作用,治疗青光眼效力全面,且以平肝潜阳,祛风凉血,润肝明目为主可治本,菊花有疏风,消热,明目,解毒的功能为佐药,川芎有行气开郁,祛风燥湿,活血止痛的功能为使药,与下余诸药是治标。
本发明药物具有平肝潜阳,除热明目,祛风凉血,润肝明目,疏风消热的功能,用于治疗青光眼,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治青光眼门诊患者共39例。
2、诊断标准
典型症状为是眼内压间断或持续性升高的水平超过眼球所能耐受的程度而给眼球各部分组织和视功能带来损害,导致视神经萎缩、视野缩小、视力减退,在急性发作期24-48小时即可完全失明。青光眼属双眼性病变,可双眼同时发病,或一眼起病,继发双眼失明。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,8天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:青光眼症状消失,体质恢复正常,痊愈;
好转:青光眼症状明显好转,视力视野逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗青光眼患者39例,结果显效32例,显效率为82.1%,好转5例,好转率为12.8%,无效2例,总有效率为94.9%。
Claims (3)
1.一种治疗青光眼的药物,其特征在于:它是由下列重量范围内的原料药制成:
石决明20-30克,白薇5-15克,白术5-15克,决明子10-20克,防风4-8克,羌活4-8克,蝉蜕4-8克,密蒙花4-8克,白芷4-8克,细辛4-8克,生地黄4-8克,桂枝3-5克,菊花5-15克,夏枯草15-25克,香附5-15克,当归5-15克,川芎4-8克,熟地黄10-20克,珍珠母15-25克,车前草15-25克,乌梅10-20克,槟榔4-8克,荷叶15-25克,甘草4-8克,酸枣仁15-25克,五味子10-20克,寒水石15-25克,知母5-15克,黄柏5-15克,黄芩5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
石决明25克,白薇10克,白术10克,决明子15克,防风6克,羌活6克,蝉蜕6克,密蒙花6克,白芷6克,细辛6克,生地黄6克,桂枝3克,菊花10克,夏枯草20克,香附10克,当归10克,川芎6克,熟地黄15克,珍珠母20克,车前草20克,乌梅15克,槟榔6克,荷叶20克,甘草6克,酸枣仁20克,五味子15克,寒水石20克,知母10克,黄柏10克,黄芩10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)石决明:洗净晾干,敲成碎块;
(2)白薇:拣净杂质,除去茎苗,洗净,稍浸,润透,切段,晒干;
(3)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(4)决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
(5)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(6)羌活:拣去杂质,洗净,润透,切片,晾干;
(7)蝉蜕:拣去杂质,洗净晒干;
(8)密蒙花:拣去杂质,筛净灰土;
(9)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(10)细辛:除净杂质,用水喷润,及时切段,晒干;
(11)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(12)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(13)菊花:拣净叶梗、花柄及泥屑杂质;
(14)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(15)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(16)当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
(17)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(18)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(19)珍珠母:拣去杂质,敲成碎块,筛去灰屑;
(20)车前草:去尽泥土,晒干;
(21)乌梅:拣净杂质,筛去灰屑,洗净,晒干;
(22)槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
(23)荷叶:以水洗净,剪去蒂与边缘,切丝,晒干;
(24)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(25)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
(26)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(27)寒水石:取原药材,除去杂质,洗净,干燥,打成碎块;
(28)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(29)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(30)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(二)制备
(1)将所述重量的石决明、白薇、白术、决明子、防风、羌活、蝉蜕、密蒙花、白芷、细辛、生地黄、桂枝、菊花、夏枯草、香附、当归、川芎、熟地黄、珍珠母、车前草、乌梅、槟榔、荷叶、甘草、酸枣仁、五味子、寒水石、知母、黄柏、黄芩放入煎药容器内,加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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