CN107823402A - 一种治疗阳痿的药物及其制备方法 - Google Patents
一种治疗阳痿的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗阳痿的药物及其制备方法,其主要是由熟地黄、山萸肉、山药、茯苓、泽泻、牡丹皮、菟丝子、肉桂按一定重量配比制备而成,本发明药物具有补肝肾,通血脉,固肾益精的功能,用于治疗阳痿见效快,疗效好,无副作用。
Description
技术领域
本发明涉及一种治疗阳痿的药物,属中药领域。
背景技术
阳痿为性神经衰弱,多由纵欲过度或手淫过度而起,其症状表现为在性交时生殖器不能勃起,或见色流精,或早泄,中医认为,命门火衰,精气虚寒,或因过分思虑而使心脾亏损,或情志不舒,恐惧,经久不释,以致肾脏亏虚,均可导致本病。西药治疗效果不明显,且含有一定的毒副作用。因此,人们对有效治疗阳痿的中药存在极大的需求。
发明内容
本发明人在祖传医方的基础上,又经过临床试验的反复验证,终于成功的研制出治疗阳痿的中药药物,从而完成了本发明。
本发明是选用熟地黄、山萸肉、山药、茯苓、泽泻、牡丹皮、菟丝子、肉桂、附子、狗脊、鹿肾、红参、淫羊藿、仙茅、枸杞子、知母、黄柏、肉苁蓉、巴戟天、韭子、党参、冬虫夏草、黄芪、当归、远志、白术、龙眼肉、阳起石、锁阳、石菖蒲进行组合制备的,将这些药物组合,使得各药物功效产生协同作用,从而能够有效治疗阳痿。其中选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用山萸肉是因为其性味酸,微温,有补肝肾,涩精气的功能,治阳萎,遗精,肝虚寒热,心摇脉散。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛格阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用狗脊是因为其性味苦甘,温,入肝、肾经,有补肝肾,除风湿,健腰脚,利关节的功能,治腰背酸疼,膝痛脚弱,寒湿周痹,失溺,尿频,遗精,白带。选用鹿肾,异名,鹿茎筋,鹿鞭,鹿冲,其性味甘咸,温,入肝、肾、膀胱三经,有补肾,壮阳,益精的功能,治劳损,腰膝酸痛,肾虚耳聋,耳鸣,阳萎,宫冷不孕。选用红参是因为其性味甘、微苦,温,归脾、肺、心经,有大补元气,复脉固脱,益气摄血的功能,治体虚欲脱,肢冷脉微,气不摄血,崩漏下血,心力衰竭,心源性休克。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用仙茅是因为其性味辛,温,有毒,入肾、肝经,有温肾阳,壮筋骨的功能,治阳萎精冷,小便失禁,崩漏,心腹冷痛,腰脚冷痹,痈疽,瘰疬。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用肉苁蓉是因为其性味甘酸咸,温,入肾、大肠经,有补肾,益精,润燥,清肠的功能,治男子阳痿,女子不孕,带下,血崩,腰膝冷痛,血枯便秘。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用韭子是因为其性温,味辛咸,入足厥阴经,有补肝肾,暖腰膝,壮阳固精的功能,治阳萎梦遗,小便频数,遗尿,腰膝酸软冷痛,泻痢,带下,淋浊。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用冬虫夏草是因为其性味甘,温,入肺、肾二经,有补虚损,益精气的功能,治痰饮喘嗽,虚喘,痨嗽,咯血,自汗盗汗,阳痿遗精,腰膝酸痛,病后久虚不复。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用远志是因为其性味苦辛,温,入心、肾经,有安神益智,祛痰,解郁的功能,治惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用龙眼肉是因为其性味甘,温,入心、脾经,有益心脾,补气血,安神的功能,治虚功羸弱,失眠,健忘,惊悸,怔仲。选用阳起石是因为其性味咸,温,入肾经,有温补命门的功能,治下焦虚寒,腰膝冷痹,男子阳痿,女子宫冷,癥瘕崩漏。选用锁阳是因为其性味甘,温,归脾、肾、大肠经,有补肾阳,益精血,润肠通便的功能,治腰膝痿软,阳痿滑精,肠燥便秘。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。
具体实施方式
本发明药物的组方用量也是发明人经过大量的摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
熟地黄 45-55克 山萸肉 20-30克 山药 20-30克
茯苓 15-25克 泽泻 15-25克 牡丹皮 15-25克
菟丝子 20-30克 肉桂 15-25克 附子 15-25克
狗脊 0.5-1.5克 鹿肾 20-30克 红参 20-30克
淫羊藿 15-25克 仙茅 15-25克 枸杞子 15-25克
知母 15-25克 黄柏 15-25克 肉苁蓉 15-25克
巴戟天 15-25克 韭子 15-25克 党参 25-35克
冬虫夏草 10-20克 黄芪 25-35克 当归 5-15克
远志 5-15克 白术 5-15克 龙眼肉 7-15克
阳起石 5-15克 锁阳 25-35克 石菖蒲 5-7克。
优选为:
熟地黄 50克 山萸肉 25克 山药 25克
茯苓 20克 泽泻 20克 牡丹皮 20克
菟丝子 25克 肉桂 20克 附子 20克
狗脊 1克 鹿肾 25克 红参 25克
淫羊藿 20克 仙茅 20克 枸杞子 20克
知母 20克 黄柏 20克 肉苁蓉 20克
巴戟天 20克 韭子 20克 党参 30克
冬虫夏草 15克 黄芪 30克 当归 10克
远志 10克 白术 10克 龙眼肉 12克
阳起石 10克 锁阳 30克 石菖蒲 6克。
本发明的制备方法如下:
一、备料
1、熟地黄:选干净熟地黄即可;
2、山萸肉:洗净,除去果核及杂质,晒干;
3、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
4、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
5、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
6、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
7、菟丝子:过箩去净杂质,洗净,晒干;
8、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
9、附子:用水浸泡,捞出,切片,晾干;
10、狗脊:取沙子置锅内炒至轻松,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛除沙子,风晾后,撞去或刮净黄绒毛;
11、鹿肾:将鹿肾洗净,温水浸润,切片,晒干;
12、红参:取原药材,润透,切薄片,干燥;
13、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
14、仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤;
15、枸杞子:簸净杂质,摘去残留的梗和蒂;
16、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
17、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
18、肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次(如系咸苁蓉,泡尽盐分),润透,纵向切片,晒干;
19、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
20、韭子:洗净,晒干,生用或炒用;
21、党参:洗净泥沙后润透去芦,切片或切段,晒干;
22、冬虫夏草:除去杂质;
23、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
24、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
25、远志:拣去杂质,切段,筛去灰屑;
26、白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
27、龙眼肉:取原药材,除去杂质;
28、阳起石:洗净,砸碎;
29、锁阳:除去杂质,洗净,润透,切薄片,干燥;
30、石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干。
二、制备
1、将炮制好的熟地黄、山萸肉、山药、茯苓、泽泻、牡丹皮、菟丝子、肉桂、附子、狗脊、鹿肾、红参、淫羊藿、仙茅、枸杞子、知母、黄柏、肉苁蓉、巴戟天、韭子、党参、冬虫夏草、黄芪、当归、远志、白术、龙眼肉、阳起石、锁阳、石菖蒲磨成碎药粉;
2、另取炼蜜400克置于煎药容器内,加热20分钟后,再加入上述磨碎的药粉,再用文火煎煮30分钟,待温制成蜜丸即得,每丸重1.5克。
组方中鹿肾有补肾、壮阳、益精的功能为君药;狗脊有补肝肾,除湿,健腰脚,利关节的功能;淫羊藿有补肾壮阳,祛风除湿,治阳痿不举的功能,二者为臣药,三味药共同发挥补肾壮阳,祛风除淡,健腰益精的作用,且以补肾,壮阳,益精为主,可治本;肉苁蓉有补肾益精,润燥滑肠的功能为佐药;锁阳有补肾阳,益精血,润肠通便的功能为使药,与下余诸药是治标。
本发明药物具有补肝肾,通血脉,固肾益精,健脾益胃的功能,用于治疗阳痿见效快,疗效好,无毒副作用。
以下通过试验例来进一步阐述本发明药物的有益效果,这些试验例包括动物的毒性试验和临床疗效观察资料。
[试验例1]本发明的动物毒性试验
[试验例1]本发明药物的动物毒性试验报告:
取新西兰家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量组,另一组为正常量组。超常量组为0.4g/kg,正常量为0.2g/kg,给药方式为稀释灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治门诊患者共33例。
2、诊断标准
阳痿患者虽有性欲需求,但阴茎不能勃起,或勃起程度不足,妨碍正常的性生活。
3、治疗方法
取上述蜜丸给患者服用,每次5-6丸,每天早、晚各服一次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:阳痿症状消失,性生活恢复正常,痊愈;
好转:阳痿症状好转,阴茎勃起程度增强,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗阳痿患者33例,结果显效25例,显效率为75.75%,好转6例,好转率为18.18%,无效2例,总有效率为93.94%。
Claims (3)
1.一种治疗阳痿的药物,其特征在于:它是由下列重量范围内的原料药制成:
熟地黄 45-55克 山萸肉 20-30克 山药 20-30克
茯苓 15-25克 泽泻 15-25克 牡丹皮 15-25克
菟丝子 20-30克 肉桂 15-25克 附子 15-25克
狗脊 0.5-1.5克 鹿肾 20-30克 红参 20-30克
淫羊藿 15-25克 仙茅 15-25克 枸杞子 15-25克
知母 15-25克 黄柏 15-25克 肉苁蓉 15-25克
巴戟天 15-25克 韭子 15-25克 党参 25-35克
冬虫夏草 10-20克 黄芪 25-35克 当归 5-15克
远志 5-15克 白术 5-15克 龙眼肉 7-15克
阳起石 5-15克 锁阳 25-35克 石菖蒲 5-7克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
熟地黄 50克 山萸肉 25克 山药 25克
茯苓 20克 泽泻 20克 牡丹皮 20克
菟丝子 25克 肉桂 20克 附子 20克
狗脊 1克 鹿肾 25克 红参 25克
淫羊藿 20克 仙茅 20克 枸杞子 20克
知母 20克 黄柏 20克 肉苁蓉 20克
巴戟天 20克 韭子 20克 党参 30克
冬虫夏草 15克 黄芪 30克 当归 10克
远志 10克 白术 10克 龙眼肉 12克
阳起石 10克 锁阳 30克 石菖蒲 6克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)熟地黄:选干净熟地黄即可;
(2)山萸肉:洗净,除去果核及杂质,晒干;
(3)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(4)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(5)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(6)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(7)菟丝子:过箩去净杂质,洗净,晒干;
(8)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(9)附子:用水浸泡,捞出,切片,晾干;
(10)狗脊:取沙子置锅内炒至轻松,加入拣净的狗脊,用武火炒至鼓起并显深黄色,取出,筛除沙子,风晾后,撞去或刮净黄绒毛;
(11)鹿肾:将鹿肾洗净,温水浸润,切片,晒干;
(12)红参:取原药材,润透,切薄片,干燥;
(13)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(14)仙茅:取净仙茅用黄酒拌匀,润透后,置锅内微炒至干,取出,晾干,每仙茅100斤,用黄酒10—20斤;
(15)枸杞子:簸净杂质,摘去残留的梗和蒂;
(16)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(17)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(18)肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次,如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干;
(19)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(20)韭子:洗净,晒干,生用或炒用;
(21)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(22)冬虫夏草:除去杂质;
(23)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(24)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(25)远志:拣去杂质,切段,筛去灰屑;
(26)白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干;
(27)龙眼肉:取原药材,除去杂质;
(28)阳起石:洗净,砸碎;
(29)锁阳:除去杂质,洗净,润透,切薄片,干燥;
(30)石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
(二)制备
(1)将炮制好的熟地黄、山萸肉、山药、茯苓、泽泻、牡丹皮、菟丝子、肉桂、附子、狗脊、鹿肾、红参、淫羊藿、仙茅、枸杞子、知母、黄柏、肉苁蓉、巴戟天、韭子、党参、冬虫夏草、黄芪、当归、远志、白术、龙眼肉、阳起石、锁阳、石菖蒲磨成碎药粉;
(2)另取炼蜜400克置于煎药容器内,加热20分钟后,再加入上述磨碎的药粉,再用文火煎煮30分钟,待温制成蜜丸即得。
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