CN106795484B - 用于在产生岩藻糖基化低聚糖时使用的α(1，2)岩藻糖基转移酶变种 - Google Patents

用于在产生岩藻糖基化低聚糖时使用的α(1，2)岩藻糖基转移酶变种 Download PDF

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CN106795484B
CN106795484B CN201580028020.2A CN201580028020A CN106795484B CN 106795484 B CN106795484 B CN 106795484B CN 201580028020 A CN201580028020 A CN 201580028020A CN 106795484 B CN106795484 B CN 106795484B
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CN106795484A (zh
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J·M·麦科伊
M·I·海特曼
M·梅里吉
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CN201580028020.2A 2014-05-15 2015-05-14 用于在产生岩藻糖基化低聚糖时使用的α(1，2)岩藻糖基转移酶变种 Active CN106795484B (zh)

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US201461993742P 2014-05-15 2014-05-15
US61/993,742 2014-05-15
PCT/US2015/030823 WO2015175801A1 (en) 2014-05-15 2015-05-14 Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides

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US (2) US11046984B2 (enExample)
EP (2) EP3083938B1 (enExample)
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CN (1) CN106795484B (enExample)
AU (1) AU2015259088B2 (enExample)
CA (1) CA2945661C (enExample)
ES (1) ES2962258T3 (enExample)
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MX (1) MX2016014807A (enExample)
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DE14769797T1 (de) 2013-03-14 2016-06-23 Glycosyn LLC Mikroorganismen und Verfahren zur Herstellung sialylierter und N-acetylglucosamin-haltiger Oligosaccharide
SG11201609366TA (en) 2014-05-15 2016-12-29 Glycosyn LLC Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
EP3390652B1 (en) * 2015-12-18 2024-12-04 Glycom A/S Fermentative production of oligosaccharides
WO2017106864A1 (en) * 2015-12-18 2017-06-22 The Regents Of The University Of California Te2ft enzyme for enzymatic synthesis of alpha1-2-fucosides
CN106190937B9 (zh) * 2016-07-18 2020-12-01 南开大学 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法
DK3375291T3 (da) * 2017-03-17 2022-10-31 Chr Hansen Hmo Gmbh Fremgangsmåde til hæmning af isomerisering af et reducerende saccharid efter termisk behandling
EP3425052A1 (en) * 2017-07-07 2019-01-09 Jennewein Biotechnologie GmbH Fucosyltransferases and their use in producing fucosylated oligosaccharides
EP3438122A1 (en) * 2017-08-01 2019-02-06 OligoScience Biotechnology GmbH Microorganism for producing human milk oligosaccharide
KR101953375B1 (ko) * 2017-11-20 2019-02-28 고려대학교 산학협력단 다양하고 신규한 퓨코실 올리고당의 제조법 및 이의 용도
CN109402020B (zh) * 2018-11-30 2020-08-04 江南大学 一株高产精氨酸氨肽酶的瑞士乳杆菌及其应用
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
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JP2023506287A (ja) * 2019-12-17 2023-02-15 インバイオス エン．フェー． ラクトースを変換するアルファ－１，２－フコシルトランスフェラーゼ酵素
CN111218488B (zh) * 2020-02-10 2022-11-15 中国科学院上海高等研究院 一种利用大肠杆菌生产2’-岩藻糖基乳糖的方法
CN111471606B (zh) * 2020-03-17 2022-03-08 山东大学 一株优化的高产岩藻糖基乳糖的酿酒酵母菌株及其应用
CN111471605B (zh) * 2020-03-17 2022-03-08 山东大学 一株高产岩藻糖基乳糖的酿酒酵母工程菌株及其应用
KR102719035B1 (ko) * 2020-04-20 2024-10-18 주식회사 리비옴 혈관 작동성 장 펩티드를 발현하는 미생물, 및 그의 용도
EP3954769A1 (en) * 2020-08-10 2022-02-16 Inbiose N.V. Production of oligosaccharide mixtures by a cell
US11331329B2 (en) 2020-05-13 2022-05-17 Glycosyn LLC Fucosylated oligosaccharides for prevention of coronavirus infection
CA3178736A1 (en) 2020-05-13 2021-11-18 Ardythe L. Morrow 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation
CN113969256A (zh) * 2020-07-24 2022-01-25 上海交通大学 一种生产n-乙酰氨基葡萄糖的菌株及其构建方法和应用
EP4192944A1 (en) 2020-08-10 2023-06-14 Inbiose N.V. Production of oligosaccharide mixtures by a cell
EP4200318A4 (en) * 2020-08-19 2024-06-12 Conagen Inc. BIOSYNTHETIC PRODUCTION OF 2-FUCOSYLLACTOSE
KR102793833B1 (ko) * 2020-12-31 2025-04-11 주식회사 삼양사 푸코오스 전이효소를 발현하는 재조합 미생물 및 이를 이용한 2’-푸코실락토오스 제조방법
KR102633804B1 (ko) * 2020-12-31 2024-02-05 주식회사 삼양사 재조합 바실러스 속 미생물 및 이를 이용한 모유올리고당 제조방법
WO2023182970A1 (en) * 2021-02-19 2023-09-28 The Regents Of The University Of California Methods for production of fucosylated oligosaccharides in recombinant cell culture
WO2022176994A1 (ja) * 2021-02-19 2022-08-25 協和発酵バイオ株式会社 改変されたα１，２－フコシルトランスフェラーゼ活性を有する蛋白質及びフコース含有糖質の製造法
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
EP4370664A1 (en) * 2021-07-16 2024-05-22 Inbiose N.V. Lacto-n-biose converting fucosyltransferases
CN113817701B (zh) * 2021-09-30 2023-08-18 中南大学 α-1,2-岩藻糖基转移酶突变体及其应用
CN113832092B (zh) * 2021-10-20 2023-10-03 江南大学 一种提高乳酰-n-岩藻五糖产量的基因工程菌及其生产方法
CN116286919A (zh) * 2021-12-03 2023-06-23 虹摹生物科技(上海)有限公司 基因工程菌及利用其制备岩藻糖基化寡糖的方法
KR20240017427A (ko) * 2022-07-29 2024-02-08 주식회사 진켐 3-푸코실락토스 생산용 유전자 조작 미생물 및 이를 이용한 방법
CN116042671B (zh) * 2023-02-14 2024-11-22 华熙生物科技股份有限公司 一种用于制备母乳寡糖的核酸分子、表达载体和微生物
CN116769808B (zh) * 2023-02-27 2025-06-10 江南大学 一种专一生产2′-岩藻糖基乳糖的菌株及应用
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US20220056497A1 (en) 2022-02-24
JP2022173457A (ja) 2022-11-18
EP4293033A2 (en) 2023-12-20
EP4293033A3 (en) 2024-04-10
ES2962258T3 (es) 2024-03-18
SG11201609366TA (en) 2016-12-29
MX2016014807A (es) 2017-05-10
EP3083938C0 (en) 2023-11-08
CN106795484A (zh) 2017-05-31
EP3083938A1 (en) 2016-10-26
KR20230113650A (ko) 2023-07-31
SG10202010599TA (en) 2020-11-27
CA2945661A1 (en) 2015-11-19
KR20170035835A (ko) 2017-03-31
EP3083938A4 (en) 2017-05-31
JP2017515455A (ja) 2017-06-15
WO2015175801A9 (en) 2016-10-20
EP3083938B1 (en) 2023-11-08
AU2015259088A2 (en) 2018-06-28
JP2020188761A (ja) 2020-11-26
US11643675B2 (en) 2023-05-09
NZ722185A (en) 2023-12-22
AU2015259088A1 (en) 2016-08-04
US11046984B2 (en) 2021-06-29
AU2015259088B2 (en) 2021-11-11
US20170081353A1 (en) 2017-03-23
WO2015175801A1 (en) 2015-11-19
HUE064860T2 (hu) 2024-04-28
CA2945661C (en) 2023-10-17

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