JP2017515455A - フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン - Google Patents

フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン Download PDF

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JP2017515455A
JP2017515455A JP2016549476A JP2016549476A JP2017515455A JP 2017515455 A JP2017515455 A JP 2017515455A JP 2016549476 A JP2016549476 A JP 2016549476A JP 2016549476 A JP2016549476 A JP 2016549476A JP 2017515455 A JP2017515455 A JP 2017515455A
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gene
lactose
fucosyltransferase
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ジョン エム． マッコイ
ジョン エム． マッコイ
マシュー イアン ハイトマン
マシュー イアン ハイトマン
マッシモ メリーギ
マッシモ メリーギ
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グリコシン リミテッド ライアビリティー カンパニー
グリコシン リミテッド ライアビリティー カンパニー
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01069—Galactoside 2-alpha-L-fucosyltransferase (2.4.1.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01086—Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase (2.4.1.86)
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01149—N-Acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (2.4.1.149)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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JP2016549476A 2014-05-15 2015-05-14 フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン Withdrawn JP2017515455A (ja)

Applications Claiming Priority (3)

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US201461993742P 2014-05-15 2014-05-15
US61/993,742 2014-05-15
PCT/US2015/030823 WO2015175801A1 (en) 2014-05-15 2015-05-14 Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides

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JP2020086439A Pending JP2020188761A (ja) 2014-05-15 2020-05-18 フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン
JP2022156260A Pending JP2022173457A (ja) 2014-05-15 2022-09-29 フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン

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JP2022156260A Pending JP2022173457A (ja) 2014-05-15 2022-09-29 フコシル化オリゴ糖の生産に使用するためのアルファ（１，２）フコシルトランスフェラーゼ・シンジーン

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EP (2) EP3083938B1 (enExample)
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KR (2) KR20230113650A (enExample)
CN (1) CN106795484B (enExample)
AU (1) AU2015259088B2 (enExample)
CA (1) CA2945661C (enExample)
ES (1) ES2962258T3 (enExample)
HU (1) HUE064860T2 (enExample)
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WO2020246585A1 (ja) 2019-06-05 2020-12-10 森永乳業株式会社 栄養組成物
JP2022515566A (ja) * 2019-03-04 2022-02-18 セロリクス アクチェンゲゼルシャフト 塩化物誘導性の原核生物系発現システム
JP2023523214A (ja) * 2020-04-20 2023-06-02 株式会社 リビオム 血管作動性腸ペプチドを発現する微生物、及びその用途
JP2023534879A (ja) * 2020-07-24 2023-08-14 上海交通大学 Ｎ－アセチルグルコサミン産生菌株並びにその構築方法及び使用
JP2023113646A (ja) * 2017-08-01 2023-08-16 オリゴサイエンス バイオテクノロジー ゲーエムベーハー 人乳オリゴ糖産生微生物
JP2024502061A (ja) * 2020-12-31 2024-01-17 サムヤン コーポレイション 組換えバチルス属微生物およびこれを用いた母乳オリゴ糖製造方法
JP2024502062A (ja) * 2020-12-31 2024-01-17 サムヤン コーポレイション フコース転移酵素を発現する組換え微生物およびこれを用いた２’－フコシルラクトース製造方法
JP2024028710A (ja) * 2017-07-07 2024-03-05 クリスチャン．ハンセン・ハー・エム・オー・ゲー・エム・ベー・ハー フコシル基転移酵素及びフコシル化オリゴ糖の生産におけるその使用

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JP6129821B2 (ja) 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用
US9029136B2 (en) * 2012-07-25 2015-05-12 Glycosyn LLC Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
DE14769797T1 (de) 2013-03-14 2016-06-23 Glycosyn LLC Mikroorganismen und Verfahren zur Herstellung sialylierter und N-acetylglucosamin-haltiger Oligosaccharide
SG11201609366TA (en) 2014-05-15 2016-12-29 Glycosyn LLC Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
EP3390652B1 (en) * 2015-12-18 2024-12-04 Glycom A/S Fermentative production of oligosaccharides
WO2017106864A1 (en) * 2015-12-18 2017-06-22 The Regents Of The University Of California Te2ft enzyme for enzymatic synthesis of alpha1-2-fucosides
CN106190937B9 (zh) * 2016-07-18 2020-12-01 南开大学 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法
DK3375291T3 (da) * 2017-03-17 2022-10-31 Chr Hansen Hmo Gmbh Fremgangsmåde til hæmning af isomerisering af et reducerende saccharid efter termisk behandling
KR101953375B1 (ko) * 2017-11-20 2019-02-28 고려대학교 산학협력단 다양하고 신규한 퓨코실 올리고당의 제조법 및 이의 용도
CN109402020B (zh) * 2018-11-30 2020-08-04 江南大学 一株高产精氨酸氨肽酶的瑞士乳杆菌及其应用
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
JP2023506287A (ja) * 2019-12-17 2023-02-15 インバイオス エン．フェー． ラクトースを変換するアルファ－１，２－フコシルトランスフェラーゼ酵素
CN111218488B (zh) * 2020-02-10 2022-11-15 中国科学院上海高等研究院 一种利用大肠杆菌生产2’-岩藻糖基乳糖的方法
CN111471606B (zh) * 2020-03-17 2022-03-08 山东大学 一株优化的高产岩藻糖基乳糖的酿酒酵母菌株及其应用
CN111471605B (zh) * 2020-03-17 2022-03-08 山东大学 一株高产岩藻糖基乳糖的酿酒酵母工程菌株及其应用
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US11331329B2 (en) 2020-05-13 2022-05-17 Glycosyn LLC Fucosylated oligosaccharides for prevention of coronavirus infection
CA3178736A1 (en) 2020-05-13 2021-11-18 Ardythe L. Morrow 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation
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EP4200318A4 (en) * 2020-08-19 2024-06-12 Conagen Inc. BIOSYNTHETIC PRODUCTION OF 2-FUCOSYLLACTOSE
WO2023182970A1 (en) * 2021-02-19 2023-09-28 The Regents Of The University Of California Methods for production of fucosylated oligosaccharides in recombinant cell culture
WO2022176994A1 (ja) * 2021-02-19 2022-08-25 協和発酵バイオ株式会社 改変されたα１，２－フコシルトランスフェラーゼ活性を有する蛋白質及びフコース含有糖質の製造法
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EP4370664A1 (en) * 2021-07-16 2024-05-22 Inbiose N.V. Lacto-n-biose converting fucosyltransferases
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