CN106255513A - 用于药物偶联物的含磺酰胺连接系统 - Google Patents
用于药物偶联物的含磺酰胺连接系统 Download PDFInfo
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- CN106255513A CN106255513A CN201480076445.6A CN201480076445A CN106255513A CN 106255513 A CN106255513 A CN 106255513A CN 201480076445 A CN201480076445 A CN 201480076445A CN 106255513 A CN106255513 A CN 106255513A
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Cell Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Oncology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
Description
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US61/921242 | 2013-12-27 | ||
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US62/051899 | 2014-09-17 | ||
PCT/CA2014/000920 WO2015095953A1 (en) | 2013-12-27 | 2014-12-29 | Sulfonamide-containing linkage systems for drug conjugates |
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CN106255513B CN106255513B (zh) | 2022-01-14 |
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EP3086815A1 (en) | 2016-11-02 |
IL246457B (en) | 2019-12-31 |
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CA2935077C (en) | 2022-03-15 |
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CN106255513B (zh) | 2022-01-14 |
AU2014373574A1 (en) | 2016-07-14 |
IL246457A0 (en) | 2016-08-31 |
KR102384740B1 (ko) | 2022-04-07 |
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PL3086815T3 (pl) | 2022-06-13 |
RU2016130933A (ru) | 2018-02-01 |
US20230265173A1 (en) | 2023-08-24 |
KR20160124751A (ko) | 2016-10-28 |
MX2016008444A (es) | 2017-01-11 |
US20170029490A1 (en) | 2017-02-02 |
CA2935077A1 (en) | 2015-07-02 |
RU2729194C2 (ru) | 2020-08-05 |
JP2019172710A (ja) | 2019-10-10 |
RU2016130933A3 (zh) | 2018-09-13 |
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DK3086815T3 (da) | 2022-05-23 |
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