CN106233142B - 用于检测目的标志物的组合产品 - Google Patents

用于检测目的标志物的组合产品 Download PDF

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Publication number
CN106233142B
CN106233142B CN201580021174.9A CN201580021174A CN106233142B CN 106233142 B CN106233142 B CN 106233142B CN 201580021174 A CN201580021174 A CN 201580021174A CN 106233142 B CN106233142 B CN 106233142B
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binding
molecule
bonding agent
antibody
binding agent
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CN106233142A (zh
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大林弘
大林弘一
藤田佳誉子
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Nichirei Biosciences Inc
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Nichirei Biosciences Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201580021174.9A 2014-04-23 2015-04-23 用于检测目的标志物的组合产品 Active CN106233142B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014-089675 2014-04-23
JP2014089675 2014-04-23
PCT/JP2015/062423 WO2015163424A1 (ja) 2014-04-23 2015-04-23 標的マーカー検出用組合せ物

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CN106233142A CN106233142A (zh) 2016-12-14
CN106233142B true CN106233142B (zh) 2019-03-08

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US (2) US10324084B2 (enExample)
EP (1) EP3136096B1 (enExample)
JP (2) JP6019254B2 (enExample)
KR (1) KR102190207B1 (enExample)
CN (1) CN106233142B (enExample)
BR (1) BR112016024624B1 (enExample)
RU (1) RU2678108C2 (enExample)
WO (1) WO2015163424A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE538541C2 (en) * 2015-01-19 2016-09-13 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
CN107209176B (zh) 2015-01-21 2020-08-14 克罗姆尼贡公司 免疫标记复合物的形成方法及用途
FR3044680B1 (fr) * 2015-12-02 2017-12-22 Univ Limoges Methode de detection de cellules souches cancereuses
EP3465204B1 (en) * 2016-05-25 2023-08-02 Kromnigon AB Method for preparing a biological sample for use in an immunolabeling process
WO2019197365A1 (en) * 2018-04-09 2019-10-17 Expedeon Ltd. Chemical and biological complexes and conjugates with multiple labels and applications thereof
CN112834736B (zh) * 2020-12-02 2024-09-06 杭州百凌生物科技有限公司 一种检测多种抗原的病理检测试剂盒及其制备方法和应用
CN113588936B (zh) * 2021-06-30 2024-12-31 株洲市中医伤科医院 用于纸质酶联免疫吸附测定的酶标板的制作方法

Citations (2)

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GB2098730A (en) * 1981-04-21 1982-11-24 Welsh Nat School Med Immunolocalisation
US20050208529A1 (en) * 2003-12-01 2005-09-22 Lars Winther Methods and compositions for immuno-histochemical detection

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US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
AU707172B2 (en) 1995-01-23 1999-07-01 Bio-Rad Innovations Immunoenzymatic conjugate, preparation method therefor and uses thereof
JP3524401B2 (ja) 1998-09-16 2004-05-10 株式会社ニチレイ 酵素抗体複合体およびその製造方法
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
JP4422291B2 (ja) * 2000-04-21 2010-02-24 大日精化工業株式会社 ヒトメダラシンの免疫学的測定方法
JP4193055B2 (ja) * 2001-09-19 2008-12-10 積水メディカル株式会社 発光性高分子化合物、及びそのバイオアッセイにおける利用
CA2554801C (en) 2004-02-03 2011-12-06 Asahi Kasei Kabushiki Kaisha Method of detecting analyte using magnetic beads
WO2006070582A1 (ja) * 2004-12-09 2006-07-06 Techno Network Shikoku. Co., Ltd. 標識分子含有シリカ球の調製方法
MX2010008820A (es) * 2008-02-12 2010-09-07 Novartis Ag Metodo para aislar acidos nucleicos fetales o apoptoticos libres de celulas.
JP5721639B2 (ja) 2009-02-19 2015-05-20 ダコ・デンマーク・エー／エス 分子標的の検出のための方法と化合物
CN102762982B (zh) 2010-02-05 2014-09-24 株式会社日冷生物科学 免疫组织化学染色用前处理液和其浓缩液
CN101833000A (zh) * 2010-05-13 2010-09-15 北京海瑞祥天生物科技有限公司 高效级联放大的抗体检测法
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EP2632434B1 (en) 2010-10-26 2025-08-20 AC Immune S.A. Liposome-based construct comprising a peptide modified through hydrophobic moieties
JP2012132753A (ja) * 2010-12-21 2012-07-12 Kaneka Corp 糖鎖相互作用解析法
JP5899908B2 (ja) 2011-12-26 2016-04-06 株式会社Ｊｖｃケンウッド 試料分析用ディスク
CN102565383B (zh) * 2011-12-30 2013-12-11 吴坚 信号放大型免疫荧光探针及其制备方法和应用
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US20050208529A1 (en) * 2003-12-01 2005-09-22 Lars Winther Methods and compositions for immuno-histochemical detection

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JPWO2015163424A1 (ja) 2017-04-20
JP2017026631A (ja) 2017-02-02
JP6019254B2 (ja) 2016-11-02
WO2015163424A1 (ja) 2015-10-29
KR102190207B1 (ko) 2020-12-15
RU2016145600A3 (enExample) 2018-05-25
CN106233142A (zh) 2016-12-14
US10324084B2 (en) 2019-06-18
KR20160147830A (ko) 2016-12-23
RU2678108C2 (ru) 2019-01-23
US11156602B2 (en) 2021-10-26
BR112016024624B1 (pt) 2023-10-24
BR112016024624A2 (pt) 2017-08-15
RU2016145600A (ru) 2018-05-25
US20190324020A1 (en) 2019-10-24
EP3136096A1 (en) 2017-03-01
JP6293837B2 (ja) 2018-03-14
EP3136096A4 (en) 2017-09-13
US20170045502A1 (en) 2017-02-16
EP3136096B1 (en) 2021-12-01

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