KR102190207B1 - 표적 마커 검출용 조합물 - Google Patents

표적 마커 검출용 조합물 Download PDF

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KR102190207B1
KR102190207B1 KR1020167031831A KR20167031831A KR102190207B1 KR 102190207 B1 KR102190207 B1 KR 102190207B1 KR 1020167031831 A KR1020167031831 A KR 1020167031831A KR 20167031831 A KR20167031831 A KR 20167031831A KR 102190207 B1 KR102190207 B1 KR 102190207B1
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binding
molecule
antibody
binding agent
target marker
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KR20160147830A (ko
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히로카즈 오바야시
카요코 후지타
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가부시키가이샤 니찌레이 바이오사이언스
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
KR1020167031831A 2014-04-23 2015-04-23 표적 마커 검출용 조합물 Active KR102190207B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2014-089675 2014-04-23
JP2014089675 2014-04-23
PCT/JP2015/062423 WO2015163424A1 (ja) 2014-04-23 2015-04-23 標的マーカー検出用組合せ物

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KR20160147830A KR20160147830A (ko) 2016-12-23
KR102190207B1 true KR102190207B1 (ko) 2020-12-15

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US (2) US10324084B2 (enExample)
EP (1) EP3136096B1 (enExample)
JP (2) JP6019254B2 (enExample)
KR (1) KR102190207B1 (enExample)
CN (1) CN106233142B (enExample)
BR (1) BR112016024624B1 (enExample)
RU (1) RU2678108C2 (enExample)
WO (1) WO2015163424A1 (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
SE538541C2 (en) * 2015-01-19 2016-09-13 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
CN107209176B (zh) 2015-01-21 2020-08-14 克罗姆尼贡公司 免疫标记复合物的形成方法及用途
FR3044680B1 (fr) * 2015-12-02 2017-12-22 Univ Limoges Methode de detection de cellules souches cancereuses
WO2017204729A1 (en) * 2016-05-25 2017-11-30 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
WO2019197365A1 (en) * 2018-04-09 2019-10-17 Expedeon Ltd. Chemical and biological complexes and conjugates with multiple labels and applications thereof
CN112834736B (zh) * 2020-12-02 2024-09-06 杭州百凌生物科技有限公司 一种检测多种抗原的病理检测试剂盒及其制备方法和应用
CN113588936B (zh) * 2021-06-30 2024-12-31 株洲市中医伤科医院 用于纸质酶联免疫吸附测定的酶标板的制作方法

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WO2006070582A1 (ja) 2004-12-09 2006-07-06 Techno Network Shikoku. Co., Ltd. 標識分子含有シリカ球の調製方法
WO2010094283A1 (en) 2009-02-19 2010-08-26 Dako Denmark A/S Conjugate molecules

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GB2098730B (en) * 1981-04-21 1985-02-06 Welsh Nat School Med Immunolocalisation
US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
DE69610948T2 (de) 1995-01-23 2001-06-07 Pasteur Sanofi Diagnostics, Marnes La Coquette Immunoenzymatisches konjugat, herstellungsverfahren dafür und verwendungen
JP3524401B2 (ja) 1998-09-16 2004-05-10 株式会社ニチレイ 酵素抗体複合体およびその製造方法
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
JP4422291B2 (ja) * 2000-04-21 2010-02-24 大日精化工業株式会社 ヒトメダラシンの免疫学的測定方法
US8183060B2 (en) 2001-09-19 2012-05-22 Daiichi Pure Chemicals Co., Ltd. Luminescent polymer and use thereof in bioassay
JP4646003B2 (ja) 2004-02-03 2011-03-09 旭化成株式会社 磁気ビーズを用いた被検物質の検出方法
CN101999003A (zh) * 2008-02-12 2011-03-30 诺瓦蒂斯公司 分离无细胞凋亡或胎儿核酸的方法
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CN101833000A (zh) * 2010-05-13 2010-09-15 北京海瑞祥天生物科技有限公司 高效级联放大的抗体检测法
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JP2012132753A (ja) * 2010-12-21 2012-07-12 Kaneka Corp 糖鎖相互作用解析法
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WO2005054860A1 (en) * 2003-12-01 2005-06-16 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
WO2006070582A1 (ja) 2004-12-09 2006-07-06 Techno Network Shikoku. Co., Ltd. 標識分子含有シリカ球の調製方法
WO2010094283A1 (en) 2009-02-19 2010-08-26 Dako Denmark A/S Conjugate molecules

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Publication number Publication date
BR112016024624B1 (pt) 2023-10-24
RU2016145600A3 (enExample) 2018-05-25
US11156602B2 (en) 2021-10-26
BR112016024624A2 (pt) 2017-08-15
WO2015163424A1 (ja) 2015-10-29
JP6293837B2 (ja) 2018-03-14
CN106233142B (zh) 2019-03-08
RU2678108C2 (ru) 2019-01-23
US20190324020A1 (en) 2019-10-24
JP2017026631A (ja) 2017-02-02
US10324084B2 (en) 2019-06-18
EP3136096A4 (en) 2017-09-13
EP3136096B1 (en) 2021-12-01
JPWO2015163424A1 (ja) 2017-04-20
EP3136096A1 (en) 2017-03-01
KR20160147830A (ko) 2016-12-23
CN106233142A (zh) 2016-12-14
RU2016145600A (ru) 2018-05-25
JP6019254B2 (ja) 2016-11-02
US20170045502A1 (en) 2017-02-16

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