BR112016024624B1 - Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica - Google Patents

Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica Download PDF

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Publication number
BR112016024624B1
BR112016024624B1 BR112016024624-1A BR112016024624A BR112016024624B1 BR 112016024624 B1 BR112016024624 B1 BR 112016024624B1 BR 112016024624 A BR112016024624 A BR 112016024624A BR 112016024624 B1 BR112016024624 B1 BR 112016024624B1
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Brazil
Prior art keywords
binding
binding agent
binding molecule
molecule
labeling substance
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BR112016024624-1A
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English (en)
Portuguese (pt)
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BR112016024624A2 (pt
Inventor
Hirokazu Ohbayashi
Kayoko FUJITA
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Nichirei Biosciences Inc.
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Publication of BR112016024624A2 publication Critical patent/BR112016024624A2/pt
Publication of BR112016024624B1 publication Critical patent/BR112016024624B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
BR112016024624-1A 2014-04-23 2015-04-23 Produto de combinação para detectar marcador alvo, método para detectar um marcador alvo em uma amostra biológica obtida de um indivíduo e uso de um produto de combinação para detectar um marcador alvo em uma amostra biológica BR112016024624B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014089675 2014-04-23
JP2014-089675 2014-04-23
PCT/JP2015/062423 WO2015163424A1 (ja) 2014-04-23 2015-04-23 標的マーカー検出用組合せ物

Publications (2)

Publication Number Publication Date
BR112016024624A2 BR112016024624A2 (pt) 2017-08-15
BR112016024624B1 true BR112016024624B1 (pt) 2023-10-24

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Country Status (8)

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US (2) US10324084B2 (enExample)
EP (1) EP3136096B1 (enExample)
JP (2) JP6019254B2 (enExample)
KR (1) KR102190207B1 (enExample)
CN (1) CN106233142B (enExample)
BR (1) BR112016024624B1 (enExample)
RU (1) RU2678108C2 (enExample)
WO (1) WO2015163424A1 (enExample)

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SE538541C2 (en) * 2015-01-19 2016-09-13 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
EP3248007B1 (en) 2015-01-21 2022-01-12 Kromnigon AB Method for the formation and use of an immunolabeling complex
FR3044680B1 (fr) * 2015-12-02 2017-12-22 Univ Limoges Methode de detection de cellules souches cancereuses
WO2017204729A1 (en) * 2016-05-25 2017-11-30 Fogelstrand Per Method for preparing a biological sample for use in an immunolabeling process
WO2019197365A1 (en) * 2018-04-09 2019-10-17 Expedeon Ltd. Chemical and biological complexes and conjugates with multiple labels and applications thereof
CN112834736B (zh) * 2020-12-02 2024-09-06 杭州百凌生物科技有限公司 一种检测多种抗原的病理检测试剂盒及其制备方法和应用
CN113588936B (zh) * 2021-06-30 2024-12-31 株洲市中医伤科医院 用于纸质酶联免疫吸附测定的酶标板的制作方法

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US4657853A (en) * 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
PT752102E (pt) * 1995-01-23 2001-04-30 Pasteur Sanofi Diagnostics Conjugado imunoenzimatico seu processo de preparacao e as suas aplicacoes
JP3524401B2 (ja) 1998-09-16 2004-05-10 株式会社ニチレイ 酵素抗体複合体およびその製造方法
JP3781934B2 (ja) * 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
JP4422291B2 (ja) * 2000-04-21 2010-02-24 大日精化工業株式会社 ヒトメダラシンの免疫学的測定方法
WO2003031974A1 (en) * 2001-09-19 2003-04-17 Daiichi Pure Chemicals Co., Ltd. Luminescent polymer and use thereof in bioassay
WO2005054860A1 (en) * 2003-12-01 2005-06-16 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
JP4646003B2 (ja) 2004-02-03 2011-03-09 旭化成株式会社 磁気ビーズを用いた被検物質の検出方法
JP4982687B2 (ja) * 2004-12-09 2012-07-25 株式会社テクノネットワーク四国 標識分子含有シリカ球の調製方法
CN101999003A (zh) * 2008-02-12 2011-03-30 诺瓦蒂斯公司 分离无细胞凋亡或胎儿核酸的方法
US8435735B2 (en) 2009-02-19 2013-05-07 Dako Denmark A/S Methods and compounds for detection of molecular targets
RU2546293C2 (ru) * 2010-02-05 2015-04-10 Нитирей Байосайенсиз Инк. Раствор для предварительной обработки для иммуногистохимического окрашивания и конденсированный раствор
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JP5899908B2 (ja) 2011-12-26 2016-04-06 株式会社Ｊｖｃケンウッド 試料分析用ディスク
CN102565383B (zh) * 2011-12-30 2013-12-11 吴坚 信号放大型免疫荧光探针及其制备方法和应用
JP6226976B2 (ja) 2012-07-13 2017-11-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物を検出するための方法
WO2014046248A1 (ja) 2012-09-24 2014-03-27 三菱化学株式会社 肝臓癌の検出方法および肝硬変の検出方法

Also Published As

Publication number Publication date
KR20160147830A (ko) 2016-12-23
JPWO2015163424A1 (ja) 2017-04-20
BR112016024624A2 (pt) 2017-08-15
CN106233142B (zh) 2019-03-08
US10324084B2 (en) 2019-06-18
EP3136096A4 (en) 2017-09-13
US20190324020A1 (en) 2019-10-24
CN106233142A (zh) 2016-12-14
RU2016145600A (ru) 2018-05-25
RU2678108C2 (ru) 2019-01-23
KR102190207B1 (ko) 2020-12-15
JP2017026631A (ja) 2017-02-02
JP6019254B2 (ja) 2016-11-02
JP6293837B2 (ja) 2018-03-14
US20170045502A1 (en) 2017-02-16
RU2016145600A3 (enExample) 2018-05-25
US11156602B2 (en) 2021-10-26
EP3136096A1 (en) 2017-03-01
EP3136096B1 (en) 2021-12-01
WO2015163424A1 (ja) 2015-10-29

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