CN106232122A - Irak抑制剂和其用途 - Google Patents

Irak抑制剂和其用途 Download PDF

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Publication number
CN106232122A
CN106232122A CN201480061479.8A CN201480061479A CN106232122A CN 106232122 A CN106232122 A CN 106232122A CN 201480061479 A CN201480061479 A CN 201480061479A CN 106232122 A CN106232122 A CN 106232122A
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China
Prior art keywords
disease
compound
cancer
irak
compounds
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Pending
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CN201480061479.8A
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Chinese (zh)
Inventor
多纳·L·罗曼罗
克雷格·E·马斯
肖奈希·罗宾逊
杰里米·罗伯特·格林伍德
杰拉尔丁·哈里曼
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Nimbus Iris Inc
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Nimbus Iris Inc
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Publication of CN106232122A publication Critical patent/CN106232122A/zh
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CN201480061479.8A 2013-09-27 2014-09-25 Irak抑制剂和其用途 Pending CN106232122A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883497P 2013-09-27 2013-09-27
US61/883,497 2013-09-27
PCT/US2014/057444 WO2015048281A1 (en) 2013-09-27 2014-09-25 Irak inhibitors and uses thereof

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CN106232122A true CN106232122A (zh) 2016-12-14

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US (2) US9518065B2 (enExample)
EP (1) EP3049086A4 (enExample)
JP (1) JP2016531870A (enExample)
KR (1) KR20160092991A (enExample)
CN (1) CN106232122A (enExample)
BR (1) BR112016006319A2 (enExample)
CA (1) CA2925211A1 (enExample)
MX (1) MX2016003843A (enExample)
RU (1) RU2016110852A (enExample)
TW (1) TW201522349A (enExample)
WO (1) WO2015048281A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020001449A1 (zh) * 2018-06-25 2020-01-02 南京明德新药研发有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
CN111655261A (zh) * 2017-12-19 2020-09-11 X4 制药有限公司 非环状cxcr4抑制剂和其用途
CN112236429A (zh) * 2018-04-05 2021-01-15 默克专利有限公司 用作ii型irak抑制剂的杂芳基化合物及其用途
WO2021147968A1 (zh) * 2020-01-21 2021-07-29 正大天晴药业集团股份有限公司 一种irak4抑制剂的结晶及其制备方法
WO2024179393A1 (zh) * 2023-02-27 2024-09-06 科辉智药(深圳)新药研究中心有限公司 亚砜酰亚胺化合物及其作为lrrk2蛋白激酶抑制剂的应用

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017004133A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
DK3331877T3 (da) * 2015-08-04 2022-01-03 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Pyrazolpyrimidinderivat og anvendelser deraf
CA2993661A1 (en) 2015-08-04 2017-02-09 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
KR102110573B1 (ko) * 2015-08-13 2020-05-13 베이징 한미 파마슈티컬 컴퍼니 리미티드 Irak4억제제 및 이의 용도
KR102048719B1 (ko) * 2015-08-13 2019-11-26 베이징 한미 파마슈티컬 컴퍼니 리미티드 Irak4억제제 및 이의 용도
GB201518456D0 (en) * 2015-10-19 2015-12-02 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases
SG10201508795XA (en) * 2015-10-23 2017-05-30 Agency Science Tech & Res Method for treating cancer
WO2017205762A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
WO2017205766A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
ES2886973T3 (es) * 2016-11-28 2021-12-21 Jiangsu Hengrui Medicine Co Derivado pirazolo-heteroarilo, método de preparación y uso médico del mismo
JP7142646B2 (ja) 2017-02-01 2022-09-27 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム エルティーディー． がんを治療するためのｃｋ１及び／又はｉｒａｋ１インヒビターとしてのｎ１－（４－（５－（シクロプロピルメチル）－１－メチル－１ｈ－ピラゾール－４－イル）ピリジン－２－イル）シクロヘキサン－１，４－ジアミン誘導体及び関連化合物
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
CA3076613A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
JP7623943B2 (ja) 2018-11-30 2025-01-29 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
AU2020360000B2 (en) 2019-10-02 2023-04-20 Kainos Medicine, Inc. N-(1H-imidazol-2-yl)benzamide compound and pharmaceutical composition comprising the same as active ingredient
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
WO2022070287A1 (ja) 2020-09-30 2022-04-07 旭化成ファーマ株式会社 マクロサイクル化合物
KR20230084145A (ko) 2020-09-30 2023-06-12 아사히 가세이 파마 가부시키가이샤 피리미딘 함유 함질소 2환 화합물
AR124547A1 (es) 2020-12-30 2023-04-05 Kymera Therapeutics Inc Degradadores de irak y sus usos
MX2023009527A (es) 2021-02-15 2023-08-24 Kymera Therapeutics Inc Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos.
AR125798A1 (es) 2021-05-07 2023-08-16 Kymera Therapeutics Inc Degradadores cdk2 y usos de los mismos
EP4422635A4 (en) 2021-10-29 2025-11-26 Kymera Therapeutics Inc IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS
CA3243560A1 (en) 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Iraqi Degradation Agents and Their Uses
IL315677A (en) 2022-03-23 2024-11-01 Rigel Pharmaceuticals Inc Pyrimid-2-yl-pyrazole compounds as irak inhibitors
WO2024155601A1 (en) * 2023-01-17 2024-07-25 Septerna, Inc. Compounds, compositions and methods of use to treat hypoparathyroidism and osteoporosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679456A (zh) * 2007-06-12 2010-03-24 霍夫曼-拉罗奇有限公司 噻唑并嘧啶类和它们作为磷脂酰肌醇3-激酶的抑制剂的应用
US20130190297A1 (en) * 2010-05-26 2013-07-25 Katholieke Universiteit Leuven, K.U.Leuven R&D Antiviral Activity of Novel Bicyclic Heterocycles
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937459A1 (de) 1968-08-02 1970-02-05 Ciba Geigy Neue Pyrimidinderivate und Verfahren zu ihrer Herstellung
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JP3109012B2 (ja) 1992-06-18 2000-11-13 クミアイ化学工業株式会社 チアゾロ［５，４−ｄ］ピリミジン誘導体及び農園芸用殺菌剤
ES2219033T3 (es) 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
US5948911A (en) 1998-11-20 1999-09-07 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives
KR20010105399A (ko) 1999-03-30 2001-11-28 쓰끼하시 다미까따 티에노피리미딘 화합물 및 그의 염, 및 그들의 제조 방법
US6297238B1 (en) 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
EP1401840A4 (en) 2001-04-30 2007-05-16 Bayer Corp NEW 4-AMINO-5,6-SUBSTITUTED THIOPHENO 2,3 D | PYRIMIDINE
WO2003057149A2 (en) 2001-12-28 2003-07-17 Bayer Corporation 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
AU2003270701B2 (en) 2002-10-31 2009-11-12 Amgen Inc. Antiinflammation agents
WO2004089312A2 (en) 2003-03-31 2004-10-21 Predix Pharmaceuticals Holdings, Inc. New piperidinylamino-thieno[2,3-d] pyrimidine compounds
US7977366B2 (en) 2003-10-14 2011-07-12 Cornell Research Foundation, Inc. Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation
ATE455777T1 (de) 2004-07-23 2010-02-15 Medicines Co Leipzig Gmbh Substituierte pyridoä3',2':4,5üthienoä3,2- düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü- pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung
UA90707C2 (en) * 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
CA2655799A1 (en) 2005-06-22 2006-12-28 Develogen Aktiengesellschaft Thienopyrimidines for pharmaceutical compositions
WO2007117995A2 (en) 2006-03-30 2007-10-18 Takeda San Diego, Inc. Kinase inhibitors
WO2008005303A2 (en) 2006-06-30 2008-01-10 Janssen Pharmaceutica N.V. Thiazolopyrimidine modulators of trpv1
EP2132211A4 (en) 2006-11-09 2011-12-07 Ardea Biosciences Inc 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER
TW200942549A (en) 2007-12-17 2009-10-16 Janssen Pharmaceutica Nv Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US20100227853A1 (en) 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
US20110165183A1 (en) * 2008-08-01 2011-07-07 Biocryst Pharmaceuticals, Inc. Piperidine derivatives as jak3 inhibitors
TW201024307A (en) 2008-09-10 2010-07-01 Kalypsys Inc Aminopyrimidine inhibitors of histamine receptors for the treatment of disease
AR074343A1 (es) 2008-11-14 2011-01-12 Amgen Inc Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10
TWI396689B (zh) 2008-11-14 2013-05-21 Amgen Inc 作為磷酸二酯酶１０抑制劑之吡衍生物
WO2010103130A2 (en) * 2009-03-13 2010-09-16 Katholieke Universiteit Leuven, K.U.Leuven R&D Novel bicyclic heterocycles
WO2011029054A1 (en) 2009-09-04 2011-03-10 The Regents Of The University Of Michigan Compositions and methods for treatment of leukemia
US8557808B2 (en) 2009-12-10 2013-10-15 North Carolina Central University Selective beta-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents
MX358682B (es) 2010-07-13 2018-08-31 Hoffmann La Roche Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
JP6042331B2 (ja) 2010-07-23 2016-12-14 プレジデント アンド フェローズ オブ ハーバード カレッジ プロテアソーム活性を向上させる三環系化合物
KR20180099933A (ko) * 2010-11-19 2018-09-05 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
EP3239154A1 (en) 2011-01-10 2017-11-01 Nimbus Iris, Inc. Irak inhibitors and uses thereof
GB201114212D0 (en) * 2011-08-18 2011-10-05 Ucb Pharma Sa Therapeutic agents
WO2013078126A1 (en) 2011-11-23 2013-05-30 Cancer Research Technology Limited Thienopyrimidine inhibitors of atypical protein kinase c
WO2014011911A2 (en) 2012-07-11 2014-01-16 Nimbus Iris, Inc. Irak inhibitors and uses thereof
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
JP2015528801A (ja) 2012-07-11 2015-10-01 ニンバス アイリス， インコーポレイテッド Ｉｒａｋ阻害剤およびその使用
BR112015014034A2 (pt) 2013-01-10 2017-07-11 Nimbus Iris Inc inibidores de irak e usos dos mesmos
WO2014194242A2 (en) 2013-05-31 2014-12-04 Nimbus Iris, Inc. Flt3 inhibitors and uses thereof
WO2014194201A2 (en) 2013-05-31 2014-12-04 Nimbus Iris, Inc. Cdk8 inhibitors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679456A (zh) * 2007-06-12 2010-03-24 霍夫曼-拉罗奇有限公司 噻唑并嘧啶类和它们作为磷脂酰肌醇3-激酶的抑制剂的应用
US20130190297A1 (en) * 2010-05-26 2013-07-25 Katholieke Universiteit Leuven, K.U.Leuven R&D Antiviral Activity of Novel Bicyclic Heterocycles
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
O. B. RYABOVA等: "New method for the synthesis of thieno[2,3-d] pyrimidines", 《CHEMISTRY OF HETEROCYCLIC COMPOUNDS》 *
RICHARD C.ANDERSON等: "Isothiazoles. Ⅲ.Synthesis of Isothiazolo[5,4-d] pyrimidines(1,2)", 《JOURNAL OF HETEROCYCLIC CHEMISTRY》 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111655261A (zh) * 2017-12-19 2020-09-11 X4 制药有限公司 非环状cxcr4抑制剂和其用途
CN112236429A (zh) * 2018-04-05 2021-01-15 默克专利有限公司 用作ii型irak抑制剂的杂芳基化合物及其用途
WO2020001449A1 (zh) * 2018-06-25 2020-01-02 南京明德新药研发有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
CN112243438A (zh) * 2018-06-25 2021-01-19 正大天晴药业集团股份有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
CN112243438B (zh) * 2018-06-25 2022-03-15 正大天晴药业集团股份有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
US11459337B2 (en) 2018-06-25 2022-10-04 Chia Tai Tianqing Pharmaceutical Group Co., Inc. Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
AU2019296118B2 (en) * 2018-06-25 2024-09-26 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Isothiazolo(5,4-d)pyrimidine compound as IRAK4 inhibitor
WO2021147968A1 (zh) * 2020-01-21 2021-07-29 正大天晴药业集团股份有限公司 一种irak4抑制剂的结晶及其制备方法
CN114929695A (zh) * 2020-01-21 2022-08-19 正大天晴药业集团股份有限公司 一种irak4抑制剂的结晶及其制备方法
US12358927B2 (en) 2020-01-21 2025-07-15 Chia Tai Tianqing Pharmaceutical Group Co., Inc. IRAK4 inhibitor crystal and preparation method therefor
WO2024179393A1 (zh) * 2023-02-27 2024-09-06 科辉智药(深圳)新药研究中心有限公司 亚砜酰亚胺化合物及其作为lrrk2蛋白激酶抑制剂的应用

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