CN114929695A - 一种irak4抑制剂的结晶及其制备方法 - Google Patents

一种irak4抑制剂的结晶及其制备方法 Download PDF

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Publication number
CN114929695A
CN114929695A CN202180008516.9A CN202180008516A CN114929695A CN 114929695 A CN114929695 A CN 114929695A CN 202180008516 A CN202180008516 A CN 202180008516A CN 114929695 A CN114929695 A CN 114929695A
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degrees
compound
formula
radiation
angles
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CN202180008516.9A
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English (en)
Inventor
张杨
王建非
谭海忠
邢玉海
黎健
陈曙辉
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

提供了一种式(I)化合物的结晶、其盐、其盐的结晶、及其所述结晶制备方法，还包括所述化合物及所述结晶在制备治疗与IRAK4相关疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202180008516.9A 2020-01-21 2021-01-21 一种irak4抑制剂的结晶及其制备方法 Pending CN114929695A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2020100715739 2020-01-21
CN202010071573 2020-01-21
CN202010753615 2020-07-30
CN2020107536157 2020-07-30
PCT/CN2021/073152 WO2021147968A1 (zh) 2020-01-21 2021-01-21 一种irak4抑制剂的结晶及其制备方法

Publications (1)

Publication Number Publication Date
CN114929695A true CN114929695A (zh) 2022-08-19

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ID=76993294

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180008516.9A Pending CN114929695A (zh) 2020-01-21 2021-01-21 一种irak4抑制剂的结晶及其制备方法

Country Status (6)

Country Link
US (1) US20230060905A1 (zh)
EP (1) EP4083040A4 (zh)
CN (1) CN114929695A (zh)
AU (1) AU2021211828A1 (zh)
CA (1) CA3167676A1 (zh)
WO (1) WO2021147968A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023104195A1 (zh) * 2021-12-10 2023-06-15 正大天晴药业集团股份有限公司 一种异噻唑并[5,4-d]嘧啶类IRAK4抑制剂的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016110852A (ru) * 2013-09-27 2017-10-30 Нимбус Айрис, Инк. Ингибиторы irak и их применения
WO2017004133A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017205766A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
CN112243438B (zh) * 2018-06-25 2022-03-15 正大天晴药业集团股份有限公司 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物

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Publication number Publication date
EP4083040A1 (en) 2022-11-02
CA3167676A1 (en) 2021-07-29
US20230060905A1 (en) 2023-03-02
WO2021147968A1 (zh) 2021-07-29
EP4083040A4 (en) 2024-04-24
AU2021211828A1 (en) 2022-08-04

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