TW201522349A - Irak抑制劑及彼等之用途 - Google Patents

Irak抑制劑及彼等之用途 Download PDF

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Publication number
TW201522349A
TW201522349A TW103133657A TW103133657A TW201522349A TW 201522349 A TW201522349 A TW 201522349A TW 103133657 A TW103133657 A TW 103133657A TW 103133657 A TW103133657 A TW 103133657A TW 201522349 A TW201522349 A TW 201522349A
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TW
Taiwan
Prior art keywords
disease
compound
cancer
irak
group
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TW103133657A
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English (en)
Chinese (zh)
Inventor
Donna Romero
Craig E Masse
Shaughnessy Robinson
Jeremy Robert Greenwood
Geraldine C Harriman
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Nimbus Iris Inc
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Publication of TW201522349A publication Critical patent/TW201522349A/zh

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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Epidemiology (AREA)
  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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TW103133657A 2013-09-27 2014-09-26 Irak抑制劑及彼等之用途 TW201522349A (zh)

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US201361883497P 2013-09-27 2013-09-27

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US (2) US9518065B2 (enExample)
EP (1) EP3049086A4 (enExample)
JP (1) JP2016531870A (enExample)
KR (1) KR20160092991A (enExample)
CN (1) CN106232122A (enExample)
BR (1) BR112016006319A2 (enExample)
CA (1) CA2925211A1 (enExample)
MX (1) MX2016003843A (enExample)
RU (1) RU2016110852A (enExample)
TW (1) TW201522349A (enExample)
WO (1) WO2015048281A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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TWI760390B (zh) * 2016-11-28 2022-04-11 大陸商江蘇恆瑞醫藥股份有限公司 吡唑並雜芳基類衍生物、其製備方法及其在醫藥上的應用

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JP6541871B2 (ja) 2015-08-13 2019-07-10 北京韓美薬品有限公司 Irak4阻害剤、及びその応用
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GB201518456D0 (en) * 2015-10-19 2015-12-02 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases
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WO2017205766A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
ES2902885T3 (es) 2017-02-01 2022-03-30 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Derivados de N1-(4-(5-(ciclopropilmetil)-1-metil-1H-pirazol-4-il)piridin-2-il)ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de CK1 y/o IRAK1 para el tratamiento del cáncer
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
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WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
CN111655261A (zh) * 2017-12-19 2020-09-11 X4 制药有限公司 非环状cxcr4抑制剂和其用途
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