RU2016110852A - Ингибиторы irak и их применения - Google Patents
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- RU2016110852A RU2016110852A RU2016110852A RU2016110852A RU2016110852A RU 2016110852 A RU2016110852 A RU 2016110852A RU 2016110852 A RU2016110852 A RU 2016110852A RU 2016110852 A RU2016110852 A RU 2016110852A RU 2016110852 A RU2016110852 A RU 2016110852A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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| US201361883497P | 2013-09-27 | 2013-09-27 | |
| US61/883,497 | 2013-09-27 | ||
| PCT/US2014/057444 WO2015048281A1 (en) | 2013-09-27 | 2014-09-25 | Irak inhibitors and uses thereof |
Publications (2)
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| RU2016110852A true RU2016110852A (ru) | 2017-10-30 |
| RU2016110852A3 RU2016110852A3 (enExample) | 2018-06-25 |
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| RU2016110852A RU2016110852A (ru) | 2013-09-27 | 2014-09-25 | Ингибиторы irak и их применения |
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| EP (1) | EP3049086A4 (enExample) |
| JP (1) | JP2016531870A (enExample) |
| KR (1) | KR20160092991A (enExample) |
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| BR (1) | BR112016006319A2 (enExample) |
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| TW (1) | TW201522349A (enExample) |
| WO (1) | WO2015048281A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2801942C2 (ru) * | 2018-06-25 | 2023-08-21 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | СОЕДИНЕНИЯ НА ОСНОВЕ ИЗОТИАЗОЛО[5,4-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРА IRAK4 |
| US12358927B2 (en) | 2020-01-21 | 2025-07-15 | Chia Tai Tianqing Pharmaceutical Group Co., Inc. | IRAK4 inhibitor crystal and preparation method therefor |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017004133A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| DK3331877T3 (da) | 2015-08-04 | 2022-01-03 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Pyrazolpyrimidinderivat og anvendelser deraf |
| EP3331879B1 (en) | 2015-08-04 | 2020-05-20 | Rigel Pharmaceuticals, Inc. | Benzazole compounds and methods for making and using the compounds |
| JP6541871B2 (ja) | 2015-08-13 | 2019-07-10 | 北京韓美薬品有限公司 | Ｉｒａｋ４阻害剤、及びその応用 |
| CN107531725B (zh) * | 2015-08-13 | 2021-03-19 | 北京韩美药品有限公司 | Irak4抑制剂及其应用 |
| GB201518456D0 (en) * | 2015-10-19 | 2015-12-02 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases |
| SG10201508795XA (en) * | 2015-10-23 | 2017-05-30 | Agency Science Tech & Res | Method for treating cancer |
| WO2017205762A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
| WO2017205766A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
| RU2748833C2 (ru) * | 2016-11-28 | 2021-05-31 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Производное пиразоло-гетероарила, способ его получения и медицинское применение |
| ES2902885T3 (es) | 2017-02-01 | 2022-03-30 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivados de N1-(4-(5-(ciclopropilmetil)-1-metil-1H-pirazol-4-il)piridin-2-il)ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de CK1 y/o IRAK1 para el tratamiento del cáncer |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| IL322809A (en) | 2017-09-22 | 2025-10-01 | Kymera Therapeutics Inc | Protein Decomposers and Their Uses |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| CN111655261A (zh) * | 2017-12-19 | 2020-09-11 | X4 制药有限公司 | 非环状cxcr4抑制剂和其用途 |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3774797B1 (en) * | 2018-04-05 | 2025-11-19 | Merck Patent GmbH | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
| PL3816164T3 (pl) * | 2018-06-25 | 2024-08-12 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Związek izotiazolo[5,4-d]pirymidynowy jako inhibitor irak4 |
| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CA3119773A1 (en) | 2018-11-30 | 2020-06-04 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| JP7386576B2 (ja) | 2019-10-02 | 2023-11-27 | カイノス・メディスン・インコーポレイテッド | Ｎ－（１ｈ－イミダゾール－２－イル）ベンズアミド化合物および該化合物を活性成分として含む医薬組成物 |
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- 2014-09-25 RU RU2016110852A patent/RU2016110852A/ru not_active Application Discontinuation
- 2014-09-25 KR KR1020167011026A patent/KR20160092991A/ko not_active Withdrawn
- 2014-09-25 BR BR112016006319A patent/BR112016006319A2/pt active Search and Examination
- 2014-09-25 MX MX2016003843A patent/MX2016003843A/es unknown
- 2014-09-25 JP JP2016517346A patent/JP2016531870A/ja active Pending
- 2014-09-25 US US14/496,501 patent/US9518065B2/en not_active Expired - Fee Related
- 2014-09-25 CN CN201480061479.8A patent/CN106232122A/zh active Pending
- 2014-09-25 WO PCT/US2014/057444 patent/WO2015048281A1/en not_active Ceased
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2016
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2801942C2 (ru) * | 2018-06-25 | 2023-08-21 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | СОЕДИНЕНИЯ НА ОСНОВЕ ИЗОТИАЗОЛО[5,4-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРА IRAK4 |
| RU2801942C9 (ru) * | 2018-06-25 | 2024-01-12 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | СОЕДИНЕНИЯ НА ОСНОВЕ ИЗОТИАЗОЛО[5,4-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРА IRAK4 |
| RU2805595C1 (ru) * | 2019-09-11 | 2023-10-20 | Пфайзер Инк. | Лечение гидраденита ингибиторами jak |
| US12358927B2 (en) | 2020-01-21 | 2025-07-15 | Chia Tai Tianqing Pharmaceutical Group Co., Inc. | IRAK4 inhibitor crystal and preparation method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150094305A1 (en) | 2015-04-02 |
| KR20160092991A (ko) | 2016-08-05 |
| EP3049086A4 (en) | 2017-02-22 |
| RU2016110852A3 (enExample) | 2018-06-25 |
| MX2016003843A (es) | 2017-02-15 |
| TW201522349A (zh) | 2015-06-16 |
| EP3049086A1 (en) | 2016-08-03 |
| CA2925211A1 (en) | 2015-04-02 |
| CN106232122A (zh) | 2016-12-14 |
| BR112016006319A2 (pt) | 2017-08-01 |
| US20170035766A1 (en) | 2017-02-09 |
| WO2015048281A1 (en) | 2015-04-02 |
| JP2016531870A (ja) | 2016-10-13 |
| US9518065B2 (en) | 2016-12-13 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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