PL4223368T3 - Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnych - Google Patents
Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnychInfo
- Publication number
- PL4223368T3 PL4223368T3 PL20956215.6T PL20956215T PL4223368T3 PL 4223368 T3 PL4223368 T3 PL 4223368T3 PL 20956215 T PL20956215 T PL 20956215T PL 4223368 T3 PL4223368 T3 PL 4223368T3
- Authority
- PL
- Poland
- Prior art keywords
- qunaxoline
- irak
- quinoline
- piperidine
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2020/037046 WO2022070287A1 (ja) | 2020-09-30 | 2020-09-30 | マクロサイクル化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4223368T3 true PL4223368T3 (pl) | 2025-08-11 |
Family
ID=80951511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20956215.6T PL4223368T3 (pl) | 2020-09-30 | 2020-09-30 | Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnych |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230357271A1 (pl) |
| EP (1) | EP4223368B1 (pl) |
| JP (1) | JP7422242B2 (pl) |
| KR (1) | KR102871840B1 (pl) |
| CN (1) | CN116348472B (pl) |
| AU (1) | AU2020470423B2 (pl) |
| CA (1) | CA3194090A1 (pl) |
| ES (1) | ES3033780T3 (pl) |
| MX (1) | MX2023003690A (pl) |
| PL (1) | PL4223368T3 (pl) |
| WO (1) | WO2022070287A1 (pl) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2668834T3 (es) | 2008-09-08 | 2018-05-22 | Merck Serono Sa | Pirimidinas macrociclicas como inhibidores de proteína quinasas |
| ES2672203T3 (es) | 2010-11-19 | 2018-06-13 | Ligand Pharmaceuticals Inc. | Aminas heterocíclicas y usos de las mismas |
| WO2013042137A1 (en) | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| WO2014143672A1 (en) * | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases |
| BR112016006319A2 (pt) | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| EP3536685B1 (en) | 2014-04-04 | 2022-02-16 | Pfizer Inc. | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
| AU2015292827B2 (en) * | 2014-07-21 | 2019-11-14 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| EP3200787B1 (en) | 2014-09-30 | 2019-09-04 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| NZ732538A (en) * | 2015-02-05 | 2022-04-29 | Merck Patent Gmbh | Macrocyclic compounds as irak1/4 inhibitors and uses thereof |
| ES2841452T3 (es) * | 2015-02-06 | 2021-07-08 | Merck Patent Gmbh | Macrociclos de piridazinona como inhibidores de IRAK y sus usos |
| EP3267996B1 (en) | 2015-03-12 | 2020-11-11 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
| LT3341367T (lt) * | 2015-08-27 | 2021-04-26 | Pfizer Inc. | Biciklinis sulietas heteroarilas arba arilo junginiai kaip irak4 moduliatoriai |
-
2020
- 2020-09-30 PL PL20956215.6T patent/PL4223368T3/pl unknown
- 2020-09-30 JP JP2022553285A patent/JP7422242B2/ja active Active
- 2020-09-30 CA CA3194090A patent/CA3194090A1/en active Pending
- 2020-09-30 WO PCT/JP2020/037046 patent/WO2022070287A1/ja not_active Ceased
- 2020-09-30 EP EP20956215.6A patent/EP4223368B1/en active Active
- 2020-09-30 MX MX2023003690A patent/MX2023003690A/es unknown
- 2020-09-30 AU AU2020470423A patent/AU2020470423B2/en active Active
- 2020-09-30 US US18/028,578 patent/US20230357271A1/en active Pending
- 2020-09-30 KR KR1020237010762A patent/KR102871840B1/ko active Active
- 2020-09-30 ES ES20956215T patent/ES3033780T3/es active Active
- 2020-09-30 CN CN202080105435.6A patent/CN116348472B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020470423B2 (en) | 2024-01-18 |
| JP7422242B2 (ja) | 2024-01-25 |
| US20230357271A1 (en) | 2023-11-09 |
| CN116348472B (zh) | 2024-12-03 |
| EP4223368A1 (en) | 2023-08-09 |
| KR102871840B1 (ko) | 2025-10-15 |
| CN116348472A (zh) | 2023-06-27 |
| EP4223368A4 (en) | 2024-06-19 |
| CA3194090A1 (en) | 2022-04-07 |
| EP4223368B1 (en) | 2025-05-21 |
| AU2020470423A1 (en) | 2023-05-04 |
| JPWO2022070287A1 (pl) | 2022-04-07 |
| WO2022070287A1 (ja) | 2022-04-07 |
| KR20230092883A (ko) | 2023-06-26 |
| MX2023003690A (es) | 2023-06-15 |
| ES3033780T3 (en) | 2025-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL288061A (en) | Compounds and methods for treating covid-19 | |
| PT4065585T (pt) | Compostos macrocíclicos substituídos e métodos de tratamento relacionados | |
| IL299704A (en) | Tetrahydropyrazolo-pyrazinyl-dihydroimidazolone or tetrahydropyrazolo-pyridinyl-dihydroimidazolone compounds and methods of using them | |
| EP3923994A4 (en) | COMPOSITIONS AND METHODS FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY | |
| IL241549B (en) | inh-1c preparations and methods for preventing and treating disorders associated with esterase inhibitor 1c deficiency | |
| PH12014502757B1 (en) | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | |
| EP4442318A3 (en) | Heterocyclic inhibitors of mct4 | |
| EP4225923A4 (en) | COMPOSITIONS AND METHODS FOR PREVENTING AND/OR TREATING COVID-19 | |
| EP2536432A4 (en) | METHOD FOR TREATING AUTOIMMUNE DEMYELIZING DISEASES AND OTHER AUTOIMMUNE OR INFLAMMATORY DISEASES | |
| IL276817A (en) | 7-mutated sulfonimidylfuranone compounds and implications for the treatment and prevention of liver cancer | |
| IL278978A (en) | Preparations and methods for treating eczema | |
| EP4263520A4 (en) | HETEROCYCLIC PCSK9 INHIBITORS | |
| PL4223368T3 (pl) | Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnych | |
| EP4125835A4 (en) | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING INFLAMMATORY CONDITIONS | |
| LT4214210T (lt) | Junginiai ir kompozicijos kaip sppl2a inhibitoriai | |
| GB201913122D0 (en) | Compositions and methods for treatment of cholangiocarcinoma | |
| PL3716989T3 (pl) | Wyciąg z Helichrysum gymnocephalum do leczenia i profilaktyki dermatoz zapalnych | |
| GB202108485D0 (en) | Treatment of inflammatory conditions or diseases | |
| GB202212451D0 (en) | Methods and compositions for the treatment of hemangioma | |
| WO2022006377A3 (en) | Heterocyclic inhibitors of rho gtpases for the treatment of disease | |
| EP4142664A4 (en) | METHODS FOR TREATING ALLERGIC CONJUNCTIVITIS | |
| GB201913121D0 (en) | Compositions and methods for treatment of cholangiocarcinoma | |
| MX2024008528A (es) | Inhibidores heterociclicos de glut9 para el tratamiento de enfermedades. | |
| SMT202000194T1 (it) | Composizione comprendente un estere di alfa-tocoferolo per la prevenzione e il trattamento della rinite allergica | |
| HK40109554A (en) | Methods and compositions for monitoring the treatment of relapsed and/or refractory multiple myeloma |