PL4223368T3 - Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnych - Google Patents
Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnychInfo
- Publication number
- PL4223368T3 PL4223368T3 PL20956215.6T PL20956215T PL4223368T3 PL 4223368 T3 PL4223368 T3 PL 4223368T3 PL 20956215 T PL20956215 T PL 20956215T PL 4223368 T3 PL4223368 T3 PL 4223368T3
- Authority
- PL
- Poland
- Prior art keywords
- qunaxoline
- irak
- quinoline
- piperidine
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2020/037046 WO2022070287A1 (ja) | 2020-09-30 | 2020-09-30 | マクロサイクル化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4223368T3 true PL4223368T3 (pl) | 2025-08-11 |
Family
ID=80951511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20956215.6T PL4223368T3 (pl) | 2020-09-30 | 2020-09-30 | Makrocykliczne związki zawierające piperydynę i chinolinę lub chinoksalinę jako inhibitory irak-4 do leczenia stanów zapalnych |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12577258B2 (pl) |
| EP (1) | EP4223368B1 (pl) |
| JP (1) | JP7422242B2 (pl) |
| KR (1) | KR102871840B1 (pl) |
| CN (1) | CN116348472B (pl) |
| AU (1) | AU2020470423B2 (pl) |
| ES (1) | ES3033780T3 (pl) |
| MX (1) | MX2023003690A (pl) |
| PL (1) | PL4223368T3 (pl) |
| WO (1) | WO2022070287A1 (pl) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7871334B2 (en) | 2008-09-05 | 2011-01-18 | Nike, Inc. | Golf club head and golf club with tension element and tensioning member |
| US8815872B2 (en) * | 2008-09-08 | 2014-08-26 | Merck Patent Gmbh | Macrocyclics pyrimidines as aurora kinase inhibitors |
| KR20180099933A (ko) | 2010-11-19 | 2018-09-05 | 리간드 파마슈티칼스 인코포레이티드 | 복소환 아민 및 이의 용도 |
| WO2013042137A1 (en) | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| EP2970334B1 (en) * | 2013-03-15 | 2018-05-23 | Biogen MA Inc. | Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases |
| BR112016006319A2 (pt) | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| MA39838B1 (fr) | 2014-04-04 | 2019-05-31 | Pfizer | Composés bicycliques hétéroaryle ou aryle fusionnés et leur utilisation en tant qu'inhibiteurs irak4 |
| TN2016000435A1 (en) | 2014-04-11 | 2018-04-04 | Bayer Pharma AG | Novel macrocyclic compounds. |
| US10457691B2 (en) * | 2014-07-21 | 2019-10-29 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| US9969749B2 (en) | 2014-09-30 | 2018-05-15 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| EP3253764B1 (en) | 2015-02-05 | 2021-06-09 | Merck Patent GmbH | Macrocyclic compounds as irak1/4 inhibitors and uses thereof |
| BR112017014970B1 (pt) | 2015-02-06 | 2022-11-16 | Merck Patent Gmbh | Macrociclos de piridazinona como inibidores de irak, seus usos, e composição farmacêutica |
| EP3267996B1 (en) | 2015-03-12 | 2020-11-11 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
| ES2865199T3 (es) | 2015-08-27 | 2021-10-15 | Pfizer | Compuestos de heteroarilo o arilo condensados bicíclicos como moduladores de IRAK4 |
| BR112020019399A2 (pt) | 2018-03-28 | 2021-01-05 | Fochon Pharmaceuticals, Ltd. | Compostos macrocíclicos como inibidores de trk quinases |
-
2020
- 2020-09-30 PL PL20956215.6T patent/PL4223368T3/pl unknown
- 2020-09-30 KR KR1020237010762A patent/KR102871840B1/ko active Active
- 2020-09-30 EP EP20956215.6A patent/EP4223368B1/en active Active
- 2020-09-30 CN CN202080105435.6A patent/CN116348472B/zh active Active
- 2020-09-30 ES ES20956215T patent/ES3033780T3/es active Active
- 2020-09-30 JP JP2022553285A patent/JP7422242B2/ja active Active
- 2020-09-30 WO PCT/JP2020/037046 patent/WO2022070287A1/ja not_active Ceased
- 2020-09-30 MX MX2023003690A patent/MX2023003690A/es unknown
- 2020-09-30 US US18/028,578 patent/US12577258B2/en active Active
- 2020-09-30 AU AU2020470423A patent/AU2020470423B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20230357271A1 (en) | 2023-11-09 |
| AU2020470423B2 (en) | 2024-01-18 |
| EP4223368A4 (en) | 2024-06-19 |
| CA3194090A1 (en) | 2022-04-07 |
| EP4223368B1 (en) | 2025-05-21 |
| US12577258B2 (en) | 2026-03-17 |
| CN116348472A (zh) | 2023-06-27 |
| KR20230092883A (ko) | 2023-06-26 |
| CN116348472B (zh) | 2024-12-03 |
| WO2022070287A1 (ja) | 2022-04-07 |
| JPWO2022070287A1 (pl) | 2022-04-07 |
| EP4223368A1 (en) | 2023-08-09 |
| MX2023003690A (es) | 2023-06-15 |
| AU2020470423A1 (en) | 2023-05-04 |
| KR102871840B1 (ko) | 2025-10-15 |
| JP7422242B2 (ja) | 2024-01-25 |
| ES3033780T3 (en) | 2025-08-07 |
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