MX2023003690A - Compuesto macrociclico. - Google Patents
Compuesto macrociclico.Info
- Publication number
- MX2023003690A MX2023003690A MX2023003690A MX2023003690A MX2023003690A MX 2023003690 A MX2023003690 A MX 2023003690A MX 2023003690 A MX2023003690 A MX 2023003690A MX 2023003690 A MX2023003690 A MX 2023003690A MX 2023003690 A MX2023003690 A MX 2023003690A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- macrocycle compound
- irak
- salt
- macrocycle
- Prior art date
Links
- -1 Macrocycle compound Chemical class 0.000 title 1
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 abstract 2
- 101710199010 Interleukin-1 receptor-associated kinase 4 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto representado por la fórmula general (1) o una sal del mismo, el cual tiene una actividad inhibidora de IRAK-4 superior, y es útil como ingrediente activo de medicamentos para tratamiento profiláctico y/o tratamiento terapéutico de enfermedades que se refieren a inhibición de IRAK-4. (ver Fórmula).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2020/037046 WO2022070287A1 (ja) | 2020-09-30 | 2020-09-30 | マクロサイクル化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003690A true MX2023003690A (es) | 2023-06-15 |
Family
ID=80951511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023003690A MX2023003690A (es) | 2020-09-30 | 2020-09-30 | Compuesto macrociclico. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230357271A1 (es) |
| EP (1) | EP4223368A1 (es) |
| JP (1) | JP7422242B2 (es) |
| KR (1) | KR20230092883A (es) |
| CN (1) | CN116348472A (es) |
| AU (1) | AU2020470423B2 (es) |
| CA (1) | CA3194090A1 (es) |
| MX (1) | MX2023003690A (es) |
| WO (1) | WO2022070287A1 (es) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110073500A (ko) * | 2008-09-08 | 2011-06-29 | 메르크 파텐트 게엠베하 | 오로라 키나아제 억제제로서 마크로사이클릭 피리미딘 |
| EP2730564B1 (en) | 2010-11-19 | 2018-04-18 | Ligand Pharmaceuticals Inc. | Heterocycle amines and uses thereof |
| WO2013042137A1 (en) | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| EP3049086A4 (en) | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| EA032559B1 (ru) | 2014-04-04 | 2019-06-28 | Пфайзер Инк. | Бициклические аннелированные гетероарильные или арильные соединения и их применение в качестве ингибиторов irak4 |
| CA2954187C (en) * | 2014-07-21 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Macrocyclic kinase inhibitors and uses thereof |
| EP3200787B1 (en) | 2014-09-30 | 2019-09-04 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| WO2016144846A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of irak4 activity |
| WO2017033093A1 (en) * | 2015-08-27 | 2017-03-02 | Pfizer Inc. | Bicyclic-fused heteroaryl or aryl compounds as irak4 modulators |
-
2020
- 2020-09-30 JP JP2022553285A patent/JP7422242B2/ja active Active
- 2020-09-30 WO PCT/JP2020/037046 patent/WO2022070287A1/ja active Application Filing
- 2020-09-30 CN CN202080105435.6A patent/CN116348472A/zh active Pending
- 2020-09-30 AU AU2020470423A patent/AU2020470423B2/en active Active
- 2020-09-30 MX MX2023003690A patent/MX2023003690A/es unknown
- 2020-09-30 CA CA3194090A patent/CA3194090A1/en active Pending
- 2020-09-30 US US18/028,578 patent/US20230357271A1/en active Pending
- 2020-09-30 KR KR1020237010762A patent/KR20230092883A/ko unknown
- 2020-09-30 EP EP20956215.6A patent/EP4223368A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7422242B2 (ja) | 2024-01-25 |
| EP4223368A1 (en) | 2023-08-09 |
| KR20230092883A (ko) | 2023-06-26 |
| CA3194090A1 (en) | 2022-04-07 |
| AU2020470423B2 (en) | 2024-01-18 |
| WO2022070287A1 (ja) | 2022-04-07 |
| US20230357271A1 (en) | 2023-11-09 |
| AU2020470423A1 (en) | 2023-05-04 |
| JPWO2022070287A1 (es) | 2022-04-07 |
| CN116348472A (zh) | 2023-06-27 |
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