CN105848722B - 中和抗甲型流感抗体及其用途 - Google Patents

中和抗甲型流感抗体及其用途 Download PDF

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CN105848722B
CN105848722B CN201480053969.3A CN201480053969A CN105848722B CN 105848722 B CN105848722 B CN 105848722B CN 201480053969 A CN201480053969 A CN 201480053969A CN 105848722 B CN105848722 B CN 105848722B
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antibody
seq
antigen
antibodies
binding fragment
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CN105848722A (zh
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E.本杰明
N.卡勒瓦-勒莱
J.M.麦考利夫
F.帕尔默-希尔
L.瓦赫特
袁安迪
朱青
D.科蒂
A.兰扎维基亚
B.瓜里诺
A.德马科
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Humabs Biomed SA
MedImmune LLC
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Humabs Biomed SA
MedImmune LLC
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Priority to CN202410319772.5A priority Critical patent/CN118005782A/zh
Priority to CN202110958404.1A priority patent/CN113667013B/zh
Priority to CN202110958279.4A priority patent/CN113667012B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12P21/005—Glycopeptides, glycoproteins
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
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    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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CN201480053969.3A 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途 Active CN105848722B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202410319772.5A CN118005782A (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202110958404.1A CN113667013B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202110958279.4A CN113667012B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途

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US201361885808P 2013-10-02 2013-10-02
US61/885808 2013-10-02
US201462002414P 2014-05-23 2014-05-23
US62/002414 2014-05-23
PCT/US2014/058652 WO2015051010A1 (en) 2013-10-02 2014-10-01 Neutralizing anti-influenza a antibodies and uses thereof

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CN202110958279.4A Division CN113667012B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202110958404.1A Division CN113667013B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202410319772.5A Division CN118005782A (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途

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CN105848722B true CN105848722B (zh) 2021-09-03

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CN201480053969.3A Active CN105848722B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202110958279.4A Active CN113667012B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202110958404.1A Active CN113667013B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202410319772.5A Pending CN118005782A (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途

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CN202110958404.1A Active CN113667013B (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途
CN202410319772.5A Pending CN118005782A (zh) 2013-10-02 2014-10-01 中和抗甲型流感抗体及其用途

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US (4) US10494419B2 (OSRAM)
EP (2) EP3733244A1 (OSRAM)
JP (5) JP6535675B2 (OSRAM)
KR (4) KR20240151882A (OSRAM)
CN (4) CN105848722B (OSRAM)
AU (3) AU2014329609B2 (OSRAM)
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CA (2) CA3249435A1 (OSRAM)
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US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
RS60938B1 (sr) 2013-10-02 2020-11-30 Medimmune Llc Neutrališuća antitela na grip a i njihova upotreba
WO2016011035A2 (en) 2014-07-15 2016-01-21 Medlmmune, Llc Neutralizing anti-influenza b antibodies and uses thereof
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
PT3303384T (pt) * 2015-06-01 2021-10-14 Medimmune Llc Moléculas de ligação neutralizantes anti-influenza e suas utilizações
WO2017083627A1 (en) * 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN108883150A (zh) * 2015-11-19 2018-11-23 阿斯克雷佩西治疗公司 具有抗血管生成、抗淋巴管生成以及消水肿性质的肽和纳米粒子制剂
IL304940A (en) * 2016-01-13 2023-10-01 Medimmune Llc A method for treating type A influenza
CN109195629A (zh) 2016-02-24 2019-01-11 威特拉公司 流行性感冒抗体分子制剂
WO2017192589A1 (en) * 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to influenza ha and their use and identification
US11780907B2 (en) * 2018-01-26 2023-10-10 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
US11161900B2 (en) * 2018-12-13 2021-11-02 Argenx Bvba Antibodies that specifically bind to human complement factor C2b
CA3132521A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2020221450A1 (en) * 2019-04-30 2020-11-05 Humabs Biomed Sa Antibodies and methods for treatment of influenza a infection
US20230204567A1 (en) * 2020-05-20 2023-06-29 Takeda Vaccines, Inc. Method for determining the potency of antigens
CN112175075B (zh) * 2020-10-09 2021-08-20 中国人民解放军军事科学院军事医学研究院 一种靶向甲型流感病毒ha蛋白的广谱抗体
CA3200900A1 (en) * 2020-12-08 2022-06-16 Davide Corti Antibodies and methods for treatment of influenza a infection
US20250243261A1 (en) * 2022-04-08 2025-07-31 Cz Biohub Sf, Llc Antibody compositions and optimization methods
CN115792246B (zh) * 2023-02-03 2023-05-09 细胞生态海河实验室 直接抗人球蛋白微流控检测芯片卡及其在检测红细胞方面的应用
WO2024196133A1 (ko) * 2023-03-21 2024-09-26 고려대학교 산학협력단 교차 면역원성을 갖는 h3 아형 인플루엔자 바이러스 및 이를 포함하는 백신

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