PT3303384T - Moléculas de ligação neutralizantes anti-influenza e suas utilizações - Google Patents

Moléculas de ligação neutralizantes anti-influenza e suas utilizações

Info

Publication number
PT3303384T
PT3303384T PT16728534T PT16728534T PT3303384T PT 3303384 T PT3303384 T PT 3303384T PT 16728534 T PT16728534 T PT 16728534T PT 16728534 T PT16728534 T PT 16728534T PT 3303384 T PT3303384 T PT 3303384T
Authority
PT
Portugal
Prior art keywords
binding molecules
neutralizing binding
influenza neutralizing
influenza
molecules
Prior art date
Application number
PT16728534T
Other languages
English (en)
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of PT3303384T publication Critical patent/PT3303384T/pt

Links

Classifications

    • C07K16/108—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT16728534T 2015-06-01 2016-05-31 Moléculas de ligação neutralizantes anti-influenza e suas utilizações PT3303384T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562169272P 2015-06-01 2015-06-01

Publications (1)

Publication Number Publication Date
PT3303384T true PT3303384T (pt) 2021-10-14

Family

ID=56118059

Family Applications (1)

Application Number Title Priority Date Filing Date
PT16728534T PT3303384T (pt) 2015-06-01 2016-05-31 Moléculas de ligação neutralizantes anti-influenza e suas utilizações

Country Status (21)

Country Link
US (4) US10442854B2 (pt)
EP (2) EP3960761A1 (pt)
JP (3) JP6867306B2 (pt)
CN (2) CN113480640B (pt)
AU (2) AU2016271323B2 (pt)
BR (1) BR112017025496A2 (pt)
CA (1) CA2987816C (pt)
CY (1) CY1125793T1 (pt)
DK (1) DK3303384T3 (pt)
ES (1) ES2894777T3 (pt)
HR (1) HRP20211510T1 (pt)
HU (1) HUE056407T2 (pt)
LT (1) LT3303384T (pt)
MX (2) MX389708B (pt)
PL (1) PL3303384T3 (pt)
PT (1) PT3303384T (pt)
RS (1) RS62446B1 (pt)
RU (1) RU2721706C2 (pt)
SI (1) SI3303384T1 (pt)
SM (1) SMT202100591T1 (pt)
WO (1) WO2016196470A1 (pt)

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EP3733244A1 (en) 2013-10-02 2020-11-04 Medlmmune, LLC Neutralizing anti-influenza a antibodies and uses thereof
CN113173990B (zh) 2014-07-15 2024-10-29 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
ES2894777T3 (es) * 2015-06-01 2022-02-15 Medimmune Llc Neutralización de moléculas de unión anti-influenza y usos de las mismas
KR20250130692A (ko) 2016-01-13 2025-09-02 메디뮨 엘엘씨 인플루엔자 a의 치료 방법
EA202091563A1 (ru) 2018-01-26 2020-10-08 Регенерон Фармасьютикалз, Инк. Человеческие антитела к гемагглютинину вируса гриппа
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IL292353A (en) * 2019-10-28 2022-06-01 Regeneron Pharma Anti-haemagglutinin antibodies and methods of using them
CN113121680B (zh) * 2021-04-12 2022-03-29 华南农业大学 一种抗h5亚型禽流感纳米抗体蛋白及其编码基因与应用
WO2023196658A2 (en) * 2022-04-08 2023-10-12 Cz Biohub Sf, Llc Antibody compositions and optimization methods
CN116874606B (zh) * 2023-09-08 2023-11-24 益科思特(北京)医药科技发展有限公司 一种靶向trop2和cd3的双特异性抗体及其制备方法与应用

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Also Published As

Publication number Publication date
EP3303384B1 (en) 2021-08-25
EP3960761A1 (en) 2022-03-02
RU2017145094A (ru) 2019-07-09
MX389708B (es) 2025-03-20
JP2018518475A (ja) 2018-07-12
LT3303384T (lt) 2021-10-11
AU2016271323B2 (en) 2022-08-25
HK1253092A1 (zh) 2019-06-06
JP6867306B2 (ja) 2021-04-28
MX2022001220A (es) 2022-03-02
CN107667114A (zh) 2018-02-06
MX2017015189A (es) 2018-04-13
US10882897B2 (en) 2021-01-05
JP2021112193A (ja) 2021-08-05
RU2721706C2 (ru) 2020-05-21
CN113480640B (zh) 2024-07-30
SI3303384T1 (sl) 2021-11-30
HRP20211510T1 (hr) 2021-12-24
CA2987816A1 (en) 2016-12-08
US20230112916A1 (en) 2023-04-13
BR112017025496A2 (pt) 2018-08-07
CA2987816C (en) 2024-02-20
RS62446B1 (sr) 2021-11-30
CN107667114B (zh) 2021-07-02
SMT202100591T1 (it) 2021-11-12
US20210079069A1 (en) 2021-03-18
EP3303384A1 (en) 2018-04-11
CN113480640A (zh) 2021-10-08
US20200109187A1 (en) 2020-04-09
AU2016271323A1 (en) 2018-01-18
ES2894777T3 (es) 2022-02-15
CY1125793T1 (el) 2024-02-16
JP2023078352A (ja) 2023-06-06
US11926657B2 (en) 2024-03-12
US20180155413A1 (en) 2018-06-07
PL3303384T3 (pl) 2022-01-03
WO2016196470A1 (en) 2016-12-08
HUE056407T2 (hu) 2022-02-28
US11524993B2 (en) 2022-12-13
US10442854B2 (en) 2019-10-15
RU2017145094A3 (pt) 2019-11-06
HK1250725A1 (zh) 2019-01-11
DK3303384T3 (da) 2021-10-18
AU2022271473A1 (en) 2022-12-22

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