LT3303384T - Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas - Google Patents

Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas

Info

Publication number
LT3303384T
LT3303384T LTEPPCT/US2016/035026T LT16035026T LT3303384T LT 3303384 T LT3303384 T LT 3303384T LT 16035026 T LT16035026 T LT 16035026T LT 3303384 T LT3303384 T LT 3303384T
Authority
LT
Lithuania
Prior art keywords
binding molecules
neutralizing anti
influenza binding
influenza
neutralizing
Prior art date
Application number
LTEPPCT/US2016/035026T
Other languages
English (en)
Inventor
Nicole KALLEWAARD-LELAY
Qing Zhu
Godfrey Rainey
Cuihua Gao
Srinath Kasturirangan
Changshou Gao
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Publication of LT3303384T publication Critical patent/LT3303384T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
LTEPPCT/US2016/035026T 2015-06-01 2016-05-31 Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas LT3303384T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169272P 2015-06-01 2015-06-01
PCT/US2016/035026 WO2016196470A1 (en) 2015-06-01 2016-05-31 Neutralizing anti-influenza binding molecules and uses thereof

Publications (1)

Publication Number Publication Date
LT3303384T true LT3303384T (lt) 2021-10-11

Family

ID=56118059

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2016/035026T LT3303384T (lt) 2015-06-01 2016-05-31 Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas

Country Status (20)

Country Link
US (4) US10442854B2 (lt)
EP (2) EP3303384B1 (lt)
JP (3) JP6867306B2 (lt)
CN (2) CN107667114B (lt)
AU (2) AU2016271323B2 (lt)
BR (1) BR112017025496A2 (lt)
CA (1) CA2987816C (lt)
DK (1) DK3303384T3 (lt)
ES (1) ES2894777T3 (lt)
HK (2) HK1250725A1 (lt)
HR (1) HRP20211510T1 (lt)
HU (1) HUE056407T2 (lt)
LT (1) LT3303384T (lt)
MX (2) MX2017015189A (lt)
PL (1) PL3303384T3 (lt)
PT (1) PT3303384T (lt)
RS (1) RS62446B1 (lt)
RU (1) RU2721706C2 (lt)
SI (1) SI3303384T1 (lt)
WO (1) WO2016196470A1 (lt)

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SG11201602522VA (en) 2013-10-02 2016-04-28 Medimmune Llc Neutralizing anti-influenza a antibodies and uses thereof
CN106573154B (zh) 2014-07-15 2021-06-15 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
DK3303384T3 (da) 2015-06-01 2021-10-18 Medimmune Llc Neutraliserende anti-influenza-bindingsmolekyler og anvendelser deraf
CN116271017A (zh) 2016-01-13 2023-06-23 免疫医疗有限责任公司 治疗甲型流感的方法
EP3743442A1 (en) 2018-01-26 2020-12-02 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
EP4051707A1 (en) * 2019-10-28 2022-09-07 Regeneron Pharmaceuticals, Inc. Anti-hemagglutinin antibodies and methods of use thereof
CN113121680B (zh) * 2021-04-12 2022-03-29 华南农业大学 一种抗h5亚型禽流感纳米抗体蛋白及其编码基因与应用
CN116874606B (zh) * 2023-09-08 2023-11-24 益科思特(北京)医药科技发展有限公司 一种靶向trop2和cd3的双特异性抗体及其制备方法与应用

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Publication number Publication date
HK1250725A1 (zh) 2019-01-11
EP3960761A1 (en) 2022-03-02
US10882897B2 (en) 2021-01-05
CN113480640A (zh) 2021-10-08
AU2016271323A1 (en) 2018-01-18
HUE056407T2 (hu) 2022-02-28
HK1253092A1 (zh) 2019-06-06
US11926657B2 (en) 2024-03-12
DK3303384T3 (da) 2021-10-18
US20210079069A1 (en) 2021-03-18
BR112017025496A2 (pt) 2018-08-07
AU2022271473A1 (en) 2022-12-22
JP6867306B2 (ja) 2021-04-28
MX2022001220A (es) 2022-03-02
US11524993B2 (en) 2022-12-13
RU2017145094A (ru) 2019-07-09
WO2016196470A1 (en) 2016-12-08
RS62446B1 (sr) 2021-11-30
US20230112916A1 (en) 2023-04-13
JP2023078352A (ja) 2023-06-06
SI3303384T1 (sl) 2021-11-30
ES2894777T3 (es) 2022-02-15
JP2018518475A (ja) 2018-07-12
PT3303384T (pt) 2021-10-14
EP3303384A1 (en) 2018-04-11
JP2021112193A (ja) 2021-08-05
US20180155413A1 (en) 2018-06-07
RU2017145094A3 (lt) 2019-11-06
CN107667114B (zh) 2021-07-02
RU2721706C2 (ru) 2020-05-21
PL3303384T3 (pl) 2022-01-03
AU2016271323B2 (en) 2022-08-25
EP3303384B1 (en) 2021-08-25
CA2987816C (en) 2024-02-20
CN107667114A (zh) 2018-02-06
HRP20211510T1 (hr) 2021-12-24
US20200109187A1 (en) 2020-04-09
MX2017015189A (es) 2018-04-13
US10442854B2 (en) 2019-10-15
CA2987816A1 (en) 2016-12-08

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