CN105828834A - 检查点抑制剂和治疗剂的组合以治疗癌症 - Google Patents

检查点抑制剂和治疗剂的组合以治疗癌症 Download PDF

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Publication number
CN105828834A
CN105828834A CN201480070071.7A CN201480070071A CN105828834A CN 105828834 A CN105828834 A CN 105828834A CN 201480070071 A CN201480070071 A CN 201480070071A CN 105828834 A CN105828834 A CN 105828834A
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China
Prior art keywords
cancer
cell
tumor
cells
checkpoint inhibitor
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Pending
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CN201480070071.7A
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English (en)
Chinese (zh)
Inventor
M·L·博施
J·K·甘耶
L·F·鲍尔斯
L·M·廖
R·M·普林斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revlmmune Inc
Northwest Biotherapeutics LLC
University of California San Diego UCSD
Cognate Bioservices Inc
Original Assignee
Revlmmune Inc
Northwest Biotherapeutics LLC
University of California San Diego UCSD
Cognate Bioservices Inc
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Publication of CN105828834A publication Critical patent/CN105828834A/zh
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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CN201480070071.7A 2013-11-05 2014-11-05 检查点抑制剂和治疗剂的组合以治疗癌症 Pending CN105828834A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361900355P 2013-11-05 2013-11-05
US201361900309P 2013-11-05 2013-11-05
US61/900,309 2013-11-05
US61/900,355 2013-11-05
PCT/US2014/064133 WO2015069770A1 (en) 2013-11-05 2014-11-05 Combinations of checkpoint inhibitors and therapeutics to treat cancer

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CN105828834A true CN105828834A (zh) 2016-08-03

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US (4) US20150273033A1 (https=)
EP (2) EP3065772B1 (https=)
JP (1) JP2016540042A (https=)
KR (1) KR20160093012A (https=)
CN (1) CN105828834A (https=)
AU (1) AU2014346852A1 (https=)
BR (1) BR112016010224A2 (https=)
CA (1) CA2929407A1 (https=)
EA (1) EA201690912A1 (https=)
ES (1) ES2991853T3 (https=)
HK (1) HK1232119A1 (https=)
IL (3) IL292510A (https=)
MX (2) MX2016005925A (https=)
PH (1) PH12016500841A1 (https=)
WO (1) WO2015069770A1 (https=)

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WO2018176505A1 (zh) * 2017-03-29 2018-10-04 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
CN108728440A (zh) * 2017-04-25 2018-11-02 上海吉倍生物技术有限公司 Ctla-4基因的用途及相关药物
CN109937051A (zh) * 2016-09-26 2019-06-25 优势公司 治疗tim-3升高的方法
CN110352199A (zh) * 2017-02-28 2019-10-18 拉尔夫·克勒夫 免疫检查点治疗
CN110621334A (zh) * 2017-03-03 2019-12-27 特雷斯生物公司 个性化免疫原性肽鉴定平台
CN111093669A (zh) * 2017-08-14 2020-05-01 法斯瑞斯公司 用于治疗癌症的腺苷受体拮抗剂的微颗粒制剂
CN111148996A (zh) * 2017-07-28 2020-05-12 百时美施贵宝公司 用于检查点抑制剂的预测性外周血生物标志物
CN111751545A (zh) * 2019-03-28 2020-10-09 中国科学院上海药物研究所 一种筛选pd-l1/pd-1检测点抑制剂的方法
CN111789955A (zh) * 2019-04-08 2020-10-20 中国医药大学 包含基于树突细胞的疫苗与免疫检查点抑制剂的组合治疗
CN111971028A (zh) * 2017-11-21 2020-11-20 西奈山伊坎医学院 用治疗性纳米生物组合物促进训练免疫
CN112771067A (zh) * 2018-08-29 2021-05-07 沙塔克实验室有限公司 包含基于SIRPα的嵌合蛋白的组合疗法
CN113543809A (zh) * 2019-04-03 2021-10-22 塔尔格免疫治疗有限公司 用于治疗癌症的免疫疗法
CN113614109A (zh) * 2018-12-21 2021-11-05 Ose免疫疗法公司 双功能抗pd-1/il-7分子
CN115038439A (zh) * 2020-01-07 2022-09-09 上海华禹生物科技有限公司 使用chk抑制剂的癌症联合疗法
CN115087459A (zh) * 2019-11-13 2022-09-20 洪明奇 异种组织细胞组合物治疗癌症的用途
CN117050177A (zh) * 2023-08-25 2023-11-14 遵义北科融汇生命科技有限公司 血液分离的免疫细胞联合药物治疗癌症的用途
US11859021B2 (en) 2021-03-19 2024-01-02 Icahn School Of Medicine At Mount Sinai Compounds for regulating trained immunity, and their methods of use
CN118369120A (zh) * 2021-12-10 2024-07-19 应世生物科技(南京)有限公司 治疗肿瘤的药物组合及用途
US12377054B2 (en) 2016-04-29 2025-08-05 Icahn School Of Medicine At Mount Sinai Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis

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SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
EP3137105A4 (en) * 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
HK1244436A1 (zh) * 2015-02-09 2018-08-10 Synta Pharmaceuticals Corp. 治疗癌症的hsp90抑制剂和pd-1抑制剂的组合疗法
RU2714233C2 (ru) * 2015-02-26 2020-02-13 Мерк Патент Гмбх Ингибиторы pd-1 / pd-l1 для лечения рака
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
US11254914B2 (en) 2015-03-12 2022-02-22 Health Research, Inc. Enrichment of CD16+ monocytes to improve dendritic cell vaccine quality
WO2016145578A1 (en) 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
KR102873947B1 (ko) * 2015-05-07 2025-10-22 베이롤 칼리지 오브 메드신 수지상 세포 면역요법
SG11201708804WA (en) 2015-05-07 2017-11-29 Agenus Inc Anti-ox40 antibodies and methods of use thereof
WO2016187122A1 (en) * 2015-05-15 2016-11-24 University Of Iowa Research Foundation Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
CA2986793A1 (en) * 2015-05-28 2016-12-01 Kite Pharma, Inc. Diagnostic methods for t cell therapy
KR102349677B1 (ko) 2015-05-28 2022-01-12 카이트 파마 인코포레이티드 T 세포 요법을 위해 환자를 컨디셔닝하는 방법
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