CN105163721B - 脂质纳米颗粒组合物以及制备和使用其的方法 - Google Patents

脂质纳米颗粒组合物以及制备和使用其的方法 Download PDF

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CN105163721B
CN105163721B CN201380033174.1A CN201380033174A CN105163721B CN 105163721 B CN105163721 B CN 105163721B CN 201380033174 A CN201380033174 A CN 201380033174A CN 105163721 B CN105163721 B CN 105163721B
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lipidic nanoparticles
mir
gln
cells
lac
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CN105163721A (zh
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R·J·李
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Ohio State University
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Ohio State University
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    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • A61K38/08Peptides having 5 to 11 amino acids
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    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201380033174.1A 2012-05-23 2013-05-23 脂质纳米颗粒组合物以及制备和使用其的方法 Active CN105163721B (zh)

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US201261650729P 2012-05-23 2012-05-23
US61/650,729 2012-05-23
US201361784892P 2013-03-14 2013-03-14
US61/784,892 2013-03-14
PCT/US2013/042458 WO2013177419A2 (en) 2012-05-23 2013-05-23 Lipid nanoparticle compositions and methods of making and methods of using the same

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CN105163721A CN105163721A (zh) 2015-12-16
CN105163721B true CN105163721B (zh) 2018-05-22

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CN201380026005.5A Active CN104428005B (zh) 2012-05-23 2013-05-23 用于反义寡核苷酸递送的脂质纳米颗粒组合物
CN201380033165.2A Pending CN104582691A (zh) 2012-05-23 2013-05-23 脂膜白蛋白纳米颗粒组合物以及制备和使用其的方法

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