CN105026430A - 工程化免疫球蛋白重链-轻链对及其用途 - Google Patents
工程化免疫球蛋白重链-轻链对及其用途 Download PDFInfo
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Abstract
Description
组号 | H2_突变* | L1_突变 | L2_突变 |
C501 | A139W_V190S | WT# | F116A |
C502 | A139W_V190A | WT | F116A |
C504 | F100W | WT | F98L |
C506 | A139W | F116S | F118W_V133S |
C508 | A139V | F116A | F118W_V133S |
C512 | A139I | WT | F118W_V133S |
C516 | A139W | L135W_N137A | F116A_L135A |
C518 | A139W | L135W | F116A_L135A |
C520 | A139W | L135W | F116A_L135V |
C522 | WT | WT | S176V_T178L |
C526 | F174V_P175S_S188G | V133S | S176L |
C528 | F174V_S188L | S176L | WT |
C529 | S188L | S176L | WT |
C531 | K145T_Q179D_S188L | Q124E_Q160E_T178D | Q160K_T178R |
C533 | K145T_Q179D_S188F | Q124E_V133W_Q160E_T180E | V133A_Q160K_T178R |
组号 | H1_突变* | L1_突变 | L2_突变 |
V001 | V37W_W103H | F98L | F98W |
V004 | V37W_W103H | F98L | P44W |
V005 | V37A_W103H | P44W | F98L |
V006 | V37W_W103F | F98L | F98W |
V007 | V37W | F98A | F98W |
V009 | V37W | F98A | WT# |
V011 | V37I | WT | F98L |
V013 | V37A_W103V | P44W | F98A |
V015 | V37A_W103H | P44W | F98A |
V016 | V37A_W103H | P44W | F98W |
V020 | L45W | Y87G | P44W |
V022 | WT | F98W | F98A |
V023 | WT | WT | F98A |
V024 | Q39R | Q38E | F98A |
V026 | Q39R | Q38E | WT |
V028 | Q39R | Q38E | Q38R |
V030 | Q39R | Q38D | Q38R |
V032 | Q39M | Q38M | Q38E |
V034 | Q39K | Q38N_T85E | Q38N_T85K |
V037 | Q39E | Q38R | F98A |
V039 | Q39D | Q38R | Q38D |
V040 | V37E | L89R_F98T | WT |
V042 | V37E_F100D | L89R_F98W | WT |
V044 | V37E_F100D | L89R_F98W | F98Y |
组号 | H2_突变* | L1_突变 | L2_突变 |
V002 | V37I | F98L | F98W |
V003 | WT# | F98L | F98W |
V005 | V37A_W103H | F98L | P44W |
V007 | V37W | F98W | F98A |
V008 | V37I | F98A | F98W |
V009 | V37W | WT | F98A |
V010 | V37I | F98A | WT |
V012 | F100W | WT | F98L |
V014 | V37W | P44W | F98A |
V017 | V37A_W103V | P44W | F98W |
V018 | V37A_W103V | P44W | F98L |
V019 | V37I_F100W | P44W | F98L |
V021 | V37A_W103H | Y87G | P44W |
V025 | V37W | Q38E | F98A |
V027 | WT | Q38E | WT |
V029 | Q39E | Q38E | Q38R |
V030 | Q39R | Q38R | Q38D |
V031 | Q39E | Q38D | Q38R |
V033 | Q39R | Q38M | Q38E |
V035 | Q39D | Q38N_T85E | Q38N_T85K |
V036 | Q39E | Q38N_T85E | Q38N_T85K |
V038 | V37W | Q38R | F98A |
V041 | WT | L89R_F98T | WT |
V043 | WT | L89R_F98W | WT |
V045 | V37S_A97K | L89R_F98W | F98Y |
组号 | 组号 | H1_突变* | L1_突变 | H2_突变 | L2_突变 |
V001 | V002 | V37W_W103H | F98L | V37I | F98W |
V001 | V003 | V37W_W103H | F98L | WT# | F98W |
V004 | V005 | V37W_W103H | F98L | V37A_W103H | P44W |
V006 | V002 | V37W_W103F | F98L | V37I | F98W |
V006 | V003 | V37W_W103F | F98L | WT | F98W |
V007 | V008 | V37W | F98A | V37I | F98W |
V009 | V010 | V37W | F98A | V37I | WT |
V011 | V012 | V37I | WT | F100W | F98L |
V013 | V014 | V37A_W103V | P44W | V37W | F98A |
V015 | V014 | V37A_W103H | P44W | V37W | F98A |
V016 | V017 | V37A_W103H | P44W | V37A_W103V | F98W |
V005 | V018 | V37A_W103H | P44W | V37A_W103V | F98L |
V005 | V019 | V37A_W103H | P44W | V37I_F100W | F98L |
V020 | V021 | L45W | Y87G | V37A_W103H | P44W |
V022 | V007 | WT | F98W | V37W | F98A |
V023 | V009 | WT | WT | V37W | F98A |
V024 | V025 | Q39R | Q38E | V37W | F98A |
V026 | V027 | Q39R | Q38E | WT | WT |
V028 | V029 | Q39R | Q38E | Q39E | Q38R |
V030 | V031 | Q39R | Q38D | Q39E | Q38R |
V032 | V033 | Q39M | Q38M | Q39R | Q38E |
V034 | V035 | Q39K | Q38N_T85E | Q39D | Q38N_T85K |
V034 | V036 | Q39K | Q38N_T85E | Q39E | Q38N_T85K |
V037 | V038 | Q39E | Q38R | V37W | F98A |
V039 | V030 | Q39D | Q38R | Q39R | Q38D |
V040 | V041 | V37E | L89R_F98T | WT | WT |
V042 | V043 | V37E_F100D | L89R_F98W | WT | WT |
V044 | V045 | V37E_F100D | L89R_F98W | V37S_A97K | F98Y |
H(Kabat) | L(Kabat) |
V37 | Y36 |
Q39 | Q38 |
L45 | P44 |
W47 | L89 |
F100 | F98 |
W103 | F116 |
L124 | F118 |
A139 | V133 |
F174 | L135 |
Claims (61)
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US61/761,641 | 2013-02-06 | ||
US201361818874P | 2013-05-02 | 2013-05-02 | |
US61/818,874 | 2013-05-02 | ||
US201361869200P | 2013-08-23 | 2013-08-23 | |
US61/869,200 | 2013-08-23 | ||
PCT/CA2013/050914 WO2014082179A1 (en) | 2012-11-28 | 2013-11-28 | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
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BR (1) | BR112015012385A2 (zh) |
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