CN1049223C - 改进的脑膜炎双球菌多糖结合菌苗 - Google Patents

改进的脑膜炎双球菌多糖结合菌苗 Download PDF

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Publication number
CN1049223C
CN1049223C CN90110444A CN90110444A CN1049223C CN 1049223 C CN1049223 C CN 1049223C CN 90110444 A CN90110444 A CN 90110444A CN 90110444 A CN90110444 A CN 90110444A CN 1049223 C CN1049223 C CN 1049223C
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CN
China
Prior art keywords
gbmp
polysaccharide
binding substances
positive
acyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN90110444A
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English (en)
Chinese (zh)
Other versions
CN1055541A (zh
Inventor
哈罗德·J·詹宁斯
弗朗西斯·米琼
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National Research Council of Canada
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National Research Council of Canada
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Publication of CN1055541A publication Critical patent/CN1055541A/zh
Application granted granted Critical
Publication of CN1049223C publication Critical patent/CN1049223C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1217—Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN90110444A 1989-12-14 1990-12-14 改进的脑膜炎双球菌多糖结合菌苗 Expired - Fee Related CN1049223C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14
US07/448,195 1989-12-14

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN93119467A Division CN1036504C (zh) 1989-12-14 1993-11-22 改进脑膜炎双球菌b血清群多糖的抗原结合物的制备方法
CN93114763A Division CN1036522C (zh) 1989-12-14 1993-11-22 改进大肠杆菌k1夹膜多糖的制备方法
CN93114764A Division CN1072506C (zh) 1989-12-14 1993-11-22 改进的脑膜炎双球菌多糖结合菌苗

Publications (2)

Publication Number Publication Date
CN1055541A CN1055541A (zh) 1991-10-23
CN1049223C true CN1049223C (zh) 2000-02-09

Family

ID=23779371

Family Applications (4)

Application Number Title Priority Date Filing Date
CN90110444A Expired - Fee Related CN1049223C (zh) 1989-12-14 1990-12-14 改进的脑膜炎双球菌多糖结合菌苗
CN93114764A Expired - Fee Related CN1072506C (zh) 1989-12-14 1993-11-22 改进的脑膜炎双球菌多糖结合菌苗
CN93114763A Expired - Fee Related CN1036522C (zh) 1989-12-14 1993-11-22 改进大肠杆菌k1夹膜多糖的制备方法
CN93119467A Expired - Fee Related CN1036504C (zh) 1989-12-14 1993-11-22 改进脑膜炎双球菌b血清群多糖的抗原结合物的制备方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN93114764A Expired - Fee Related CN1072506C (zh) 1989-12-14 1993-11-22 改进的脑膜炎双球菌多糖结合菌苗
CN93114763A Expired - Fee Related CN1036522C (zh) 1989-12-14 1993-11-22 改进大肠杆菌k1夹膜多糖的制备方法
CN93119467A Expired - Fee Related CN1036504C (zh) 1989-12-14 1993-11-22 改进脑膜炎双球菌b血清群多糖的抗原结合物的制备方法

Country Status (30)

Country Link
US (3) US5576002A (enExample)
EP (1) EP0504202B1 (enExample)
JP (1) JP2637845B2 (enExample)
KR (1) KR0158436B1 (enExample)
CN (4) CN1049223C (enExample)
AR (1) AR243934A1 (enExample)
AT (1) ATE121947T1 (enExample)
AU (1) AU641715B2 (enExample)
BR (1) BR9007917A (enExample)
CA (1) CA2071811C (enExample)
CZ (1) CZ283530B6 (enExample)
DE (1) DE69019164T2 (enExample)
DK (1) DK0504202T3 (enExample)
ES (1) ES2071288T3 (enExample)
FI (2) FI104539B (enExample)
HR (1) HRP920872A2 (enExample)
HU (2) HU218146B (enExample)
IE (1) IE68414B1 (enExample)
IL (1) IL96676A (enExample)
IN (1) IN171747B (enExample)
NO (2) NO305275B1 (enExample)
NZ (1) NZ236471A (enExample)
PH (1) PH30305A (enExample)
PL (2) PL166035B1 (enExample)
RO (1) RO111416B1 (enExample)
RU (1) RU2105568C1 (enExample)
SI (1) SI20008B (enExample)
WO (1) WO1991008772A1 (enExample)
YU (1) YU24391A (enExample)
ZA (1) ZA9010065B (enExample)

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ES2160601T3 (es) * 1992-09-24 2001-11-16 Brigham & Womens Hospital Vacunas de conjugado de polisacaridos de estreptococos del grupo b tipo ii y tipo v-proteina.
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US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
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US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
DE69615362T3 (de) * 1995-06-07 2006-07-20 Smithkline Beecham Biologicals S.A. Impfstoff mit einem polysaccharidantigen-trägerprotein-konjugat und einem trägerprotein
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
US5811102A (en) 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
JP4162267B2 (ja) 1996-08-27 2008-10-08 カイロン コーポレイション Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ複合糖質およびその使用法
EP0922059B1 (en) 1996-08-27 2003-10-22 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions
US6426074B1 (en) 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
EP0994723A1 (en) 1997-06-24 2000-04-26 Chiron Corporation Methods of immunizing adults using anti-meningococcal vaccine compositions
PT1630168E (pt) * 1997-08-27 2011-07-20 Novartis Vaccines & Diagnostic Compostos miméticos moleculares de péptidos de meningococos do serogrupo b
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US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6518037B2 (en) * 1999-11-12 2003-02-11 University Of Iowa Research Foundation Two-component system that controls bacterial membrane synthesis
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
GB0011108D0 (en) * 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
RU2322451C2 (ru) * 2001-04-17 2008-04-20 Новартис Вэксинс Энд Диагностикс, Инк. Молекулярные миметики эпитопов менингококка в, которые вызывают выработку функционально активных антител
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
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CN105267974A (zh) * 2007-06-20 2016-01-27 辉瑞爱尔兰制药公司 用于缀合疫苗的经过修饰的多糖
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Also Published As

Publication number Publication date
BR9007917A (pt) 1992-10-20
FI19991917L (fi) 1999-09-09
RU2105568C1 (ru) 1998-02-27
HU9201966D0 (en) 1992-10-28
CN1055541A (zh) 1991-10-23
NO307835B1 (no) 2000-06-05
CA2071811C (en) 2003-11-04
AU6898791A (en) 1991-07-18
CN1100656A (zh) 1995-03-29
HUT64480A (en) 1994-01-28
RO111416B1 (ro) 1996-10-31
NO973311L (no) 1992-08-14
NO922316L (no) 1992-08-14
EP0504202B1 (en) 1995-05-03
IL96676A0 (en) 1991-09-16
AR243934A1 (es) 1993-09-30
HRP920872A2 (en) 1997-06-30
SI20008A (sl) 2000-02-29
CN1072506C (zh) 2001-10-10
NZ236471A (en) 1992-10-28
PL166035B1 (pl) 1995-03-31
YU24391A (sh) 1995-12-04
US5576002A (en) 1996-11-19
IE68414B1 (en) 1996-06-12
FI104539B (fi) 2000-02-29
KR0158436B1 (ko) 1998-12-01
CN1100428A (zh) 1995-03-22
US5683699A (en) 1997-11-04
HU218146B (hu) 2000-06-28
US5902586A (en) 1999-05-11
AU641715B2 (en) 1993-09-30
CZ628490A3 (en) 1997-12-17
PH30305A (en) 1997-02-20
CN1036504C (zh) 1997-11-26
ES2071288T3 (es) 1995-06-16
PL166659B1 (pl) 1995-06-30
DE69019164D1 (de) 1995-06-08
FI922737A0 (fi) 1992-06-12
IL96676A (en) 1996-09-12
ATE121947T1 (de) 1995-05-15
PL288271A1 (en) 1991-12-16
NO922316D0 (no) 1992-06-12
ZA9010065B (en) 1992-02-26
NO305275B1 (no) 1999-05-03
DE69019164T2 (de) 1995-09-07
CA2071811A1 (en) 1991-06-15
JP2637845B2 (ja) 1997-08-06
IN171747B (enExample) 1992-12-26
FI19991917A7 (fi) 1999-09-09
IE904513A1 (en) 1991-06-19
WO1991008772A1 (en) 1991-06-27
EP0504202A1 (en) 1992-09-23
JPH05505392A (ja) 1993-08-12
CZ283530B6 (cs) 1998-04-15
NO973311D0 (no) 1997-07-17
SI20008B (en) 2001-02-28
CN1096516A (zh) 1994-12-21
DK0504202T3 (da) 1995-10-02
CN1036522C (zh) 1997-11-26

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