CN104812757B - 二螺吡咯烷衍生物的晶体 - Google Patents

二螺吡咯烷衍生物的晶体 Download PDF

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Publication number
CN104812757B
CN104812757B CN201380057995.9A CN201380057995A CN104812757B CN 104812757 B CN104812757 B CN 104812757B CN 201380057995 A CN201380057995 A CN 201380057995A CN 104812757 B CN104812757 B CN 104812757B
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crystal
diffraction pattern
crystals
ray powder
compound
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CN104812757A (zh
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吉田祥子
杉本雄
杉本雄一
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Sankyo Co Ltd
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Sankyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380057995.9A 2012-09-06 2013-09-05 二螺吡咯烷衍生物的晶体 Active CN104812757B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-195761 2012-09-06
JP2012195761 2012-09-06
PCT/JP2013/073865 WO2014038606A1 (ja) 2012-09-06 2013-09-05 ジスピロピロリジン誘導体の結晶

Publications (2)

Publication Number Publication Date
CN104812757A CN104812757A (zh) 2015-07-29
CN104812757B true CN104812757B (zh) 2016-11-09

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US (8) US9359368B2 (enExample)
EP (1) EP2894156B1 (enExample)
JP (1) JP6016284B2 (enExample)
KR (1) KR102217410B1 (enExample)
CN (1) CN104812757B (enExample)
BR (1) BR112015004816B1 (enExample)
CA (1) CA2884238C (enExample)
ES (1) ES2637150T3 (enExample)
IN (1) IN2015MN00464A (enExample)
RU (1) RU2647840C2 (enExample)
TW (1) TWI586668B (enExample)
WO (1) WO2014038606A1 (enExample)

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CN117510491A (zh) 2016-12-23 2024-02-06 阿尔维纳斯运营股份有限公司 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法
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US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
IL300417A (en) 2017-01-26 2023-04-01 Arvinas Operations Inc Bifunctional benzothiophene compounds, preparations containing them and their use in therapy
WO2019099926A1 (en) 2017-11-17 2019-05-23 Arvinas, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor-associated kinase 4 polypeptides
MX2020010420A (es) 2018-04-04 2020-12-11 Arvinas Operations Inc Moduladores de la proteólisis y métodos asociados de uso.
CN112912376A (zh) 2018-08-20 2021-06-04 阿尔维纳斯运营股份有限公司 用于治疗神经变性疾病的具有E3泛素连接酶结合活性并靶向α-突触核蛋白的蛋白水解靶向嵌合(PROTAC)化合物
MX2022002415A (es) 2019-08-26 2022-03-22 Arvinas Operations Inc Metodos de tratamiento del cancer de mama con derivados de tetrahidronaftaleno como degradadores del receptor de estrogenos.
JP2023539663A (ja) 2020-08-28 2023-09-15 アルビナス・オペレーションズ・インコーポレイテッド 急速進行性線維肉腫タンパク質分解化合物及び関連する使用方法
BR112023004656A2 (pt) 2020-09-14 2023-05-09 Arvinas Operations Inc Formas cristalinas e amorfas de um composto para a degradação direcionada do receptor de estrogênio
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Also Published As

Publication number Publication date
US9884871B2 (en) 2018-02-06
US9540386B2 (en) 2017-01-10
KR20150048140A (ko) 2015-05-06
WO2014038606A1 (ja) 2014-03-13
US9359368B2 (en) 2016-06-07
US20170081336A1 (en) 2017-03-23
HK1210172A1 (en) 2016-04-15
RU2015112098A (ru) 2016-10-27
US20170081337A1 (en) 2017-03-23
CN104812757A (zh) 2015-07-29
US9718831B2 (en) 2017-08-01
US10023578B2 (en) 2018-07-17
CA2884238C (en) 2017-10-03
US9745315B2 (en) 2017-08-29
US9718830B2 (en) 2017-08-01
KR102217410B1 (ko) 2021-02-18
ES2637150T3 (es) 2017-10-11
EP2894156A1 (en) 2015-07-15
TWI586668B (zh) 2017-06-11
IN2015MN00464A (enExample) 2015-09-04
TW201410681A (zh) 2014-03-16
CA2884238A1 (en) 2014-03-13
BR112015004816A2 (pt) 2017-07-04
US20150210707A1 (en) 2015-07-30
US20180155356A1 (en) 2018-06-07
US20170081334A1 (en) 2017-03-23
EP2894156B1 (en) 2017-05-17
US10030030B2 (en) 2018-07-24
JPWO2014038606A1 (ja) 2016-08-12
US20170081335A1 (en) 2017-03-23
JP6016284B2 (ja) 2016-10-26
US20180155355A1 (en) 2018-06-07
EP2894156A4 (en) 2016-03-23
BR112015004816B1 (pt) 2022-04-26
RU2647840C2 (ru) 2018-03-21
US20160244458A1 (en) 2016-08-25

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