RU2647840C2 - Кристаллы производных диспиропирролидина - Google Patents

Кристаллы производных диспиропирролидина Download PDF

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Publication number
RU2647840C2
RU2647840C2 RU2015112098A RU2015112098A RU2647840C2 RU 2647840 C2 RU2647840 C2 RU 2647840C2 RU 2015112098 A RU2015112098 A RU 2015112098A RU 2015112098 A RU2015112098 A RU 2015112098A RU 2647840 C2 RU2647840 C2 RU 2647840C2
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crystal
diffraction pattern
angstroms
wavelength
radiation
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RU2015112098A
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Russian (ru)
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RU2015112098A (ru
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Соко ЙОСИДА
Юуити СУГИМОТО
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Дайити Санкио Компани, Лимитед
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2015112098A 2012-09-06 2013-09-05 Кристаллы производных диспиропирролидина RU2647840C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012195761 2012-09-06
JP2012-195761 2012-09-06
PCT/JP2013/073865 WO2014038606A1 (ja) 2012-09-06 2013-09-05 ジスピロピロリジン誘導体の結晶

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RU2015112098A RU2015112098A (ru) 2016-10-27
RU2647840C2 true RU2647840C2 (ru) 2018-03-21

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US (8) US9359368B2 (enExample)
EP (1) EP2894156B1 (enExample)
JP (1) JP6016284B2 (enExample)
KR (1) KR102217410B1 (enExample)
CN (1) CN104812757B (enExample)
BR (1) BR112015004816B1 (enExample)
CA (1) CA2884238C (enExample)
ES (1) ES2637150T3 (enExample)
IN (1) IN2015MN00464A (enExample)
RU (1) RU2647840C2 (enExample)
TW (1) TWI586668B (enExample)
WO (1) WO2014038606A1 (enExample)

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US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
MX2019008934A (es) 2017-01-26 2019-11-05 Arvinas Operations Inc Moduladores de la proteolisis del receptor de estrogeno y métodos asociados de uso,.
US11065231B2 (en) 2017-11-17 2021-07-20 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
CN119569702A (zh) 2018-04-04 2025-03-07 阿尔维纳斯运营股份有限公司 蛋白水解调节剂及相关使用方法
US11707452B2 (en) 2018-08-20 2023-07-25 Arvinas Operations, Inc. Modulators of alpha-synuclein proteolysis and associated methods of use
ES3061133T3 (en) 2019-08-26 2026-03-31 Arvinas Operations Inc Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
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Publication number Publication date
US20170081336A1 (en) 2017-03-23
CN104812757B (zh) 2016-11-09
EP2894156A4 (en) 2016-03-23
US20150210707A1 (en) 2015-07-30
US9745315B2 (en) 2017-08-29
RU2015112098A (ru) 2016-10-27
IN2015MN00464A (enExample) 2015-09-04
US20170081334A1 (en) 2017-03-23
TWI586668B (zh) 2017-06-11
US9540386B2 (en) 2017-01-10
US20180155355A1 (en) 2018-06-07
US9718830B2 (en) 2017-08-01
KR20150048140A (ko) 2015-05-06
US20170081335A1 (en) 2017-03-23
US9718831B2 (en) 2017-08-01
JPWO2014038606A1 (ja) 2016-08-12
JP6016284B2 (ja) 2016-10-26
CN104812757A (zh) 2015-07-29
US10023578B2 (en) 2018-07-17
ES2637150T3 (es) 2017-10-11
US10030030B2 (en) 2018-07-24
EP2894156A1 (en) 2015-07-15
BR112015004816A2 (pt) 2017-07-04
US20170081337A1 (en) 2017-03-23
CA2884238A1 (en) 2014-03-13
EP2894156B1 (en) 2017-05-17
BR112015004816B1 (pt) 2022-04-26
KR102217410B1 (ko) 2021-02-18
HK1210172A1 (en) 2016-04-15
WO2014038606A1 (ja) 2014-03-13
US20160244458A1 (en) 2016-08-25
TW201410681A (zh) 2014-03-16
US9884871B2 (en) 2018-02-06
US9359368B2 (en) 2016-06-07
US20180155356A1 (en) 2018-06-07
CA2884238C (en) 2017-10-03

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