KR102217410B1 - 디스피로피롤리딘 유도체의 결정 - Google Patents

디스피로피롤리딘 유도체의 결정 Download PDF

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KR102217410B1
KR102217410B1 KR1020157005386A KR20157005386A KR102217410B1 KR 102217410 B1 KR102217410 B1 KR 102217410B1 KR 1020157005386 A KR1020157005386 A KR 1020157005386A KR 20157005386 A KR20157005386 A KR 20157005386A KR 102217410 B1 KR102217410 B1 KR 102217410B1
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crystal
ray diffraction
powder
chloro
wavelength
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KR20150048140A (ko
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쇼코 요시다
유우이치 스기모토
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다이이찌 산쿄 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020157005386A 2012-09-06 2013-09-05 디스피로피롤리딘 유도체의 결정 Active KR102217410B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2012-195761 2012-09-06
JP2012195761 2012-09-06
PCT/JP2013/073865 WO2014038606A1 (ja) 2012-09-06 2013-09-05 ジスピロピロリジン誘導体の結晶

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KR20150048140A KR20150048140A (ko) 2015-05-06
KR102217410B1 true KR102217410B1 (ko) 2021-02-18

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US (8) US9359368B2 (enExample)
EP (1) EP2894156B1 (enExample)
JP (1) JP6016284B2 (enExample)
KR (1) KR102217410B1 (enExample)
CN (1) CN104812757B (enExample)
BR (1) BR112015004816B1 (enExample)
CA (1) CA2884238C (enExample)
ES (1) ES2637150T3 (enExample)
IN (1) IN2015MN00464A (enExample)
RU (1) RU2647840C2 (enExample)
TW (1) TWI586668B (enExample)
WO (1) WO2014038606A1 (enExample)

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JP2020505327A (ja) 2016-12-23 2020-02-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法
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US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
AU2018211975B2 (en) 2017-01-26 2022-05-26 Arvinas Operations, Inc. Modulators of estrogen receptor proteolysis and associated methods of use
US11065231B2 (en) 2017-11-17 2021-07-20 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
BR112020020307A2 (pt) 2018-04-04 2021-01-12 Arvinas Operations, Inc. Moduladores de proteólise e métodos de uso associados
US11707452B2 (en) 2018-08-20 2023-07-25 Arvinas Operations, Inc. Modulators of alpha-synuclein proteolysis and associated methods of use
CN114667147B (zh) 2019-08-26 2024-09-06 阿尔维纳斯运营股份有限公司 用四氢萘衍生物作为雌激素受体降解剂的治疗乳腺癌的方法
US12180193B2 (en) 2020-08-28 2024-12-31 Arvinas Operations, Inc. Accelerating fibrosarcoma protein degrading compounds and associated methods of use
CR20230162A (es) 2020-09-14 2023-06-02 Arvinas Operations Inc Formas cristalinas y amorfas de un compuesto para la degradación dirigida del receptor de estrógenos
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US20180155355A1 (en) 2018-06-07
CN104812757A (zh) 2015-07-29
ES2637150T3 (es) 2017-10-11
BR112015004816A2 (pt) 2017-07-04
HK1210172A1 (en) 2016-04-15
US20170081335A1 (en) 2017-03-23
RU2015112098A (ru) 2016-10-27
US20170081337A1 (en) 2017-03-23
CA2884238A1 (en) 2014-03-13
US9359368B2 (en) 2016-06-07
US9718830B2 (en) 2017-08-01
US20150210707A1 (en) 2015-07-30
WO2014038606A1 (ja) 2014-03-13
TWI586668B (zh) 2017-06-11
JP6016284B2 (ja) 2016-10-26
IN2015MN00464A (enExample) 2015-09-04
TW201410681A (zh) 2014-03-16
JPWO2014038606A1 (ja) 2016-08-12
US20170081336A1 (en) 2017-03-23
CN104812757B (zh) 2016-11-09
US9745315B2 (en) 2017-08-29
RU2647840C2 (ru) 2018-03-21
KR20150048140A (ko) 2015-05-06
US9718831B2 (en) 2017-08-01
US20160244458A1 (en) 2016-08-25
EP2894156A1 (en) 2015-07-15
US9884871B2 (en) 2018-02-06
BR112015004816B1 (pt) 2022-04-26
US20180155356A1 (en) 2018-06-07
US9540386B2 (en) 2017-01-10
US10030030B2 (en) 2018-07-24
US10023578B2 (en) 2018-07-17
US20170081334A1 (en) 2017-03-23
CA2884238C (en) 2017-10-03
EP2894156B1 (en) 2017-05-17
EP2894156A4 (en) 2016-03-23

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