CN1048015C - 双环四氢吡唑并吡啶类化合物 - Google Patents

双环四氢吡唑并吡啶类化合物 Download PDF

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Publication number
CN1048015C
CN1048015C CN94193233A CN94193233A CN1048015C CN 1048015 C CN1048015 C CN 1048015C CN 94193233 A CN94193233 A CN 94193233A CN 94193233 A CN94193233 A CN 94193233A CN 1048015 C CN1048015 C CN 1048015C
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CN
China
Prior art keywords
ethyl
oxo
tetrahydro
pyridine
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94193233A
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English (en)
Chinese (zh)
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CN1129940A (zh
Inventor
艾伦·J·杜普兰蒂尔
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Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
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Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN1129940A publication Critical patent/CN1129940A/zh
Application granted granted Critical
Publication of CN1048015C publication Critical patent/CN1048015C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN94193233A 1993-07-06 1994-06-16 双环四氢吡唑并吡啶类化合物 Expired - Fee Related CN1048015C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06
US08/088,292 1993-07-06

Publications (2)

Publication Number Publication Date
CN1129940A CN1129940A (zh) 1996-08-28
CN1048015C true CN1048015C (zh) 2000-01-05

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94193233A Expired - Fee Related CN1048015C (zh) 1993-07-06 1994-06-16 双环四氢吡唑并吡啶类化合物

Country Status (20)

Country Link
EP (1) EP0707585A1 (enExample)
JP (1) JP2944048B2 (enExample)
KR (1) KR100228949B1 (enExample)
CN (1) CN1048015C (enExample)
AU (1) AU695301B2 (enExample)
BR (1) BR9406946A (enExample)
CA (1) CA2166721C (enExample)
CZ (1) CZ3696A3 (enExample)
EG (1) EG20513A (enExample)
FI (1) FI943208A7 (enExample)
HU (1) HUT74170A (enExample)
IL (1) IL110175A (enExample)
MX (1) MX9405132A (enExample)
NO (1) NO305029B1 (enExample)
NZ (1) NZ266525A (enExample)
PL (1) PL312426A1 (enExample)
RU (1) RU2131876C1 (enExample)
TW (1) TW316904B (enExample)
WO (1) WO1995001980A1 (enExample)
ZA (1) ZA944844B (enExample)

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PL319758A1 (en) * 1994-10-20 1997-08-18 Pfizer Bicyclic tetrahydropyrasole pyridines and their application as medicines
JP3107827B2 (ja) * 1995-06-06 2000-11-13 ファイザー・インコーポレーテッド トリサイクリック５，６−ジヒドロ−９Ｈ−ピラゾロ［３，４−ｃ］−１，２，４−トリアゾロ［４，３−ａ］ピリジン類
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
AU724549B2 (en) * 1996-09-04 2000-09-28 Pfizer Inc. Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF)
EP1017384B1 (en) * 1997-09-26 2004-11-10 Zentaris GmbH Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
DE69921358T2 (de) 1998-12-23 2006-03-09 Bristol-Myers Squibb Pharma Co. Stickstoffhaltige heterobicyclen als faktor-xa-hemmer
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
EA006685B1 (ru) 1999-08-21 2006-02-24 Алтана Фарма Аг Синергетическая композиция
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
US7541354B2 (en) * 2000-08-10 2009-06-02 Pfizer Italia S.R.L. Bicyclo-pyrazoles
NZ524191A (en) * 2000-08-14 2004-11-26 Ortho Mcneil Pharm Inc Substituted pyrazoles useful for treating autoimmune diseases mediated by cathepsin S
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
WO2002085353A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors
WO2002085356A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors
JP4196678B2 (ja) 2001-04-26 2008-12-17 味の素株式会社 複素環化合物
CN102617567A (zh) * 2001-09-21 2012-08-01 百时美施贵宝公司 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
NZ541836A (en) 2003-02-27 2008-12-24 Palau Pharma Sa Pyrazolopyridine derivatives
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
MX375926B (es) 2013-08-09 2025-03-07 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
EP0531901A2 (en) * 1991-09-09 1993-03-17 Fujisawa Pharmaceutical Co., Ltd. Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
EP0531901A2 (en) * 1991-09-09 1993-03-17 Fujisawa Pharmaceutical Co., Ltd. Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA，VOI.86(5),29733C 1997.1.1 Kametani,Tetsujietal *

Also Published As

Publication number Publication date
TW316904B (enExample) 1997-10-01
CN1129940A (zh) 1996-08-28
JP2944048B2 (ja) 1999-08-30
CA2166721C (en) 1999-07-27
AU695301B2 (en) 1998-08-13
WO1995001980A1 (en) 1995-01-19
IL110175A0 (en) 1994-10-07
PL312426A1 (en) 1996-04-29
IL110175A (en) 2000-01-31
CZ3696A3 (en) 1997-06-11
FI943208L (fi) 1995-01-07
HU9503934D0 (en) 1996-03-28
EG20513A (en) 1999-06-30
NZ266525A (en) 1997-10-24
KR100228949B1 (ko) 1999-11-01
FI943208A0 (fi) 1994-07-05
CA2166721A1 (en) 1995-01-19
MX9405132A (es) 1995-01-31
NO960056D0 (no) 1996-01-05
NO305029B1 (no) 1999-03-22
NO960056L (no) 1996-01-05
FI943208A7 (fi) 1995-01-07
HUT74170A (en) 1996-11-28
EP0707585A1 (en) 1996-04-24
BR9406946A (pt) 1996-08-06
KR960703852A (ko) 1996-08-31
ZA944844B (en) 1996-01-05
RU2131876C1 (ru) 1999-06-20
AU6805794A (en) 1995-02-06
JPH08507084A (ja) 1996-07-30

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