AU695301B2 - Bicyclic tetrahydro pyrazolopyridines - Google Patents

Bicyclic tetrahydro pyrazolopyridines Download PDF

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Publication number
AU695301B2
AU695301B2 AU68057/94A AU6805794A AU695301B2 AU 695301 B2 AU695301 B2 AU 695301B2 AU 68057/94 A AU68057/94 A AU 68057/94A AU 6805794 A AU6805794 A AU 6805794A AU 695301 B2 AU695301 B2 AU 695301B2
Authority
AU
Australia
Prior art keywords
ethyl
oxo
pyrazolo
tetrahydro
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68057/94A
Other languages
English (en)
Other versions
AU6805794A (en
Inventor
Allen Jacob Duplantier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of AU6805794A publication Critical patent/AU6805794A/en
Application granted granted Critical
Publication of AU695301B2 publication Critical patent/AU695301B2/en
Priority to AU92402/98A priority Critical patent/AU9240298A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU68057/94A 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines Ceased AU695301B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU92402/98A AU9240298A (en) 1993-07-06 1998-11-13 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06
US088292 1993-07-06
PCT/IB1994/000156 WO1995001980A1 (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU92402/98A Division AU9240298A (en) 1993-07-06 1998-11-13 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (2)

Publication Number Publication Date
AU6805794A AU6805794A (en) 1995-02-06
AU695301B2 true AU695301B2 (en) 1998-08-13

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68057/94A Ceased AU695301B2 (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Country Status (20)

Country Link
EP (1) EP0707585A1 (enExample)
JP (1) JP2944048B2 (enExample)
KR (1) KR100228949B1 (enExample)
CN (1) CN1048015C (enExample)
AU (1) AU695301B2 (enExample)
BR (1) BR9406946A (enExample)
CA (1) CA2166721C (enExample)
CZ (1) CZ3696A3 (enExample)
EG (1) EG20513A (enExample)
FI (1) FI943208L (enExample)
HU (1) HUT74170A (enExample)
IL (1) IL110175A (enExample)
MX (1) MX9405132A (enExample)
NO (1) NO305029B1 (enExample)
NZ (1) NZ266525A (enExample)
PL (1) PL312426A1 (enExample)
RU (1) RU2131876C1 (enExample)
TW (1) TW316904B (enExample)
WO (1) WO1995001980A1 (enExample)
ZA (1) ZA944844B (enExample)

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JPH09511758A (ja) * 1994-10-20 1997-11-25 フアイザー・インコーポレイテツド 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用
ES2172583T3 (es) * 1995-06-06 2002-10-01 Pfizer 5,6-dihidro-9h-pirazol(3,4-c)-1,2,4-triazol(4,3-alfa)piridinas triciclicas.
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
KR100338610B1 (ko) * 1996-09-04 2002-05-27 디. 제이. 우드, 스피겔 알렌 제이 인다졸 유도체 및 포스포디에스터라제 (pde) 유형 iv 및 종양괴사인자 (tnf) 생산의 억제제로서 그의 용도
SK285357B6 (sk) * 1997-09-26 2006-11-03 Zentaris Gmbh Zlúčeniny na báze azabenzimidazolu modulujúce funkciu serínovej/treonínovej proteínkinázy
NZ511674A (en) * 1998-12-23 2003-11-28 Du Pont Pharm Co Nitrogen containing heterobicycles as factor Xa inhibitors
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
HRP20020158B1 (en) 1999-08-21 2007-08-31 Altana Pharma Ag Action of synergistic combination
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
CN102060857A (zh) * 2000-08-10 2011-05-18 辉瑞意大利有限公司 具有激酶抑制剂活性的二环吡唑类、其制备方法和包含它们的药物组合物
DE60118004T2 (de) * 2000-08-14 2006-11-16 Ortho-Mcneil Pharmaceutical, Inc. Substituierte pyrazole
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
WO2002085356A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors
EP1396493A4 (en) * 2001-04-26 2005-08-03 Ajinomoto Kk HETEROCYCLIC COMPOUNDS
AU2002341693B2 (en) * 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004076450A1 (en) 2003-02-27 2004-09-10 J. Uriach Y Compañia S.A. Pyrazolopyridine derivates
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives

Family Cites Families (7)

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FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives

Also Published As

Publication number Publication date
CN1129940A (zh) 1996-08-28
NZ266525A (en) 1997-10-24
NO960056D0 (no) 1996-01-05
AU6805794A (en) 1995-02-06
CA2166721A1 (en) 1995-01-19
HU9503934D0 (en) 1996-03-28
FI943208A7 (fi) 1995-01-07
BR9406946A (pt) 1996-08-06
WO1995001980A1 (en) 1995-01-19
TW316904B (enExample) 1997-10-01
FI943208A0 (fi) 1994-07-05
HUT74170A (en) 1996-11-28
PL312426A1 (en) 1996-04-29
RU2131876C1 (ru) 1999-06-20
MX9405132A (es) 1995-01-31
NO960056L (no) 1996-01-05
JP2944048B2 (ja) 1999-08-30
KR100228949B1 (ko) 1999-11-01
CA2166721C (en) 1999-07-27
NO305029B1 (no) 1999-03-22
CN1048015C (zh) 2000-01-05
IL110175A (en) 2000-01-31
ZA944844B (en) 1996-01-05
JPH08507084A (ja) 1996-07-30
EP0707585A1 (en) 1996-04-24
IL110175A0 (en) 1994-10-07
CZ3696A3 (en) 1997-06-11
FI943208L (fi) 1995-01-07
KR960703852A (ko) 1996-08-31
EG20513A (en) 1999-06-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired