CN104797244B - 用于结肠排空的制剂和制备制剂方法 - Google Patents

用于结肠排空的制剂和制备制剂方法 Download PDF

Info

Publication number
CN104797244B
CN104797244B CN201380049674.4A CN201380049674A CN104797244B CN 104797244 B CN104797244 B CN 104797244B CN 201380049674 A CN201380049674 A CN 201380049674A CN 104797244 B CN104797244 B CN 104797244B
Authority
CN
China
Prior art keywords
formulation
pharmaceutically acceptable
acceptable excipient
intragranular
diluent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380049674.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN104797244A (zh
Inventor
雷扎·法特希
帕特里克·劳克林·麦克林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Redhill Biopharma Ltd
Original Assignee
Redhill Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redhill Biopharma Ltd filed Critical Redhill Biopharma Ltd
Priority to CN201810101389.7A priority Critical patent/CN108175773A/zh
Publication of CN104797244A publication Critical patent/CN104797244A/zh
Application granted granted Critical
Publication of CN104797244B publication Critical patent/CN104797244B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380049674.4A 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法 Expired - Fee Related CN104797244B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810101389.7A CN108175773A (zh) 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261676608P 2012-07-27 2012-07-27
US61/676,608 2012-07-27
PCT/IB2013/001640 WO2014016671A2 (en) 2012-07-27 2013-07-26 Formulations and methods of manufacturing formulations for use in colonic evacuation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810101389.7A Division CN108175773A (zh) 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法

Publications (2)

Publication Number Publication Date
CN104797244A CN104797244A (zh) 2015-07-22
CN104797244B true CN104797244B (zh) 2018-03-09

Family

ID=49997911

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380049674.4A Expired - Fee Related CN104797244B (zh) 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法
CN201810101389.7A Pending CN108175773A (zh) 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810101389.7A Pending CN108175773A (zh) 2012-07-27 2013-07-26 用于结肠排空的制剂和制备制剂方法

Country Status (24)

Country Link
US (3) US10166219B2 (enExample)
EP (1) EP2877163B1 (enExample)
JP (1) JP6454640B2 (enExample)
KR (1) KR102152873B1 (enExample)
CN (2) CN104797244B (enExample)
AU (1) AU2013294737B2 (enExample)
BR (1) BR112015001640A2 (enExample)
CA (1) CA2880282C (enExample)
CY (1) CY1121852T1 (enExample)
DK (1) DK2877163T3 (enExample)
ES (1) ES2717282T3 (enExample)
HR (1) HRP20190550T1 (enExample)
HU (1) HUE043852T2 (enExample)
IL (1) IL236791B (enExample)
IN (1) IN2015DN00637A (enExample)
MX (1) MX366707B (enExample)
NZ (1) NZ704014A (enExample)
PH (1) PH12015500165A1 (enExample)
PL (1) PL2877163T3 (enExample)
PT (1) PT2877163T (enExample)
RU (1) RU2015106688A (enExample)
SI (1) SI2877163T1 (enExample)
TR (1) TR201904884T4 (enExample)
WO (1) WO2014016671A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011342368B2 (en) 2010-12-13 2016-11-17 Rite-Prep Pty Ltd Gastric and colonic formulations and methods for making and using them
US10166219B2 (en) 2012-07-27 2019-01-01 Redhill Bipharma Ltd. Formulations and methods of manufacturing formulations for use in colonic evacuation
IN2013MU02911A (enExample) * 2013-09-10 2015-07-03 Cadila Healthcare Ltd
KR101420315B1 (ko) 2014-03-19 2014-07-17 남봉길 약학적 액제 조성물
RU2018105869A (ru) 2015-08-17 2019-09-19 Ферринг Б.В. Жидкие составы, содержащие пикосульфат и цитрат магния
WO2018009761A1 (en) * 2016-07-08 2018-01-11 Ferring B.V. Stabilized liquid formulations containing picosulfate
EP3345591A1 (en) * 2017-01-06 2018-07-11 Oystershell NV Oral dosage form for enhanced solubilization of a poorly soluble active agent and method of preparation
JP7340572B2 (ja) * 2021-08-20 2023-09-07 セトラスホールディングス株式会社 酸化マグネシウム錠剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858403A (en) * 1995-11-03 1999-01-12 Borody; Thomas Julius Picosulfate-containing preparation for colonic evacuation
CN1762335A (zh) * 1997-08-22 2006-04-26 史密丝克莱恩比彻姆公司 快速崩解的甲基纤维素片剂
CN101406457A (zh) * 2007-10-12 2009-04-15 辉凌国际制药（瑞士）有限公司 制备药物产品的方法

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459863A (en) * 1966-10-14 1969-08-05 Merck & Co Inc Color-stable ascorbic acid tablet
US4186025A (en) 1975-09-25 1980-01-29 Merck & Co., Inc. Aqueous polysaccharide composition
US4452779A (en) 1982-02-03 1984-06-05 Cockerill Vernon Composition and method of treating lactating mammals
DK454683D0 (da) 1983-10-03 1983-10-03 Mogens Gjerloev Tarmreguleringsmiddel til behandling af diarre hos dyr samt anvendelse heraf
EP0222834A4 (en) 1985-04-18 1989-10-04 Borody Thomas J TREATMENT OF NON-ULCERATIVE DYSPEPSIA WITH BISMUTOUS SALTS.
US4766004A (en) 1986-12-19 1988-08-23 Warner-Lambert Company Crunchy, highly palatable, bulk-increasing, dietary fiber supplement composition
IL86859A (en) 1987-07-10 1991-12-15 E Z Em Inc Aqueous cathartic solution containing inorganic salts
EP0439453B1 (en) 1987-10-12 1994-01-19 Exomed Australia Pty. Ltd. (ACN 051 976 446) Improved method for treatment of gastrointestinal disorders
DE3889547T2 (de) 1987-12-24 1994-11-17 Borody Thomas J Orthostatische waschlösungen.
US5443826A (en) 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
WO1990001335A1 (en) 1988-08-02 1990-02-22 Borody Thomas J Treatment of gastro-intestinal disorders
US5213807A (en) 1990-05-03 1993-05-25 Chemburkar Pramod B Pharmaceutical composition containing ibuprofen and a prostaglandin
US5232699A (en) 1990-07-26 1993-08-03 The Proctor & Gamble Company Laxative compositions
WO1992006690A1 (en) 1990-10-22 1992-04-30 Borody Thomas J Treatment of non-inflammatory and non-infectious bowel disorders
US5519014A (en) 1990-10-22 1996-05-21 Borody; Thomas J. Treatment of non-inflammatory and non-infectious bowel disorders
US5173296A (en) 1990-11-16 1992-12-22 The Procter & Gamble Company Compositions containing psyllium
JPH06132767A (ja) 1992-10-22 1994-05-13 Rohm Co Ltd 圧電発振子
DK0686034T3 (da) 1993-02-26 2001-08-27 Procter & Gamble Bisacodyl-doseringsform
JP2974550B2 (ja) 1993-06-01 1999-11-10 ビオフェルミン製薬株式会社 経口投与用固体組成物
WO1995011024A1 (en) * 1993-10-19 1995-04-27 The Procter & Gamble Company Picosulphate dosage form
JP3850891B2 (ja) 1994-03-01 2006-11-29 ゼリア新薬工業株式会社 緩下効果を有する組成物
AUPM695294A0 (en) 1994-07-20 1994-08-11 Borody, Thomas Julius Improved combination therapy dose unit
AUPM864894A0 (en) 1994-10-07 1994-11-03 Borody, Thomas Julius Treatment of bowel-dependent neurological disorders
RU2098100C1 (ru) 1995-10-11 1997-12-10 Максимова Ирина Сергеевна Ирригационный раствор для офтальмологических операций
US6103268A (en) 1995-11-03 2000-08-15 Borody; Thomas Julius Administering osmotic colonic evacuant containing a picosulfate
AU771576B2 (en) 1995-11-03 2004-03-25 Red Hill Biopharma Ltd. Improved preparation for colonic evacuation
NZ333493A (en) 1995-11-03 2000-06-23 Nicolas Peter Shortis Method of evacuating a patient's colon by oral administration of an osmotic colonic evacuant in powder form
US6087386A (en) 1996-06-24 2000-07-11 Merck & Co., Inc. Composition of enalapril and losartan
EP1380308B1 (en) * 1996-07-12 2008-07-09 Daiichi Pharmaceutical Co., Ltd. Quickly disintegrable compression-molded materials and process for producing the same
US5948787A (en) 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
US6162464A (en) 1997-03-31 2000-12-19 Inkine Pharmaceutical, Inc. Non-aqueous colonic purgative formulations
DE69839261T2 (de) 1997-04-01 2009-03-26 Borody, Thomas Julius, Five Dock Verfahren und zusammensetzungen zur behandlung entzündlicher darmerkrankungen
US6551632B2 (en) 1997-04-01 2003-04-22 Thomas Julius Borody Methods and compositions for treating inflammatory bowel disease
EP0988858A1 (en) 1997-04-18 2000-03-29 Taisho Pharmaceutical Co., Ltd Microemulsion
AUPO665397A0 (en) 1997-05-07 1997-05-29 Borody, Thomas Julius Novel therapy for constipation
AR016827A1 (es) 1997-08-22 2001-08-01 Smithkline Beecham Corp PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
AR017512A1 (es) * 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
JP4092748B2 (ja) 1997-09-05 2008-05-28 ニプロ株式会社 腸管洗浄液
US5843477A (en) * 1997-09-30 1998-12-01 Bayer Corporation Lubricants for use in tabletting
NZ505123A (en) * 1997-12-19 2003-07-25 Smithkline Beecham Corp Process for manufacturing bite-dispersion tablets by compressing medicaments and other ingredients into granulates then compressing the granulates and other ingredients into tablets, and the tablets thereof
AUPP325398A0 (en) 1998-04-30 1998-05-21 Borody, Thomas J. Improved method for eradicating h. pylori
AUPP437698A0 (en) 1998-06-30 1998-07-23 Baumgart, Karl Methods for treatment of coronary, carotid and other vascular disease
EP1005863A1 (en) 1998-12-04 2000-06-07 Synthelabo Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
DE60040214D1 (de) 1999-02-26 2008-10-23 Shionogi & Co Kaubare weichkapseln mit verbesserten verabreichungseigenschaften sowie verfahren zu deren herstellung
US6858403B2 (en) 1999-05-11 2005-02-22 M-Biotech, Inc. Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
DE19930030B4 (de) 1999-06-30 2004-02-19 Meduna Arzneimittel Gmbh CO-3-ungesättigte Fettsäuren enthaltende orale Darreichungsform
CN1288730A (zh) 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
US6774111B1 (en) 2000-03-14 2004-08-10 Abbott Laboratories Carbohydrate system and a method for providing nutrition to a diabetic
NZ522036A (en) 2000-04-19 2004-04-30 Borody Thomas J Compositions and therapies for hyperlipidaemia-associated disorders
JP2003535903A (ja) 2000-06-19 2003-12-02 ミューコプロテック・プロプライエタリー・リミテッド プロバイオティックを用いた、粘膜表面での細菌またはウイルス感染の免疫療法または治療、およびそのための組成物
AUPQ854100A0 (en) 2000-07-03 2000-07-27 Helirad Pty Ltd Methods for monitoring treatment of helicobacter infection
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
KR20030087009A (ko) 2001-02-27 2003-11-12 랜박시 래보러터리스 리미티드 세프포독심 프록세틸의 경구용 약학 조성물
EP1367907B1 (en) 2001-03-13 2007-02-28 Kellogg Company Aerated food component
US6790453B2 (en) 2001-03-14 2004-09-14 Mccormick & Company, Inc. Encapsulation compositions and process for preparing the same
US7815956B2 (en) 2001-04-27 2010-10-19 Pepsico Use of erythritol and D-tagatose in diet or reduced-calorie beverages and food products
IL159129A0 (en) 2001-06-01 2004-05-12 Pozen Inc PHARMACEUTICAL COMPOSITIONS FOR THE COORDINATED DELIVERY OF NSAIDs
AU2002315779B2 (en) 2001-07-05 2007-03-22 Wakunaga Pharmaceutical Co.,Ltd Soft capsules
US20030092724A1 (en) 2001-09-18 2003-05-15 Huaihung Kao Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
AUPS017702A0 (en) 2002-01-25 2002-02-14 Atopic Pty Ltd Methods and compositions for the treatment of asthma and related disorders
AUPS088702A0 (en) 2002-03-04 2002-03-28 Borody, Thomas Julius Electrolyte purgative
US6753009B2 (en) 2002-03-13 2004-06-22 Mcneil-Ppc, Inc. Soft tablet containing high molecular weight polyethylene oxide
ES2320748T5 (es) 2002-04-05 2017-02-20 Euro-Celtique S.A. Matriz para la liberación sostenida, invariable e independiente de compuestos activos
US6946149B2 (en) 2002-04-30 2005-09-20 Braintree Laboratories, Inc. Salt solution for colon cleansing
JP4591742B2 (ja) 2003-01-06 2010-12-01 大正製薬株式会社 ジオクチルソジウムスルホサクシネート配合製剤およびその製造方法
AU2003900553A0 (en) 2003-02-10 2003-02-20 Borody, Thomas Julius Novel Improved Method for Detection of Dientamoeba fragilis and other Parasites
RU2005134364A (ru) 2003-04-08 2006-06-10 Проджиникс Фармасьютикалз, Инк. (Us) Комбинированное лечение запора
AU2004238321B2 (en) 2003-05-07 2009-08-27 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
US20040265378A1 (en) 2003-06-25 2004-12-30 Yingxu Peng Method and compositions for producing granules containing high concentrations of biologically active substances
US7687075B2 (en) * 2003-11-19 2010-03-30 Salix Pharmaceuticals, Ltd. Colonic purgative composition with soluble binding agent
JP2005255595A (ja) 2004-03-10 2005-09-22 Taisho Pharmaceut Co Ltd ジオクチルソジウムスルホサクシネート配合錠剤
JP2005272401A (ja) 2004-03-25 2005-10-06 Tendou Seiyaku Kk チュアブル錠
CA2559239C (en) 2004-04-13 2021-04-06 Boehringer Ingelheim International Gmbh Use of simethicone and sodium picosulphate in constipated patients suffering from bloated feeling and gas discomfort during the night
KR100749229B1 (ko) 2005-04-29 2007-08-13 (주)아모레퍼시픽 당 및 당알콜을 함유하는 변비개선용 조성물
US20060275223A1 (en) 2005-06-02 2006-12-07 Burr James B Erythritol compositions for teeth and gums
DE102006033014A1 (de) 2005-09-13 2007-04-05 Volkswagen Ag Eingabevorrichtung für ein Kraftfahrzeug
WO2007057924A1 (en) 2005-11-21 2007-05-24 Panacea Biotec Ltd Laxative composition on the basis of triphala
CA2635313C (en) 2005-12-29 2013-12-31 Osmotica Corp. Triple combination release multi-layered tablet
JP5006567B2 (ja) 2006-04-14 2012-08-22 花王株式会社 口腔用固形製剤
EP2068837A2 (en) 2006-07-28 2009-06-17 Dr. Reddy's Laboratories Ltd. Granular pharmaceutical compositions
WO2008021394A2 (en) 2006-08-15 2008-02-21 Theraquest Biosciences, Llc Pharmaceutical formulations of cannabinoids and method of use
WO2008027442A2 (en) 2006-08-30 2008-03-06 Theraquest Biosciences, Llc Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use
DE602007007355D1 (de) 2006-12-04 2010-08-05 Du Pont Beschichtungszusammensetzung aus acrylpolyol
AU2008253583A1 (en) 2007-05-17 2008-11-27 David Lubowski Combination laxative compositions comprising a colonic stimulant and a bulking laxative
CA2687192C (en) 2007-06-04 2015-11-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
WO2008148742A2 (de) 2007-06-06 2008-12-11 Basf Se Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten
JP2010529073A (ja) 2007-06-06 2010-08-26 ビーエーエスエフ ソシエタス・ヨーロピア チュアブル錠及びトローチ剤製造のための医薬製剤
DK2264042T3 (da) 2007-07-27 2012-08-20 Cargill Inc Mikronisering af polyoler
US20100233278A1 (en) 2007-09-27 2010-09-16 Akiko Ookawa Rapidly disintegrating solid preparation
PL2572705T3 (pl) 2007-10-01 2018-01-31 Lesvi Laboratorios Sl Tabletki ulegające rozpadowi w jamie ustnej
US8481083B2 (en) * 2007-10-12 2013-07-09 Ferring International Center S.A. Granular compositions of magnesium oxide and citric acid and uses thereof
MX2010004222A (es) 2007-10-19 2010-09-14 Purdue Research Foundation Formulaciones solidas de compuestos cristalinos.
JP5258268B2 (ja) 2007-11-19 2013-08-07 フロイント産業株式会社 球形粒の製造方法
US20090155363A1 (en) 2007-12-14 2009-06-18 Todd Maibach Methods for oral administration of active drugs
US20090169622A1 (en) * 2007-12-27 2009-07-02 Roxane Laboratories, Inc. Delayed-release oral pharmaceutical composition for treatment of colonic disorders
WO2009084678A1 (ja) 2007-12-28 2009-07-09 Sawai Pharmaceutical Co., Ltd. 口腔内崩壊錠およびその製造方法
US20090258090A1 (en) 2008-04-11 2009-10-15 Braintree Laboratories, Inc. Colon cleansing solution
US20100178413A1 (en) 2008-12-17 2010-07-15 Mark Gorris Food-based Supplement Delivery System
US20100285164A1 (en) 2009-05-11 2010-11-11 Jrs Pharma Orally Disintegrating Excipient
WO2010138439A1 (en) 2009-05-28 2010-12-02 Aptapharma, Inc. Multiparticulate controlled-release selective serotonin reuptake inhibitor formulations
JP2011019046A (ja) 2009-07-08 2011-01-27 Nec Commun Syst Ltd 通信制御装置、通信制御方法、プログラム、及び記録媒体
JP5674667B2 (ja) * 2009-08-11 2015-02-25 富士化学工業株式会社 崩壊性粒子組成物及び口腔内速崩壊錠
US9446055B2 (en) * 2009-08-11 2016-09-20 Fuji Chemical Industry Co., Ltd. Disintegrating particle composition and orally rapidly disintegrating tablet
JP5663238B2 (ja) 2009-08-31 2015-02-04 ライオン株式会社 内服固形製剤及びその製造方法
JP2011157348A (ja) * 2010-01-05 2011-08-18 Fuji Chem Ind Co Ltd 崩壊性高強度球状粒子組成物
JP5711520B2 (ja) 2010-01-06 2015-04-30 三洋化成工業株式会社 外用組成物
US20110218216A1 (en) 2010-01-29 2011-09-08 Kumaravel Vivek Extended release pharmaceutical composition of donepezil
JP2012079118A (ja) 2010-10-01 2012-04-19 Toyota Motor Corp 走行支援装置及び方法
AU2011342368B2 (en) * 2010-12-13 2016-11-17 Rite-Prep Pty Ltd Gastric and colonic formulations and methods for making and using them
IN2014DN03373A (enExample) 2011-10-27 2015-06-05 Borody Thomas J
US10166219B2 (en) * 2012-07-27 2019-01-01 Redhill Bipharma Ltd. Formulations and methods of manufacturing formulations for use in colonic evacuation
JP2015531770A (ja) 2012-08-29 2015-11-05 サリックス ファーマシューティカルズ，インコーポレイテッド 緩下剤組成物、ならびに便秘および関連胃腸疾患および症状を処置するための方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858403A (en) * 1995-11-03 1999-01-12 Borody; Thomas Julius Picosulfate-containing preparation for colonic evacuation
CN1762335A (zh) * 1997-08-22 2006-04-26 史密丝克莱恩比彻姆公司 快速崩解的甲基纤维素片剂
CN101406457A (zh) * 2007-10-12 2009-04-15 辉凌国际制药（瑞士）有限公司 制备药物产品的方法

Also Published As

Publication number Publication date
AU2013294737B2 (en) 2018-05-24
EP2877163A4 (en) 2015-12-09
PT2877163T (pt) 2019-05-24
NZ704014A (en) 2017-10-27
BR112015001640A2 (pt) 2017-07-04
TR201904884T4 (tr) 2019-05-21
ES2717282T3 (es) 2019-06-20
CY1121852T1 (el) 2020-07-31
EP2877163A2 (en) 2015-06-03
CN104797244A (zh) 2015-07-22
JP2015522652A (ja) 2015-08-06
US20150272937A1 (en) 2015-10-01
IL236791A0 (en) 2015-03-31
HRP20190550T1 (hr) 2019-05-31
US10493065B2 (en) 2019-12-03
PL2877163T3 (pl) 2019-08-30
WO2014016671A3 (en) 2014-03-13
JP6454640B2 (ja) 2019-01-16
MX2015000971A (es) 2015-07-14
SI2877163T1 (sl) 2019-06-28
IL236791B (en) 2020-08-31
US20200222375A1 (en) 2020-07-16
EP2877163B1 (en) 2019-03-20
CA2880282A1 (en) 2014-01-30
US20190240205A1 (en) 2019-08-08
CN108175773A (zh) 2018-06-19
RU2015106688A (ru) 2016-09-20
IN2015DN00637A (enExample) 2015-06-26
PH12015500165A1 (en) 2015-03-16
DK2877163T3 (en) 2019-04-15
US10166219B2 (en) 2019-01-01
HUE043852T2 (hu) 2019-09-30
WO2014016671A2 (en) 2014-01-30
MX366707B (es) 2019-07-22
CA2880282C (en) 2020-09-01
KR102152873B1 (ko) 2020-09-08
HK1212596A1 (zh) 2016-06-17
KR20150044027A (ko) 2015-04-23
US11058671B2 (en) 2021-07-13
AU2013294737A1 (en) 2015-02-05

Similar Documents

Publication Publication Date Title
CN104797244B (zh) 用于结肠排空的制剂和制备制剂方法
RU2692779C2 (ru) Фармацевтическая композиция и ее введения
US20130171199A1 (en) Controlled release pharmaceutical composition
JP2005513099A (ja) アジスロマイシンの直接的に圧縮可能な配合品
JP2021513524A (ja) 小児用ニラパリブ製剤および小児向け処置方法
JP7443543B2 (ja) 医薬組成物
CN102946857A (zh) 制备意图口服给药的包含一种或多种活性成分的药物组合物的方法以及包含其的组合物
JP2011503010A (ja) 水分封鎖剤を使用する湿式顆粒化
JP6630229B2 (ja) レベチラセタム含有医薬組成物及びその製造方法
HK1254513A1 (en) Formulations and methods of manufacturing formulations for use in colonic evacuation
JP5774308B2 (ja) 水溶性ビノレルビン塩の安定な医薬組成物
HK1212596B (en) Formulations and methods of manufacturing formulations for use in colonic evacuation
JP2009001520A (ja) ジフェンヒドラミン含有固形製剤
JP5843986B2 (ja) 粒状医薬組成物
RU2851454C1 (ru) Фармацевтическая композиция
RU2802442C2 (ru) Фармацевтическая композиция и ее введение
RU2600924C1 (ru) Способ получения фармацевтической композиции эритромицина
WO2022165339A1 (en) Novel formulation for treating copper metabolism-associated diseases or disorders
JP2023535829A (ja) コーティングされたａｐｉを含む医薬組成物
Saraiya Development and Characterization of iron Chelator Sprinkle Granules
JP2023070979A (ja) ベプリジルを含有する錠剤
JP2018177730A (ja) エリスリトールと多孔性無機物の複合体粒子及びそれを含む錠剤

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1212596

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1212596

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180309

CF01 Termination of patent right due to non-payment of annual fee