CN104685056A - 包含锁核酸基序的基于寡核苷酸的抑制剂 - Google Patents

包含锁核酸基序的基于寡核苷酸的抑制剂 Download PDF

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Publication number
CN104685056A
CN104685056A CN201380038840.0A CN201380038840A CN104685056A CN 104685056 A CN104685056 A CN 104685056A CN 201380038840 A CN201380038840 A CN 201380038840A CN 104685056 A CN104685056 A CN 104685056A
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Prior art keywords
mir
oligonucleotide
mirna
lna
sequence
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Pending
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CN201380038840.0A
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Chinese (zh)
Inventor
E.范鲁伊
C.M.多尔比
R.L.蒙哥马利
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Viridian Therapeutics Inc
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Miragen Therapeutics Inc
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Priority to CN201710249089.9A priority Critical patent/CN107236735B/zh
Publication of CN104685056A publication Critical patent/CN104685056A/zh
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CN201380038840.0A 2012-06-21 2013-06-21 包含锁核酸基序的基于寡核苷酸的抑制剂 Pending CN104685056A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710249089.9A CN107236735B (zh) 2012-06-21 2013-06-21 包含锁核酸基序的基于寡核苷酸的抑制剂

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261662746P 2012-06-21 2012-06-21
US61/662,746 2012-06-21
US201361801533P 2013-03-15 2013-03-15
US61/801,533 2013-03-15
PCT/US2013/047157 WO2013192576A2 (en) 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif

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US (3) US9388408B2 (enExample)
EP (2) EP2864482A4 (enExample)
JP (2) JP6208228B2 (enExample)
KR (1) KR101928418B1 (enExample)
CN (2) CN104685056A (enExample)
AU (1) AU2013278011B2 (enExample)
CA (1) CA2876180C (enExample)
DK (1) DK3354734T3 (enExample)
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HK (2) HK1209781A1 (enExample)
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Cited By (12)

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CN105435247A (zh) * 2015-12-31 2016-03-30 中国医学科学院基础医学研究所 miR-378在预防和/或治疗肥胖症中的用途
CN106011140A (zh) * 2016-06-06 2016-10-12 同济大学 反义microRNA-25及其应用
WO2017214953A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 一种特异抑制人 miRNA-424 表达的慢病毒载体的构建及其应用
WO2017214952A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 特异抑制人 miRNA-185 表达的慢病毒载体的构建及其应用
WO2017219170A1 (zh) * 2016-06-19 2017-12-28 毛侃琅 特异抑制人 miRNA-29a 和 miR-424 表达的慢病毒载体的构建及其应用
WO2017219165A1 (zh) * 2016-06-19 2017-12-28 毛侃琅 特异敲低人 miRNA-29a 和 miR-140 表达的慢病毒载体及其应用
WO2017219166A1 (zh) * 2016-06-19 2017-12-28 毛侃琅 一种同时抑制双 miRNA 表达的慢病毒载体及其应用
CN108025017A (zh) * 2015-09-22 2018-05-11 米拉根医疗股份有限公司 MiR-19调节剂及其用途
CN110433170A (zh) * 2019-07-31 2019-11-12 南京医科大学 心脏抽吸液miR-28-5p在心脏疾病中的应用
CN111118008A (zh) * 2020-01-16 2020-05-08 南京医科大学 Mcl1基因的3’-UTR序列及其应用
CN111918968A (zh) * 2018-03-14 2020-11-10 贝斯以色列女执事医疗中心 Micro-RNA 22的抑制剂
CN114555096A (zh) * 2019-09-25 2022-05-27 国际遗传工程和生物技术中心 用于治疗平滑肌瘤的抗miRNA

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CN103620035B (zh) 2011-04-25 2021-04-23 赛诺菲 用于调节mir-21活性的微rna化合物以及方法
BR112014026639A8 (pt) 2012-04-25 2018-01-16 Regulus Therapeutics Inc compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto.
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EP2757157A1 (en) * 2013-01-17 2014-07-23 Ecole Polytechnique Federale de Lausanne (EPFL) Modulation of mitophagy and use thereof
CN105188715B (zh) 2013-03-15 2018-12-25 米拉根医疗股份有限公司 Mir-145的锁定核酸抑制剂及其用途
NZ630890A (en) 2013-05-01 2017-09-29 Regulus Therapeutics Inc Microrna compounds and methods for modulating mir-122
AR101449A1 (es) * 2014-08-04 2016-12-21 Miragen Therapeutics Inc Inhibidores de myh7b y usos de los mismos
JP2017523790A (ja) 2014-08-07 2017-08-24 レグルス セラピューティクス インコーポレイテッド 代謝障害のためのマイクロｒｎａの標的化
WO2016069717A1 (en) * 2014-10-28 2016-05-06 MiRagen Therapeutics, Inc. Inhibitors of mirnas in regulation of arterial stiffness and uses thereof
SG11201705907XA (en) * 2015-01-20 2017-08-30 Miragen Therapeutics Inc Mir-92 inhibitors and uses thereof
US10538769B2 (en) 2015-09-04 2020-01-21 Oregon State University Renal selective inhibition of cytochrome P450 3A5
EP3985116A1 (en) * 2015-10-15 2022-04-20 City of Hope Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
US10357543B2 (en) 2015-11-16 2019-07-23 Ohio State Innovation Foundation Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein
EP3449001B1 (en) 2016-04-29 2021-12-08 Aptamir Therapeutics, Inc. Inhibition of mir-22 mirna by apt-110
EP3481404A4 (en) * 2016-07-07 2020-03-25 Miragen Therapeutics, Inc. METHODS OF TREATING SKIN T LYMPHOMA (CT) WITH MIR-155 INHIBITORS
CN109891245B (zh) 2016-08-12 2023-05-05 美国创新免疫科技有限公司 自身免疫疾病的诊断、预防和/或治疗
CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体
WO2018183127A1 (en) * 2017-03-25 2018-10-04 MiRagen Therapeutics, Inc. Mir-92 inhibitors for treatment of heart failure
CN110141577A (zh) * 2018-02-13 2019-08-20 上海三炬生物科技有限公司 miRNA-24-3p核苷酸类似物在制备药物中的应用
WO2019217369A1 (en) 2018-05-08 2019-11-14 Regulus Therapeutics Inc. Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect
US20220056443A1 (en) * 2018-09-06 2022-02-24 Aptamir Therapeutics, Inc. Metabolic benefits of short mir-22 mirna antagomir therapies
CN110358769A (zh) * 2019-07-30 2019-10-22 中国医学科学院血液病医院(中国医学科学院血液学研究所) 经锁核酸和硫代磷酸修饰的miRNA类似物及其在制备抗肿瘤药物中的应用
US20220395587A1 (en) * 2019-11-15 2022-12-15 Duke University Cellular molecular theranostics nanoprobe systems and methods
WO2021178344A1 (en) * 2020-03-04 2021-09-10 The Trustees Of Indiana University Methods to re-engage a fetal wound healing pathway for adult skin repair
EP4185694A1 (en) * 2020-07-23 2023-05-31 Johann Wolfgang Goethe-Universität Frankfurt Combinatorial inhibition of mirnas for treatment of heart failure
CN116801916A (zh) * 2021-01-18 2023-09-22 礼赞伊诺制药株式会社 包含miR 145抑制剂作为有效成分的用于治疗心肌梗塞的组合物
CN120584186A (zh) 2023-02-07 2025-09-02 特罗姆瑟大学-挪威北极圈大学 用于在静脉血栓栓塞的治疗中使用的药物组合物
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WO2025008641A2 (en) * 2023-07-06 2025-01-09 Imperial College Innovations Limited Rna molecule
WO2025104709A1 (en) * 2023-11-17 2025-05-22 Biorchestra Co., Ltd. Microrna-378a-3p antisense oligonucleotides and uses thereof

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