HK1209781A1 - Oligonucleotide-based inhibitors comprising locked nucleic acid motif - Google Patents

Oligonucleotide-based inhibitors comprising locked nucleic acid motif Download PDF

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Publication number
HK1209781A1
HK1209781A1 HK15110337.4A HK15110337A HK1209781A1 HK 1209781 A1 HK1209781 A1 HK 1209781A1 HK 15110337 A HK15110337 A HK 15110337A HK 1209781 A1 HK1209781 A1 HK 1209781A1
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HK
Hong Kong
Prior art keywords
oligonucleotides
chemically modified
oligonucleotide
locked nucleic
nucleic acid
Prior art date
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HK15110337.4A
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English (en)
Chinese (zh)
Inventor
Eva Van Rooij
Christina M. DALBY
Rusty L. Montgomery
Original Assignee
MiRagen Therapeutics, Inc.
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Filing date
Publication date
Application filed by MiRagen Therapeutics, Inc. filed Critical MiRagen Therapeutics, Inc.
Publication of HK1209781A1 publication Critical patent/HK1209781A1/xx

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK15110337.4A 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif HK1209781A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261662746P 2012-06-21 2012-06-21
US201261662746P 2012-06-21
US201361801533P 2013-03-15 2013-03-15
US201361801533P 2013-03-15
PCT/US2013/047157 WO2013192576A2 (en) 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK19101763.2A Division HK1259394A1 (en) 2012-06-21 2015-10-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK19101763.2A Addition HK1259394A1 (en) 2012-06-21 2015-10-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif

Publications (1)

Publication Number Publication Date
HK1209781A1 true HK1209781A1 (en) 2016-04-08

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Application Number Title Priority Date Filing Date
HK15110337.4A HK1209781A1 (en) 2012-06-21 2013-06-21 Oligonucleotide-based inhibitors comprising locked nucleic acid motif
HK18103977.1A HK1244509A1 (zh) 2012-06-21 2018-03-22 包含锁核酸基序的基於寡核苷酸的抑制剂

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HK18103977.1A HK1244509A1 (zh) 2012-06-21 2018-03-22 包含锁核酸基序的基於寡核苷酸的抑制剂

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US (3) US9388408B2 (enExample)
EP (2) EP2864482A4 (enExample)
JP (2) JP6208228B2 (enExample)
KR (1) KR101928418B1 (enExample)
CN (2) CN104685056A (enExample)
AU (1) AU2013278011B2 (enExample)
CA (1) CA2876180C (enExample)
DK (1) DK3354734T3 (enExample)
ES (1) ES2801875T3 (enExample)
HK (2) HK1209781A1 (enExample)
MX (1) MX355408B (enExample)
WO (1) WO2013192576A2 (enExample)

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