CN104086399A - 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 - Google Patents
5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 Download PDFInfo
- Publication number
- CN104086399A CN104086399A CN201410313214.4A CN201410313214A CN104086399A CN 104086399 A CN104086399 A CN 104086399A CN 201410313214 A CN201410313214 A CN 201410313214A CN 104086399 A CN104086399 A CN 104086399A
- Authority
- CN
- China
- Prior art keywords
- bromo
- alpha
- amyl group
- phenylformic acid
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/70—Monocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
药物 | 剂量(mg/kg) | n | 水肿(%) | 水肿抑制率(%) |
假手术组 | 0 | 0 | ||
模型组 | 10 | 13.66±3.46 | ||
BZP(无定型) | 20 | 10 | 2.24±1.66aa** | 88.36 |
BZP(晶型A) | 20 | 10 | 2.7±1.30aa** | 87.55 |
BZP(晶型B) | 20 | 10 | 2.87±1.56 aa** | 85.09 |
NBP-K | 15.9 | 10 | 11.04±1.48 aa** | 42.65 |
药物 | 水中溶解度(g/mL) | 稳定性(h,小时) | 甲醇溶解度(g/mL) | 稳定性(h,小时) |
BZP(无定型) | 2.98 | >24 | 1.89 | >24 |
BZP(晶型A) | 2.36 | >20 | 1.80 | >24 |
BZP(晶型B) | 2.43 | >24 | 1.63 | >24 |
BZP(混合物) | 2.13 | >12 | 1.58 | >12 |
Claims (7)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410313214.4A CN104086399B (zh) | 2013-07-17 | 2014-07-03 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
CN201480040408.XA CN105517988B (zh) | 2013-07-17 | 2014-07-10 | 5‑溴‑2‑(α‑羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
KR1020217008672A KR102279367B1 (ko) | 2013-07-17 | 2014-07-10 | 상이한 결정형의 5-브로모-2-(α-하이드록시펜틸)벤조산 나트륨 염 및 그의 제조 방법 |
RU2018102357A RU2738374C1 (ru) | 2013-07-17 | 2014-07-10 | Натриевая соль 5-бром-2-(альфа-гидроксипентил)бензойной кислоты |
PCT/CN2014/081954 WO2015007181A1 (zh) | 2013-07-17 | 2014-07-10 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
SI201431955T SI3023410T1 (sl) | 2013-07-17 | 2014-07-10 | Natrijeve soli 5-bromo-2-(alfa-hodroksipentil)benzojske kisline v različnih kristalnih oblikah in postopek njihove priprave |
HUE14826150A HUE058690T2 (hu) | 2013-07-17 | 2014-07-10 | 5-bróm-2-(alfa-hidroxipentil)benzoesav-nátriumsók különbözõ kristályformákban és eljárás ezek elõállítására |
KR1020167003719A KR102279371B1 (ko) | 2013-07-17 | 2014-07-10 | 상이한 결정형의 5-브로모-2-(α-하이드록시펜틸)벤조산 나트륨 염 및 그의 제조 방법 |
LTEPPCT/CN2014/081954T LT3023410T (lt) | 2013-07-17 | 2014-07-10 | Įvairių kristalinių formų 5-brom-2-(alfa-hidroksipentil)benzenkarboksirūgšties natrio druskos ir jų gamybos būdas |
DK14826150.6T DK3023410T3 (da) | 2013-07-17 | 2014-07-10 | 5-BROM-2-(alfa-HYDROXYPENTYL)BENZOESYRE-NATRIUMSALTE I FORSKELLIGE KRYSTALFORMER OG FREMSTILLINGSMETODE DERAF |
ES14826150T ES2913338T3 (es) | 2013-07-17 | 2014-07-10 | Sales de sodio de ácido 5-bromo-2-(alfa-hidroxipentil)benzoico en diferentes formas cristalinas, y método de preparación de las mismas |
RU2016101132A RU2643802C2 (ru) | 2013-07-17 | 2014-07-10 | НАТРИЕВАЯ СОЛЬ 5-БРОМ-2-(α-ГИДРОКСИПЕНТИЛ)БЕНЗОЙНОЙ КИСЛОТЫ В РАЗЛИЧНЫХ КРИСТАЛЛИЧЕСКИХ ФОРМАХ И СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ |
US14/905,199 US9902682B2 (en) | 2013-07-17 | 2014-07-10 | 5-bromo-2-(alpha-hydroxypentyl)benzoic acid sodium salts in different crystal forms, and preparation method thereof |
PT148261506T PT3023410T (pt) | 2013-07-17 | 2014-07-10 | Sais de sódio do ácido 5-bromo-2-(alfa-hidroxipentil)benzoico em diferentes formas de cristal e método de preparação do mesmo |
EP14826150.6A EP3023410B1 (en) | 2013-07-17 | 2014-07-10 | 5-BROMINE-2-(alpha-HYDROXYPENTYL)BENZOIC ACID SODIUM SALTS IN DIFFERENT CRYSTAL FORMS, AND PREPARATION METHOD THEREOF |
HRP20220665TT HRP20220665T1 (hr) | 2013-07-17 | 2014-07-10 | Natrijeve soli 5-brom-2-(alfa-hidroksipentil)benzojeve kiseline u različitim kristalnim oblicima i postupak njihove pripreme |
PL14826150T PL3023410T3 (pl) | 2013-07-17 | 2014-07-10 | Sole sodowe kwasu 5-bromo-2-(alfa-hydroksypentylo)benzoesowego w różnych postaciach krystalicznych i sposób ich wytwarzania |
RS20220486A RS63249B1 (sr) | 2013-07-17 | 2014-07-10 | 5-brom-2-(alfa-hidroksipentil)benzoova kiselina natrijum soli u različitim oblicima kristala i način njihove pripreme |
JP2016526427A JP6483674B2 (ja) | 2013-07-17 | 2014-07-10 | 5−ブロモ−2−(α−ヒドロキシペンチル)安息香酸ナトリウム塩の複数の異なる結晶型及びそれらの調製方法 |
US15/660,395 US10377693B2 (en) | 2013-07-17 | 2017-07-26 | 5-bromo-2-(α-hydroxypentyl)benzoic acid sodium salts in different crystal forms, and preparation method thereof |
US16/288,863 US11148991B2 (en) | 2013-07-17 | 2019-02-28 | 5-bromo-2-(alpha-hydroxypentyl)benzoic acid sodium salts in different crystal forms, and preparation method thereof |
US16/452,905 US10604471B2 (en) | 2013-07-17 | 2019-06-26 | 5-bromo-2-(alpha-hydroxypentyl)benzoic acid sodium salts in different crystal forms, and preparation method thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013102990849 | 2013-07-17 | ||
CN201310299084.9 | 2013-07-17 | ||
CN201310299084 | 2013-07-17 | ||
CN201410313214.4A CN104086399B (zh) | 2013-07-17 | 2014-07-03 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104086399A true CN104086399A (zh) | 2014-10-08 |
CN104086399B CN104086399B (zh) | 2016-08-24 |
Family
ID=51634190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410313214.4A Active CN104086399B (zh) | 2013-07-17 | 2014-07-03 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
CN201480040408.XA Active CN105517988B (zh) | 2013-07-17 | 2014-07-10 | 5‑溴‑2‑(α‑羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480040408.XA Active CN105517988B (zh) | 2013-07-17 | 2014-07-10 | 5‑溴‑2‑(α‑羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
Country Status (16)
Country | Link |
---|---|
US (4) | US9902682B2 (zh) |
EP (1) | EP3023410B1 (zh) |
JP (1) | JP6483674B2 (zh) |
KR (2) | KR102279371B1 (zh) |
CN (2) | CN104086399B (zh) |
DK (1) | DK3023410T3 (zh) |
ES (1) | ES2913338T3 (zh) |
HR (1) | HRP20220665T1 (zh) |
HU (1) | HUE058690T2 (zh) |
LT (1) | LT3023410T (zh) |
PL (1) | PL3023410T3 (zh) |
PT (1) | PT3023410T (zh) |
RS (1) | RS63249B1 (zh) |
RU (2) | RU2643802C2 (zh) |
SI (1) | SI3023410T1 (zh) |
WO (1) | WO2015007181A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105517988A (zh) * | 2013-07-17 | 2016-04-20 | 浙江奥翔药业股份有限公司 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
WO2018126897A1 (zh) * | 2017-01-06 | 2018-07-12 | 郑州大学 | 5-溴-2-(α-羟基戊基)苯甲酸钠在治疗心血管疾病药物中的应用 |
CN109223749A (zh) * | 2018-11-14 | 2019-01-18 | 郑州大学 | 5- 溴-2-(α- 羟基戊基)苯甲酸钠盐在治疗心肌肥厚和心力衰竭中的药物用途 |
CN109776466A (zh) * | 2018-03-19 | 2019-05-21 | 河南真实生物科技有限公司 | 苯甲酸类化合物及其制备方法和应用 |
WO2019218864A1 (zh) | 2018-05-17 | 2019-11-21 | 四川大学 | 一种2-(α羟基戊基)苯甲酸的有机胺酯衍生物药物 |
CN111943898A (zh) * | 2019-05-17 | 2020-11-17 | 浙江大学 | 苯联四氮唑类衍生物、制备、含其的药物组合物及其应用 |
WO2021185356A1 (zh) | 2020-03-20 | 2021-09-23 | 石药集团恩必普药业有限公司 | 丁基苯酞及其衍生物的用途 |
WO2022095965A1 (zh) * | 2020-11-06 | 2022-05-12 | 浙江大学 | 四氮唑类衍生物、制备、含其的药物组合物及其应用 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230398087A1 (en) * | 2020-10-30 | 2023-12-14 | Zhejiang Ausun Pharmaceutical Co., Ltd. | Application of bzp in treatment of ischemic cardiovascular and cerebral vascular diseases |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1523003A (zh) * | 2003-09-01 | 2004-08-25 | 北京天衡药物研究院 | 新的2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN1594270A (zh) * | 2004-06-17 | 2005-03-16 | 北京天衡药物研究院 | 新的L-2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN101054346A (zh) * | 2006-04-13 | 2007-10-17 | 温建波 | 一组新化合物及其组合物的制备方法和用途 |
CN101402565A (zh) * | 2008-11-14 | 2009-04-08 | 郑州大学 | 卤代2-(a-羟基戊基)苯甲酸盐及其制法和用途 |
CN103113210A (zh) * | 2013-02-19 | 2013-05-22 | 石药集团中奇制药技术(石家庄)有限公司 | 羟戊基苯甲酸钾晶体及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1243541C (zh) | 2002-05-09 | 2006-03-01 | 中国医学科学院药物研究所 | 2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
RU2305092C2 (ru) * | 2002-05-09 | 2007-08-27 | Инститьют Оф Материя Медика, Чайниз Экедеми Оф Медикал Сайенсез | НОВЫЕ 2-(α-ГИДРОКСИПЕНТИЛ)БЕНЗОАТЫ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ |
CN100554259C (zh) | 2007-04-12 | 2009-10-28 | 郑州大学 | 2-苯并[c]呋喃酮化合物及其应用 |
CN104086399B (zh) * | 2013-07-17 | 2016-08-24 | 浙江奥翔药业股份有限公司 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
-
2014
- 2014-07-03 CN CN201410313214.4A patent/CN104086399B/zh active Active
- 2014-07-10 EP EP14826150.6A patent/EP3023410B1/en active Active
- 2014-07-10 PL PL14826150T patent/PL3023410T3/pl unknown
- 2014-07-10 WO PCT/CN2014/081954 patent/WO2015007181A1/zh active Application Filing
- 2014-07-10 HR HRP20220665TT patent/HRP20220665T1/hr unknown
- 2014-07-10 RU RU2016101132A patent/RU2643802C2/ru active
- 2014-07-10 SI SI201431955T patent/SI3023410T1/sl unknown
- 2014-07-10 RS RS20220486A patent/RS63249B1/sr unknown
- 2014-07-10 CN CN201480040408.XA patent/CN105517988B/zh active Active
- 2014-07-10 JP JP2016526427A patent/JP6483674B2/ja active Active
- 2014-07-10 KR KR1020167003719A patent/KR102279371B1/ko active IP Right Grant
- 2014-07-10 DK DK14826150.6T patent/DK3023410T3/da active
- 2014-07-10 LT LTEPPCT/CN2014/081954T patent/LT3023410T/lt unknown
- 2014-07-10 KR KR1020217008672A patent/KR102279367B1/ko active IP Right Grant
- 2014-07-10 ES ES14826150T patent/ES2913338T3/es active Active
- 2014-07-10 HU HUE14826150A patent/HUE058690T2/hu unknown
- 2014-07-10 US US14/905,199 patent/US9902682B2/en active Active
- 2014-07-10 RU RU2018102357A patent/RU2738374C1/ru active
- 2014-07-10 PT PT148261506T patent/PT3023410T/pt unknown
-
2017
- 2017-07-26 US US15/660,395 patent/US10377693B2/en active Active
-
2019
- 2019-02-28 US US16/288,863 patent/US11148991B2/en active Active
- 2019-06-26 US US16/452,905 patent/US10604471B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1523003A (zh) * | 2003-09-01 | 2004-08-25 | 北京天衡药物研究院 | 新的2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN1594270A (zh) * | 2004-06-17 | 2005-03-16 | 北京天衡药物研究院 | 新的L-2-(α-羟基戊基)苯甲酸盐及其制法和用途 |
CN101054346A (zh) * | 2006-04-13 | 2007-10-17 | 温建波 | 一组新化合物及其组合物的制备方法和用途 |
CN101402565A (zh) * | 2008-11-14 | 2009-04-08 | 郑州大学 | 卤代2-(a-羟基戊基)苯甲酸盐及其制法和用途 |
CN103113210A (zh) * | 2013-02-19 | 2013-05-22 | 石药集团中奇制药技术(石家庄)有限公司 | 羟戊基苯甲酸钾晶体及其制备方法 |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105517988A (zh) * | 2013-07-17 | 2016-04-20 | 浙江奥翔药业股份有限公司 | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
CN105517988B (zh) * | 2013-07-17 | 2017-04-12 | 浙江奥翔药业股份有限公司 | 5‑溴‑2‑(α‑羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 |
WO2018126897A1 (zh) * | 2017-01-06 | 2018-07-12 | 郑州大学 | 5-溴-2-(α-羟基戊基)苯甲酸钠在治疗心血管疾病药物中的应用 |
CN108283633A (zh) * | 2017-01-06 | 2018-07-17 | 郑州大学 | 5-溴-2-(α-羟基戊基)苯甲酸钠在治疗心血管疾病药物中的应用 |
CN109776466A (zh) * | 2018-03-19 | 2019-05-21 | 河南真实生物科技有限公司 | 苯甲酸类化合物及其制备方法和应用 |
CN109776466B (zh) * | 2018-03-19 | 2023-01-31 | 河南真实生物科技有限公司 | 苯甲酸类化合物及其制备方法和应用 |
WO2019218864A1 (zh) | 2018-05-17 | 2019-11-21 | 四川大学 | 一种2-(α羟基戊基)苯甲酸的有机胺酯衍生物药物 |
CN109223749A (zh) * | 2018-11-14 | 2019-01-18 | 郑州大学 | 5- 溴-2-(α- 羟基戊基)苯甲酸钠盐在治疗心肌肥厚和心力衰竭中的药物用途 |
CN111943898A (zh) * | 2019-05-17 | 2020-11-17 | 浙江大学 | 苯联四氮唑类衍生物、制备、含其的药物组合物及其应用 |
WO2021185356A1 (zh) | 2020-03-20 | 2021-09-23 | 石药集团恩必普药业有限公司 | 丁基苯酞及其衍生物的用途 |
WO2022095965A1 (zh) * | 2020-11-06 | 2022-05-12 | 浙江大学 | 四氮唑类衍生物、制备、含其的药物组合物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
US10377693B2 (en) | 2019-08-13 |
HUE058690T2 (hu) | 2022-09-28 |
SI3023410T1 (sl) | 2022-06-30 |
ES2913338T3 (es) | 2022-06-01 |
PL3023410T3 (pl) | 2022-06-06 |
US20160168069A1 (en) | 2016-06-16 |
RS63249B1 (sr) | 2022-06-30 |
RU2738374C1 (ru) | 2020-12-11 |
US9902682B2 (en) | 2018-02-27 |
KR102279371B1 (ko) | 2021-07-20 |
US20190194116A1 (en) | 2019-06-27 |
CN104086399B (zh) | 2016-08-24 |
EP3023410B1 (en) | 2022-02-23 |
KR102279367B1 (ko) | 2021-07-20 |
DK3023410T3 (da) | 2022-05-23 |
JP2016528210A (ja) | 2016-09-15 |
US10604471B2 (en) | 2020-03-31 |
US20190315673A1 (en) | 2019-10-17 |
US20180127349A1 (en) | 2018-05-10 |
KR20210035336A (ko) | 2021-03-31 |
EP3023410A4 (en) | 2017-02-08 |
RU2016101132A (ru) | 2017-08-22 |
LT3023410T (lt) | 2022-09-12 |
KR20160031004A (ko) | 2016-03-21 |
EP3023410A1 (en) | 2016-05-25 |
WO2015007181A1 (zh) | 2015-01-22 |
CN105517988A (zh) | 2016-04-20 |
US11148991B2 (en) | 2021-10-19 |
HRP20220665T1 (hr) | 2022-06-24 |
CN105517988B (zh) | 2017-04-12 |
RU2643802C2 (ru) | 2018-02-06 |
PT3023410T (pt) | 2022-06-28 |
JP6483674B2 (ja) | 2019-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104086399A (zh) | 5-溴-2-(α-羟基戊基)苯甲酸钠盐的不同晶型及其制备方法 | |
CN103221414B (zh) | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 | |
CN101402565B (zh) | 卤代2-(a-羟基戊基)苯甲酸盐及其制法和用途 | |
AU2015365348B2 (en) | Processes for preparing oxathiazin-like compounds | |
CN102249975A (zh) | (s)-4-羟基-2-氧代-1-吡咯烷乙酰胺晶型ⅰ及其制备方法和用途 | |
CN101747405A (zh) | 小檗碱甘草酸对映体盐及其制备方法和用途 | |
CN101289438B (zh) | 3-(3'-羟基)-丁基苯酞酯及其制法和用途 | |
CN105753701A (zh) | 一种双效麻醉药物及其制备方法和用途 | |
CN102382133B (zh) | 一种磷丙泊酚钠的制备及纯化方法 | |
CN104211757A (zh) | N(2)-l-丙氨酰-l-谷氨酰胺新晶型及其制备方法 | |
CN107556167A (zh) | 一种麻醉类化合物及其制备方法和用途 | |
CN111747960A (zh) | 一种取代吡唑[3,4-d]嘧啶类化合物及其制备方法和应用 | |
CN103739576A (zh) | 一种新型抗病毒穿心莲内酯衍生物及其制备方法和应用 | |
CN104188979B (zh) | 闭花木酮Cleistanone的O-(吗啉基)乙基衍生物在制备治疗缺血性脑损伤药物中的应用 | |
CN114748496B (zh) | 吉西他滨增敏剂 | |
CN107935848A (zh) | 一种六茜素衍生物及其制备方法和应用 | |
CN101659629A (zh) | 鱼腥草素类高水溶性、稳定性前体药物及其制备方法与运用 | |
CN101624360B (zh) | 取代的有机硫化合物及其用途 | |
CN106474117A (zh) | Ternatusine A在制备治疗急性痛风药物中的应用 | |
CN106074531A (zh) | 阿掏比克酸三唑基与1h‑四氮唑基衍生物的组合物用于制备抗急性痛风药物 | |
CN106074520A (zh) | Artalbic acid衍生物的组合物用于制备抗急性痛风药物 | |
CN106074534A (zh) | 阿掏比克酸三唑基与1h‑四氮唑基衍生物的组合物用于制备抗急性肾衰药物 | |
CN104490897A (zh) | 闭花木酮的o-(咪唑基)乙基衍生物在制备治疗缺血性脑损伤药物中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHENGZHOU UNIVERSITY Effective date: 20150330 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 450001 ZHENGZHOU, HENAN PROVINCE TO: 317016 TAIZHOU, ZHEJIANG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20150330 Address after: 317016 Zhejiang chemical raw materials base in the East China Sea Park Road, No. fourth, No. 5 Applicant after: Zhejiang Ao Xiang medicine company limited-liability company Address before: 450001 science and technology zone, Zhengzhou, Henan, No. 100 Applicant before: Zhengzhou University |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |