CN103974930B - 高纯度神经酰胺类的制造方法 - Google Patents

高纯度神经酰胺类的制造方法 Download PDF

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Publication number
CN103974930B
CN103974930B CN201280059943.0A CN201280059943A CN103974930B CN 103974930 B CN103974930 B CN 103974930B CN 201280059943 A CN201280059943 A CN 201280059943A CN 103974930 B CN103974930 B CN 103974930B
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China
Prior art keywords
carbon atoms
ceramide
group
purity
general formula
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Expired - Fee Related
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CN201280059943.0A
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English (en)
Chinese (zh)
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CN103974930A (zh
Inventor
石田贤哉
八木健司
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Shanghai Takasago Union Fragrances & Flavors Co ltd
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Takasago International Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
CN201280059943.0A 2011-12-22 2012-11-07 高纯度神经酰胺类的制造方法 Expired - Fee Related CN103974930B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-281654 2011-12-22
JP2011281654A JP5825672B2 (ja) 2011-12-22 2011-12-22 高純度セラミド類の製造方法
PCT/JP2012/007122 WO2013094108A1 (ja) 2011-12-22 2012-11-07 高純度セラミド類の製造方法

Publications (2)

Publication Number Publication Date
CN103974930A CN103974930A (zh) 2014-08-06
CN103974930B true CN103974930B (zh) 2016-09-28

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CN201280059943.0A Expired - Fee Related CN103974930B (zh) 2011-12-22 2012-11-07 高纯度神经酰胺类的制造方法

Country Status (6)

Country Link
US (1) US9079826B2 (https=)
EP (1) EP2796444B1 (https=)
JP (1) JP5825672B2 (https=)
CN (1) CN103974930B (https=)
IN (1) IN2014MN01086A (https=)
WO (1) WO2013094108A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6232008B2 (ja) 2015-03-19 2017-11-15 国立大学法人北海道大学 酸化抑制剤及びこれを用いた油脂含有飲食品
CN112759535B (zh) * 2019-11-01 2024-04-05 广东东阳光药业股份有限公司 一种pf-06651600中间体的制备方法
CN119013246A (zh) 2022-02-21 2024-11-22 柯泰亚生物科技(上海)有限公司 鞘脂生产
WO2024189590A1 (en) * 2023-03-16 2024-09-19 Cataya Bio (Shanghai) Co. Production of ceramides
CN121219259A (zh) 2023-05-29 2025-12-26 柯泰亚生物科技(上海)有限公司 脂质共混物
CN117567310A (zh) * 2023-11-28 2024-02-20 重庆智合生物医药有限公司 一种神经酰胺np1的合成方法
CN117567311A (zh) * 2023-11-28 2024-02-20 重庆智合生物医药有限公司 一种高效制备α-羟基脂肪酸神经酰胺的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831125A (en) * 1996-10-11 1998-11-03 Takasago International Corporation Method of making primary amide derivative
WO2008041571A1 (en) * 2006-09-26 2008-04-10 Kaneka Corporation Process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid ester

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692349B2 (ja) 1986-03-06 1994-11-16 和光純薬工業株式会社 光学活性不飽和アミノアルコール誘導体の新規な製法
AU2135095A (en) 1994-03-18 1995-10-09 Gist-Brocades B.V. Linoleoylamide based ceramide derivative and its use in cosmetic preparations for the treatment of dry skin
EP0688871A3 (en) 1994-06-24 1998-07-08 Quest International B.V. Preparation of phytosphingosine derivative
FR2732680B1 (fr) 1995-04-05 1997-05-09 Oreal Composes de type ceramides, leur procede de preparation et leur utilisation
JP3148136B2 (ja) 1996-12-26 2001-03-19 高砂香料工業株式会社 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒
JP3485232B2 (ja) 1997-01-31 2004-01-13 高砂香料工業株式会社 光学活性化合物及びその製造方法
JP3549390B2 (ja) 1998-03-23 2004-08-04 高砂香料工業株式会社 ルテニウム−ホスフィン錯体及びその製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831125A (en) * 1996-10-11 1998-11-03 Takasago International Corporation Method of making primary amide derivative
WO2008041571A1 (en) * 2006-09-26 2008-04-10 Kaneka Corporation Process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid ester

Also Published As

Publication number Publication date
EP2796444A4 (en) 2015-12-16
US20140364649A1 (en) 2014-12-11
JP2013129640A (ja) 2013-07-04
JP5825672B2 (ja) 2015-12-02
WO2013094108A1 (ja) 2013-06-27
IN2014MN01086A (https=) 2015-07-03
CN103974930A (zh) 2014-08-06
EP2796444B1 (en) 2017-03-15
US9079826B2 (en) 2015-07-14
EP2796444A1 (en) 2014-10-29

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C06 Publication
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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20170519

Address after: No. 456, Yi Yi Road, Shanghai, Pudong New Area

Patentee after: Shanghai Takasago-Union Fragrances & Flavors Co.,Ltd.

Address before: Tokyo, Japan

Patentee before: TAKASAGO INTERNATIONAL Corp.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160928